Outstanding marine molecules: chemistry, biology, analysis
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Wiley Blackwell
2014
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| Beschreibung: | XXII, 511 S. Ill., graph. Darst. |
| ISBN: | 9783527334650 9783527681501 |
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Datensatz im Suchindex
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CONTENTS
LIST OF CONTRIBUTORS XIII
FOREWORD
XIX
PREFACE
XXI
PART ONE OUTSTANDING MARINE MOLECULES FROM A CHEMICAL
POINT OF VIEW /
1 MARINE CYANOTOXINS POTENTIALLY HARMFUL TO HUMAN
HEALTH 3
MELANIE ROUE,
MURIEL CUGGER, STJEPKO COLUBIC,
ZOUHER AMZIL, ROMULO ARAOZ.JEAN TURQUET,
MIREILLE CHINAIN, AND DPMINIQUE
LAURENT
1.1 INTRODUCTION 3
1.2 MARINE CYANOBACTERIA AS CAUSATIVE AGENT OF
CIGUATERA-LIKE POISONING 4
1.2.1 CIGUATERA FISH POISONING 4
1.2.2 CIGUATERA SHELLFISH POISONING (CSP): A NEW
ECOTOXICOLOGICAL PHENOMENON 7
1.2.3 CIGUATERA-LIKE POISONINGS INVOLVE COMPLEX
MIXTURES OF CYANOTOXINS 7
1.2.3.1 CIGUATOXINS AND HOMOANATOXLN 7
1.2.3.2 CIGUATOXINS AND SAXITOXINS
8
1.2.3.3 CIGUATOXINS AND PALYTOXINS 8
1.3 MARINE CYANOBACTERIA: A POTENTIAL RISK FOR
SWIMMERS 10
1.4 MICROCYSTINS COULD ALSO BE FOUND IN THE SEA 12
1.5 RISK OF NEURODEGENERATIVE DISEASE IN THE SEA 13
1.6 CONCLUSION AND FUTURE PROSPECTS 13
ACKNOWLEDGMENTS 16
REFERENCES 16
2 OUTSTANDING MARINE BIOTOXINS: STX, TTX, AND
CTX 23
PHILIPPE AMADE,
MOHAMED MEHIRI, AND RICHARDJ.
LEWIS
2.1 INTRODUCTION 23 .
2.2 SAXITOXINS (STXS) IN PARALYTIC SHELLFISH
POISONING 24
2.2.1 CAUSES OF PARALYTIC SHELLFISH POISONING 24
2.2.2 SAXITOXINS (STXS) 24
2.2.2.1 CHEMICAL ASPECTS OF THE STXS 25
2.2.2.2 DETECTION OF PSP TOXINS 27
2.2.2.3 . POISONING RECORDS 27
2.3 TETRODOTOXIN (TTX) IN PUFFER FISH POISONING
(PFP) 28
2.3.1 PUFFER FISH POISONING (PFP) 28
2.3.1.1 CHEMICAL ASPECTS OF TTX 30
2.3.1.2 DETECTION OF TTXS 32
2.4 CIGUATOXIN (CTX) IN CIGUATERA FISH POISONING
(CFP) 33
2.4.1 CIGUATERA FISH POISONING (CFP) 33
2.4.2 CIGUATOXINS 34
2.4.2.1 CHEMICAL ASPECTS 35
2.4.2.2 DETECTION OF CTX TOXINS 36
2.4.2.3 POISONING RECORDS 37-
2.4.2.4 PERSISTENCE AND RECURRENCE OF SYMPTOMS 37
2.4.2.5 FISH CONTAINING CIGUATOXINS 37
2.4.2.6 QUALITATIVE AND QUANTITATIVE METHODS FOR TOXINS
DETECTION 38 '
