Mass spectrometry for drug discovery and drug development:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, NJ
Wiley
2013
|
| Schriftenreihe: | Wiley-Interscience series on mass spectrometry
|
| Schlagworte: | |
| Online-Zugang: | FRO01 UBT01 Volltext |
| Beschreibung: | This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781118516126 9781118516140 9781118516157 9781283917520 |
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| 505 | 0 | |a 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens | |
| 650 | 4 | |a Drug discovery | |
| 650 | 4 | |a Mass spectrometry / Methods | |
| 650 | 4 | |a Peptides / Analysis | |
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| contents | 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens |
| ctrlnum | (OCoLC)823389939 (DE-599)BVBBV041829130 |
| dewey-full | 615.1 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1 |
| dewey-search | 615.1 |
| dewey-sort | 3615.1 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Electronic eBook |
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| spelling | Mass spectrometry for drug discovery and drug development edited by Walter A. Korfmacher Hoboken, NJ Wiley 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Wiley-Interscience series on mass spectrometry This book presents a summary of the ways mass spectrometry is used in various stages of drug discovery and development including early support of medicinal chemistry, drug metabolism studies, distribution, degradation, and various development assays. The book includes a balance of basic and advanced information. Specific chapters relate to various stages in the process (e.g., discovery) as well as chapters on topics of current interest (lipidomics and SiRNA) are covered 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens Drug discovery Mass spectrometry / Methods Peptides / Analysis Pharmaceutical preparations / Analysis Proteins / Analysis MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Drug Discovery Mass Spectrometry / methods Peptides / analysis Pharmaceutical Preparations / analysis Proteins / analysis Drug development fast Drugs / Analysis fast Mass spectrometry fast Medizin Drugs / Analysis Drug development Mass spectrometry Massenspektrometrie (DE-588)4037882-2 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Massenspektrometrie (DE-588)4037882-2 s Arzneimittelentwicklung (DE-588)4143176-5 s b DE-604 Korfmacher, Walter A. Sonstige oth Erscheint auch als Druckausgabe 978-0-470-94238-3 https://onlinelibrary.wiley.com/doi/book/10.1002/9781118516157 Verlag Volltext |
| spellingShingle | Mass spectrometry for drug discovery and drug development 1. Overview of the various types of mass spectrometers that are used in drug discovery and drug development / Gerard Hopfgartner -- 2. Utility of high resolution mass spectrometry for new drug discovery applications / William Bart Emary and Nanyan Rena Zhang -- 3. Quantitative mass spectrometry considerations in a regulated environment / Mohammed Jemal and Yuan-Qing Xia -- 4. Mass spectrometry for quantitative in vitro ADME assays / Jun Zhang and Wilson Z. Shou -- 5. Metabolite identification using mass spectrometry in drug development / Natalia Penner, Joanna Zgoda-Pols, and Chandra Prakash -- 6. MS analysis of biological drugs, proteins, and peptides / Yi Du, John Mehl, and Pavlo Pristatsky -- 7. Characterization of impurities and degradation products in small molecule pharmaceuticals and biologics / Hui Wei, Guodong Chen and Adrienne A. Tymiak -- 8. Liquid extraction surface analysis (LESA) : a new mass spectrometry-based technique for ambient surface profiling / Dan Eikel and Jack Henion -- 9. MS applications in support of medicinal chemistry sciences / Maarten Honing, Benno Ingelse, and Birendraÿ N. Pramanik -- 10. Imaging mass spectrometry of proteins and peptides / Michelle L. Reyzer and Richard M. Caprioli -- 11. Imaging mass spectrometry for drugs and metabolites / Stacey R. Oppenheimer -- 12. Screening reactive metabolites : role of liquid chromatography-high resolution mass spectrometry in combination with 'intelligent' data mining tools / Shuguang Ma and Swapan K. Chowdhury -- 13. Mass spectrometry of siRNA / Mark Cancilla and Mike Flanagan -- 14. Mass spectrometry for metabolomics / Petia Shipkova and Michael D. Reily -- 15. Quantitative analysis of peptides with mass spectrometry : selected reaction monitoring or high resolution full scan? / Lieve Dillen and Filip Cuyckens Drug discovery Mass spectrometry / Methods Peptides / Analysis Pharmaceutical preparations / Analysis Proteins / Analysis MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Drug Discovery Mass Spectrometry / methods Peptides / analysis Pharmaceutical Preparations / analysis Proteins / analysis Drug development fast Drugs / Analysis fast Mass spectrometry fast Medizin Drugs / Analysis Drug development Mass spectrometry Massenspektrometrie (DE-588)4037882-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4037882-2 (DE-588)4143176-5 (DE-588)4143413-4 |
| title | Mass spectrometry for drug discovery and drug development |
| title_auth | Mass spectrometry for drug discovery and drug development |
| title_exact_search | Mass spectrometry for drug discovery and drug development |
| title_full | Mass spectrometry for drug discovery and drug development edited by Walter A. Korfmacher |
| title_fullStr | Mass spectrometry for drug discovery and drug development edited by Walter A. Korfmacher |
| title_full_unstemmed | Mass spectrometry for drug discovery and drug development edited by Walter A. Korfmacher |
| title_short | Mass spectrometry for drug discovery and drug development |
| title_sort | mass spectrometry for drug discovery and drug development |
| topic | Drug discovery Mass spectrometry / Methods Peptides / Analysis Pharmaceutical preparations / Analysis Proteins / Analysis MEDICAL / Drug Guides bisacsh MEDICAL / Nursing / Pharmacology bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh Drug Discovery Mass Spectrometry / methods Peptides / analysis Pharmaceutical Preparations / analysis Proteins / analysis Drug development fast Drugs / Analysis fast Mass spectrometry fast Medizin Drugs / Analysis Drug development Mass spectrometry Massenspektrometrie (DE-588)4037882-2 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | Drug discovery Mass spectrometry / Methods Peptides / Analysis Pharmaceutical preparations / Analysis Proteins / Analysis MEDICAL / Drug Guides MEDICAL / Nursing / Pharmacology MEDICAL / Pharmacology MEDICAL / Pharmacy Drug Discovery Mass Spectrometry / methods Peptides / analysis Pharmaceutical Preparations / analysis Proteins / analysis Drug development Drugs / Analysis Mass spectrometry Medizin Massenspektrometrie Arzneimittelentwicklung Aufsatzsammlung |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9781118516157 |
| work_keys_str_mv | AT korfmacherwaltera massspectrometryfordrugdiscoveryanddrugdevelopment |