Microbial biochemistry:
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| Main Author: | |
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| Format: | Book |
| Language: | English |
| Published: |
Dordrecht [u.a.]
Springer
2014
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| Edition: | 3. ed. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXVIII, 611 S. graph. Darst. |
| ISBN: | 9789401789073 |
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| 100 | 1 | |a Cohen, Georges N. |d 1920- |e Verfasser |0 (DE-588)142904864 |4 aut | |
| 245 | 1 | 0 | |a Microbial biochemistry |c G.N. Cohen |
| 250 | |a 3. ed. | ||
| 264 | 1 | |a Dordrecht [u.a.] |b Springer |c 2014 | |
| 300 | |a XXVIII, 611 S. |b graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| adam_text |
Titel: Microbial biochemistry
Autor: Cohen, Georges N
Jahr: 2014
Contents
1 Bacterial Growth.1
The Lag Phase.1
The Exponential Phase.2
Linear Growth.2
The Yield of Growth.3
Variation of the Growth Rate at Limiting Carbon Source
Concentrations.4
Continuous Growth: The Chemostat.5
Advantages of the Continuous Exponential Culture.7
Diauxic Growth.8
Quorum Sensing and Quorum Quenching.10
Selected References.12
2 The Outer Membrane of Gram-Negative Bacteria
and the Cytoplasmic Membrane.13
The Outer Membrane of Gram-Negative Bacteria.13
The Cytoplasmic Membrane.15
Energy Generation.16
ATP Synthase.16
Subunit Composition of ATP Synthase.17
ATP Synthesis in Archaea.20
Selected References.21
3 Peptidoglycan Synthesis and Cell Division.23
General Structure.23
Assembly of the Peptidoglycan Unit.24
Formation of UDP-MurNAc.24
Peptide Addition.24
The Membrane Steps.26
Assembly of the Murein Sacculus.27
xiv Contents
Penicillin Sensitivity.27
Cell Division.27
Selected References.30
4 Cellular Permeability.31
Accumulation, Crypticity, and Selective Permeability.32
ß-Galactoside Permease.33
Accumulation in Induced Cells: Kinetics and Specificity.33
The Induced Synthesis of Galactoside Permease.37
Functional Significance of Galactoside Permease.
Specific Crypticity.38
Functional Relationships of Permease: Induction.40
Genetic Relationships of Galactosidase and Galactoside
Permease.40
Galactoside Permease as Protein.41
Periplasmic Binding Proteins and ATP Binding Cassettes.45
Phosphotransferases: The PTS System.48
TRAP Transporters.50
A Few Well-Identified Cases of Specific Cellular Permeability.51
Amino Acid Permeases.51
Peptide Permeases.52
Porins.52
Iron Uptake.56
Conclusion.57
Selected References.57
5 AHosteric Enzymes.59
Allosteric Inhibition and Activation.62
Polymeric Nature of Allosteric Enzymes. The model
of Monod, Wyman and Changeux.64
An Alternative Model.69
Probing Allostery Through DNA.70
Conclusion.71
Selected References.71
6 Glycolysis, Gluconeogenesis and Glycogen
and Cellulose Synthesis.73
Glycogen Degradation.73
Glycolysis.73
Hexokinase.75
Glucose-6-Phosphate Isomerase.75
Phosphofructokinase.76
Regulation of Phosphofructokinase in Bacteria.77
Fructose 1,6-Bisphosphate Aldolase.77