2.5 CONCLUSIONS 39
REFERENCES 40
3 IMPACT OF MARINE-DERIVED
PENICILLIUM
SPECIES IN THE
DISCOVERY OF NEW POTENTIAL ANTITUMOR DRUGS 45
MARIEKE VANSTEELANDT, CATHERINE ROULLIER,
ELODIE BLANCHET, YANN CUITTON, YVES-FRANQOIS POUCHUS,
NICOLAS RUIZ, AND OLIVIER GROVEL
3.1 INTRODUCTION 45
3.2 MOLECULES ISOLATED FROM MARINE-DERIVED PENICILLIUM
SPECIES WITH POTENT CYTOTOXIC ACTIVITY 46
3.3 MARINE-DERIVED CYTOTOXIC PENICILLIUM 46
3.3.1 WHERE WERE MARINE-DERIVED PENICILLIUM SEARCHED
AND ISOLATED? 46
3.3.2 WHICH PENICILLIUM SPECIES? 46
3.4 WHAT ARE THESE PROMISING MOLECULES FROM MARINE
PENICILLIUM? 57
3.4.1 STATISTICS 57
3.4.2 FOCUS ON INTERESTING MOLECULES 59
3.4.2.1 CYTOTOXIC ALKALOIDS:
THE EXAMPLE OF
COMMUNESINS 59
3.4.3 CYTOTOXIC ALKALOIDS/DIKETOPIPERAZINE COMPOUNDS:
EXAMPLES OF FRUCTIGENINE A AND VERTICILLIN
DERIVATIVES 68
3.4.3.1 FRUCTIGENINE A (= RUGULOSOVIN B =
PUBERULIN) 68
3.4.3.2 VERTICILLIN A AND DERIVATIVES
68
HTTP://D-NB.INFO/1043456562
VI CONTENTS
3.4.4 CYTOTOXIC SESQUITERPENES: LIGERIN, A CHLORINATED
SESQUITERPENE 72
3.4.4.1 LIGERIN IS PRODUCED BY A NEW SPECIES OF
PENICILLIUM 72
3.4.4.2 ISOLATION OF LIGERIN 72
3.4.4.3 THE CHLORINE ATOM: THE ORIGINALITY OF LIGERIN'S
CHEMICAL STRUCTURE 74
3.4.4.4 THE MANY STRUCTURAL ANALOGS OF LIGERIN 74
3.4.4.5 LIGERIN SEMISYNTHESIS 75
3.4.4.6 BIOACTIVITIES 75
3.5 CONCLUSIONS 75
REFERENCES 76
4 ASTONISHING FUNGAL DIVERSITY IN DEEP-SEA
HYDROTHERMAL ECOSYSTEMS: AN UNTAPPED RESOURCE
OF BIOTECHNOLOGICAL POTENTIAL? 85
CAETAN BURGAUD, LAURENCE
MESLET-CLADIERE,
GEORGES BARBIER, AND VIRGINIA
P. EDGCOMB
4.1 INTRODUCTION 85
4.2 DEEP-SEA HYDROTHERMAL VENTS AS LIFE HABITATS 85
4.2.1 GENERATION OF MARINE HYDROTHERMAL SYSTEMS: A
STORY OF INTERACTIONS
86
4.2.2 DIFFERENT VENT-FLUID COMPOSITIONS SHAPING
DIFFERENT ECOLOGICAL NICHES 86
4.2.3 HYDROTHERMAL LIFESTYLES AT THE MACRO- AND
MICROSCOPIC SCALE 87
4.3 THE FIVE "W"S OF MARINE FUNGI: WHO? WHAT?
WHEN? WHERE? WHY? 89
4.3.1 DEFINITION AND NOVEL CONCEPT 89 .
4.3.2 PATTERNS OF DISTRIBUTION 90
4.3.3 ECOLOGICAL ROLES 90
4.3.4 ORIGIN OF MARINE FUNGI 91
4.4 FUNGI IN DEEP-SEA HYDROTHERMAL VENTS 91
4.4.1 HYDROTHERMAL VENTS AS LIFE OASES FOR FUNGI 92
4.4.2 PHYSIOLOGICAL ADAPTATIONS 92
4.4.3 BIOTECHNOLOGICAL POTENTIAL 93
4.5 CONCLUSIONS 94
ACKNOWLEDGMENTS 94
REFERENCES 94
5 GLYCOLIPIDS FROM MARINE INVERTEBRATES 99
CILLES BAMATHAN, AURELIE COUZINET-MOSSION,
AND CDETANE WIELGOSZ-COLLIN
5.1 INTRODUCTION 99
5.2 GLYCOSPHINGOLIPIDS FROM MARINE INVERTEBRATES:
OCCURRENCE, CHARACTERIZATION, AND BIOLOGICAL
ACTIVITY
101
5.2.1 A-GLYCOPYRANOSYLCERAMIDES 102
5.2.1.1 A-MONOGLYCOSYLCERAMIDES 102
5.2.1.2 A-DIGLYCOSYLCERAMIDES 102
5.2.1.3 A-TRIGLYCOSYLCERAMIDES 109
5.2.1.4 A-TETRAGLYCOSYLCERAMIDES 109
5.2.2 P-GLYCOPYRANOSYLCERAMIDES 109
5.2.2.1 P-GLYCOPYRANOSYLCERAMIDES WITH
SATURATED, MONO-, AND DIUNSATURATED SPHINGOID
BASES 109
5.2.2.2 P-GLYCOPYRANOSYLCERAMIDES WITH TRIUNSATURATED
SPHINGOID BASES 125
5.2.3 BIOLOGICAL AND PHARMACOLOGICAL PROPERTIES OF GSLS
FROM MARINE INVERTEBRATES 127
5.2.3.1 IMMUNOSTIRNULATING AND ANTITUMOR PROPERTIES OF
A-GALACTOSYLCERAMIDES 127
5.2.3.2- BIOLOGICAL ACTIVITY OF P-GLYCOSYLCERAMIDES 128
5.3 GANGLIOSIDES 129
5.3.1 OCCURRENCE AND STRUCTURE 129
5.3.1.1 INOSITOLPHOSPHOCERAMIDE GANGLIOSIDES 130
5.3.1.2 LACTOSYLCERAMIDE GANGLIOSIDES 131
5.3.1.3 - GLUCOSYLCERAMIDE GANGLIOSIDES 136
5.3.2 BIOLOGICAL ACTIVITY 143
5.3.3 CONCLUSION 145
5.4 ATYPICAL GLYCOLIPIDS 145
5.4.1 OCCURRENCE AND STRUCTURE 146
5.4.2 BIOLOGICAL ACTIVITY 152
5.4.3 CONCLUSION 155
5.5 GENERAL CONCLUSION 155
LIST OF ABBREVIATIONS 155
REFERENCES 155
6 PIGMENTS OF LIVING FOSSIL CRINOIDS 7 63
