Therapeutic applications of ribozymes and riboswitches: methods and protocols
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Humana Press
2014
|
| Schriftenreihe: | Methods in molecular biology
1103 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 278 S. Ill., graph. Darst. |
| ISBN: | 9781627037297 |
Internformat
MARC
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Datensatz im Suchindex
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Titel: Therapeutic applications of ribozymes and riboswitches
Autor: Lafontaine, Daniel
Jahr: 2014
Contents
Preface. v
Contributors.
1 Identification of Regulatory RNA in Bacterial Genomes
by Genome-Scale Mapping of Transcription Start Sites. 1
Navjot Singh and Joseph T. Wade
2 Screening Inhibitory Potential of Anti-HIV RT RNA Aptamers. 11
Margaret J. Lange and Donald H. Burke
3 Design and Evaluation of Clinically Relevant SOFA-HDV Ribozymes
Targeting HIV RNA. 31
Robert J. Scarborough, Michel V. Lévesque, Jean-Pierre Perreault,
and Anne Gatignol
4 Directing RNase P-Mediated Cleavage of Target mRNAs
by Engineered External Guide Sequences in Cultured Cells. 45
Xiaohong Jiang, Naresh Sunkara, Sangwei Lu, and FenyongLiu
5 Design and Analysis of Hammerhead Ribozyme Activity Against
an Artificial Gene Target. 57
James R. Carter, Pruksa Nawtaisong, Velmurugan Balaraman,
and Malcolm J. Fraser Jr.
6 Knockdown Strategies for the Study of Proprotein Convertases
and Proliferation in Prostate Cancer Cells. 67
François D'Anjou, Frédéric Couture, Roxane Desjardins, and Robert Day
7 Use of Tumor-Targeting Tram--Splicing Ribozyme for Cancer Treatment . 83
Seong-Wook Lee and Jin-Sook Jeong
8 Characterization of Hairpin Ribozyme Reactions. 97
Preeti Bajaj and Christian Hammann
9 Finding Instances of Riboswitches and Ribozymes
by Homology Search of Structured RNA with Infernal. 113
Amell Fl Korbt, Jonathan Ouellet, Mohammad Reza Naghdi,
and Jonathan Perreault
10 Structure-Based Virtual Screening for the Identification
of RNA-Binding Ligands. 127
Peter Daldrop and Ruth Brenk
11 Probing Riboswitch Binding Sites with Molecular Docking,
Focused Libraries, and In-line Probing Assays. 141
Francesco Colizzi, Anne-Marie Lamontagne, Daniel A. Lafontaine,
and Giovanni Bussi
vii
viii
Contents
12 Discovery of Small Molecule Modifiers of microRNAs
for the Treatment of HCV Infection. 153
Valerie T. Tripp and Douglas D. Young
13 Bacterial Flavin Mononucleotide Riboswitches as Targets
for Flavin Analogs. 165
Danielle Biscaro Pedrolli and Matthias Mack
14 Construction and Application of Riboswitch-Based Sensors
That Detect Metabolites Within Bacterial Cells. 177
Casey C. Fowler and Tingfu Li
15 Screening Assays to Identify Artificial glmS Ribozyme Activators. 199
Christina E. Lünse and Günter Mayer
16 Analysis of Riboswitch Structure and Ligand Binding
Using Small-Angle X-ray Scattering (SAXS). 211
Nathan J. Baird and Adrian R. Ferré-D'Amaré
17 Use of SHAPE to Select 2AP Substitution Sites for RNA-Ligand
Interactions and Dynamics Studies. 227
Marie F. Soulière and Ronald Micura
18 Cell Internalization SELEX: In Vitro Selection for Molecules
That Internalize into Cells. 241
Amy Tan and Matthew Levy
19 DNA Electronic Switches Based on Analyte-Responsive Aptamers. 267
Jason M. Thomas, Hua-Zhong Tu, and Dipankar Sen
Index. 277 |
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| series | Methods in molecular biology |
| series2 | Methods in molecular biology Springer protocols |
| spelling | Therapeutic applications of ribozymes and riboswitches methods and protocols ed. by Daniel Lafontaine ... New York, NY [u.a.] Humana Press 2014 XI, 278 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in molecular biology 1103 Springer protocols Riboswitch (DE-588)7721130-3 gnd rswk-swf Therapie (DE-588)4059798-2 gnd rswk-swf Ribozym (DE-588)4356469-0 gnd rswk-swf Ribozym (DE-588)4356469-0 s Therapie (DE-588)4059798-2 s DE-604 Riboswitch (DE-588)7721130-3 s Lafontaine, Daniel Sonstige (DE-588)1050016211 oth Erscheint auch als Online-Ausgabe Lafontaine, Daniel Therapeutic Applications of Ribozymes and Riboswitches Methods in molecular biology 1103 (DE-604)BV035362695 1103 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027220708&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Therapeutic applications of ribozymes and riboswitches methods and protocols Methods in molecular biology Riboswitch (DE-588)7721130-3 gnd Therapie (DE-588)4059798-2 gnd Ribozym (DE-588)4356469-0 gnd |
| subject_GND | (DE-588)7721130-3 (DE-588)4059798-2 (DE-588)4356469-0 |
| title | Therapeutic applications of ribozymes and riboswitches methods and protocols |
| title_auth | Therapeutic applications of ribozymes and riboswitches methods and protocols |
| title_exact_search | Therapeutic applications of ribozymes and riboswitches methods and protocols |
| title_full | Therapeutic applications of ribozymes and riboswitches methods and protocols ed. by Daniel Lafontaine ... |
| title_fullStr | Therapeutic applications of ribozymes and riboswitches methods and protocols ed. by Daniel Lafontaine ... |
| title_full_unstemmed | Therapeutic applications of ribozymes and riboswitches methods and protocols ed. by Daniel Lafontaine ... |
| title_short | Therapeutic applications of ribozymes and riboswitches |
| title_sort | therapeutic applications of ribozymes and riboswitches methods and protocols |
| title_sub | methods and protocols |
| topic | Riboswitch (DE-588)7721130-3 gnd Therapie (DE-588)4059798-2 gnd Ribozym (DE-588)4356469-0 gnd |
| topic_facet | Riboswitch Therapie Ribozym |
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