Trióse Phosphate Isomerase.78
Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH).78
Phosphoglycerate Kinase.78
Contents xv
Phosphoglyceromutase.78
Enolase.79
Pyruvate Kinase.79
L-Glucose Catabolic Pathway.80
Gluconeogenesis.80
Fructose Bisphosphatase in Microorganisms.80
Glycogen Synthesis.81
Glycogen Synthase.81
Control of Glycogen Biosynthesis.82
Branching Enzyme.82
Cellulose Synthesis.83
Selected References.83
7 The Pentose Phosphate and Entner-Doudoroff Pathways.85
The Pentose Phosphate Pathway.85
The Enzymes of the Oxidative Phase.85
Glucose-6-Phosphate Dehydrogenase.85
6-Phosphogluconolactonase.86
6-Phosphogluconate Dehydrogenase (Decarboxylating).86
Ribose Phosphate Isomerase.86
The Enzymes of the Non Oxidative Phase.86
Transketolase.87
Transaldolase.88
Ribulose-5-Phosphate-3-Epimerase.88
Regulation of the Pentose Phosphate Pathway.88
The Entner-Doudoroff Pathway.88
Selected References.90
8 The Tricarboxylic Acid Cycle and the Glyoxylate Bypass.91
The Origin of Acetyl CoA: The Pyruvate Dehydrogenase Complex--------91
Overview of the Tricarboxylic Acid (TCA) Cycle.93
Origin of the Oxaloacetate.94
Citrate Synthase.94
Aconitase (From Citrate to Isocitrate Through eis-Aconitate).96
Isocitrate Dehydrogenase (IDH).98
E. coli Isocitrate Dehydrogenase Kinase-Phosphatase.100
a-Ketoglutarate Dehydrogenase Complex.101
Succinyl CoA Synthetase.102
Succinate Dehydrogenase.103
Enmarase.105
Malaie Dehydrogenase.107
Organization of the Enzymes of the Tricarboxylic Acid Cycle.108
The Tricarboxylic Acid Cycle Is a Source
of Biosynthetic Precursors.110
The Anaplerotic Glyoxylic Pathway Bypass.110
Selected References.112
113
113
113
116
117
117
118
118
119
120
121
122
122
123
124
127
127
128
128
128
129
133
134
134
135
136
137
139
139
140
140
141
141
141
143
145
147
149
151
151
152
ATP-Generating Processes: Respiration and Fermentation .
The Biological Oxidation of Organic Metabolites Is the Removal
of Electrons.
Respiration.
Fermentation.
Acetone-butanol Fermentation.
The Stickland Reaction.
Ornithine Fermentation.
Glycine and Proline Degradation.
Threonine Degradation.
Glutamate Degradation.
Lysine Degradation.
Arginine Fermentation.
Methionine Degradation.
D-selenocystine and D-cysteine Degradation.
Selected References.
Biosynthesis of Lipids.
Biosynthesis of Short Chain Fatty Acids.
Biosynthesis of Long-chain Fatty Acids.
Synthesis of acetyl CoA.
Synthesis of Malonyl CoA.
From Malonyl CoA to Palmitate.
Regulation of Yeast Fatty Acid Synthesis at the Genetic Level. .
Regulation of Fatty Acid Synthesis in Bacteria.
Biosynthesis of Triglycerides.
Biosynthesis of Phosphoglycerides.
Cyclopropane Fatty Acid Synthase (CFA Synthase).
Selected References.
Iron-Sulfur Proteins.
Iron-Sulfur Clusters.
2Fe-2S Clusters.
4Fe-4S Clusters.
3Fe-4S Clusters.
Other Fe-S Clusters.
Biosynthesis of Fe-S Clusters.
Iron-Sulfur Proteins.
Selected References.
The Archaea.
Chemical Characteristics of Archaea.
Archaea: Fossil Record.
Economic Importance of the Archaea.
Selected References.
