Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Electronic eBook |
| Language: | English |
| Published: |
Cham
Springer
2013
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| Series: | Springer theses
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| Subjects: | |
| Online Access: | UBT01 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource |
| ISBN: | 9783319007076 9783319007083 |
| DOI: | 10.1007/978-3-319-00708-3 |
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Record in the Search Index
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| adam_text | TOWARDS DUAL AND TARGETED CANCER THERAPY WITH NOVEL PHTHALOCYANINE-BASED
PHOTOSENSITIZERS
/ LAU, JANET T F.
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
A ZINC(II) PHTHALOCYANINE CONJUGATED WITH AN OXALIPLATIN DERIVATIVE FOR
DUAL CHEMO- AND PHOTODYNAMIC THERAPY
ZINC(II) PHTHALOCYANINE-POLYAMINE CONJUGATES AS EFFICIENT
PHOTOSENSITIZERS FOR PHOTODYNAMIC THERAPY
A REDOX-RESPONSIVE SILICON(IV) PHTHALOCYANINE FOR TARGETED PHOTODYNAMIC
THERAPY
A DUAL PH- AND REDOX-RESPONSIVE PHTHALOCYANINE-BASED PHOTOSENSITIZER FOR
TARGETED PHOTODYNAMIC THERAPY
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
TOWARDS DUAL AND TARGETED CANCER THERAPY WITH NOVEL PHTHALOCYANINE-BASED
PHOTOSENSITIZERS
/ LAU, JANET T F.
: 2013
ABSTRACT / INHALTSTEXT
JANET LAU S THESIS DESCRIBES HER STUDIES INTO THE USE OF
PHTHALOCYANINE-BASED PHOTOSENSITIZERS IN COMBINED CHEMO- AND
PHOTODYNAMIC THERAPY (PDT) AND TARGETED PDT. IN ORDER TO CARRY OUT THIS
STUDY, LAU USES SEVERAL APPROACHES: CONJUGATION WITH A CHEMOTHERAPEUTIC
OXALIPLATIN DERIVATIVE, USE OF A POLYAMINE LIGAND 2 WITH A VIEW TO
TARGETING THE POLYAMINE TRANSPORTERS OVER-EXPRESSED IN TUMOR CELLS, AND
EMPLOYMENT OF A QUENCHER THAT CAN INHIBIT THEIR PHOTODYNAMIC ACTIVITY
BUT CAN STILL BE REMOVED UNDER A TUMOR-ASSOCIATED ENVIRONMENT SUCH AS
LOW PH AND HIGH THIOL CONCENTRATION. THIS THESIS REPORTS DUAL
ACTIVATABLE PHOTOSENSITIZERS FOR THE FIRST TIME. OVERALL THE STUDIES
INCLUDED ARE ORIGINAL AND THE EFFECTS HAVE BEEN WELL DEMONSTRATED AT THE
CELLULAR LEVEL. THE WORK IN THIS THESIS IS OF MUCH CURRENT INTEREST AND
IMPORTANCE, AND CAN PAVE FOUNDATION FOR FURTHER DEVELOPMENTS.
ACCORDINGLY, PARTS OF THE RESULTS HAVE BEEN PUBLISHED IN PRESTIGIOUS
SCIENTIFIC JOURNALS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Lau, Janet T. F. Verfasser aut Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers Janet T. F. Lau Cham Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Springer theses Thesis (PhD.)-- The Chinese University of Hong Kong Chemistry Oncology Chemistry, Physical organic Biochemistry Medicinal Chemistry Cancer Research Photosensitizing compounds Cancer / Photochemotherapy MEDICAL / Chemotherapy bisacsh Chemie Medizin (DE-588)4113937-9 Hochschulschrift gnd-content https://doi.org/10.1007/978-3-319-00708-3 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026174459&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026174459&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Lau, Janet T. F. Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers Chemistry Oncology Chemistry, Physical organic Biochemistry Medicinal Chemistry Cancer Research Photosensitizing compounds Cancer / Photochemotherapy MEDICAL / Chemotherapy bisacsh Chemie Medizin |
| subject_GND | (DE-588)4113937-9 |
| title | Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers |
| title_auth | Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers |
| title_exact_search | Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers |
| title_full | Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers Janet T. F. Lau |
| title_fullStr | Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers Janet T. F. Lau |
| title_full_unstemmed | Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers Janet T. F. Lau |
| title_short | Towards dual and targeted cancer therapy with novel phthalocyanine-based photosensitizers |
| title_sort | towards dual and targeted cancer therapy with novel phthalocyanine based photosensitizers |
| topic | Chemistry Oncology Chemistry, Physical organic Biochemistry Medicinal Chemistry Cancer Research Photosensitizing compounds Cancer / Photochemotherapy MEDICAL / Chemotherapy bisacsh Chemie Medizin |
| topic_facet | Chemistry Oncology Chemistry, Physical organic Biochemistry Medicinal Chemistry Cancer Research Photosensitizing compounds Cancer / Photochemotherapy MEDICAL / Chemotherapy Chemie Medizin Hochschulschrift |
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