Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2013
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XI, 127 S. Ill., graph. Darst. |
Internformat
MARC
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| 245 | 1 | 0 | |a Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary |c von Johanna Leitenbacher |
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| 502 | |a München, Univ., Diss., 2013 | ||
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Datensatz im Suchindex
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| adam_text | TABLE OF CONTENTS V
TABLE OF CONTENTS
1 INTRODUCTION 1
2 LITERATURE REVIEW 3
2.1 THE EQUINE PITUITARY GLAND 3
2.1.1 ANATOMY OF THE PITUITARY GLAND 3
2.1.2 INNERVATION OF THE PITUITARY LOBES 5
2.1.3 HISTOLOGY OF THE PITUITARY GLAND 5
2.1.4 PHYSIOLOGY OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS 7
2.1.5 PHYSIOLOGY OF PARS INTERMEDIA HORMONE PROCESSING 10
2.1.6 ELECTRON MICROSCOPIC FEATURES OF PITUITARY CELLS 13
2.2 CUSHING S DISEASE IN MAN, DOGS AND CATS 15
2.2.1 DEFINITION AND PREVALENCE 15
2.2.2 PATHOPHYSIOLOGY 16
2.2.3 CLINICAL SIGNS OF CUSHING S DISEASE 17
2.2.4 DIAGNOSIS OF CUSHING S DISEASE 19
2.3 EQUINE PITUITARY PARS INTERMEDIA DYSFUNCTION (PPID) 22
2.3.1 EPIDEMIOLOGY 22
2.3.2 ETIOLOGY 23
2.3.3 PATHOGENESIS AND PATHOPHYSIOLOGY 23
2.3.4 CLINICAL SIGNS OF PPID 26
2.3.5 PATHOLOGIC FINDINGS 28
2.3.6 DIAGNOSIS OF PPID 29
2.3.7 TREATMENT 32
2.3.8 DISCRIMINATION BETWEEN PPID AND CLASSICAL CUSHING S DISEASE 32
HTTP://D-NB.INFO/1047206099
TABLE OF CONTENTS VI
3 RESEARCH DESIGN AND METHODS 34
3.1 HORSES 34
3.2 ORGAN PREPARATION 34
3.2.1 GRAVIMETRIC ANALYSES 34
3.2.2 QUANTIFICATION OF THE SPECIFIC WEIGHT OF EQUINE PITUITARY 35
/
/
3.2.3 PITUITARY PREPARATION FOR HISTOLOGY 35
3.3 HISTOLOGICAL TECHNIQUES 35
3.3.1 PARAFFIN HISTOLOGY 35
3.3.2 PLASTIC HISTOLOGY 40
3.4 IMMUNOHISTOCHEMICAL PROCEDURES 41
3.4.1 ACTH IMMUNOSTAINING OF PITUITARY SECTIONS 42
3.4.2 A-MSH IMMUNOSTAINING OF PITUITARY SECTIONS 42
3.5 QUANTITATIVE STEREOLOGICAL INVESTIGATIONS OF THE PITUITARY 44
3.5.1 QUANTIFICATION OF THE PITUITARY VOLUME FRACTIONS 44
3.5.2 QUANTIFICATION OF THE TOTAL PITUITARY VOLUMES ;... 44
3.5.3 DETERMINATION OF THE PITUITARY TISSUE SHRINKING 45
3.5.4 DETERMINATION OF NUMBER AND SIZE OF PARS INTERMEDIA CELLS (PICS)
45
3.6 QUALITATIVE HISTOLOGICAL INVESTIGATIONS OF THE PITUITARY 46
3.7 TRANSMISSION ELECTRON MICROSCOPIC INVESTIGATIONS 47
3.8 STATISTICAL ANALYSIS AND DATA PRESENTATION 50
4 RESULTS 52
4.1 QUALITATIVE AND SEMIQUANTITATIVE HISTOLOGICAL FINDINGS OF THE PARS
INTERMEDIA..