Contents xvii
13 Methanogens and Methylotrophs.153
Methanogens and Methanogenesis.154
Reduction of C02.154
Formylmethanofuran Dehydrogenase.156
Formylmethanofuran: Tetrahydromethanopterin
Formyltransferase.157
Methenyltetrahydromethanopterin Cyclohydrolase.158
5, 10-methylenetetrahydromethanopterin Dehydrogenase.158
5, 10-methylenetetrahydromethanopterin F420 Oxidoreductase.159
The Methylreductase. Methyl Coenzyme M Reductase.159
Simplification of the Methylreductase System.161
Structure of the Methylreductase.162
Source of the Energy Needed for the Growth of Methanogens.163
Biosynthesis of Some Cofactors Involved in Methanogenesis.163
Methanofuran.163
Methanopterin.164
Coenzyme M.164
7-mercaptoheptanoylthreoninephosphate(Coenzyme B).165
Biosynthesis of Coenzyme F420 .167
Biosynthesis of Factor F430 .167
Biosynthesis of Factor III.168
The Aerobic Formation of Methane.168
Methylotrophs.169
Methanotrophs.169
Metabolism of Methyl Compounds.170
Anaerobic Oxidation of Methane.171
Methylamine Dehydrogenase.171
Carbon Assimilation by Methylotrophs.172
Carboxydotrophs.174
Selected References.175
14 Enzyme Induction in Catabolic Systems.179
The Specificity of Induction.179
De novo Synthesis of ß-galactosidase.180
Constitutive Mutants.182
Pleiotropy of the Constitutive Mutants.183
The Genetic Control and the Cytoplasmic Expression of Inducibility
in the Synthesis of ß-galactosidase in E. coli. The Lac Repressor.184
Operators and Operons.189
Selected References.193
15 Transcription: RNA Polymerase.195
The Synthesis of Messenger RNA. The Bacterial RNA Polymerase. 196
Termination of Transcription in Prokaryotes.200
xviii
Contents
Yeast RNA Polymerases.201
Archaeal RNA Polymerases.202
Transcription Termination and PolyA Tails.203
Selected References.203
16 Negative Regulation.205
Induction Is Correlated with the Synthesis of a Specific Messenger. . 205
Isolation of the Lac Repressor.207
The lac Operator Is a DNA Sequence.211
Direct Observation of Transcription Factor Dynamics
in a Living Cell.216
Selected References.216
17 Enzyme Repression in Anabolic Pathways.219
Description of the Phenomenon.219
Isolation of Derepressed (Constitutive) Mutants in Biosynthetic
Pathways. The Use of Structural Analogues.223
Replacement of Methionine by Selenomethionine in Proteins.224
Selected References.225
18 Positive Regulation.227
The Promoter Region.228
Role of Cyclic AMP and of the CAP Protein in the Binding
of RNA Polymerase to the Promoter Region.229
The Synthesis and Degradation of Cyclic AMP.231
How Does Glucose Exert Its Inhibitory Effect on E. coli
ß-galactosidase Synthesis?.232
Coordination of Bacterial Proteome with Metabolism
by Cyclic AMP Signalling.233
Selected References.233
19 The Ribosomes, Translation, Chaperones and Chaperonins.235
The Components of E. coli Ribosomes.236
The Ribosomes of Eukaryotes and of Archaea.238
Post-translational Modifications of Ribosomal Proteins.238
Mechanistic Aspects of Translation of Messenger RNA to Protein
by Ribosomes.238
Chaperones and Chaperonins.241
Extraribosomal Functions.243
Selected References.244
20 The Genetic Code, the Transfer RNAs
and the Aminoacyl-tRNA-Synthetases.247
The Genetic Code.247
The Transfer RNAs.251
Modulation of tRNA Function.257