CECILE DEBITUS AND JEAN-MICHEL KOMPROBST
6.1 THE DISCOVERY OF STALKED CRINOIDS 163
6.2 ANTHRAQUINONIC PIGMENTS OF STALKED CRINOIDS 163
6.3 AXIAL CHIRALITY OF GYMNOCHROMES AND
HYPOCHROMINES 165
6.4 TOWARDS A FUNGAL ORIGIN OF GYMNOCHROMES? 167
6.5 BIOLOGICAL ACTIVITIES OF GYMNOCHROMES 168
6.6 PERSPECTIVES 168
REFERENCES 169
PART TWO OUTSTANDING MARINE MOLECULES FROM AN ECOLOGICAL
POINT
OF VIEW
171
7 BACTERIAL COMMUNICATION SYSTEMS 7 73
TILMANN HARDER, SCOTT A. RICE,
SERGEY DOBRETSOV,
TORSTEN THOMAS, ALYSSIA CARFE-MLOUKA, STAFFAN
KJELLEBERG,
PETER D. STEINBERG, AND
DIANE
MCDOUGALD
7.1 COORDINATION OF MULTICELLULAR BEHAVIOR IN
BACTERIA 173
7.2 THE REPERTOIRE OF CHEMICAL SIGNALS 174
7.3 MOLECULAR MECHANISMS OF QS 175
7.4 THE EFFECTIVE RANGE OF QS-REGULATED
PROCESSES 175
7.5 THE INHIBITION OF QS: QUORUM
QUENCHING 176
7.6 EXAMPLES OF CROSS-KINGDOM SIGNALING IN THE
MARINE ENVIRONMENT 179
7.6.1 CHEMICAL DEFENSE OF THE RED SEAWEED DELISEA
PULCHRA 179
7.6.2 THE MUTUALISTIC ASSOCIATION OF VIBRIOJISCHERI WITH
THE HAWAIIAN BOBTAIL SQUID 180
7.6.3 EXPLOITATION OF BACTERIAL QS DURING SETTLEMENT OF
MARINE SPORES AND INVERTEBRATE LARVAE 182
CONTENTS I VII
7.7 "-OMIC" APPROACHES TO QS 182
7.8 CONCLUDING REMARKS 183
REFERENCES 183
8 DOMOICACID
189
STEPHANE LA BANE, STEPHEN S. BATES,
AND MICHAEL
A QUILLIAM
8.1 HISTORICAL BACKGROUND 190
8.2 CASE STUDIES 192
8.2.1 CASE STUDY #1: THE 1987 OUTBREAK ON PRINCE
EDWARD ISLAND 192
8.2.2 CASE STUDY #2: THE 1991 BIRD INTOXICATION EVENT IN
CALIFORNIA 193
8.2.3 CASE STUDY #3: MASSIVE SEA LION MORTALITY IN JUST A
. FEW WEEKS 194
8.3 CHEMISTRY 194
8.3.1 PHYSICO-CHEMICAL PROPERTIES 194
8.3.2 STRUCTURE DETERMINATION 194
8.3.2.1 THE KAINIC ACID FAMILY 194
8.3.2.2 NUCLEAR MAGNETIC RESONANCE (NMR)
SPECTROSCOPY 195
8.3.2.3 MASS SPECTROMETRY (MS) 196
8.3.2.4 UV SPECTROSCOPY (UV) 196
8.3.3 EXTRACTION, SEPARATION, PURIFICATION, AND DETECTION
OF DA 197
8.3.3.1 EXTRACTION AND CLEANUP 197
8.3.3.2 SEPARATION AND PURIFICATION 197
8.3.3.3 DETECTION, QUANTIFICATION, AND MONITORING IN FOOD
SAMPLES 197
8.3.3.4 IMMUNOLOGICAL METHOD 198
8.3.4 DOMOIC ACID AND RELATED MOLECULES 198
8.3.5 . SYNTHESIS 198
8.3.6 BIOSYNTHESIS 199
8.3.6.1 LABELED PRECURSOR INVESTIGATIONS 199
8.3.6.2 REGULATION OF DA PRODUCTION 200
8.3.7 DEGRADATION 201
8.3.7.1 PHOTODEGRADATION 201
8.3.7.2 . ' PHOTO-OXIDATIVE DEGRADATION 201
8.3.7.3 '* BACTERIAL AND ENZYMATIC
DEGRADATION 201
8.4 DA-PRODUCING ORGANISMS 201
8.4.1 RED ALGAE 201
8.4.2 DIATOMS 202
8.5 MOLECULAR BASIS OF DA ACUTE AND CHRONIC
POISONING 203
8.5.1 THE KAINOIDS' MODE OF ACTION 203
8.5.1.1 GLUTAMATE RECEPTORS 204
8.5.2 SHORT- AND LONG-TERM NEUROLOGICAL PROBLEMS
ASSOCIATED WITH DA 207
8.5.2.1 . MAMMAL STUDIES 207
8.5.3 CURES AGAINST ASP 207
8.6 UNDERSTANDING AND PREDICTING TOXIGENIC DIATOM
- .BLOOMS (MACROSCOPIC SCALE) 207
8.7 NATURAL FACTORS THAT ENHANCE BLOOM FORMATION
AND/OR DA PRODUCTION 209
8.7.1 . SILICON 209
8.7.2 PHOSPHORUS 209
8.7.3 NITROGEN 209
8.7.4 IRON 209
8.7.5 THE ROLE OF BACTERIA IN THE BIOSYNTHESIS OF DA BY
TOXIGENIC DIATOMS 209
8.8 FUNCTIONAL GENOMICS OF DIATOMS 210
8.8.1 THE KEY TO THE EVOLUTIONARY SUCCESS OF
DIATOMS 210
8.8.2 GENOMICS OF DA BIOSYNTHESIS AND REGULATION
NETWORKS 210
8.8.2.1 GENOMIC ASPECTS 210
8.8.2.2 TRANSCRIPTOMICS OF DA-PRODUCING
DIATOMS 210
8.9 CONCLUSIONS 210
ACKNOWLEDGMENTS 211
REFERENCES 211
9
ALGAL MORPHO-LNDUCERS
217
ZOFIA NEHR AND BENEDICTS CHARRIER
9.1 INTRODUCTION 217
9.1.1 MARINE MACROALGAE: DIFFERENT EVOLUTIONARY
HISTORIES LEADING TO SIMILAR
MORPHOLOGIES 217
9.1.2 MACROALGAL MORPHOLOGIES AND ADAPTATION 217
9.1.3 WHAT EXACDY DOES THE TERM "ALGAL MORPHO-
INDUCER" COVER? 219
