Placebo and pain: from bench to bedside
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| Format: | Book |
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier, AP
2013
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII, 292 S. Ill., graph. Darst. |
| ISBN: | 9780123979285 |
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Titel: Placebo and pain
Autor: Colloca, Luana
Jahr: 2013
Contents
Preface ix
Contributors xi
1 Historical Aspects of Placebo Analgesia
DAMIEN FINN1SS
Introduction 1
Definitions and Conceptualization 1
Placebos as Controls 2
Placebos as a Treatment 2
Placebo in the Early 20th Century 3
Placebo as more than Just an Experimental Control 4
The Emergence of the Study of Placebo Mechanisms 5
Using History to Further Explore Placebo Analgesia 7
References 7
2 Neurochemistry of Placebo Analgesia: Opioids,
Cannabinoids and Cholecystokinin
FABRIZIO BENEDETTI, ELISA FRISALDI
Introduction 9
Some Types of Placebo Analgesia are Mediated by Endogenous
Opioids 9
Endocannabinoids are Involved in Some Types of Placebo
Analgesia 11
Nocebo Hyperalgesia is Mediated by Cholecystokinin 12
Conclusions 13
References 13
3 Placebo Analgesia in Rodents
JIAN-YOU GUO, JIN-YAN WANG, FEI LUO
Introduction 15
The Placebo Effect in Animals 15
Studying Placebo Analgesia in Animal Models 17
Dissection of Placebo Analgesia in Mice 17
Placebo Analgesia Affects the Behavioral Despair Tests in Mice 18
The Opioid Receptors Involved in the Placebo Response in Rats 20
The Pros and Cons of Studying Placebo in the Animal Model 20
Conclusion and Future Directions 22
Acknowledgments 22
References 22
4 Molecular Mechanisms of Placebo Responses in
Humans
MARTA PECINA, JON-KAR ZUBIETA
Introduction 25
Placebo-Induced Activation of Regional Endogenous Opioid
Neurotransmission 28
Dopaminergic Mechanisms in the Formation of Placebo Analgesic
Effects 30
Theories of Placebo Analgesia and Placebo-Induced Activation of
Regional Endogenous Opioid Neurotransmission 31
Personality Predictors of Placebo-Induced Activation of Regional
Endogenous Opioid Neurotransmission 33
Conclusions 34
Acknowledgments 35
References 35
5 How does EEG Contribute to Our Understanding of
the Placebo Response?
ANTHONY JONES, CHRISTOPHER BROWN, WAEL EL-DEREDY
Theoretical Models of Placebo Analgesia 37
EEG Measures of Pain and its Anticipation 38
Pain Anticipation and its Role in Pain Perception 38
EEG Studies of Placebo Analgesia 40
Conclusion 42
References 42
6 Spinal Mechanisms of Placebo Analgesia and
Nocebo Hyperalgesia: Descending Inhibitory and
Facilitatory Influences
SERGE MARCHAND
Introduction 45
Pain and Placebo have E ynamic Interactions 45
Facilitatory Mechanisms 46
Inhibitory Mechanisms 47
Conclusion 50
References 51
7 Spinal and Supraspinal Mechanisms of Placebo
Analgesia
FALK EIPPERT, CHRISTIAN BUCHEL
Introduction 53
The Anatomy of Descending Pain Control 53
Descending Control in Placebo Analgesia 56
Placebo Analgesia and the Spinal Cord 60
Conclusions and Open Questions 64
Acknowledgments 65
References 65
V
vi
CONTENTS
8 Positive and Negative Emotions and Placebo
Analgesia
MAGNE ARVE FLATEN, PER M. ASLAKSEN, PETER S. LYBY
Emotion and Motivation 73
Reduction in Negative Emotions: Methodologic Issues and
Empirical Studies 74
Individual Differences in Negative Emotions and the Effectiveness
of Placebo Interventions on Pain 75
Negative Emotions Reduce the Effectiveness of Opioids 78
Placebo Analgesia, Emotions, and Opioid Activity 78
The Nocebo Response: Negative Placebo Effect or Separate
Process? 78
Clinical Implications 79
Conclusion and Future Perspectives 79
References 80
9 Placing Placebo in Normal Brain Function with
Neuroimaging
MARTIN INGVAR, PREDRAG PETROVIC, KARIN JENSEN
Acknowledgments 87
References 88
10 Brain Predictors of Individual Differences in
Placebo Responding
LEONIE KOBAN, LUKA RUZIC, TOR D. WAGER
Brain Predictors of Individual Differences in Placebo
Responding 89
Personality and Brain Predictors of Placebo Analgesia 89
Limitations of Studies on Individual Differences in PA 97
Solutions 99
How can Brain Imaging Studies Find Brain Predictors of PA?