Selected References.258
Contents xix
21 Attenuation.261
Regulation of the trp Operon in Bacillus subtilis.265
General Remarks on Regulatory Mechanisms.266
Selected References.267
22 Regulation by RNAs and Ribos witches.269
Mechanisms of Riboswitches.272
Selected References.274
23 The Biological Fixation of Nitrogen.275
Control of Nitrogenase Synthesis and Activity.278
Selected References.281
24 How Biosynthetic Pathways Have Been Established.283
Use of Isotopes.283
Use of Auxotrophic Mutants.286
Enzymatic Analysis.287
Selected References.288
25 The Aspartic Acid Family of Amino Acids: Biosynthesis.289
The Biosynthesis of Aspartic Acid and Asparagine.289
Biosynthesis of Lysine from Aspartate Semialdehyde in Bacteria.292
The Synthesis of Dipicolinic Acid, a Substance Present
in the Spores of Gram-Positive Bacilli.294
The Reduction of Aspartate Semialdehyde to Homoserine,
the Common Precursor of Methionine and Threonine.295
Biosynthesis of Methionine from Homoserine.296
S-Adenosylmethionine (SAM) Biosynthesis.300
Biosynthesis of Threonine from Homoserine.302
Biosynthetic Threonine Dehydratase.303
Isoleucine Biosynthesis.304
Ectoine Biosynthesis.305
Selected References.307
26 Regulation of the Biosynthesis of the Amino Acids
of the Aspartic Acid Family in Enterobacteriaceae.309
A Paradigm of Isofunctional and Multifunctional Enzymes
and of the Allosteric Equilibrium.309
Two Aspartokinases in E. Coli.310
The Threonine-Sensitive Homoserine Dehydrogenase of E. Coli . 312
Isolation of a Mutant Lacking the Lysine-Sensitive Aspartokinase
and of Revenants Thereof.312
Evidence That the Threonine-Sensitive Aspartokinase
and Homoserine Dehydrogenase of E. Coli Are Carried
by the Same Bifunctional Protein.314
The Binding of Threonine to Aspartokinase
I-Homoserine Dehydrogenase I.317
xx Contents
The Binding of Pyridine Nucleotides to Aspartokinase
I-Homoserine Dehydrogenase I.318
The Effects of Threonine on Aspartokinase I-Homoserine
Dehydrogenase I Are Not Only due to Direct Interactions.318
The Allosteric Transition of Aspartokinase I-Dehydrogenase 1.321
Aspartokinase II-Homoserine Dehydrogenase II.324
Aspartokinase III.325
From Homoserine to Methionine.326
From Threonine to Isoleucine.326
Multifunctional Proteins.327
Regulations at the Genetic Level.329
The Threonine Operon.329
Regulation of the Lysine Regulon at the Genetic Level.330
Regulation of Methionine Biosynthesis at the Genetic Level.331
The Methionine Repressor.332
The metR Gene and Its Product.337
The Regulation of Isoleucine Synthesis at the Genetic Level.337
Appendix: More on Régulons.338
Selected References.340
27 Other Patterns of Regulation of the Synthesis of Amino Acids
of the Aspartate Family.343
Concerted Feedback Inhibition of Aspartokinase Activity
in Rhodobacter capsulatus (Formerly Rhodopseudomonas
capsulata).343
Pseudomonads.344
Specific Reversal of a Particular Feedback Inhibition by Other
Essential Metabolites. The Case of Rhodospirillum Rubrum.346
Archaea.347
The Particular Case of Spore-Forming Bacilli.349
Some Other Cases.350
Conclusion.351
Selected References.351
28 Biosynthesis of the Amino Acids of the Glutamic Acid Family
and Its Regulation.353
The Biosynthesis of Glutamine.353
Biosynthesis of Glutamine. Cumulative Feedback Inhibition.353