9.2 MORPHO-LNDUCERS OF ANIMALS AND LAND PLANTS
PRODUCED BY MACROALGAE 219
9.2.1 ALGAL COMPOUNDS AS MORPHO-LNDUCERS OF
ANIMALS 219
9.2.2 ALGAL COMPOUNDS AS MORPHO-LNDUCERS OF LAND
PLANTS: PHYTOHORMONES 219
9.2.2.1 AUXINS 219
9.2.2.2 CYTOKININ 220
9.3 MORPHO-LNDUCERS OF MACROALGAE 220
9.3.1 ARE MACROALGAL PHYTOHORMONES ALSO MORPHO-
LNDUCERS. ON ALGAE? 220
9.3.2 MORPHO-LNDUCERS OF MACROALGAE PRODUCED BY
BACTERIA 221
9.4 CONCLUSIONS 222
ACKNOWLEDGMENT 222
REFERENCES 222
10 HALOGENATION AND VANADIUM HALOPEROXIDASES 225
JEAN-BAPTISTE FOUMIER AND CATHERINE LEBLANC
10.1 INTRODUCTION 225
10.2 BIOCHEMICAL CHARACTERIZATION OF VANADIUM-
DEPENDENT HALOPEROXIDASES (VHPOS) 227
10.2.1 OCCURRENCE OF VHPO ACTIVITIES IN LIVING
ORGANISMS 227
10.2.2 ENZYMATIC ASSAYS AND BIOCHEMICAL
PROPERTIES 228
10.2.3 BIOLOGICAL FUNCTIONS OF VHPOS 229
10.3 STRUCTURAL CHARACTERIZATION OF VHPOS 230
10.3.1 PROTEIN SEQUENCES OF VHPOS 230
10.3.2 OVERALL QUATERNARY STRUCTURES OF VHPOS 231
VIII CONTENTS
10.3.3 TERTIARY STRUCTURE OF VHPOS 231
10.3.4 ACTIVE SITE STRUCTURE OF VHPOS 232
10.3.5 FINE STRUCTURE AND VANADATE COORDINATION INTO THE
ACTIVE SITE 232
10.4 CATALYTIC CYCLE AND HALIDE SPECIFICITY 234
10.4.1 ACID PHOSPHATASES, "COUSINS" OF VHPOS 234
10.4.2 INHIBITION OF VHPOS 235
10.4.3 REACTION WITH HYDROGEN PEROXIDE 236
10.4.4 OXIDATION OF HALIDES 236
10.4.5 SITE-DIRECTED MUTAGENESIS STUDIES AND CATALYTIC
MECHANISMS 236
REFERENCES 238
O&QIDFRSG (§MSGFI)^
GMAGGFLFLGAMSIB 333
11 PROMISING MARINE MOLECULES IN PHARMACOLOGY 245
MARIE-USE BOURGUET-KONDRACKI AND JEAN-MICHEL
KOMPMB
ST
11.1 INTRODUCTION 245
11.2 PROMISING SUBSTANCES ISOLATED FROM
MICROORGANISMS 248
11.2.1 SALINOSPORAMIDE A 248
11.2.2 THIOCORALINE 249
11.2.3 AMMOSAMIDES 251
11:2.4 LARGAZOLE 252
11.3 PROMISING SUBSTANCES ISOLATED FROM MACROALGAE
AND INVERTEBRATES 254
11.3.1 GRIFFITHSIN 254
11.3.2 PM-050489 AND PM-060184; TWO NEW SPONGE
POLYKETIDES 254
11.3.3 IMMUCOTHEL (KEYHOLE LIMPET HEMOCYANIN;
KLH) 255
11.3.4 JORUMYCIN (ZALYPSIS) 255
11.4 PROMISING SUBSTANCES SYNTHESIZED FROM NATURAL
MODELS 255
11.4.1 PLITDIDEPSIN FROM THE ASCIDIAN APLIDIUM
ALBICANS 255
11.4.2 ROSCOVITINE (SELICICLIB, CYC202): A SYNTHETIC
ANALOG OF NATURAL PURINES 255
11.4.3 DMXBA (GTS-21): A SYNTHETIC
ANALOG OF
ANABASEIHE 256
11.4.4 BRYOLOGS: SYNTHETIC ANALOGS OF BRYOSTATINS 258
11.5 CONCLUSION 259
REFERENCES 259
12 PROMISES OF THE UNPRECEDENTED AMINOSTEROL
SQUALAMINE 265
MARIE-USE BOURGUET-KONDRACKI AND
JEAN-MICHEL
BRUNEI
12.1 INTRODUCTION 265
12.2 DISCOVERY OF THE UNPRECEDENTED AMINOSTEROL
SQUALAMINE 265
12.3 SYNTHESES OF SQUALAMINE 268
12.4 BIOLOGICAL-ACTIVITIES 270.
12.4.1 ANTIMICROBIAL ACTIVITIES OF SQUALAMINE AND ITS
MIMICS 270
12.4.2 ANTIANGIOGENIC ACTIVITY OF SQUALAMINE 274
12.4.3 ANTITUMOR ACTIVITY OF SQUALAMINE 274
12.4.4 ANTIVIRAL ACTIVITIES 275
12.5 MECHANISM OF ANTIANGIOGENIC ACTIVITY OF
SQUALAMINE 275
12.6 PRECLINICAL STUDIES OF SQUALAMINE 276
12.6.1 ANTITUMOR THERAPY 276
12.6.2 RETINOPATHY 277
12.7 CLINICAL STUDIES OF SQUALAMINE 277
12.7.1 HUMAN CANCERS 277
12.7.2 AGE-RELATED MACULAR DEGENERATION 278
12.8 BIOACTIVE POTENTIAL OF TRODUSQUEMINE, A NATURAL
SQUALAMINE DERIVATIVE 278
12.9 CONCLUSION 280
REFERENCES 280
13 MARINE PEPTIDE SECONDARY METABOLITES 285
BERNARD BANAIGS,
ISABELLE BONNARD,
ANNE WITCZAK, AND
NICOLAS INGUIMBERT
13.1 INTRODUCTION 285
13^2 RIBOSOMAL- AND NONRIBOSOMAL-DERIVED PEPTIDES: A
VIRTUALLY UNLIMITED SOURCE OF NEW ACTIVE
COMPOUNDS 286
13.3 LAXAPHYCINS AND THEIR DERIVATIVES: PEPTIDES NOT SO
EASY TO SYNTHESIZE 291
13.4 DOLASTATINS: FROM DECEPTION TO HOPE THROUGH
STRUCTURAL MODIFICATION LEADING TO REDUCED
