Cellular plasticity within the central nervous system of synucleinopathies: = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | Volltext Volltext http://d-nb.info/1035540703/34 Inhaltsverzeichnis |
| Physical Description: | V, 107 S. Ill., graph. Darst. 21 cm |
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| 245 | 1 | 0 | |a Cellular plasticity within the central nervous system of synucleinopathies |b = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien |c vorgelegt von Verena Elisabeth Luise May |
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENT
CONTENT
CONTENT 1
LIST OF FIGURES IV
LIST OF TABLES V
1. SUMMARY/ZUSAMMENFASSUNG 1
1.1. SUMMARY 1
1.2. ZUSAMMENFASSUNG 4
2. INTRODUCTION 7
2.1. SYNUDEINOPATHIES: SPORADIC AND ATYPICAL PARKINSON S DISEASE, CLINIC
AND NEUROPATHOLOGY. 7
2.1.1. A-SYNUCLEIN 7
2.1.1.1. STRUCTURE AND PHYSIOLOGICAL FUNCTION 7
2.1.1.2. ROLE IN NEURODEGENERATIVE DISEASES 8
2.1.2. PARKINSON S DISEASE - LEWY BODIES/NEURITES AND A-SYNUCLEIN 8
2.1.3. MULTIPLE SYSTEM ATROPHY - GLIAL CYTOPLASMIC INCLUSIONS AND
A-SYNUCLEIN 10
2.2. HISTORY OF ADULT NEUROGENESIS 10
2.3. REGULATION OF ADULT OLFACTORY NEUROGENESIS 12
2.4. MODELS OF PO AND ADULT OLFACTORY NEUROGENESIS 13
2.5. OLIGODENDROCYTES AND ADULT OLIGODENDROCYTES PRECURSOR CELLS 14
2.E. REGULATION OF ADULT OLIGODENDROGENESIS 16
2.7. MODELS OF MSA 17
2.8. HYPOTHESES OF THE THESIS 18
3. MATERIALS AND METHODS 20
3.1. MATERIALS 20
3.1.1. CHEMICALS 20
3.1.2. KITS AND MASTER MIXES 20
3.1.3. DNA AND PROTEIN STANDARDS 20
3.1.4. BUFFERS AND SOLUTIONS 21
3.1.5. CELL CULTURE MEDIA 24
3.1.6. REAGENTS AND DISPOSABLES 26
3.1.7. TECHNICAL DEVICES 27
3.1.8. SOFTWARE 28
3.2. HISTOLOGICAL METHODS 29
3.2.1. ANIMALS AND EXPERIMENTAL DESIGN 29
I
HTTP://D-NB.INFO/1038603897
IMAGE 2
CONTENT
3.2.1.1 CAMK_A-SYN TRANSGENIC MICE 29
3.2.1.2 MBP TRANSGENIC MICE 30
3.2.2. STAINING PROCEDURES 30
3.2.3. COUNTING PROCEDURES 33
3.3. CELL CULTURE METHODS 35
3.3.1. POLY-L-ORNITHINE (PORN) COATING 35
3.3.2. CULTURING AND PASSAGING OF CG4 CELLS 35
3.3.3. STABLE TRANSFECTION OF CG4 CELLS 36
3.3.4. CRYOCONSERVATION OF CG4 CELLS 37
3.4. MOLECULARBIOLOGICAL METHODS 37
3.4.1. PLASMID CONSTRUCTION 37
3.4.2. CLONING OF PLASMIDS 39
3.4.2.1. POURING PLATES 39
3.4.2.2. TRANSFORMATION OF COMPETENT CELLS 39
3.4.2.3. PLASMID ISOLATION - MINI PREP 40
3.4.2.4. RESTRICTION DIGESTION 40
3.4.2.5. PLASMID ISOLATION - MAXI PREP 40
3.4.2.6. GLYCEROL STOCKS 41
3.4.3. ISOLATION OF TOTAL RNA FROM CG4 CELLS AND TISSUES 41
3.4.4. REVERSE TRANSCRIPTION 42
3.4.5. PRIMER DESIGN 43
3.4.6. QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION (QRT-PCR) 44
3.4.7. AGAROSE GEL ELECTROPHORESIS 45
3.4.8. HARVESTING OF CG4, CG4_VENUS, AND CG4_WT-A-SYN CELLS 46
3.4.9. DETERMINATION OF PROTEIN CONCENTRATION 46
3.4.10. WESTERN BLOT 46
3.5. STATISTICS 48
4. RESULTS 49
4.1. IMPAIRED OB NEUROGENESIS DEPENDS ON THE PRESENCE OF HUMAN WILD-TYPE
A-SYN 49
4.1.1. EXPRESSION ANALYSIS OF A-SYN IN THE FOREBRAIN 49
4.1.2. PROLIFERATION OF NEWLY GENERATED CELLS IS NOT ALTERED IN THE SVZ
53
4.1.3. DECREASED OB NEUROGENESIS IN CAM_A-SYN ANIMALS 54
4.1.4. PARTIAL RESTORATION OF OB NEUROGENESIS AFTER CESSATION OF A-SYN
EXPRESSION 56
4.1.5. GLIAL DIFFERENTIATION IN THE OB 57
4.2. A-SYN DELAYS OLIGODENDROGENESIS IN MSA AND ITS MODELS 59
II
IMAGE 3
CONTENT
4.2.1. ANATOMICAL EXPRESSION PATTERN OF A-SYN IN MBP TG MICE 59
4.2.2. MYELINATION, OLIGODENDROGLIA, AND MICROGLIA IN MSA 61
4.2.3. OLIGODENDROGENESIS IN MBP TG MICE 64
4.2.4. GENERATION OF THE SLEEPING BEAUTY CONSTRUCT CONTAINING HUMAN
WILD-TYPE A-SYN 68
4.2.5. INTRACELLULAR A-SYN DELAYS OLIGODENDROCYTES DIFFERENTIATION 70
5. DISCUSSION 74
5.1. CELLULAR PLASTICITY IN P0: ADULT NEUROGENESIS 74
5.1.1. REGULATABLE A-SYN EXPRESSION MODELS PD WITH ASSOCIATED NON-MOTOR
SYMPTOMS 75
5.1.2. A-SYN INDUCED IMPAIRMENT OF OB NEUROGENESIS 75
5.1.3. POTENTIAL INFLUENCE OF A-SYN ON GLIAL CELLS WITHIN THE OB 77
5.1.4. A-SYN INTERFERES WITH INTEGRATION OF NEWLY GENERATED CELLS 78
5.1.5. COMPARING ADULT OB NEUROGENESIS IN DIFFERENT PD MODELS 78
5.1.6. ADULT NEUROGENESIS AND PROLIFERATION IN HUMANS 80
5.2. CELLULAR PLASTICITY IN MSA: ADULT OLIGODENDROGENESIS 83
5.2.1. PRESENCE OF A-SYN IN OLIGODENDROCYTES AS GCIS IN THE COURSE OF
MSA 83
5.2.2. USAGE OF SLEEPING BEAUTY TRANSPOSON SYSTEM 85