Biosynthesis of Glutamine. The Covalent Modification
of Glutamine Synthetase.355
Glutamine Synthetase Structure.356
Reversible Adenylylation of the Glutamine Synthetase.358
Regulation of Glutamine Synthetase Activity
by Covalent Adenylylation.360
The Regulation of the Synthesis of Glutamine Synthetase
Also Involves the Two Forms of PII and UTase/UR.362
Glutamine Synthetase in Other Microorganisms.363
Contents xxi
The Biosynthesis of Glutamate.365
Glutamate Dehydrogenase.365
Glutamate Synthase.365
Glutamate Decarboxylase.366
Biosynthesis of Proline.367
In Enterobacteriaceae.367
In Other Genera.368
Utilization of Proline.369
Degradation of Hydroxyproline.369
The Biosynthesis of Arginine and Polyamines.369
Biosynthesis of Arginine.369
Regulation of Arginine Biosynthesis at the Transcriptional Level. 373
The Arginine Repressor.373
Polyamine Biosynthesis.374
Utilization of Arginine as Sole Nitrogen Source by B. Subtilis.378
Nitric Oxide Synthase in Bacteria.378
The Biosynthesis of Lysine in Yeasts and Molds.379
The Aminoadipic Acid Pathway.380
Selected References.383
29 Biosynthesis of Amino Acids Derived from Phosphoglyceric
Acid and Pyruvic Acid.387
Biosynthesis of Glycine and Serine.387
Regulation of Serine Hydroxymethyltransferase
at the Transcriptional Level.390
Biosynthesis of Cysteine.390
O-acetylation of Serine.392
Cysteine Synthesis in Methanogens.392
Allosteric Regulation of Cysteine Synthesis.394
Regulation of Cysteine Synthesis at the Genetic Level.394
Biosynthesis of Alanine.395
Biosynthesis of Valine.396
Biosynthesis of Leucine.398
Isoleucine Synthesis from Pyruvate.400
Regulation of Valine, Isoleucine and Leucine Biosynthesis.400
Selected References.402
30 Selenocysteine and Selenoproteins.405
Outlook.405
Selenium Binding Protein.406
Enzymes Containing Selenocysteine.406
Formate Dehydrogenases.406
The Glycine Reductase Complex.407
The Nicotinic Acid Hydroxylase of Clostridium barken.408
Hydrogenases.409
Xanthine Dehydrogenase.409
Acetoacetyl CoA Thiolase.409
xxii
Contents
Gene Products Involved in Selenocysteine Biosynthesis
and Incorporation.410
Selenocysteine Synthase.410
Selenophosphate Synthetase.410
Selenocysteine Lyase.411
Selenocysteyl tRNA.411
Insertion Sequences (SECIS Elements).412
Selenocysteine and Archaea.413
Biochemical Function of the Selenocysteine Residue in Catalysis . 413
Selected References.414
31 Biosynthesis of Aromatic Amino Acids and Its Regulation.415
The Common Pathway (Shikimic Pathway).415
Formation of Shikimic Acid.415
Formation of Chorismic Acid.419
Physiological Aspects of the Regulation of the Common Pathway . 421
Characteristics of the Common Pathway in Several Organisms.422
Biosynthesis of Phenylalanine and Tyrosine from Chorismic Acid. . 423
The tyrR regulon.425
Regulation of the pheA Gene by Attenuation.426
Other Organisms. The Arogenate Pathway of Phenylalanine
and Tyrosine Biosynthesis.426
Aspartate as a Presursor of Aromatic Amino Acids.427
The Biosynthesis of Tryptophan from Chorismic Acid.428
Anthranilate Synthase-Anthranilate Phosphoribosyltransferase . 428
Phosphoribosylanthranilate Isomerase-Indoleglycerophosphate
Synthase.429
Tryptophan Synthase.430
Regulation of Tryptophan Biosynthesis at the Genetic Level.