TOXICITY
294
13.5 DIDEMNINS AND RELATED DEPSIPEPTIDES: HOW
PERSEVERANCE SHOULD LEAD TO THEIR LOW-COST
PRODUCTION 297
13.6 KAHALALIDE F: A STUDY IN CHEMICAL ECOLOGY AS A
STARTING POINT FOR NEW ARITITUMORAL AGENT
DISCOVERY 299
13.7 AZOLE/AZOLINE-CONTAINING CYANOBACTINS ISOLATED
FROM INVERTEBRATES: AN EXAMPLE OF NATURE'S OWN
COMBINATORIAL CHEMISTRY 304
13.8 CONCLUSION 310
ACKNOWLEDGMENTS 311
REFERENCES 311
14 CONOTOXINS AND OTHER CONOPEPTIDES 3 J 9
QUENTIH KAAS AND DAVIDJ. CRAIK
14.1 BACKGROUND 319
14.1.1 HISTORICAL INTEREST IN CONE SNAILS 319
14.1.2 BIOLOGY OF CONE SNAILS 319
14.1.3 CONE SNAIL VENOMS, THEIR CONOPEPTIDES AND
MOLECULAR TARGETS 320
14.2 DIVERSITY OF CONOPEPTIDES 321
14.2.1 CONOPEPTIDE MATURATION AND THE ORIGIN OF VENOM
DIVERSITY 321
14.2.2 DIVERSIFICATION AT THE GENE LEVEL 321
CONTENTS I IX
14.2.3 ADDITIONAL'DIVERSITY AT THE PROTEIN LEVEL 322
14.2.4 NOMENCLATURE AND CLASSIFICATION SCHEMES 323
14.2.4.1 GENE SUPERFAMILIES 323
14.2.4.2 CYSTEINE FRAMEWORKS 323
14.2.4.3 PHARMACOLOGICAL FAMILIES 323
14.3 ISOLATION TECHNIQUES 323
14.3.1 TRANSCRIPTOMICS-BASED CONOPEPTIDE DISCOVERY 324
14.3.2 PROTEOMICS STUDIES OF CONOPEPTIDES 324
14.4 CONOPEPTIDE THREE-DIMENSIONAL STRUCTURES 325
14.4.1 TWO-DISULFIDE CONOTOXINS 325
14.4.2 TRI-DISULFIDE CONOTOXINS 327
14.5 CONOPEPTIDE PHARMACOLOGICAL ACTIVITIES 327
14.6 OUTLOOK 328
ACKNOWLEDGMENTS 328
' REFERENCES 328
15 MYCOSPORINE-LIKE AMINO ACIDS (MAAS) IN BIOLOGICAL
PHOTOSYSTEMS 333
STEPHANE LA BANE, CATHERINE ROULLIER, AND
JOEL BOUSTIE
15.1 BACKGROUND 333
15.1.1 LIFE IN FULL LIGHT AND ITS CONSTRAINTS 333
15.1.2 MAAS: TO PROTECT
AND SERVE, OCCASIONALLY TO
DEFEND 334
15.2 CHEMISTRY 335
15.2.1 PHYSICO-CHEMICAL CHARACTERISTICS OF MAAS 335
15.2.2 . MAAS AND RELATED MOLECULES 335
15.2.2.1 MAAS IN THE MARINE WORLD 335
15.2.2.2 MAAS AND RELATED MOLECULES IN LICHENS 335
15.2.3 EXTRACTION, SEPARATION, PURIFICATION, AND
DETECTION 335
15.2.3.1 EXTRACTION, SEPARATION, AND PURIFICATION 335
15.2.3.2 DETECTION, QUANTIFICATION, AND MONITORING IN LIVE
SAMPLES 339
15.2.4 STRUCTURE DETERMINATION 339
15.2.4.1 . ULTRAVIOLET (UV) SPECTROSCOPY 339
15.2.4.2 MASS SPECTROMETRY (MS) 339
15.2.4.3 NUCLEAR MAGNETIC RESONANCE (NMR)
SPECTROSCOPY 340
15.2.5 SYNTHESIS 341
15.2.6 BIOSYNTHESIS: LABELED PRECURSOR
INVESTIGATIONS 341
15.2.6.1 THE SHIKIMIC ACID PATHWAY 341
15.2.6.2 THE PENTOSE PHOSPHATE PATHWAY 342
15.2.7 REGULATION OF MAA PRODUCTION: LIGHT AND
NUTRIENTS 342
15.2.7.1 LIGHT 342
15.2.7.2 NUTRIENTS 343
15.2.8 DEGRADATION 344
15.3 MAA-PRODUCING ORGANISMS 344
15.3.1 CHEMICAL PROTECTION AGAINST ABIOTIC STRESS 344
15.3.1.1 SYMBIONT-ASSISTED METABOLISM 344
15.3.1.2 THE "MENAGE A TROIS" SOLUTION 344
15.3.1.3 THE CHEMICAL ANSWER TO AN EXPOSED MODE OF
LIFE 345
15.3.1.4 SIMPLE, EFFECTIVE, AND UBIQUITOUS: WHY CHANGE A
WINNING RECIPE? 345
15.4 HERMATYPIC CORALS: LIVING UNDER TIGHT
CONSTRAINTS 345
15.4.1 CORAL REEFS ARE MONUMENTAL
BIOCONSTRUCTIONS 345
15.4.2 CORALS ARE HIGHLY EFFICIENT
PHOTOSYNTHESIZERS 345
15.4.3 HIGH TEMPERATURES AND UV EXPOSURES INDUCE
OXIDATIVE STRESS AND BLEACHING IN CORALS 346
15.4.4 THE CHEMICAL ACCLIMATION OF SCLERACTINIAN CORALS
TO AN EXPOSED LIFESTYLE 346
15.4.5 BIOGENIC SOURCES OF MAAS IN SCLERACTINIAN
CORALS 347
15.4.6 THE PHYLOGENOMICS OF MAAS IN SCLERACTINIAN
CORALS 347
15.5 IICHENIC SYSTEMS: LIVING IN THE EXTREMES 347
15.6 MODES OF ACTION AND APPLICATIONS TO HUMAN
WELFARE 348
15.6.1 SKIN CARE AND COSMETICS 349
15.6.2 BIOTECHNOLOGICAL APPLICATIONS 349
15.7 CONCLUSIONS 349
ACKNOWLEDGMENTS 349
15.A APPENDIX 15A.1 PROTON NMR DATA OF MYCOSPORINES
AND MYCOSPORINE-LIKE AMINO ACIDS (MAAS) 350
