Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Electronic eBook |
| Language: | English |
| Published: |
Dordrecht [u.a.]
Springer
2014
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| Series: | Springer Theses
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| Subjects: | |
| Online Access: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource |
| ISBN: | 9789401788199 |
| DOI: | 10.1007/978-94-017-8819-9 |
Staff View
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Record in the Search Index
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| adam_text | STUDIES OF PLURIPOTENCY IN EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT
STEM CELLS
/ ZHAO, XIAOYANG
: 2014
TABLE OF CONTENTS / INHALTSVERZEICHNIS
ABSTRACT
INTRODUCTION
ESTABLISHMENT OF HIGHLY EFFICIENT SOMATIC CELL REPROGRAMMING SYSTEM TO
GENERATE IPSC LINES- ESTABLISHMENT OF HIGHLY EFFICIENT SOMATIC CELL
REPROGRAMMING SYSTEM AND ESTABLISHMENT OF IPSC LINES
PLURIPOTENCY OF IPSC AND UNDERLINING MECHANISM
DEVELOPMENTAL POTENTIAL OF MOUSE IPSC
CONCLUSIONS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
STUDIES OF PLURIPOTENCY IN EMBRYONIC STEM CELLS AND INDUCED PLURIPOTENT
STEM CELLS
/ ZHAO, XIAOYANG
: 2014
ABSTRACT / INHALTSTEXT
STEM CELLS HAVE THE ABILITY TO DIFFERENTIATE INTO ALL TYPES OF CELLS
WITHIN THE BODY, THUS HAVE GREAT THERAPEUTIC POTENTIAL FOR REGENERATIVE
MEDICINE TO TREAT COMPLICATED DISORDERS, LIKE PARKINSON’S DISEASE AND
SPINAL CORD INJURY. THERE WILL ALSO BE MANY APPLICATIONS IN DRUG
DEVELOPMENT. HOWEVER, SEVERAL ROADBLOCKS, SUCH AS SAFETY ISSUES AND LOW
EFFICIENCY OF PLURIPOTENT STEM CELL (PSC) LINE DERIVATION NEED TO BE
RESOLVED BEFORE THEIR CLINICAL APPLICATION. THIS THESIS FOCUSES ON THESE
TWO AREAS, SO AS TO FIND METHODS TO OVERCOME THE LIMITATION. IT COVERS
DERIVING EMBRYONIC STEM CELLS (ESCS) FROM SEVERAL DIFFERENT SPECIES, AND
REPORTS AN EFFICIENT SYSTEM TO GENERATE INDUCED PLURIPOTENT STEM CELLS
(IPSCS), AND THE FIRST IPSC MICE IN THE WORLD. THE RESULTS IN THIS
THESIS CONFIRM THAT SOMATIC CELLS CAN BE FULLY REPROGRAMMED WITH THE
FOUR YAMANAKA FACTORS. IN ADDITION, WE HAVE FOUND THAT THE DLK1-DIO3
REGION CAN BE A POTENTIAL MOLECULAR MARKER TO DISTINGUISH THE FULLY
REPROGRAMMED IPSCS FROM PARTIALLY REPROGRAMMED ONES. ALL OF THESE
RESULTS WILL HELP IMPROVE THE SAFETY OF PSCS IN THE CLINICAL
APPLICATIONS, AND INCREASE THE CURRENT LOW INDUCTION EFFICIENCY OF THEIR
PRODUCTION
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Zhao, Xiaoyang Verfasser aut Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells Xiaoyang Zhao Dordrecht [u.a.] Springer 2014 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Springer Theses Zugl.: Peking, University of Chinese Academy of Sciences, Diss. Biowissenschaften Life sciences Stem cells Cell culture Developmental biology Life Sciences (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Druckausgabe 978-94-017-8818-2 https://doi.org/10.1007/978-94-017-8819-9 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027361720&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027361720&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Zhao, Xiaoyang Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells Biowissenschaften Life sciences Stem cells Cell culture Developmental biology Life Sciences |
| subject_GND | (DE-588)4113937-9 |
| title | Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells |
| title_auth | Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells |
| title_exact_search | Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells |
| title_full | Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells Xiaoyang Zhao |
| title_fullStr | Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells Xiaoyang Zhao |
| title_full_unstemmed | Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells Xiaoyang Zhao |
| title_short | Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells |
| title_sort | studies of pluripotency in embryonic stem cells and induced pluripotent stem cells |
| topic | Biowissenschaften Life sciences Stem cells Cell culture Developmental biology Life Sciences |
| topic_facet | Biowissenschaften Life sciences Stem cells Cell culture Developmental biology Life Sciences Hochschulschrift |
| url | https://doi.org/10.1007/978-94-017-8819-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027361720&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027361720&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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