The role of non-coding RNAs in biology:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London
Portland Press
2013
|
| Series: | Essays in biochemistry
54 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XVIII, 150 S. Ill., graph. Darst. |
| ISBN: | 9781855781900 |
Staff View
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Record in the Search Index
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| adam_text | A
ESSAYS IN BIOCHEMISTRY
it L
volume 54 2013
The Role of Non-Coding
RNAs in Biology
Edited by Mark A Lindsay and
Sam Griffiths-Jones
J
Series Editor
Nigel Hooper (Leeds, U K )
Advisory Board
G Banting (Bristol, U K )
E Blair (Leeds, U K )
P Brookes (Rochester, NY, USA)
S Gutteridge (Newark, DE, USA)
J Pearson (London, U K )
J Rossjohn (Melbourne, Australia)
E Shephard (London, U K )
J Tavare (Bristol, U K )
C Tournier (Manchester, U K )
portlandpresslimited
publishing innovation
Preface ix
Authors xi
Abbreviations xv
IThe dark matter rises: the expanding world of regulatory RNAs
Michael B Clark, Anupma Choudhary, Martin A Smith,
Ryan J Taft and John S Mattick
Abstract 1
Introduction 2
The animal genome and the non-coding universe 2
Small ncRNAs 3
IncRNAs (long ncRNAs) 6
Regulatory RNAs in prokaryotes 7
The role of ncRNAs in evolutionary innovation 8
Conclusions 9
Summary 9
References 10
2 Biogenesis and the regulation of the maturation of miRNAs
Nham Tran and Gyorgy Hutvagner
Abstract 17
Introduction 18
Transcription and processing of pri-miRNAs (primary miRNAs)
in the nucleus 18
Regulation of pri-miRNA processing 19
Pre-miRNA processing in the cytoplasm 19
Regulation of pre-miRNA processing 20
Loading and activation of miRNAs 20
Regulation of mature miRNA stability 21
Alternative pathways for miRNA biogenesis 21
sno-miRNAs [snoRNA (small nucleolar RNA)-derived miRNAs] 23
Virus-derived miRNAs 24
Conclusion 24
Summary 25
References 25
© 2013 Biochemical Society
vi Essays in Biochemistry volume 54 2013
3 Mechanism of miRNA-mediated repression of mRNA translation
Tamas Dalmay
Abstract 29
Introduction 29
Target recognition 30
Animal miRNAs repress translation 30
Animal miRNAs cause target degradation 31
Plant miRNAs repress translation 33
Plant miRNAs cleave target mRNAs 34
Conclusions 36
Summary 36
References 37
4Piwi-interacting RNAs: biological functions and biogenesis
Kaoru Sato and Mikiko C Siomi
Abstract 39
Introduction 40
Targets of piRNA-mediated silencing 40
pif^NA biogenesis 41
p,iRNA pathway factors in Drosophila 44
the possible role(s) of piRNAs in cancer 48
Conclusions 49
Summary : 49
References 49
5 Small nucleolar RNAs and RNA-guided post-transcriptional modification
i Lauren Lui and Todd Lowe
Abstract 53
Introduction 54
Composition and structure of snoRNPs 56
Functions of snoRNAs beyond ribosomal processing and modification 58
Diversity in expression and organization among species 61
Computational search methods and databases 62
snoRNP biogenesis 67
Conclusions 70
Summary 70
References 70
© The Authors Journal compilation © 2013 Biochemical Society
Contents ™
6 Role of small nuclear RNAs in eukaryotic gene expression
Saba Valadkhan and Lalith S Gunawardane
Abstract 79
Introduction: the challenge of splicing and evolution
of eukaryotic snRNAs (small nuclear RNAs) 80
Roles of snRNAs in the spliceosome 82
Beyond splicing: other biological roles of snRNAs 87
Conclusion 87
Summary 88
References 88
7 The functions of natural antisense transcripts Megan Wight and Andreas Werner
Abstract 91
Introduction 91
How do NATs regulate gene expression? 93
RNA masking 93
A-to-l editing 95
RNAi (RNA interference) 95
Tl (transcriptional interference) 96
NAT-induced chromatin changes 96
NATs as drug targets 97
Is there a bigger picture? 97
Conclusions 99
Summary 99
References 100
8Pseudogenes as regulators of biological function Ryan C Pink and Dauid R F Carter
Abstract 103
Introduction 103
Transcription 105
Evidence for function 106
Antisense pairing and siRNA (small interfering RNA) production 106
Regulation of mRNA stability 108
Conclusion 109
Summary 109
References 110
© 2013 Biochemical Society
viii Essays in Biochemistry volume 54 2013
9 Identification and function of long non-coding RNAs Robert S Young and Chris P Ponting
Abstract 113
Introduction 113
lincRNA identification 115
Genome-wide indicators of lincRNA functionality 116
IncRNA molecular mechanisms 117
lincRNAs have been implicated in diverse human diseases 121
Conclusions 122
Summary 122
References 123
^ Therapeutic targeting of non-coding RNAs
^ Thomas C Roberts and Matthew J A Wood
Abstract 127
Introduction 128
miRNAs 128
miRNA therapeutics 128
miRNA antagonism 128
miRNA replacement therapy 132
miRNA-mediated transgene inactivation 132
IncFJNAs 132
IncRNA function 133
IncRNA in disease 135
Cross-talk between short and long RNAs 137
Conclusions 138
Summary 140
References 140
i Index 147
©The Authors Journal compilation © 2013 Biochemical Society
|
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| spelling | The role of non-coding RNAs in biology ed. by Mark A. Lindsay ... London Portland Press 2013 XVIII, 150 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Essays in biochemistry 54 Non-coding RNA (DE-588)7650051-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Non-coding RNA (DE-588)7650051-2 s b DE-604 Lindsay, Mark A. Sonstige oth Essays in biochemistry 54 (DE-604)BV026536280 54 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027431600&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | The role of non-coding RNAs in biology |
| title_auth | The role of non-coding RNAs in biology |
| title_exact_search | The role of non-coding RNAs in biology |
| title_full | The role of non-coding RNAs in biology ed. by Mark A. Lindsay ... |
| title_fullStr | The role of non-coding RNAs in biology ed. by Mark A. Lindsay ... |
| title_full_unstemmed | The role of non-coding RNAs in biology ed. by Mark A. Lindsay ... |
| title_short | The role of non-coding RNAs in biology |
| title_sort | the role of non coding rnas in biology |
| topic | Non-coding RNA (DE-588)7650051-2 gnd |
| topic_facet | Non-coding RNA Aufsatzsammlung |
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