APPENDIX 15A.2 CARBON THIRTEEN DATA OF
MYCOSPORINES AND MYCOSPORINE-LIKE AMINO
ACIDS
354
REFERENCES 357
16 EXTRACELLULAR HEMOGLOBINS FROM ANNELIDS, AND THEIR
POTENTIAL USE IN BIOTECHNOLOGY 361
FRANCK ZAL AND
MORGANE ROUSSELOT
16.1 INTRODUCTION 361
16.2 ANNELID EXTRACELLULAR HEMOGLOBINS 362
16.3 ARCHITECTURE ' 364
16.4 MODEL OF QUATERNARY STRUCTURES 366
16.4.1 ELECTRON MICROSCOPY 366
16.4.2 ESTIMATION OF HEME NUMBER AND MINIMAL
MOLECULAR WEIGHT 367
16.4.3 . SMALL-ANGLE LIGHT SCATTERING 368
16.4.4 LOW- AND HIGH-PRESSURE LIQUID CHROMATOGRAPHY
ANDSDS-PAGE 369
16.4.5 ELECTROSPRAY IONIZATION-MASS SPECTROMETRY 369
16.5 BIOTECHNOLOGY APPLICATIONS 370
16.6 ORGAN PRESERVATION 370
16.6.1 PRESERVATION SOLUTIONS 370
16.6.2 HYPOTHERMIC CONTINUOUS REPERFIISION 371
16.7 ANEMIA 371
16.7.1 HEMOGLOBIN OXYGEN CARRIERS 372
16.7.2 NORMOVOLEMIC HEMODILUTION 372
16.7.2.1 HEMOXYCARRIER 372
16.8 CONCLUSION 372
ACKNOWLEDGMENTS 373
REFERENCES 373
X | CONTENTS
17 LAMELLARINS: A TRIBE OF BIOACTIVE MARINE NATURAL
PRODUCTS 377
CHRISTIAN BAILLY
17.1 INTRODUCTION 377
17.2 LAMELLARINS: BIOACTIVE MARINE NATURAL PRODUCTS 378
17.3 ANTICANCER ACTIVITIES OF LAMELLARINS 379
17.4 INHIBITION OF TOPOISOMERASE I BY LAMELLARINS 380
17.5 INHIBITION OF PROTEIN KINASES BY LAMELLARINS 380
17.6 LAMELLARIN-INDUCED MITOCHONDRIAL
PERTURBATIONS 380
17.7 ANTIVIRAL ACTIVITY OF SULFATED LAMELLARINS 382
17.8 SYNTHESIS OF LAMELLARINS 382
17.9 NON-NATURAL LAMELLARIN ANALOGS 383
17.10 CONCLUSION 384
REFERENCES 384
PART FOUR NEW TRENDS IN ANALYTICAL METHODS 387
18 NMR TO ELUCIDATE STRUCTURES 389
CAELLE SIMON, NELLY KERVAREC, AND STEPHANE CERANTOLA
18.1 INTRODUCTION 389
18.2 NMR TO ELUCIDATE STRUCTURES 389
18.3 SAMPLE PREPARATION 390
18.4 CONVENTIONAL "LIQUID" PROBES: OBTAINING ID AND
2D SPECTRA OF ALL NMR-OBSERVABLE NUCLEI 393
18.4.1 *H SPECTRA 393
18.4.1.1 CHEMICAL SHIFT 394
18.4.1.2 MULTIPLICITY 394
18.4.1.3 INTEGRATION 396
18.4.1.4 SPECIAL FEATURES OF SAMPLE 396
18.4.2
13
C SPECTRA 400
18.4.3 2D SPECTRA 402
18.4.4 OTHER NUCLEI SPECTRA 408
18.4.4.1 ISOTOPES WITH NO NMR PROPERTIES 408
18.4.4.2 ISOTOPES (I = 1/2) WITH 100% ABUNDANCE 408
18.4.4.3 ISOTOPES (I = 1/2) WITH LOW ABUNDANCE 411
18.4.4.4 ISOTOPES (I 1/2) WITH LONG T
R
VALUES 415
18.4.4.5 ISOTOPES (I 1/2) WITH SHORT ^-VALUES 415
18.5 CRYOPROBES: OBTAINING ID AND 2D SPECTRA MAINLY
IN'H,
13
C 417
18.6 HRMAS NMR: OBTAINING 'H,
I3
C,
31
P,
15
N ID
AND 2D SPECTRA 417
18.6.1 STUDIES OF BACTERIAL STRAINS FROM THE
MARINE DEEP 420
18.6.2 DIFFERENTIATION BETWEEN TWO SPECIES 421
18.6.3 EFFECT OF EXPOSURE TO POLLUTANTS ON SPECIES
METABOLISM AND POSSIBLE POLLUTANT
BIOACCUMULATION
421
18.6.4 ' APPLICATION OF'H HRMAS NMR TO DEFINE ORGAN
CARTOGRAPHY 423
18.6.5 IDENTIFICATION OF DIFFERENT CULTIVABLE MARINE
BACTERIA 424
18.6.6 MONITORING QUANTITATIVE SEASONAL VARIATIONS OF A
MOLECULE 424
18.6.7 UNDERSTANDING THE METABOLISM OF A
SPECIES 425
18.7 CPMAS NMR: OBTAINING ALL NMR OBSERVABLE
NUCLEI SPECTRA 425
18.8 CONCLUSION 426
REFERENCES 428
19 AN INTRODUCTION TO OMICS 431
JONAS COLLEN AND CATHERINE BOYEN
19.1 WHAT ARE "OMICS"? 431
REFERENCES 434
20 GENE MINING FOR ENVIRONMENTAL STUDIES AND
APPLICATIONS: EXAMPLES FROM MARINE
ORGANISMS 435
SIMON M. DITTAMI AND THIERRY TONON
20.1 INTRODUCTION. 435
20.2 TECHNIQUES 435
20.2.1 SAMPLING AND EXTRACTION: AN OVERVIEW 435
20.2.2 PROPERTIES OF NUCLEIC ACIDS 436
20.2.2.1 GENOMIC DNA 436
20.2.2.2 RNA 436
20.2.2.3 MRNA, RRNA, AND RDNA 437
20.2.3 RECENT TECHNOLOGICAL ADVANCES IN MOLECULAR
BIOLOGY AND THEIR IMPACT ON MARINE
BIOLOGY 437
20.2.3.1 SEQUENCING TECHNOLOGY 437
20.2.3.2 GENE EXPRESSION PROFILING 437
20.3 CURRENT APPLICATIONS 439
