Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems:
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2014
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IX, 157 S. Ill., graph. Darst. |
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Record in the Search Index
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| adam_text | CONTENT
ABBREVIATIONS V
LIST OF SYMBOLS IX
1 INTRODUCTION 1
2 STATE OF KNOWLEDGE 3
2.1 DRUG DELIVERY SYSTEMS 3
2.1.1 NANOSCOPIC DRUG DELIVERY SYSTEMS FOR IV ADMINISTRATION 4
2.1.2 MICELLES AS DDS FOR HYDROPHOBIC DRUGS 7
2.1.2.1 SYNTHESIS OF AMPHIPHILIC POLYMERS VIA LIVING POLYMERIZATION 8
2.1.2.2 CRITIC
AL MICELLE CONCENTRATION 9
2.1.2.3 STABILITY OF MICELLES 10
2.1.2.4 STRATEGIES TO IMPROVE MICELLAR DDS 11
2.2 A SHORT PROFILE OF CANCER 14
2.2.1 POTENTIAL AND LIMITS OF CHEMOTHERAPY 16
2.2.2 TARGETING CANCEROUS TISSUE 20
2.3 POLY(2-OXAZOLINE)S 23
2.3.1 2-OXAZOLINES - THE BUILDING BLOCKS OF POX 25
2.3.2 POLY(2-OXAZOLINE)S IN NANOMEDICINE 26
3 MOTIVATION 29
4 RESULTS AND DISCUSSION 31
4.1 SYNTHESIS OF MONOMERS FOR THE CORE FORMING POLYMER SEGMENT 31
4.2 SYNTHESIS OF POLY(2-OXAZOLINE)S 33
4.3 INFLUENCE OF THE POLYMER COMPOSITION AND STRUCTURE ON THE MICELLES
PROPERTIES.. 37
4.3.1 AGGREGATION BEHAVIOR: DIBLOCK VS. TRIBLOCK 43
4.3.2 POLARITY OF THE CORE FORMING BLOCK 52
I
HTTP://D-NB.INFO/105020834X
4.3.3 HYDROPHOBICITY OF THE CORE FORMING BLOCK 55
4.3.4 CYTOTOXICITY OF POX 59
4.3.5 CELLULAR UPTAKE OF SELECTED POX 64
4.4 POX AS DDS FOR PTX 69
4.4.1 SOLUBILIZATION CAPACITY OF VARIOUS AMPHIPHILIC POX 69
4.4.2 STABILITY OF PTX-POX FORMULATION 71
4.4.3 PTX STABILITY IN POX FORMULATION 74
4.4.4 INFLUENCES OF PTX ON THE AGGREGATION BEHAVIOR 75
4.4.5 INFLUENCE OF PTX ON THE GLASS TRANSITION OF POX 79
4.4.6 PTX RELEASE PROFILE FROM DIFFERENT MICELLAR CORES 80
4.4.7 SOLUBILIZATION CAPACITY FOR PTX DERIVATIVES 82
4.4.8 SOLUBILIZATION CAPACITY OF OTHER HYDROPHOBIC DRUGS 83
4.5 CROSSLINKING POX BASED MICELLES 85
4.5.1 SYNTHESIS OF REACTIVE 2-OXAZOLINES 85
4.5.2 TEMPORARY CROSSLINKED POX BASED MICELLES VIA COPPER CATALYZED
ALKYNE-
AZIDE CYCLOADDITION 87
4.5.3 SHELL CROSSLINKED POX VIA COPPER CATALYZED ALKYNE-AZIDE
CYCLOADDITION 90
5 SUMMARY 93
6 EXPERIMENTAL 97
6.1 EQUIPMENT AND UTILITIES 97
6.2 REAGENT AND SOLVENTS 100
6.3 MONOMER SYNTHESIS 101
6.3.1 MONOMERS FOR THE CORE FORMING POLYMER SEGMENT 101
6.3.1.1 MONOMER SYNTHESIS WITH NITRILES AND AMINOETHANOL, GENERAL
SYNTHETIC
PROCEDURE 1, GSP 1 101
6.3.2 MONOMERS BEARING A FUNCTIONAL GROUP 105
6.3.2.1 ETHYNYL-2-OXAZOLINE 105
II
6.3.2.2 2-(PENT-4-YNYL)-2-OXAZOLINE 107
6.4 LINKER SYNTHESIS 108
6.5 POLYMERIZATIONS 109
6.5.1 LCROP OF 2-OXAZOLINES-L.5 G SCALE, GSP 2 109
6.5.2 LCROP OF 2-OXAZOLINES-L5 G SCALE, GSP 3 110
6.5.3 HOMOPOLYMERS 110
6.5.4 DIBLOCK COPOLYMERS 114
6.5.5 TRIBLOCK COPOLYMERS 118
6.5.6 CROSSLINKABLE POX 125
6.6 POLYMER ANALOG MODIFICATIONS 129
6.6.1 REMOVAL OF BOC-PROTECTION GROUP 129
6.6.2 DEPROTECTION OF BOC GROUP VIA TFA, GSP 4 129
6.6.3 DEPROTECTION OF BOC GROUP VIA PHOSPHORIC ACID, GSP 5 129
6.6.3.1 DIBLOCK COPOLYMERS 130
6.6.3.2 TRIBLOCK COPOLYMERS 132
6.6.3.3 CROSSLINKABLE POX 137
6.6.4 CROSSLINKING POX 139
6.6.5 DYE LABELING 139
6.7 EXPERIMENTS 140
6.7.1 ATOMIC FORCE MICROSCOPY 140
6.7.2 DRUG SOLUBILIZATION 140
6.7.3 DROP SHAPE ANALYSIS 141
6.7.4 DYNAMIC LIGHT SCATTERING 142
6.7.5 PYRENE ASSAY- CRITICAL MICELLE CONCENTRATION MEASUREMENT 142
6.7.6 SMALL-ANGLE NEUTRON SCATTERING 143
6.7.7 TRANSMISSION ELECTRON MICROSCOPY 143
6.8 CELL CULTURE 144
III
6.8.1 CYTOTOXICITY ASSAY-MTT 144
6.8.2 CYTOTOXICITY ASSAY-CCK8 144
6.8.3 FLOW CYTOMETRY - CELLULAR UPTAKE STUDY 144
6.8.4 CONFOCAL FLUORESCENCE MICROSCOPY 145
7 REFERENCES 146
ACKNOWLEDGMENT 153
PICTURE CREDITS 155
ERKLARUNG 157
IV
|
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| discipline | Chemie / Pharmazie Medizin |
| format | Thesis Book |
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| spelling | Schulz, Anita 1985- Verfasser (DE-588)1049271211 aut Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems von Anita Schulz 2014 IX, 157 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Dresden, Techn. Univ., Diss., 2014 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027305432&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schulz, Anita 1985- Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems |
| subject_GND | (DE-588)4113937-9 |
| title | Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems |
| title_auth | Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems |
| title_exact_search | Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems |
| title_full | Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems von Anita Schulz |
| title_fullStr | Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems von Anita Schulz |
| title_full_unstemmed | Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems von Anita Schulz |
| title_short | Investigation of structure-property relationships of poly(2-oxazoline) based drug delivery systems |
| title_sort | investigation of structure property relationships of poly 2 oxazoline based drug delivery systems |
| topic_facet | Hochschulschrift |
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