Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Gießen
DVG Service
2013
|
| Edition: | 1. Aufl. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IV, 192 S. Ill., graph. Darst. |
| ISBN: | 9783863451837 |
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MARC
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| 245 | 1 | 0 | |a Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis |c by Yanyong Sun |
| 246 | 1 | 0 | |a janus-kinase-signal transducer and activator of transcription |
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| 650 | 7 | |a pathogenesis |2 cabt | |
| 650 | 7 | |a demyelination |2 cabt | |
| 650 | 7 | |a nervous system diseases |2 cabt | |
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
CONTENTS
1. AIMS OF STUDY 1
2. INTRODUCTION 5
2.1 THEIIER S MURINE ENCEPHALOMYELITIS (TIME) 5
2.1.1 ANIMAL MODELS FOR MULTIPLE SCLEROSIS 5
2.1.2 THEIIER S MURINE ENCEPHALOMYELITIS VIRUS (TMEV) 6
2.1.3 CLINICAL FEATURES
OF THE CHRONIC DEMYELINATING TME 6
2.1.4 PATHOHISTOLOGICAL FEATURES
OF THE CHRONIC DEMYELINATING
TME 7
2.1.5 PATHOGENESIS
OF THE CHRONIC DEMYELINATING TME 8
2.1.6 IMMUNOPATHOLOGY OF THE CHRONIC
DEMYELINATING TME 10
2.1.6.1 CD4* CELLS 10
2.1.6.2 CD8* CELLS 10
2.1.6.3 TH17 CELLS 11
2.1.6.4 REGULATORY T CELLS (TREG) 11
2.1.6.5 NATURAL KILLER T (NKT) CELLS 11
2.1.6.6 MACROPHAGES/MICROGLIA 11
2.1.6.7 ANTIBODIES 12
2.2 MACROGLIA 12
2.2.1 GLIOGENESIS 12
2.2.2 OLIGODENDROCYTE PRECURSOR CELLS (OPCS) 14
2.2.3 OLIGODENDROCYTES 15
2.2.4 ASTROCYTES 16
2.2.5 BO-1 CELL LINE 16
2.3 THE JAK-STAT SIGNALING PATHWAY 17
2.3.1 THE JAK-STAT PATHWAY IN THE CNS 21
2.3.1.1 NEURAL STEM CELLS (NSCS) 21
2.3.1.2 OLIGODENDROGLIAL LINEAGE
CELLS 22
2.3.1.3 ASTROCYTES 23
I
HTTP://D-NB.INFO/1047872994
CONTENTS
2.3.1.4 MICROGLIA 24
2.3.1.5 NEURONS 25
2.3.2 THE JAK-STAT PATHWAY
IN CNS PATHOLOGIES 25
2.3.2.1 INFLAMMATION 25
2.3.2.2 NEOPLASIA 26
2.3.2.3 DEMYELINATING DISEASE 27
3. HIGHLY MALIGNANT BEHAVIOR OF A MURINE OLIGODENDROCYTE PRECURSOR CELL
LINE
FOLLOWING TRANSPLANTATION INTO THE DEMYELINATED AND NON-DEMYELINATED
CENTRAL
NERVOUS SYSTEM
29
4. SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3 REPRESENTS A
MOLECULAR
SWITCH INDUCING ASTROGLIAL INSTEAD OF OLIGODENDROGLIAL DIFFERENTIATION
OF
OLIGODENDROGLIAL PROGENITOR CELLS IN THEILER S MURINE ENCEPHALOMYELITIS
31
5. DISCUSSION 93
5.1 HIGHLY MALIGNANT BEHAVIOR OF A MURINE
OLIGODENDROCYTE PRECURSOR CELL LINE
FOLLOWING TRANSPLANTATION INTO THE DEMYELINATED AND NON-DEMYELINATED
CENTRAL
NERVOUS SYSTEM
93
5.2 SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 3
REPRESENTS A MOLECULAR SWITCH
INDUCING ASTROGLIAL INSTEAD OF OLIGODENDROGLIAL
DIFFERENTIATION OF OLIGODENDROGLIAL
PROGENITOR CELLS
IN THEILER S MURINE ENCEPHALOMYELITIS 96
5.3 PROJECT OVERSPANNING INTERPRETATION 99
6. SUMMARY 101
7. ZUSAMMENFASSUNG 103
8. REFERENCES 105
9. APPENDICES 145
10. ACKNOWLEDGEMENTS 191
II
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| isbn | 9783863451837 |
| language | English |
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| spelling | Sun, Yanyong Verfasser aut Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis by Yanyong Sun janus-kinase-signal transducer and activator of transcription 1. Aufl. Gießen DVG Service 2013 IV, 192 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: Hannover, Tierärztl. Hochsch., Diss., 2013 muridae cabt mice cabt pathogenesis cabt demyelination cabt nervous system diseases cabt Theilers murine encephalomyelitis virus cabt Theilovirus cabt (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027089779&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Sun, Yanyong Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis muridae cabt mice cabt pathogenesis cabt demyelination cabt nervous system diseases cabt Theilers murine encephalomyelitis virus cabt Theilovirus cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis |
| title_alt | janus-kinase-signal transducer and activator of transcription |
| title_auth | Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis |
| title_exact_search | Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis |
| title_full | Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis by Yanyong Sun |
| title_fullStr | Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis by Yanyong Sun |
| title_full_unstemmed | Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis by Yanyong Sun |
| title_short | Role of JAK-STAT signaling in the pathogenesis of astrogliosis in chronic demyelinating Theilers̉ murine encephalomyelitis |
| title_sort | role of jak stat signaling in the pathogenesis of astrogliosis in chronic demyelinating theilers murine encephalomyelitis |
| topic | muridae cabt mice cabt pathogenesis cabt demyelination cabt nervous system diseases cabt Theilers murine encephalomyelitis virus cabt Theilovirus cabt |
| topic_facet | muridae mice pathogenesis demyelination nervous system diseases Theilers murine encephalomyelitis virus Theilovirus Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027089779&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT sunyanyong roleofjakstatsignalinginthepathogenesisofastrogliosisinchronicdemyelinatingtheilersmurineencephalomyelitis AT sunyanyong januskinasesignaltransducerandactivatoroftranscription |