A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Gießen
DVG Service
2013
|
| Edition: | 1. Aufl. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 197 S. Ill., graph. Darst. |
| ISBN: | 9783863451851 |
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| 245 | 1 | 0 | |a A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases |c by Charlotte Philippine Lempp |
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| 300 | |a 197 S. |b Ill., graph. Darst. | ||
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| 650 | 7 | |a neurons |2 cabt | |
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
CONTENTS
1 INTRODUCTION 1
2 LITERATURE REVIEW 3
2.1 THE AXON- STRUCTURE AND TRANSPORT MECHANISMS 3
2.2 MECHANISMS OF AXONAL INJURY 7
2.3 INHIBITION OF AXONAL OUTGROWTH 10
2.4 PROMOTION OF AXONAL OUTGROWTH 14
2.4.1 THE RALE OF ERYTHROPOIETIN 14
2.5 CANINE DISTEMPER VIRUS 17
2.5.1 PATHOGENESIS OF DISTEMPER IN DOGS 18
2.5.2 CDV ENCEPHALITIS AND ITS ROLE AS AN ANIMAL MODEL FOR MULTIPLE
SCLEROSIS 20
2.6 INTERVERTEBRAL DISK DISEASE AND SPINAL CORD INJURY 23
2.6.1 PATHOGENESIS OF SPINAL CORD INJURY 23
2.6.2 AXONAL PATHOLOGY IN SPINAL CORD INJURY 25
3 MATERIALS AND METHODS 27
3.1 INVESTIGATED ANIMALS 27
3.1.1 ANIMALS USED IN THE CANINE DISTEMPER ENCEPHALITIS STUDY 27
3.1.2 DOGS WITH INTERVERTEBRAL DISK DISEASE 28
3.2 NECROPSY AND TISSUE SAMPLING 31
3.2.1 TISSUE SAMPLES FOR HISTOCHEMISTRY AND IMMUNOHISTOCHEMISTRY 31
3.3 MORPHOLOGICAL CLASSIFICATION OF THE CEREBELLAR LESIONS IN DOGS WITH
CDV ENCEPHALITIS 32
3.4 CLASSIFICATION OF DOGS WITH INTERVERTEBRAL DISK DISEASE 33
3.5 IMMUNOHISTOCHEMISTRY 33
3.5.1 ANTIBODIES AND SERA 33
3.5.1.1 BLOCKING SERUM 34
HTTP://D-NB.INFO/1048463907
3.5.1.2 SECONDARY ANTIBODIES 34
3.5.1.3 DETECTION SYSTEM 34
3.5.1.4 IMMUNOHISTOCHEMISTRY (ABC METHOD) 36
3.5.1.5 DEMASKING OF ANTIGENS 37
3.5.1.6 POSITIVE AND NEGATIVE CONTROLS 37
3.6 EVALUATION 37
3.6.1 QUANTITATIVE ANALYSIS 37
3.6.2 STATISTICAL ANALYSIS 38
4 RESULTS 39
4.1 DOGS WITH CANINE DISTEMPER ENCEPHALITIS 39
4.1.1 CLINICAL SIGNS 39
4.1.2 MACROSCOPIC AND HISTOLOGICAL FINDINGS IN NON-CNS ORGANS 39
4.1.3 HISTOPATHOLOGY OF THE CEREBELLUM 39
4.2 IMMUNOHISTOCHEMICAI INVESTIGATION IN DOGS WITH CANINE DISTEMPER
ENCEPHALITIS 42
4.2.1 CANINE DISTEMPER VIMS ANTIGEN (CDV) 42
4.2.2 MYELIN BASIC PROTEIN 45
4.2.3 PHOSPHORYLATED NEUROFILAMENT 48
4.2.4 NON-PHOSPHORYLATED NEUROFILAMENT 51
4.2.5 AMYLOID PRECURSOR PROTEIN (APP) 54
4.2.6 ALPHA-ACETYLATED TUBULIN 57
4.2.7 |3-TUBULIN III 60
4.2.8 KINESIN 63
4.2.9 DYNEIN 66
4.2.10 TAU-1 69
4.2.11 NOGO-A 72
4.2.12 LINGO-1 75
4.2.13 GAP-43 78
4.2.14 ERYTHROPOIETIN (EPO) 80
4.2.15 ERYTHROPOIETIN RECEPTOR (EPO-R) 83
4.2.16 HYPOXIA-INDUCIBLE FACTOR 1-ALPHA (HIF-1A) 86
4.3 DOGS WITH SPINAL CORD INJURY DUE TO INTERVERTEBRAL DISK DISEASE
4.3.1 CLINICAL SIGNS
4.3.2 HISTOPATHOLOGY OF THE SPINAL CORD
89
89
89
CONTENTS
4.4 IMMUNOHISTOCHEMICAL INVESTIGATION IN DOGS WITH INTERVERTEBRAL DISK
DISEASE 90
4.4.1 ALPHA-ACETYLATED TUBULIN 90
4.4.2 B-TUBULIN III 93
4.4.3 KINESIN 96
4.4.4 DYNEIN 99
4.4.5 TAU-1 102
4.4.6 NOGO-A 105
4.4.7 LINGO-1 108
4.4.8 ERYTHROPOIETIN (EPO) 111
4.4.9 ERYTHROPOIETIN-RECEPTOR (EPO-R) 114
4.4.10 HYPOXIA-INDUCIBLE FACTOR 1A (HIF-1A) 117
4.5 RESULTS FROM PREVIOUS INVESTIGATIONS IN DOGS WITH SPINAL CORD INJURY
DUE TO
INTERVERTEBRAL DISK DISEASE 120
5 DISCUSSION 121
5.1 DEMYELINATING LEUKOENCEPHALITIS IN CANINE DISTEMPER 121
5.1.1 CDV-INFECTION AND DEMYELINATION 121
5.1.1.1 EVIDENCE OF ANTIGEN 121
5.1.1.2 DEMYELINATION 122
5.1.2 THE AXONAL CYTOSKELETON 122
5.1.3 AXONAL TRANSPORT MECHANISMS 124
5.1.4 INHIBITORS OF AXONAL OUTGROWTH 127
5.1.5 PROMOTERS OF AXONAL OUTGROWTH 128
