Verfügbarkeit: Membrane structural biology

Membrane structural biology: with biochemical and biophysical foundations

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Bibliographische Detailangaben
1. Verfasser:	Luckey, Mary 1948- (VerfasserIn)
Format:	Buch
Sprache:	English
Veröffentlicht:	Cambridge [u.a.] Cambridge Univ. Press 2014
Ausgabe:	2. ed.
Schlagworte:	Cell Membrane > physiology Membrane Lipids > physiology Membrane Proteins > physiology Membrane lipids Membrane proteins Membranes (Biology) Membranproteine Biomembran Biochemie Physiologie
Online-Zugang:	Inhaltsverzeichnis
Beschreibung:	XIV, 411 S. zahlr. Ill., graph. Darst.
ISBN:	9781107030633 9780521856553

Internformat

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Datensatz im Suchindex

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adam_text	Titel: Membrane structural biology Autor: Luckey, Mary Jahr: 2014 CONTENTS List of boxes xiii Membrane solubilization 49 Preface xiv Lipid removal Model membranes 51 51 1 INTRODUCTION 1 Monolayers Planar bilayers 52 54 General features of membranes 1 Patch clamps 57 Paradigm 1: the amphiphilic molecules in Supported bilayers 57 membranes assemble spontaneously due Liposomes from SUVs to GUVs 60 to the hydrophobic effect 4 Multilamellar vesicles 60 Paradigm 2: the Fluid Mosaic Model Small unilamellar vesicles 61 describes the membrane structure 5 Large unilamellar vesicles 61 A shift in the paradigm: biomembranes have Short-chain/long-chain unilamellar lateral domains that form rafts 9 vesicles 62 A view for the future: dynamic protein Giant unilamellar vesicles 62 complexes crowd the membrane Mixed micelles and bicelles 63 interior and extend its borders 9 Blebs and blisters 64 For further reading 13 Nanodiscs 66 Conclusion 67 2 THE DIVERSITY OF MEMBRANE For further reading 67 UPIDS 14 4 PROTEINS IN 0R AT THE BILAYER 69 The acyl chains 14 Complex lipids 17 Classes of proteins that interact with Phospholipids 19 the membrane 69 Sphingolipids 20 Proteins at the bilayer surface 70 Sterols and linear isoprenoids 21 Extrinsic/peripheral membrane proteins 70 The lipid bilayer matrix 22 Amphitropic proteins 74 Structure of bilayer lipids 22 Lipid-anchored proteins 74 Diffusion of bilayer lipids 24 Reversible interactions of peripheral Lipid asymmetry and membrane thickness 27 proteins with the lipid bilayer 77 Lipid polymorphism 28 Effects of peripheral protein binding on Lamellar phase 28 membrane lipids 77 Hexagonal phase and the amphiphile Interactions between peripheral proteins shape hypothesis 29 and lipids 78 Cubic phase 30 Domains involved in binding Miscibility of bilayer lipids 31 the membrane 81 Lateral domains and lipid rafts 34 Curvature 83 Detergent-resistant membranes 35 Modulation of binding 84 Diversity of lipids 37 Proteins and peptides that insert Conclusion 39 into the membrane 85 For further reading 41 Toxins Colicins 86 88 3 TOOLS FOR STUDYING MEMBRANE Peptides 88 COMPONENTS: DETERGENTS AND SecA: protein acrobatics 90 Proteins embedded in the membrane 91 MODEL SYSTEMS 42 Monotopic proteins Integral membrane proteins 91 91 Detergents 43 Protein-lipid interactions 97 Types of detergents 43 Hydrophobic mismatch 101 Mechanism of detergent action 46 For further reading 103 Contents 5 BUNDLES AND BARRELS 105 Helical bundles 105 Bacteriorhodopsin 105 Photosynthetic reaction center 109 The proteins 110 Lipids 112 The cofactors 112 Antennae 113 The reaction cycle 114 /3-barrels 115 Porins 117 OmpF and OmpC 118 VDAC, a mitochondrial porin 122 Specific porins 123 PhoE, the phosphoporin 123 LamB, the maltoporin 124 Other /3-barrel transporters 124 Iron receptors 125 