20.3.1 DEVELOPMENT OF GENOMIC AND TRANSCRIPTOMIC
RESOURCES FOR MOLECULAR ANALYSIS OF ORGANISMS
UNDER ENVIRONMENTAL THREATS: APPLICATION TO CORAL
PHYSIOLOGY 439
20.3.1.1 CONTEXT 439
20.3.1.2 SELECTION OF CORAL TRANSCRIPTOMICS STUDIES IN
RELATION TO CLIMATE CHANGE 440
20.3.1.3 CONCLUDING REMARKS 443
20.3.2 SEARCH'
FOR GENES INVOLVED IN TOXIN PRODUCTION
WITHIN THE DINOFLAGELLATE HAYSTACK - 443
20.3.2.1 CONTEXT 443
20.3.2.2 GENES INVOLVED IN THE SYNTHESIS OF POLYKETIDE
DINOTOXINS 444
20.3.2.3 MOLECULAR BASES OF DINOFLAGELLATE SAXITOXIN
PRODUCTION 445
20.3.2.4 INFLUENCE OF ABIOTIC AND BIOTIC FACTORS ON
DINOTOXIN BIOSYNTHETIC PATHWAYS 446
20.3.2.5 CONCLUDING REMARKS 448
20.3.3 MOLECULAR BIOMONITORING OF MARINE
ENVIRONMENTS 448
20.3.3.1 HIERARCHICAL TAXON-SPECIFIC AND FUNCTION-SPECIFIC
DNA PROBES 448
20.3.3.2 QUANTIFYING BIOMASS. 449 . .
20.3.3.3 SHORT AND MID-TERM MONITORING OF MARINE BACTERIA
AND MICROALGAE 450
20.3.3.4 MOLECULAR BIOMONITORING OF HARMFUL ALGAE 450
20.4 CONCLUSIONS AND OUTLOOK 452
REFERENCES 452
CONTENTS I XI
21 PROTEOMICS AND METABOLOMICS OF MARINE
ORGANISMS: CURRENT STRATEGIES AND KNOWLEDGE 45 7
FANNY CAILLARD AND PHILIPPE
POTIN
21.1 INTRODUCTION 457
21.2 GENERAL STRATEGIES FOR PROTEOMICS AND PECULIARITIES
OF THE MARINE ENVIRONMENT 458
21.2.1 PROTEIN EXTRACTION 458
21.2.2 PREFRACTIONATION 460
21.2.3 QUANTIFICATION 460
21.2.3.1 RELATIVE QUANTIFICATION 460
21.2.3.2 ABSOLUTE QUANTIFICATION 461
21.2.4 DIRECT CELL OR TISSUE ANALYSIS 461
21.3 GENERAL STRATEGIES FOR METABOLOMICS, AND
PECULIARITIES OF THE MARINE ENVIRONMENT 461
21.3.1 EXPERIMENTAL DESIGN AND SAMPLE PREPARATION FOR
METABOLOMICS 462
21.3.1.1 EXPERIMENTAL DESIGN 462
21.3.1.2 SAMPLE PREPARATION 462
21.3.2 ANALYTICAL TOOLS FOR METABOLOMICS 464
21.3.2.1 NUCLEAR MAGNETIC RESONANCE (NMR) 464
21.3.2.2 MASS SPECTROMETRY (MS) 464
21.3.3 SPECTRAL SIGNAL PROCESSING IN NMR AND MS
METABOLOMICS 465
21.3.4 STATISTICAL ANALYSIS 466
21.3.5 CHALLENGES OF METABOLITE IDENTIFICATION 466
21.3.6 CURRENT APPLICATIONS OF MARINE METABOLOMICS 466
21.3.6.1 HEALTH AND DISEASE OF MARINE ORGANISMS 466
21.3.6.2 BIODIVERSITY AND CHEMOMETRY 467
21.3.6.3 SIGNALS IN THE SEA: METABOLOMICS AND MARINE
- CHEMICAL ECOLOGY 467
21.4 CONCLUSIONS 468
ACKNOWLEDGMENTS 468
REFERENCES 469
22 GENOMICS OF THE BIOSYNTHESIS OF NATURAL PRODUCTS:
FROM GENES TO METABOLITES 473
OLIVIER PLOUX AND ANNICK
MEJEAN "
22.1 ' INTRODUCTION 473
22.2 . BIOSYNTHESIS OF PKS, NRPS AND RIPPS: BASIC
PRINCIPLES 474
22.2.1 THE PKSS POLYMERIZE ACETATE UNITS 474
22.2.2 THE NRPSS: A BIOLOGICAL SOLID-PHASE PEPTIDE
SYNTHESIS 475
22.2.3 CONNECTING BIOSYNTHETIC GENES TO NATURAL PRODUCT
STRUCTURE 475
22.2.4 THE DIVERSITY OF RIPPS 476
22.3 CONNECTING GENES AND METABOLITES: SELECTED
EXAMPLES OF AQUATIC NATURAL PRODUCT
BIOSYNTHESIS 476
22.3.1 CURACINS 477
22.3.2 ANATOXIN-A AND HOMONATOXIN-A 478
22.3.3 MICROCYSTES 480
22.3.4 CYANOBACTINS 482
22.4 CONCLUSIONS AND PERSPECTIVES 483
ABBREVIATIONS 483
REFERENCES 484
23 HIGH-THROUGHPUT SCREENING OF MARINE
RESOURCES 489
AMAUD HOCHARD, LUC REININGER, SANDRINE
RUCHAUD,
AND STEPHANE BACH
23.1 INTRODUCTION 489
23.2 HIGH-THROUGHPUT SCREENING AND DRUG
DEVELOPMENT 490
23.2.1 SCREENING ASSAY DEVELOPMENT AND
VALIDATION 490
23.2.2 STATISTICAL TOOLS FOR QUALITY ASSESSMENT OF HTS
ASSAYS 491
23.2.3 CHOICE OF SCREENING STRATEGY 492
23.2.4 DATA ANALYSIS: FROM HITS TO LEADS 492
23.2.4.1 HITS 492
23.2.4.2 LEADS 493
23.2.5 FROM HTS ASSAY TO MARKET: THE DRUG
DEVELOPMENT PROCESS 493
23.3 EXAMPLES OF HIGH-THROUGHPUT SCREENING 493
23.3.1 CHEMICAL LIBRARIES: THE FUEL OF HTS 493
23.3.2 BIOCHEMICAL ASSAY. THE EXAMPLE OF PROTEIN