5.2 SPINAL CORD INJURY IN CONSEQUENCE OF CANINE INTERVERTEBRAL DISK
DISEASE 130
5.2.1 THE AXONAL CYTOSKELETON 130
5.2.2 AXONAL TRANSPORT 131
5.2.3 INHIBITORS OF AXONAL OUTGROWTH - 132
5.2.4 PROMOTERS OF AXONAL OUTGROWTH 134
5.3 MEASUREMENT AND INTERPRETATION OF AXONAL DAMAGE IN THE CEREBELLAR
AND SPINAL CORD
WHITE MATTER 135
5.4 COMPARATIVE REVIEW OF THE VIRAL AND TRAUMATIC PATHOGENETIC MODEL OF
AXONAL INJURY 136
5.4.1 THE MECHANISM OF INJURY 136
5.4.2 OUTSIDE-IN VERSUS INSIDE-OUT MODEL 137
5.4.3 INHIBITION AND PROMOTION OF AXONAL REGENERATION 138
5.5 CONCLUSION 141
6 SUMMARY 143
7 ZUSAMMENFASSUNG 147
8 LITERATURE 151
9 APPENDIX 187
9.1 SOURCES OF CHEMICALS, REAGENTS AND ANTIBODIES 187
9.2 SOURCES FOR EQUIPMENT AND DISPOSABLE ITEMS 189
9.3 SOLUTIONS FOR IMMUNOHISTOCHEMISTRY 190
9.4 ABBREVIATIONS 195
10 ACKNOWLEDGEMENTS 197
|
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| author | Lempp, Charlotte Philippine |
| author_facet | Lempp, Charlotte Philippine |
| author_role | aut |
| author_sort | Lempp, Charlotte Philippine |
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| bvnumber | BV041619521 |
| ctrlnum | (OCoLC)869862607 (DE-599)GBV775219363 |
| dewey-full | 636.70897483044 |
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| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
| edition | 1. Aufl. |
| format | Thesis Book |
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| indexdate | 2024-07-10T01:01:02Z |
| institution | BVB |
| isbn | 9783863451851 |
| language | English |
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| physical | 197 S. Ill., graph. Darst. |
| publishDate | 2013 |
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| spelling | Lempp, Charlotte Philippine Verfasser aut A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases by Charlotte Philippine Lempp 1. Aufl. Gießen DVG Service 2013 197 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zugl.: Hannover, Tierärztl. Hochsch., Diss., 2013 central nervous system cabt viruses cabt pathogens cabt viral diseases cabt dogs cabt neurons cabt nervous system cabt (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027060584&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lempp, Charlotte Philippine A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases central nervous system cabt viruses cabt pathogens cabt viral diseases cabt dogs cabt neurons cabt nervous system cabt |
| subject_GND | (DE-588)4113937-9 |
| title | A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases |
| title_auth | A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases |
| title_exact_search | A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases |
| title_full | A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases by Charlotte Philippine Lempp |
| title_fullStr | A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases by Charlotte Philippine Lempp |
| title_full_unstemmed | A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases by Charlotte Philippine Lempp |
| title_short | A comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases |
| title_sort | a comparative investigation on the pathogenesis of axonal injury and the involvement of axonal transport mechanisms in viral and traumatic canine central nervous system diseases |
| topic | central nervous system cabt viruses cabt pathogens cabt viral diseases cabt dogs cabt neurons cabt nervous system cabt |
| topic_facet | central nervous system viruses pathogens viral diseases dogs neurons nervous system Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=027060584&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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