52
4.1.1 SEMIQUANTITATIVE GRADING OF PARS INTERMEDIA ALTERATIONS 52
4.1.2 QUALITATIVE HISTOLOGICAL ANALYSES OF THE PITUITARY 58
TABLE OF CONTENTS VII
4.1.3 ASSOCIATION OF HISTOLOGICAL FINDINGS WITH HISTOLOGIC GRADE AND
PPID
DIAGNOSIS 63
4.2 QUANTITATIVE-STEREOLOGICAL ANALYSES OF THE PITUITARY 66
4.2.1 GRAVIMETRIC AND VOLUMETRIC EXAMINATION OF THE PITUITARY AND
ADRENAL
GLAND 66
4.2.2 QUANTITATIVE-STEREOLOGICAL INVESTIGATION OF THE PITUITARY LOBES 66
4.2.3 CORRELATION BETWEEN AGE AND PITUITARY VOLUMETRIC PARAMETERS OR
HISTOLOGIC GRADE 67
4.2.4 CORRELATION BETWEEN HISTOLOGIC GRADE AND PITUITARY VOLUMETRIC
PARAMETERS
70
4.2.5 COMPARISON OF PITUITARY VOLUMETRIC PARAMETERS BETWEEN PITUITARIES
WITH
AND WITHOUT ADENOMA OF THE PARS INTERMEDIA 73
4.2.6 COMPARISON OF AGE, HISTOLOGIC GRADE AND PITUITARY VOLUMETRIC
PARAMETERS
BETWEEN SMALL AND LARGE HORSE BREEDS 75
4.2.7 COMPARISON OF AGE, HISTOLOGIC GRADE AND PITUITARY VOLUMETRIC
PARAMETERS
BETWEEN MARES, GELDINGS AND STALLIONS 76
4.2.8 CORRELATION BETWEEN PITUITARY VOLUMETRIC ALTERATIONS AND ADRENAL
SIZE .. 79
4.3 QUANTITATIVE STEREOLOGICAL ANALYSIS OF NUMBER AND SIZE OF PARS
INTERMEDIA CELLS
80
4.3.1 CORRELATION BETWEEN AGE AND NUMBER AND SIZE OF PARS INTERMEDIA
CELLS...
80
4.3.2 COMPARISON OF NUMBER AND SIZE OF PARS INTERMEDIA CELLS OF
PITUITARIES
WITH AND WITHOUT ADENOMA OF THE PARS INTERMEDIA 81
4.4 IMMUNOHISTOCHEMICAL EVALUATIONS 83
4.5 TRANSMISSION ELECTRON MICROSCOPY 85
5 DISCUSSION 91
5.1 DEFINITION OF AGE-RELATED ALTERATIONS OF THE EQUINE PITUITARY AND
DISTINCTION FROM
PPID-RELATED ALTERATIONS OF THE PI 92
TABLE OF CONTENTS VIII
5.1.1 PREVALENCE OF PITUITARY PL-TUMOURS 92
5.1.2 SEMIQUANTITATIVE HISTOLOGIC GRADING 93
5.1.3 QUALITATIVE HISTOLOGICAL ANALYSES OTHER THAN PL-ADENOMAS 96
5.1.4 QUANTITATIVE STEREOLOGICAL ANALYSES OF THE PITUITARY LOBES 97
5.1.5 QUANTITATIVE-STEREOLOGICAL ANALYSES OF NUMBER AND SIZE OF PICS 100
5.2 RELEVANCE OF IMMUNOHISTOCHEMICAL AND ELECTRON MICROSCOPIC
EXAMINATION OF
THE EQUINE PITUITARY FOR PPID DIAGNOSIS 101
5.2.1 IMMUNOHISTOCHEMICAL INVESTIGATION 101
5.2.2 TRANSMISSION ELECTRON MICROSCOPIC INVESTIGATION 103
5.3 ABSENCE OF ADRENAL ENLARGEMENT WITH PITUITARY PL-ADENOMAS 104
5.4 CONCLUSION 105
6 SUMMARY 107
7 ZUSAMMENFASSUNG 109
8 REFERENCES 112
9 APPENDIX 122
10 ACKNOWLEDGEMENTS 127
|
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| author | Leitenbacher, Johanna |
| author_GND | (DE-588)1044670673 |
| author_facet | Leitenbacher, Johanna |
| author_role | aut |
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| bvnumber | BV041447348 |
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| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau |
| format | Thesis Book |
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| spelling | Leitenbacher, Johanna Verfasser (DE-588)1044670673 aut Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary von Johanna Leitenbacher 2013 XI, 127 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Univ., Diss., 2013 Mit einer Zssfassung in dt. Sprache (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026893987&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Leitenbacher, Johanna Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary |
| subject_GND | (DE-588)4113937-9 |
| title | Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary |
| title_auth | Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary |
| title_exact_search | Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary |
| title_full | Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary von Johanna Leitenbacher |
| title_fullStr | Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary von Johanna Leitenbacher |
| title_full_unstemmed | Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary von Johanna Leitenbacher |
| title_short | Age-related qualitative-histological and quantitative-stereological alterations of the equine pituitary |
| title_sort | age related qualitative histological and quantitative stereological alterations of the equine pituitary |
| topic_facet | Hochschulschrift |
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