Computational modeling of rupture risk in abdominal aortic aneurysms:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
München
Verl. Dr. Hut
2013
|
| Edition: | 1. Aufl. |
| Series: | Advances in computational mechanics, 16
|
| Subjects: | |
| Online Access: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121011-1109985-0-2 Inhaltsverzeichnis |
| Physical Description: | X, 183 S. Ill., graph. Darst. |
| ISBN: | 9783843910668 |
Staff View
MARC
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| 100 | 1 | |a Maier, Andreas |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Computational modeling of rupture risk in abdominal aortic aneurysms |c Andreas Maier |
| 250 | |a 1. Aufl. | ||
| 264 | 1 | |a München |b Verl. Dr. Hut |c 2013 | |
| 300 | |a X, 183 S. |b Ill., graph. Darst. | ||
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| 490 | 0 | |a Advances in computational mechanics, 16 | |
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Record in the Search Index
| _version_ | 1804150495907938304 |
|---|---|
| adam_text | IMAGE 1
CONTENTS
1 INTRODUCTION 1 1.1 MEDICAL BACKGROUND 2 1.2 THE CLINICAL MANAGEMENT
DILEMMA S 1.3 ENGINEERING SOLUTIONS & OUTLINE OF THE WORK 6 2 FROM
IMAGING TO SIMULATION 11 2.1 IMAGING 11 2.2 SEGMENTATION 13 2.2.1 A
CONDENSED VERSION OF THE SEGMENTATION PROTOCOL 14 2.3 FE MESH GENERATION
16 2.4 NONLINEAR ELASTICITY 17 2.4.1 KINEMATICS 17 2.4.2 STRESS AND
EQUILIBRIUM 19 2.4.3 ELASTICITY 21 2.5 MATERIALS 23 2.5.1 INTRALUMINAL
THROMBUS (ILT) 23 2.5.2 CALCIFICATION 31 2.5.3 ARTERIAL WALL OF AAAS 46
2.6 NUMERICAL SOLUTION 56 2.6.1 BOUNDARY VALUE PROBLEM 56 2.6.2
PRESTRESSING 56 2.6.3 SOLUTION AND PERFORMANCE DETAILS 58 2.7
POSTPROCESSING 59 3 SOME STATISTICAL METHODS 63 3.1 HYPOTHESIS TESTING
AND STATISTICAL SIGNIFICANCE 63 3.1.1 HYPOTHESIS TESTING 63 3.1.2
STATISTICAL SIGNIFICANCE: THE P-VALUE 64 3.1.3 TYPES OF STATISTICAL
TESTS 65 3.2 REGRESSION AND OUTLIER DETECTION 68 3.2.1 REGRESSION
ANALYSIS 68 3.2.2 OUTLIER DETECTION 70 4 MECHANOTRANSDUCTION IN
ABDOMINAL AORTIC ANEURYSMS 75 4.1 FDG-PET/CT IMAGING FOR ENGINEERS 76
4.2 LITERATURE REVIEW 77 4.3 CORRELATION OF METABOLIC ACTIVITY TO
BIOMECHANICAL LOADING 85 V HTTP://D-NB.INFO/1036471446
IMAGE 2
CONTENTS
4.3.1 METHODS 85
4.3.2 RESULTS 89
4.3.3 DISCUSSION 93
4.4 CONCLUSION - MECHANOTRANSDUCTION IN AAA 96
5 MECHANICAL TESTING OF AAA WALL 99
5.1 METHODS 100
5.1.1 STUDY POPULATION AND TISSUE SAMPLING 100
5.1.2 MECHANICAL TESTING 102
5.1.3 ASSESSMENT OF TESTING RESULTS 103
5.1.4 NON-INVASIVELY ASSESSABLE EXPLANATORY VARIABLES 105
5.2 TENSILE TEST RESULTS 108
5.3 SIMPLE REGRESSION 109
5.3.1 REGRESSION RESULTS 110
5.3.2 INTERPRETATION AND DISCUSSION OF THE RESULTS 120
5.4 NORMAL ABDOMINAL AORTIC (AA) WALL 125
5.4.1 TENSILE TEST RESULTS FOR NORMAL AA WALL 125
5.4.2 COMPARISON BETWEEN AAA WALL AND NORMAL AA WALL 127
5.4.3 INTERPRETATION AND DISCUSSION 130
5.5 MULTIPLE REGRESSION 132
5.5.1 METHODS 132
5.5.2 RESULTS 133
5.5.3 GENERAL DISCUSSION OF MULTIPLE LINEAR REGRESSION MODELS 146
5.6 CONCLUSION 147
6 INCORPORATING TESTING RESULTS INTO FE ANALYSIS OF PATIENT-SPECIFIC
AAAS 149 6.1 METHODS 149
6.1.1 STUDY POPULATION 149
6.1.2 AAA GEOMETRY RECONSTRUCTION, MODEL VARIATIONS AND FE ANALYSIS . .
150 6.1.3 STATISTICAL EVALUATION 151
6.2 RESULTS 152
6.3 DISCUSSION 152
6.3.1 INTERPRETATION OF THE RESULTS 152
6.3.2 LIMITATIONS 154
6.4 CONCLUSION 155
7 CONCLUSION AND OUTLOOK 157
A APPENDIX: SEGMENTATION 159
A.L STRUCTURE OF THE AAA DATA BASE 159
A.2 SEGMENTATION PROTOCOL 159
A.3 MESHING PROTOCOL 164
B APPENDIX: BIOMECHANICS AND PET/CT 167
