Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
München
Verl. Dr. Hut
2013
|
| Ausgabe: | 1. Aufl. |
| Schriftenreihe: | Organische Chemie
|
| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:19-163774 Inhaltsverzeichnis |
| Beschreibung: | Getr. Zählung Ill., graph. Darst. 210 mm x 148 mm, 284 g |
| ISBN: | 9783843912792 3843912793 |
Internformat
MARC
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| 100 | 1 | |a Lischke, Ulrike |d 1981- |e Verfasser |0 (DE-588)1046435019 |4 aut | |
| 245 | 1 | 0 | |a Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives |c Ulrike Lischke |
| 250 | |a 1. Aufl. | ||
| 264 | 1 | |a München |b Verl. Dr. Hut |c 2013 | |
| 300 | |a Getr. Zählung |b Ill., graph. Darst. |c 210 mm x 148 mm, 284 g | ||
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| 337 | |b n |2 rdamedia | ||
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| 490 | 0 | |a Organische Chemie | |
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Datensatz im Suchindex
| _version_ | 1804151657633677312 |
|---|---|
| adam_text | INDEX
SUMMARY V
1 INTRODUCTION 1
1.1 DNA - THE MOLECULE OF LIFE 1
1.2 EPIGENETICS 2
1.2.1 THE ROLE
OF DNA-METHYIATION 3
1.2.2 METHYLATION BY DNMTS 4
1.2.3 TET-ENZYMES AND
THEIR ROLE IN THE OXIDATION OF MC 6
1.2.4 DEMETHYLATION MECHANISMS OF DNA 9
1.2.5 BASE-PAIRING PROPERTIES
OF MC
AND ITS
OXIDIZED FORMS 11
1.2.6 CANCER AND OTHER
DISEASES 12
1.3 DNA DAMAGE 13
1.3.1 BIOLOGICAL IMPLICATIONS OF REACTIVE OXYGEN
SPECIES 14
1.3.2 OXIDATION OF PURINE BASES 15
1.3.2.1 OXIDATION OF GUANINE 15
1.3.2.2 OXIDATION OF ADENINE 17
1.3.2.3 EPIMERIZATION AND
DEGLYCOSYLATION OF FORMAMIDOPYRIMIDINES 19
1.3.2.4 BIOISOSTERIC ANALOGS OF THE FORMAMIDOPYRIMIDINES 21
1.3.2.4.1 C-NUDEOSIDE ANALOGS 22
1.3.2.4.2 CARBOCYDIC ANALOGS 23
1.4 REPLICATION OF OXIDATIVE LESIONS 24
1.5 POLYMERASES 25
1.5.1 THE PROKARYOTIC POLYMERASES
OF THE A-FAMILY 26
1.5.1.1 E. COLI DNA POL
I AND ITS
LARGE FRAGMENT KLENOW 27
I
HTTP://D-NB.INFO/1045228737
28
31
33
34
35
36
40
41
43
45
45
47
49
51
69
G. STEAROTHERMOPHILUS DNA POL I AND ITS
LARGE FRAGMENT BST POL
I
REPLICATION OF A
DNA LESION
WITHIN BST POL
I
THE EUKARYOTIC Y- FAMILY POLYMERASES
POLYMERASE N
POLYMERASE
K
BASE EXCISION REPAIR
BIOLOGICAL IMPLICATIONS OF THE FAPY- AND
8-OXO-LESIONS
BIOLOGICAL IMPLICATIONS
OF IMIDAZOLONE AND OXAZOLONE
MAIN OBJECTIVES OF THE THESIS
ABSTRACTS OF THE PUBLIKATIONS
GEHRKE, T.H.,
1
LISCHKE, U.,
1
GASTEIGER,
K. L,
1
SCHNEIDER, S.,
1
ARNOLD,
S., MIIL-
LER, H. C., STEPHENSON, D. S., ZIPSE, H., CARELL, T. UNEXPECTED NON-
HOOGSTEEN-BASED MUTAGENICITY MECHANISM OF FAPY-DNA
LESIONS. NAT.
CHEM. BIO. 2013,9,455-461.