Outer membrane secretory proteins: not /3-barrels 126 Conclusion 127 For further reading 127 6 FUNCTIONS AND FAMIUES 130 Membrane enzymes 130 Diacylglycerol kinase 132 Presenilin, an intra-membrane protease 134 P450 cytochromes 136 Transport proteins 137 Transport Classification System 138 Superfamilies of ATPases 139 ABC transporter superfamily 140 Group translocation 140 Symporters 142 Antiporters 142 Ion Channels 143 Membrane receptors 144 Nicotinic acetylcholine receptor 144 G protein-coupled receptors 145 Bioinformatics tools for membrane protein families 146 Predicting TM segments 146 Hydrophobicity plots 148 Orientation of membrane proteins 149 The positive-inside rule 150 Inverted repeats 151 Genomic analysis of membrane proteins 153 Proteomics of membrane proteins 163 Predicting /3-barrels 164 For further reading 165 7 PROTEIN F0LDING AND BIOGENESIS 168 Protein folding 169 Folding a-helical membrane proteins 170 bR folding studies 173 Folding studies of /3-barrel membrane proteins 175 Other folding studies 177 Whole protein hydrophobicity scale 178 Biogenesis of membrane proteins 178 Export from the cytoplasm 180 The translocon 187 The translocon structure 187 TM insertion 189 Biological hydrophobicity scale 191 Topogenesis in membrane proteins 195 Misfolding diseases 198 For further reading 201 8 DIFFRACTI0N AND SIMULATION 203 Back to the bilayer 203 Liquid crystallography 204 Liquid crystal theory 206 Joint refinement of x-ray and neutron diffraction data 207 Modeling the bilayer 209 Simulations of lipid bilayers 209 Molecular dynamics 209 Monte Carlo 213 Lipids observed in x-ray structures of membrane proteins 215 Crystallography of membrane proteins 219 A multidisciplinary approach 223 For further reading 225 9 MEMBRANE ENZYMES 226 Prostaglandin H2 synthase 227 OMPLA 230 Membrane proteases 234 Omptins 234 Intramembrane proteases 235 Rhomboid protease 236 Structure of the bacterial rhomboid GlpG 237 C7) Contents Formate dehydrogenase 239 P-type ATPases 243 Ca2+ ATPases 243 Na+, K+ ATPase 250 Other P-type ATPases 254 Conclusion 255 For further reading 255 10 MEMBRANE RECEPTORS 257 G protein-coupled receptors 258 Rhodopsin, a light-sensitive GPCR 259 Ground state rhodopsin 260 Activated rhodopsin 261 Rhodopsin as prototype 263 Adrenergic receptors 267 ß2AR structure 268 ßiAR structure 270 Activated /32AR in complex with Gs 270 Neurotransmitter receptors 274 Glutamate receptors: GluA2 274 Cys-loop receptors and GluCl 278 Conclusion 282 For further reading 282 11 TRANSPORTERS 284 Secondary transporters 284 MFS transporters 285 LacY, a scrutinized symporter 285 GlpT, an MFS antiporter 288 EmrD, an MFS exporter in an occluded conformation 289 FucP, an MFS symporter in co conformation 290 A paradigm for MFS transporters 291 Mitochondrial ADP/ATP carrier 291 AAC structure 291 Neurotransmitter transporters 294 Glutamate transporters and GltPh 294 Neurotransmitter sodium symporters and LeuT 296 LeuT structure 298 Transport mechanism of LeuT 300 The NSS family and the LeuT (APC-fold) superfamily 300 BetP and osmoregulated transport 303 The vitamin B12 uptake system 310 BtuCD-BtuF, an ABC transport system 311 BtuB, an outer membrane transporter energized by TonB 313 Drug efflux Systems 316 Savl866 and P-glycoprotein, ABC exporters 316 EmrE, an example of dual topology 318 Tripartite drug efflux via a membrane vacuum ABC transporters and beyond Maltose transporter 306 306 cleaner 320 AcrB, a peristaltic pump 321 Alternating site mechanism of AcrB 322 AcrA, a periplasmic adaptor protein 323 TolC, the channel-tunnel 323 Partners of TolC 325 Conclusion 325 For further reading 326 12 CHANNELS 