BIBLIOGRAPHY 171
VI
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| any_adam_object | 1 |
| author | Maier, Andreas |
| author_facet | Maier, Andreas |
| author_role | aut |
| author_sort | Maier, Andreas |
| author_variant | a m am |
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| bvnumber | BV041109524 |
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| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Physik Biologie Medizin |
| edition | 1. Aufl. |
| format | Thesis Book |
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| physical | X, 183 S. Ill., graph. Darst. |
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| series2 | Advances in computational mechanics, 16 |
| spelling | Maier, Andreas Verfasser aut Computational modeling of rupture risk in abdominal aortic aneurysms Andreas Maier 1. Aufl. München Verl. Dr. Hut 2013 X, 183 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in computational mechanics, 16 München, Techn. Univ., Diss., 2012 Risiko (DE-588)4050129-2 gnd rswk-swf Biomechanik (DE-588)4006880-8 gnd rswk-swf Bauchaorta (DE-588)4199585-5 gnd rswk-swf Computersimulation (DE-588)4148259-1 gnd rswk-swf Aneurysma (DE-588)4131419-0 gnd rswk-swf Ruptur (DE-588)4126608-0 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Aneurysma (DE-588)4131419-0 s Bauchaorta (DE-588)4199585-5 s Biomechanik (DE-588)4006880-8 s Computersimulation (DE-588)4148259-1 s Risiko (DE-588)4050129-2 s Ruptur (DE-588)4126608-0 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20121011-1109985-0-2 http://mediatum.ub.tum.de/node?id=1109985 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121011-1109985-0-2 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026085758&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Maier, Andreas Computational modeling of rupture risk in abdominal aortic aneurysms Risiko (DE-588)4050129-2 gnd Biomechanik (DE-588)4006880-8 gnd Bauchaorta (DE-588)4199585-5 gnd Computersimulation (DE-588)4148259-1 gnd Aneurysma (DE-588)4131419-0 gnd Ruptur (DE-588)4126608-0 gnd |
| subject_GND | (DE-588)4050129-2 (DE-588)4006880-8 (DE-588)4199585-5 (DE-588)4148259-1 (DE-588)4131419-0 (DE-588)4126608-0 (DE-588)4113937-9 |
| title | Computational modeling of rupture risk in abdominal aortic aneurysms |
| title_auth | Computational modeling of rupture risk in abdominal aortic aneurysms |
| title_exact_search | Computational modeling of rupture risk in abdominal aortic aneurysms |
| title_full | Computational modeling of rupture risk in abdominal aortic aneurysms Andreas Maier |
| title_fullStr | Computational modeling of rupture risk in abdominal aortic aneurysms Andreas Maier |
| title_full_unstemmed | Computational modeling of rupture risk in abdominal aortic aneurysms Andreas Maier |
| title_short | Computational modeling of rupture risk in abdominal aortic aneurysms |
| title_sort | computational modeling of rupture risk in abdominal aortic aneurysms |
| topic | Risiko (DE-588)4050129-2 gnd Biomechanik (DE-588)4006880-8 gnd Bauchaorta (DE-588)4199585-5 gnd Computersimulation (DE-588)4148259-1 gnd Aneurysma (DE-588)4131419-0 gnd Ruptur (DE-588)4126608-0 gnd |
| topic_facet | Risiko Biomechanik Bauchaorta Computersimulation Aneurysma Ruptur Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1109985 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121011-1109985-0-2 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026085758&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT maierandreas computationalmodelingofruptureriskinabdominalaorticaneurysms |