5.2.3. TRANSCRIPTIONAL CONTROL OF DIFFERENTIATION IN OLIGODENDROCYTES
PROGENITORS 86
5.2.4. FUNCTIONAL ASPECTS OF OLIGODENDROCYTES IN MSA AND ITS MODELS 88
5.2.4.1. BDNF AND GDNF 89
5.2.4.2. MCT1 89
5.2.4.3. ATTEMPTS TO RESCUE FUNCTIONAL DEFICITS OF A-SYN BEARING
OLIGODENDROCYTES 90
5.3. CONCLUSION 91
ABBREVIATIONS 92
REFERENCES 94
ILL
|
| any_adam_object | 1 |
| author | May, Verena Elisabeth Luise |
| author_GND | (DE-588)1038603749 |
| author_facet | May, Verena Elisabeth Luise |
| author_role | aut |
| author_sort | May, Verena Elisabeth Luise |
| author_variant | v e l m vel velm |
| building | Verbundindex |
| bvnumber | BV041265554 |
| collection | ebook |
| ctrlnum | (OCoLC)858929109 (DE-599)DNB1038603897 |
| dewey-full | 570 610 |
| dewey-hundreds | 500 - Natural sciences and mathematics 600 - Technology (Applied sciences) |
| dewey-ones | 570 - Biology 610 - Medicine and health |
| dewey-raw | 570 610 |
| dewey-search | 570 610 |
| dewey-sort | 3570 |
| dewey-tens | 570 - Biology 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| spelling | May, Verena Elisabeth Luise Verfasser (DE-588)1038603749 aut Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien vorgelegt von Verena Elisabeth Luise May Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien 2013 V, 107 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Erlangen-Nürnberg, Univ., Diss., 2013 Riechkolben (DE-588)4326243-0 gnd rswk-swf Glia (DE-588)4136720-0 gnd rswk-swf Neurogenese (DE-588)4331352-8 gnd rswk-swf Parkinson-Krankheit (DE-588)4044683-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Parkinson-Krankheit (DE-588)4044683-9 s Riechkolben (DE-588)4326243-0 s Glia (DE-588)4136720-0 s Neurogenese (DE-588)4331352-8 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:29-opus-46830 https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-46830 Resolvingsystem kostenfrei Volltext http://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/470 Verlag kostenfrei Volltext http://d-nb.info/1035540703/34 Langzeitarchivierung Nationalbibliothek DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026239270&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | May, Verena Elisabeth Luise Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien Riechkolben (DE-588)4326243-0 gnd Glia (DE-588)4136720-0 gnd Neurogenese (DE-588)4331352-8 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd |
| subject_GND | (DE-588)4326243-0 (DE-588)4136720-0 (DE-588)4331352-8 (DE-588)4044683-9 (DE-588)4113937-9 |
| title | Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien |
| title_alt | Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien |
| title_auth | Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien |
| title_exact_search | Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien |
| title_full | Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien vorgelegt von Verena Elisabeth Luise May |
| title_fullStr | Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien vorgelegt von Verena Elisabeth Luise May |
| title_full_unstemmed | Cellular plasticity within the central nervous system of synucleinopathies = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien vorgelegt von Verena Elisabeth Luise May |
| title_short | Cellular plasticity within the central nervous system of synucleinopathies |
| title_sort | cellular plasticity within the central nervous system of synucleinopathies zellulare plastizitat im zentralen nervensystem bei synukleinopathien |
| title_sub | = Zelluläre Plastizität im zentralen Nervensystem bei Synukleinopathien |
| topic | Riechkolben (DE-588)4326243-0 gnd Glia (DE-588)4136720-0 gnd Neurogenese (DE-588)4331352-8 gnd Parkinson-Krankheit (DE-588)4044683-9 gnd |
| topic_facet | Riechkolben Glia Neurogenese Parkinson-Krankheit Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:29-opus-46830 http://opus4.kobv.de/opus4-fau/frontdoor/index/index/docId/470 http://d-nb.info/1035540703/34 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026239270&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mayverenaelisabethluise cellularplasticitywithinthecentralnervoussystemofsynucleinopathieszellulareplastizitatimzentralennervensystembeisynukleinopathien AT mayverenaelisabethluise zellulareplastizitatimzentralennervensystembeisynukleinopathien |