328 Aquaporins and glyceroaquaporins 329 Structure of aquaporins 330 Glyceroaquaporins: GlpF 331 Human aquaporins: AQP4 333 Potassium Channels 335 KcsA structure and selectivity 336 Gating and activation 337 Voltage gating 339 Gating in human potassium Channels 341 Chloride Channels and the CLC family 343 CIC-ecl 344 CLC Channels as broken transporters 346 Mechanosensitive ion Channels 347 MscL 349 MscS 350 MS Channel gating 351 Gap junction Channels 354 Conclusion 356 For further reading 356 13 ELECTRON TRANSPORT AND ENERGY TRANSDUCTI0N 358 Complexes of the respiratory chain 359 Complex I 359 Conformational coupling mechanism 363 Cytochrome bc i 365 The Q cycle 366 Fligh-resolution structures 366 Cytochrome c oxidase High-resolution structures Oxygen reduction Proton pathways F1F0-ATP synthase Subunit structure and function Fi Domain F0 Domain Regulation of the F\|F0-ATPase Catalytic mechanism of a rotary motor Rotational catalysis Conclusions For further reading Contents 14 IN PURSUIT OF COMPLEXITY 385 Complex formation 386 Conformational changes and dynamics 390 For further reading 392 Appendix I: Abbreviations 393 Appendix II: Single-Letter Codes for Amino Acids 397 Index 399 371 371 373 374 375 377 377 379 379 380 380 383 383
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spelling	Luckey, Mary 1948- Verfasser (DE-588)1052352936 aut Membrane structural biology with biochemical and biophysical foundations Mary Luckey 2. ed. Cambridge [u.a.] Cambridge Univ. Press 2014 XIV, 411 S. zahlr. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Membranproteine (DE-588)4130026-9 gnd rswk-swf Biomembran (DE-588)4006884-5 gnd rswk-swf Biochemie (DE-588)4006777-4 gnd rswk-swf Physiologie (DE-588)4045981-0 gnd rswk-swf Membranproteine (DE-588)4130026-9 s DE-604 Biomembran (DE-588)4006884-5 s Biochemie (DE-588)4006777-4 s Physiologie (DE-588)4045981-0 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026998809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Luckey, Mary 1948- Membrane structural biology with biochemical and biophysical foundations Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Membranproteine (DE-588)4130026-9 gnd Biomembran (DE-588)4006884-5 gnd Biochemie (DE-588)4006777-4 gnd Physiologie (DE-588)4045981-0 gnd
subject_GND	(DE-588)4130026-9 (DE-588)4006884-5 (DE-588)4006777-4 (DE-588)4045981-0
title	Membrane structural biology with biochemical and biophysical foundations
title_auth	Membrane structural biology with biochemical and biophysical foundations
title_exact_search	Membrane structural biology with biochemical and biophysical foundations
title_full	Membrane structural biology with biochemical and biophysical foundations Mary Luckey
title_fullStr	Membrane structural biology with biochemical and biophysical foundations Mary Luckey
title_full_unstemmed	Membrane structural biology with biochemical and biophysical foundations Mary Luckey
title_short	Membrane structural biology
title_sort	membrane structural biology with biochemical and biophysical foundations
title_sub	with biochemical and biophysical foundations
topic	Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Membranproteine (DE-588)4130026-9 gnd Biomembran (DE-588)4006884-5 gnd Biochemie (DE-588)4006777-4 gnd Physiologie (DE-588)4045981-0 gnd
topic_facet	Cell Membrane physiology Membrane Lipids physiology Membrane Proteins physiology Membrane lipids Membrane proteins Membranes (Biology) Membranproteine Biomembran Biochemie Physiologie
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026998809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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