Small animal X-ray phase-contrast imaging:
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20130723-1145092-0-1 Inhaltsverzeichnis |
| Physical Description: | III, 120 S. Ill., graph. Darst. |
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Record in the Search Index
| _version_ | 1804151353224724480 |
|---|---|
| adam_text | CONTENTS I
CONTENTS
1 INTRODUCTION 1
1.1 MOTIVATION 1
1.2 OUTLINE 3
1.3 GENERAL REMARKS 4
2 THEORETICAL BACKGROUND 5
2.1 X-RAYS AND THEIR INTERACTION WITH MATTER 5
2.1.1 REFRACTIVE INDEX 6
2.1.2 COHERENCE 9
2.1.3 FREE-SPACE PROPAGATION 11
2.2 X-RAY SOURCES 13
2.2.1 X-RAY TUBE 13
2.2.2 SYNCHROTRON RADIATION 14
2.3 GRATING-BASED PHASE-CONTRAST IMAGING 15
2.3.1 INTRODUCTION 15
2.3.2 TALBOT EFFECT 16
2.3.3 GRATING INTERFEROMETER 18
2.3.4 USE OF INCOHERENT RADIATION 24
2.3.5 GEOMETRICAL MAGNIFICATION: FAN-BEAM GEOMETRY .... 27
2.4 COMPUTED TOMOGRAPHY 28
2.4.1 GENERAL PRINCIPLE 28
2.4.2 RECONSTRUCTION OF TRIMODAL TOMOGRAPHIC SLICES 31
2.5 EFFECTIVE ENERGY OF POLYCHROMATIC X-RAY SPECTRUM 33
2.6 PRODUCTION OF GRATINGS 35
3 IMAGING OF MOUSE MODELS OF CANCER 39
3.1 MOTIVATION 39
3.2 OUTLINE 41
3.3 DESCRIPTION OF X-RAY PHASE-CONTRAST IMAGING SETUPS 42
3.3.1 SYNCHROTRON RADIATION SOURCE 43
3.3.2 TUBE SOURCE 45
HTTP://D-NB.INFO/1044096004
II
CONTENTS
3.4 IMAGING OF A HEALTHY MOUSE 45
3.4.1 INTRODUCTION 45
3.4.2 DESCRIPTION OF CRYO-IMAGING SETUP 47
3.4.3 IMAGING PARAMETERS AND DATA ANALYSIS 47
3.4.4 IMAGING RESULTS 49
3.4.5 DISCUSSION 51
3.5 IMAGING OF A MOUSE MODEL OF PANCREATIC CANCER 53
3.5.1 INTRODUCTION 53
3.5.2 TUMOR MODEL AND IMAGING PARAMETERS 54
3.5.3 MEASUREMENT OF X-RAY DOSE 55
3.5.4 IMAGING RESULTS 57
3.5.5 DISCUSSION 65
3.5.6 SUMMARY 65
3.6 IMAGING OF A COLON CARCINOMA-BEARING MOUSE 67
3.6.1 INTRODUCTION 67
3.6.2 TUMOR MODEL AND IMAGING PARAMETERS 67
3.6.3 IMAGING RESULTS 68
3.6.4 SUMMARY 72
3.7 IMAGING OF MOUSE MODELS OF CANCER: SUMMARY 72
4 DEVELOPMENT OF A SMALL-ANIMAL PHASE-CONTRAST CT SCANNER 73
4.1 MOTIVATION 73
4.2 OUTLINE 74
4.3 TECHNICAL DEVELOPMENT 74
4.3.1 GENERAL DESIGN CONSIDERATIONS 74
4.3.2 STATIONARY-GANTRY PROTOTYPE 78
4.3.3 ROTATING-GANTRY CT SCANNER 80
4.4 RESULTS FROM THE STATIONARY-GANTRY PROTOTYPE 82
4.4.1 QUANTITATIVE PHANTOM STUDY 83
4.4.2 COLOR CODING OF IMAGE CONTRASTS 87
4.4.3 SUMMARY 89
4.5 RESULTS FROM THE ROTATING-GANTRY CT SCANNER 90
4.5.1 STABILITY 90
4.5.2 ADAPTIVE DIFFERENTIAL PHASE RECOVERY 91
4.5.3 QUANTITATIVE CT IMAGING RESULTS 95
4.5.4 CT SCAN OF EXCISED MOUSE LIVER 99
4.5.5 SUMMARY 101
4.6 FURTHER DEVELOPMENT AND TECHNICAL ISSUES 101
4.6.1 IMPROVEMENT OF ROTATIONAL STABILITY 102
4.6.2 ADJUSTMENT OF INTERFEROMETER DESIGN ENERGY 103
4.6.3 REDUCTION OF SILICON WAFER THICKNESS 104
CONTENTS
III
4.6.4 DATA ACQUISITION AND CT RECONSTRUCTION 105
4.6.5 DETERIORATION OF SOURCE GRATING 105
4.7 SUMMARY AND OUTLOOK 106
5 SUMMARY, CONCLUSIONS AND OUTLOOK 109
BIBLIOGRAPHY 120
PUBLICATIONS AND SCIENTIFIC PRESENTATIONS 121
ACKNOWLEDGMENTS 125
|
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| spelling | Tapfer, Arne Verfasser aut Small animal X-ray phase-contrast imaging Arne Tapfer 2013 III, 120 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20130723-1145092-0-1 http://mediatum.ub.tum.de/node?id=1145092 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20130723-1145092-0-1 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026738242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Tapfer, Arne Small animal X-ray phase-contrast imaging |
| subject_GND | (DE-588)4113937-9 |
| title | Small animal X-ray phase-contrast imaging |
| title_auth | Small animal X-ray phase-contrast imaging |
| title_exact_search | Small animal X-ray phase-contrast imaging |
| title_full | Small animal X-ray phase-contrast imaging Arne Tapfer |
| title_fullStr | Small animal X-ray phase-contrast imaging Arne Tapfer |
| title_full_unstemmed | Small animal X-ray phase-contrast imaging Arne Tapfer |
| title_short | Small animal X-ray phase-contrast imaging |
| title_sort | small animal x ray phase contrast imaging |
| topic_facet | Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1145092 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20130723-1145092-0-1 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026738242&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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