Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 141 S. Ill., graph. Darst. |
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| adam_text | IMAGE 1
TABLE OF CONTENTS 1
TABLE OF CONTENTS
TABLE OF CONTENTS 1
LIST OF FIGURES 3
LIST OF TABLES 4
ABBREVIATIONS 5
1 ZUSAMMENFASSUNG 9
2 SUMMARY 11
3 INTRODUCTION 13
3.1 STAPYHLOCOCCUS AUREUS AND ITS ROLE IN ENVIRONMENT 13
3.2 ANTIBIOTIC RESISTANCE 15
3.3 FUNCTION OF DNA TOPOISOMERASES AND THE ROLE OF GYRASE 16
3.4 GYRASE INHIBITORS 19
3.5 COILING OF DNA 27
3.6 RECA 27
3.7 THE SOS RESPONSE 28
3.8 OBJECTIVES 31
4 MATERIAL AND METHODS 33
4.1 MATERIAL 33
4.2 METHODS 49
5 RESULTS 69
5.1 CONSTRUCTION AND CHARACTERIZATION OF STRAINS, ANTIBIOTIC EFFECTS AND
INTERACTION 69
5.2 OPPOSING EFFECTS OF NOVOBIOCIN AND CIPROFLOXACIN ON RECA EXPRESSION
70
5.3 NOVOBIOCIN PARTIALLY INHIBITS THE CIPROFLOXACIN INDUCED SOS RESPONSE
72
5.4 THE IMPACT OF THE TRANSCRIPTIONAL AND POST-TRANSLATIONAL ACTIVATION
OF RECA ON THE INDUCTION OF THE SOS RESPONSE 74
5.5 EFFECT OF NOVOBIOCIN AND CIPROFLOXACIN ON RESISTANCE DEVELOPMENT 76
5.6 NOVOBIOCIN REDUCES THE FORMATION OF NON-HEMOLYTIC VARIANTS 77
5.7 NOVOBIOCIN DECREASES THE PHAGE TRANSDUCTION OF CHROMOSOMAL MARKERS
79
5.8 NOVOBIOCIN HAS NO INFLUENCE ON PHAGE REPLICATION 80
5.9 TRANSCRIPTIONAL RESPONSE TO NOVOBIOCIN TREATMENT 81
HTTP://D-NB.INFO/1038106257
IMAGE 2
TABLE OF CONTENTS 2
5.10 NACL DOES NOT INHIBIT THE NOVOBIOCIN EFFECT 85
5.11 GENE EXPRESSION ALTERED BY NOVOBIOCIN IS LIKELY DUE TO GYRASE
INHIBITION 86
5.12 ARLR IS NOT INVOLVED IN REGULATION OF SUPERCOILING PER SE 87
5.13 HOW DOES SUPERCOILING AFFECT GENE TRANSCRIPTION IN S. AUREUS ? 89
5.14 CHANGE IN ATP LEVEL AFTER ANTIBIOTIC TREATMENT 91
5.15 ROLE OF SOS RESPONSE IN CELLULAR DEATH 92
6 DISCUSSION 95
6.1 CIPROFLOXACIN INDUCES SOS RESPONSE, MUTATION FREQUENCY, ADAPTABILITY
AND PHAGE REPLICATION 95
6.2 NOVOBIOCIN REDUCES RECA EXPRESSION 96
6.3 INFLUENCE OF NOVOBIOCIN ON SOS GENE EXPRESSION 97
6.4 THE CONSEQUENCES OF RECA INHIBITION BY NOVOBIOCIN 97
6.5 INSPECTING BACTERIAL CELL DEATH MECHANISMS 99
6.6 EFFECTS OF NOVOBIOCIN ON GENE EXPRESSION MEDIATED BY SUPERCOILING
103
6.7 PERSPECTIVES IN ANTIMICROBIAL DRUG THERAPY 106
7
REFERENCES.........................................................................................................
109
8
ACKNOWLEDGEMENT............................................................................................
125
9 CURRICULUM VITAE 126
10 LIST OF PUBLICATIONS 128
11 APPENDIX 131
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| discipline | Biologie Medizin |
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| spelling | Schröder, Wiebke 1983- Verfasser (DE-588)1036113337 aut Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus vorgelegt von Wiebke Schröder 2013 141 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Tübingen, Univ., Diss., 2013 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=026084496&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Schröder, Wiebke 1983- Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus |
| subject_GND | (DE-588)4113937-9 |
| title | Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus |
| title_auth | Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus |
| title_exact_search | Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus |
| title_full | Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus vorgelegt von Wiebke Schröder |
| title_fullStr | Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus vorgelegt von Wiebke Schröder |
| title_full_unstemmed | Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus vorgelegt von Wiebke Schröder |
| title_short | Influence of aminocoumarins on gene expression, SOS response and adaptability in Staphylococcus aureus |
| title_sort | influence of aminocoumarins on gene expression sos response and adaptability in staphylococcus aureus |
| topic_facet | Hochschulschrift |
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