STATHIS, D.,
1
LISCHKE, U., KOCH, S.C. DEIML, C. A., CARELL, T. DISCOVERY
AND
MUTAGENICITY OF A GUANIDINOFORMIMINE LESION AS A NEW INTERMEDIATE OF THE
OXIDATIVE DEOXYGUANOSINE DEGRADATION PATHWAY. J. AM. CHEM. SOC. 2012,
134,4925-4930.
MIINZEL, M.,
1
LISCHKE,
U., STATHIS,
D. PFAFFENEDER, T.,
GNERLICH, F. A., DEIML,
C. A., KOCH, S. C., KARAGHIOSOFF, K., CARELL, T. IMPROVED SYNTHESIS AND
MU
TAGENICITY
OF OLIGONUCLEOTIDES CONTAINING 5-HYDROXYMETHYLCYTOSINE, 5-
FORMYLCYTOSINE AND 5-CARBOXYLCYTOSINE. CHEMISTRY 2011, 17, 13782-
13788.
REFERENCES
ABBREVIATIONS
II
PUBLICATIONS (FULL
VERSIONS) 73
GEHRKE, T.H.,
1
LISCHKE, U.,
1
GASTEIGER,
K. L,
1
SCHNEIDER, S.,
1
ARNOLD, S., 73
MULLER, H. C., STEPHENSON, D. S., ZIPSE, H., CARELL, T. UNEXPECTED NON-
HOOGSTEEN-BASED MUTAGENICITY MECHANISM OF FAPY-DNA
LESIONS. NAT.
CHEM. BIO. 2013,9,455-461.
STATHIS, D.,
1
LISCHKE,
U., KOCH,
S.C. DEIML, C. A., CARELL,
T. DISCOVERY AND 125
MUTAGENICITY OF A GUANIDINOFORMIMINE LESION AS A NEW INTERMEDIATE OF
THE OXIDATIVE
DEOXYGUANOSINE DEGRADATION PATHWAY. J. AM.
CHEM. SOC.
2012,134,4925-4930.
MUNZEL, M.,
1
LISCHKE, U., STATHIS, D. PFAFFENEDER, T., GNERLICH, F. A., 145
DEIML, C. A., KOCH,
S. C., KARAGHIOSOFF, K.,
CARELL, T. IMPROVED SYNTHESIS
AND MUTAGENICITY OF OLIGONUCLEOTIDES CONTAINING 5-HYDROXYMETHYLCYTO-
SINE,
5-FORMYLCYTOSINE AND 5-CARBOXYLCYTOSINE. CHEMISTRY 2011, 17,
13782-13788.
CURRICULUM VITAE 169
III
|
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| dewey-sort | 3572.86459 |
| dewey-tens | 570 - Biology |
| discipline | Chemie / Pharmazie Biologie |
| edition | 1. Aufl. |
| format | Thesis Book |
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| spelling | Lischke, Ulrike 1981- Verfasser (DE-588)1046435019 aut Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives Ulrike Lischke 1. Aufl. München Verl. Dr. Hut 2013 Getr. Zählung Ill., graph. Darst. 210 mm x 148 mm, 284 g txt rdacontent n rdamedia nc rdacarrier Organische Chemie Zugl.: München, Univ., Diss., 2013 DNS-Reparatur (DE-588)4150347-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content DNS-Reparatur (DE-588)4150347-8 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:19-163774 X:MVB text/html http://edoc.ub.uni-muenchen.de/16377/ Verlag kostenfrei Inhaltstext https://nbn-resolving.org/urn:nbn:de:bvb:19-163774 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026994988&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives |
| title_auth | Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives |
| title_exact_search | Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives |
| title_full | Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives Ulrike Lischke |
| title_fullStr | Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives Ulrike Lischke |
| title_full_unstemmed | Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives Ulrike Lischke |
| title_short | Investigation of the mutagenic potential of naturally occurring oxidized DNA nucleobase derivatives |
| title_sort | investigation of the mutagenic potential of naturally occurring oxidized dna nucleobase derivatives |
| topic | DNS-Reparatur (DE-588)4150347-8 gnd |
| topic_facet | DNS-Reparatur Hochschulschrift |
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| work_keys_str_mv | AT lischkeulrike investigationofthemutagenicpotentialofnaturallyoccurringoxidizeddnanucleobasederivatives |