The Tryptophan Repressor.434
A Unitary Model for Induction and Repression.436
Isolation of the Trp Repressor.436
Enterochelin (Enterobactin) Biosynthesis.438
The Synthesis of 2,3-Dihydroxybenzoic Acid.438
Selected References.440
32 The Biosynthesis of Histidine and Its Regulation.443
Regulation of Histidine Biosynthesis at the Genetic Level.446
Synthesis of Diphthamide, a Modified Histidine, by Archaea.451
Selected References.452
33 The Biosynthesis of Nucleotides.453
The Biosynthesis of Pyrimidine Nucleotides.453
Synthesis of 5-Phosphoribosyl-l-Pyrophosphate (PRPP).453
Synthesis of Carbamylphosphate.454
Synthesis of Cytidine and Uridine Triphosphates.456
Contents xxiii
Direct Utilization of Pyrimidines and of Their Derivatives.459
Aspartate Transcarbamylase of E. coli.459
Regulation of Pyrimidine Nucleotide Synthesis
at the Genetic Level.466
The Biosynthesis of Purine Nucleotides.467
Biosynthesis of 5-Amino-4-Imidazole Carboxamide
Ribonucleotide.467
Synthesis of Inosinic Acid.470
Synthesis of Guanylic and Adenylic Acids.471
Remarks on the Control of Purine Nucleotide Biosynthesis.472
From Nucleoside Monophosphates to Nucleoside Diphosphates
and Triphosphates.474
Selected References.475
34 The Biosynthesis of Deoxyribonucleotides.477
The Formation of Deoxyribonucleoside Diphosphates
from Ribose Nucleoside Diphosphates.477
The Ribosenucleoside Diphosphate (NDP) 'Reductase System
of E. coli'.478
Thioredoxin and Thioredoxin Reductase.478
Ribonucleoside Reductase.480
Regulation of the Activity of Ribonucleoside Diphosphate
Reductase.482
dCMP Deaminase and Thymidylate Synthase.484
dUTPase.486
The Ribonucleoside Phosphate Reductase of Other Organisms.486
A Ribonucleotide Triphosphate Reductase Reaction in E. coli
Grown Under Anaerobic Conditions.487
The Synthesis of Deoxyribonucleoside Triphosphates
from the Diphosphates.488
Organization of DNA Precursor Synthesis in Eukaryotic Cells.488
Selected References.489
35 Biosynthesis of Some Water-Soluble Vitamins
and of Their Coenzyme Forms.491
Biosynthesis of Thiamin and Cocarboxylase.491
Control of Thiamin Biosynthesis.494
Biosynthesis of Riboflavin.495
Biosynthesis of Nicotinamide, NAD+ and NADP+.498
Regulation of the Biosynthesis of Nicotinamide and Its Derivatives. 501
NAD+ and the ADP-Ribosylation of Proteins.501
Biosynthesis of Para-aminobenzoic Acid, of Folic Acid
and Its Derivatives.502
Biosynthesis of Vitamin B6 Ppyridoxine, and of Its Derivatives,
Pyridoxal, Pyridoxamine and Pyridoxal Phosphate.506
Biosynthesis of Biotin, Biotin C02, and Biocytin.508
xxjv Contents
The Biotin Operon and Its Repressor.512
Biosynthesis of Lipoic Acid.513
Biosynthesis of Pantothenate and Coenzyme A.515
The Synthesis of Pantothenic Acid.515
The Synthesis of Coenzyme A from Pantothenic Acid.516
The Acyl Carrier Protein.517
The Biosynthesis of Inositol.517
The Degradation of Myo inositol by Bacillus subtilis.518
Biosynthesis of Pyrroloquinoline Quinone.519
Selected References.521
36 Biosynthesis of Carotene, Vitamin A, Sterols, Ubiquinones
and Menaquinones.523
Synthesis of the Common Precursor.523
The Non-mevalonate Pathway of Isoprenoid Precursor
(Dimethylallyl Pyrophosphate) Biosynthesis.525
Synthesis of ß-Carotene, Carotenoids and Vitamin A.527
Synthesis of the Carotenoids.527
Regulation of Carotenoid Synthesis.530
Synthesis of Vitamin A.531
Synthesis of Sterols.531
The Biosynthesis of Ubiquinones and Menaquinones.533
Selected References.537
37 Biosynthesis of the Tetrapyrrole Ring System.539
Synthesis of Protoporphyrin.539
Synthesis of Heme from Protoporphyrin.544
Heme Biosynthesis in Archaea.545
Synthesis of Chlorophyll from Protoporphyrin.546
Biosynthesis of the Phycobilin Chromophores.