KINASES 494
23.3.3 PROTEIN-PROTEIN INTERACTIONS (PPIS) 494
23.3.4 CELL-BASED ASSAY: THE EXAMPLE OF BRYOSTATINS 495
23.4 CONCLUSIONS AND PERSPECTIVES 495
LIST OF ABBREVIATIONS 496
ACKNOWLEDGMENTS 496
REFERENCES 496
INDEX 499 |
| any_adam_object | 1 |
| author_GND | (DE-588)1050327586 |
| building | Verbundindex |
| bvnumber | BV041883838 |
| classification_rvk | VK 8500 |
| ctrlnum | (OCoLC)881288538 (DE-599)DNB1043456562 |
| dewey-full | 547.7 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 547 - Organic chemistry |
| dewey-raw | 547.7 |
| dewey-search | 547.7 |
| dewey-sort | 3547.7 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie Biologie Medizin |
| format | Book |
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| id | DE-604.BV041883838 |
| illustrated | Illustrated |
| indexdate | 2024-08-03T01:31:09Z |
| institution | BVB |
| isbn | 9783527334650 9783527681501 |
| language | English |
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| owner_facet | DE-188 DE-703 |
| physical | XXII, 511 S. Ill., graph. Darst. |
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| spelling | Outstanding marine molecules chemistry, biology, analysis ed. by Stéphane La Barre ... Weinheim Wiley Blackwell 2014 XXII, 511 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Biologische Aktivität (DE-588)4291566-1 gnd rswk-swf Sekundärmetabolit (DE-588)4300564-0 gnd rswk-swf Organismus (DE-588)4043831-4 gnd rswk-swf Meer (DE-588)4038301-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Meer (DE-588)4038301-5 s Organismus (DE-588)4043831-4 s Sekundärmetabolit (DE-588)4300564-0 s Biologische Aktivität (DE-588)4291566-1 s DE-604 La Barre, Stéphane Sonstige (DE-588)1050327586 oth Erscheint auch als Online-Ausgabe, EPUB 978-3-527-68153-2 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-68151-8 Erscheint auch als Online-Ausgabe, PDF 978-3-527-68152-5 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=4485864&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027327905&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Outstanding marine molecules chemistry, biology, analysis Biologische Aktivität (DE-588)4291566-1 gnd Sekundärmetabolit (DE-588)4300564-0 gnd Organismus (DE-588)4043831-4 gnd Meer (DE-588)4038301-5 gnd |
| subject_GND | (DE-588)4291566-1 (DE-588)4300564-0 (DE-588)4043831-4 (DE-588)4038301-5 (DE-588)4143413-4 |
| title | Outstanding marine molecules chemistry, biology, analysis |
| title_auth | Outstanding marine molecules chemistry, biology, analysis |
| title_exact_search | Outstanding marine molecules chemistry, biology, analysis |
| title_full | Outstanding marine molecules chemistry, biology, analysis ed. by Stéphane La Barre ... |
| title_fullStr | Outstanding marine molecules chemistry, biology, analysis ed. by Stéphane La Barre ... |
| title_full_unstemmed | Outstanding marine molecules chemistry, biology, analysis ed. by Stéphane La Barre ... |
| title_short | Outstanding marine molecules |
| title_sort | outstanding marine molecules chemistry biology analysis |
| title_sub | chemistry, biology, analysis |
| topic | Biologische Aktivität (DE-588)4291566-1 gnd Sekundärmetabolit (DE-588)4300564-0 gnd Organismus (DE-588)4043831-4 gnd Meer (DE-588)4038301-5 gnd |
| topic_facet | Biologische Aktivität Sekundärmetabolit Organismus Meer Aufsatzsammlung |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=4485864&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027327905&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT labarrestephane outstandingmarinemoleculeschemistrybiologyanalysis |