Recommendations and Conclusions 99
Acknowledgments 100
References 101
11 Placebo Responses, Antagonistic Responses,
and Homeostasis
MAGNE ARVE FLATEN
Placebo Responses and Homeostasis 103
Theoretical Background 103
Classical Conditioning and Pain 104
Conditioning with Administration of Painkillers to Pain-Free
Subjects 104
Conditioning with the Administration of Painkillers as the
Unconditioned Stimulus to Individuals in Pain 105
Conditioning with Reduction in, or Absence of, Pain as the
US 105
Conditioning with an Increase in Pain as the US 106
Active Placebo 111
Compensatory Responses and the Nocebo Effect 111
Summary and Conclusions 112
References 112
12 Placebo Analgesia, Nocebo Hyperalgesia, and
Acupuncture
JIAN KONG, RANDY L. GOLLUB
Is Acupuncture a Form of Placebo Treatment ? 116
Challenges and Issues in Placebo/Sham Acupuncture Studies 118
Subjective and Objective Measurements in Acupuncture and
Placebo Studies 118
Contribution of Neuroimaging to Acupuncture and Placebo/
Nocebo Response 119
Summary and Future Directions 123
References 124
13 The Relevance of Placebo and Nocebo Mechanisms
for Analgesic Treatments
ULRIKE BINGEL
Placebo and Nocebo in Pain Treatments: Behavioral
Evidence 127
Understanding the Neural Mechanisms Underlying the Effects of
Expectation and Learning on Drug Efficacy 129
Modulating Expectations to Optimize Analgesic Outcome 132
Exploiting Learning Mechanisms to Optimize Analgesic
Outcome 133
Future Aims and Challenges 133
Conclusion 134
References 135
14 How Placebo Responses are Formed: From Bench
to Bedside
LUANA COLLOCA
Introduction 137
Instructional Learning 137
Associative Learning 139
Social Learning 143
Expectations 144
Evolutionary Principles Behind Placebo Analgesia 145
Conclusion 146
Conflicts of Interest 146
Acknowledgments 146
References 146
15 Methodologic Aspects of Placebo Research
MAGNE ARVE FLATEN, KARIN MEISSNER, LUANA COLLOCA
Methodology of Studies Investigating Placebo Analgesia and
Nocebo Hyperalgesia 149
Induced Pain and Clinical Pain 150
Quantification of Pain 150
Response Bias 151
Design 151
Within-Subjects versus Between-Subjects Designs 152
The Pre-Test 153
Researchers' and Subjects' Perception of the Treatment
Allocation 153
Single-Blind versus Double-Blind Designs 154
CONTENTS
'Itf-rl'i
vii
Induction of Placebo Analgesia by Classic Conditioning:
Methodological Issues 154
Measurement of Expectations 155
Conclusion 155
Acknowledgment 155
References 156
16 Balanced Placebo Design, Active Placebos, and
Other Design Features for Identifying, Minimizing and
Characterizing the Placebo Response
PAUL ENCK, KATJA WEIMER, SIBYLLE KLOSTERHALFEN
Introduction 159
Minimize versus Maximize 159
The 'Additive Model' Assumptions 161
The Balanced Placebo Design 161
The Balanced Cross-Over Design 162
The 'Delayed Response' Test 163
Active Placebos 164
Effective Blinding 165
No-Treatment and Waiting-List Controls 166
The Free-Choice Paradigm 167
Ethics of Placebo Research 169
Summary 170
Acknowledgment 170
References 170
17 Psychological Processes that can Bias Responses to
Placebo Treatment for Pain
BEN COLAGIURI, PETER F. LOVIBOND
Theoretical Model 175
Demand Characteristics 177
The Hawthorne Effect 178
Response Shift 179
Returning to the Theoretical Model 181
Importance of Objective Outcomes 181
Conclusions and Future Directions 181
References 182
18 Against 'Placebo.' The Case for Changing our
Language, and for the Meaning Response
DANIEL E. MOERMAN
A Summary of the Argument 183
A Brief Review of the Data 184
Conclusions 187
References 187
19 Placebo Effects in Complementary and Alternative
Medicine: The Self-Healing Response
HARALD WALACH
Background 189
Is Cam 'All Placebo'? A Note on Specificity and the Efficacy
Paradox 191
Jerome D Frank's Model of General Healing Effects or Common
Factors in Therapy 194
The Common Myth 194
The Ritual 195
Relationship and the Alleviation of Anxiety 196
Insignia of Power 198
Empowering Patients and Mobilizing Resources 198
Summing Up: The Specificity of Nonspecific Effects and the
Elegance of Reducing Side-Effects by 'Placebo' 199
References 199
20 Conceptualizations and Magnitudes of Placebo
Analgesia Effects Across Meta-Analyses and
Experimental Studies
LENE VASE, GITTE LAUE PETERSEN
Introduction 203
Developments in the Conceptualizations and Definitions
of Placebo Effects 203
Meta-Analyses of Placebo Analgesia Effects 205
Experimental Studies of Factors Influencing the Magnitude of
Placebo Analgesia Effects 207
Current Status of Meta-Analyses of the Magnitude of Placebo
Analgesia Effects 210
Acknowledgment 211
References 211
21 The Contribution of Desire, Expectation,
and Reduced Negative Emotions to Placebo
Anti-Hyperalgesia in Irritable Bowel Syndrome
DONALD D. PRICE, LENE VASE
Introduction 215
Evidence for Visceral and Somatic Hyperalgesia in IBS Patients 215
Visceral and Somatic Hyperalgesia is Dynamically Maintained by
Tonic Peripheral Impulse Input 216
Animal Models of Hyperalgesia in IBS 218
Psychologic Contributions to Hyperalgesia and Anti-Hyperalgesia
in IBS 218
Central Nervous System Modulation of Pain in IBS 222
Neurochemical Basis of Anti-Hyperalgesia in Placebo Anti-
Hyperalgesic Mechanisms 223
A Synergistic Interaction between Peripheral Impulse Input and
Central Facilitation? 224
Acknowledgment 224
References 225
22 The Wound that Heals: Placebo, Pain
and Surgery
WAYNE B. JONAS, CINDY CRAWFORD, KAR1N MEISSNER,
LUANA COLLOCA
Background 227
Placebo and Brain Stimulation for the Treatment of Pain 230
Conclusions 231
References 232
_
vrn
CONTENTS
23 What are the Best Placebo Interventions for the
Treatment of Pain?