Chromatic Adaptation.548
A Type of Chromatic Adaptation Under Conditions
of Sulfur Starvation.552
Selected References.553
38 Biosynthesis of Cobalamins Including Vitamin B12.555
Cobinamide Biosynthesis.559
From GDP-Cobinamide to Cobalamin.561
Elucidation of the Anaerobic Pathway for the Corrin Component
of Vitamin B12.563
Selected References.564
39 Interactions Between Proteins and DNA.567
DNA-Binding Proteins.567
Study of the Protein-DNA Complexes.570
Some Other Types of DNA-Binding Proteins.575
Selected References.578
Contents xxv
40 Evolution of Biosynthetic Pathways.579
Principles of Protein Evolution.579
Two Theories for the Evolution of Biosynthetic Pathways.579
The Methionine and Cysteine Biosynthetic Pathways.580
The Threonine, Isoleucine, Cysteine and Tryptophan Biosynthetic
Pathways.583
The Evolutionary Pathway Leading to the Three Isofunctional
Aspartokinases in Escherichia coli.588
The Aspartokinase and Homoserine Dehydrogenase Activities
of Microorganisms Other Than Enterobacteriaceae.592
Transmembrane Facilitators.595
DNA-Binding Regulator Proteins.595
Selected References .596
Index.599 |
| any_adam_object | 1 |
| author | Cohen, Georges N. 1920- |
| author_GND | (DE-588)142904864 |
| author_facet | Cohen, Georges N. 1920- |
| author_role | aut |
| author_sort | Cohen, Georges N. 1920- |
| author_variant | g n c gn gnc |
| building | Verbundindex |
| bvnumber | BV041849226 |
| classification_rvk | WF 1350 |
| ctrlnum | (OCoLC)897004398 (DE-599)BVBBV041849226 |
| discipline | Biologie |
| edition | 3. ed. |
| format | Book |
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| id | DE-604.BV041849226 |
| illustrated | Illustrated |
| indexdate | 2025-04-02T14:00:50Z |
| institution | BVB |
| isbn | 9789401789073 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-027293722 |
| oclc_num | 897004398 |
| open_access_boolean | |
| owner | DE-11 DE-29T DE-20 |
| owner_facet | DE-11 DE-29T DE-20 |
| physical | XXVIII, 611 S. graph. Darst. |
| publishDate | 2014 |
| publishDateSearch | 2014 |
| publishDateSort | 2014 |
| publisher | Springer |
| record_format | marc |
| spelling | Cohen, Georges N. 1920- Verfasser (DE-588)142904864 aut Microbial biochemistry G.N. Cohen 3. ed. Dordrecht [u.a.] Springer 2014 XXVIII, 611 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Mikroorganismus (DE-588)4039226-0 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf Mikroorganismus (DE-588)4039226-0 s Biochemie (DE-588)4006777-4 s DE-604 Molekularbiologie (DE-588)4039983-7 s 1\p DE-604 Erscheint auch als Online-Ausgabe 978-94-017-8908-0 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027293722&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Cohen, Georges N. 1920- Microbial biochemistry Mikroorganismus (DE-588)4039226-0 gnd Biochemie (DE-588)4006777-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4039226-0 (DE-588)4006777-4 (DE-588)4039983-7 |
| title | Microbial biochemistry |
| title_auth | Microbial biochemistry |
| title_exact_search | Microbial biochemistry |
| title_full | Microbial biochemistry G.N. Cohen |
| title_fullStr | Microbial biochemistry G.N. Cohen |
| title_full_unstemmed | Microbial biochemistry G.N. Cohen |
| title_short | Microbial biochemistry |
| title_sort | microbial biochemistry |
| topic | Mikroorganismus (DE-588)4039226-0 gnd Biochemie (DE-588)4006777-4 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Mikroorganismus Biochemie Molekularbiologie |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027293722&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT cohengeorgesn microbialbiochemistry |