KARIN ME1SSNER, KLAUS LINDE
Introduction 235
The Efficacy Paradox 235
Hypotheses from the Literature 236
Evidence from Direct Comparisons 237
Evidence from Indirect Comparisons 238
Discussion 239
Implications for Clinical Trial Methodology and
Decision-Making 240
Conclusions and Future Directions 241
References 241
24 How Communication between Clinicians and
Patients may Impact Pain Perception
ARNSTEIN F1NSET
Introduction 243
The Impact of Expectancy in Clinical Studies 244
The Impact of Emotional Communication 249
Promoting Patient Involvement and Common Ground:
The Patient-Centered Interview 251
Psychosocial Interventions in Pain Management 253
Discussion and Conclusion; Suggestions for Future Research 253
References 254
25 Nocebos in Daily Clinical Practice
BETTINA K. DOERING, WINFRIED RIEF
Introduction 257
Beliefs About Illnesses and Medications 258
Communicating a Diagnosis and Test Results 259
Initiating a Treatment 260
Treatment Implementation 262
The Role of Treatment Experience 263
Conclusions 264
References 265
26 The Potential of the Analgesic Placebo Effect
in Clinical Practice - Recommendations for Pain
Management
REGINE KLINGER, HERTA FLOR
Introduction 267
Placebo Responses in Patients 267
Comparison of Placebo Effects in Healthy Controls and
Patients 269
Use of Placebo Effects in Clinical Practice 270
Placebo Analgesia: Interactions with Attitudes Towards Medication
and Prior Experience 274
Summary 274
Acknowledgment 274
References 275
27 Placebo and Nocebo: Ethical Challenges and
Solutions
LUANA COLLOCA, FRANKLIN G. MILLER
Introduction 277
Towards Placebos in Clinical Practice 278
Clinicians' Attitudes Towards Placebos 278
Patients' Attitudes Towards Placebos 279
Placebos and the Declaration of Helsinki 280
The Dilemma of Deception 280
The Impact of the Clinician-Patient Relationship 282
The Nocebo and its Implications for how Doctors Consult with
their Patients 283
What Translational Research is Being Done, or Should be
Done? 284
Acknowledgments 284
References 284
Index 287 |
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| spelling | Placebo and pain from bench to bedside ed. by Luana Colloca ... Amsterdam [u.a.] Elsevier, AP 2013 XII, 292 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Pain Placebos (Medicine) Pain / Treatment Analgesia Placebo (DE-588)4046191-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Placebo (DE-588)4046191-9 s DE-604 Colloca, Luana edt Erscheint auch als Online-Ausgabe 978-0-12-397931-5 (DE-604)BV042312869 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026816728&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Placebo and pain from bench to bedside |
| title_auth | Placebo and pain from bench to bedside |
| title_exact_search | Placebo and pain from bench to bedside |
| title_full | Placebo and pain from bench to bedside ed. by Luana Colloca ... |
| title_fullStr | Placebo and pain from bench to bedside ed. by Luana Colloca ... |
| title_full_unstemmed | Placebo and pain from bench to bedside ed. by Luana Colloca ... |
| title_short | Placebo and pain |
| title_sort | placebo and pain from bench to bedside |
| title_sub | from bench to bedside |
| topic | Pain Placebos (Medicine) Pain / Treatment Analgesia Placebo (DE-588)4046191-9 gnd |
| topic_facet | Pain Placebos (Medicine) Pain / Treatment Analgesia Placebo Aufsatzsammlung |
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