Epigenetics and cancer:
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Dordrecht
Springer Netherlands
2013
|
| Subjects: | |
| Online Access: | FAN01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource |
| ISBN: | 9789400766112 9789400766129 |
| DOI: | 10.1007/978-94-007-6612-9 |
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Record in the Search Index
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| adam_text | EPIGENETICS AND CANCER
/
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PREFACE
SYSTEMS AND NETWORK BIOLOGY TO INVESTIGATE EPIGENETIC DE-REGULATORY
MECHANISMS OF MICRORNAS IN PANCREATIC CANCER
ROLE OF MICRORNAS IN CANCER EPIGENETICS
EPIGENETIC REGULATION OF EZH2 AND ITS TARGETED MICRORNAS
EPIGENETICS AND MICRORNAS IN RENAL CANCER
EPIGENETIC REGULATION OF MICRORNA IN COLON CANCER
EPIGENETIC REGULATION OF MIRNAS IN BREAST CANCER FORMATION AND
PROGRESSION
EPIGENETIC VARIATIONS OF STEM CELL MARKERS IN CANCER
RECENT UPDATES ON EPIGENETIC BIOMARKERS FOR PROSTATE CANCER
EPIGENETICS AND RACIAL DISPARITIES IN PROSTATE CANCER
EPIGENETIC SIGNATURES OF BREAST CANCER GENES
EXPLOITING EPIGENETIC MODIFIERS TO CIRCUMVENT MELANOMA DUAL RESISTANCE
TO TCR-ENGINEERED IMMUNOTHERAPY- AND BRAFV600E-KINASE INHIBITOR
THE ROLE OF EPIGENETICS IN RADIATION THERAPY AND THE DNA DAMAGE RESPONSE
PLANT POLYPHENOLS AS EPIGENETIC MODULATORS OF GLUTATHIONE S-TRANSFERASE
P1 ACTIVITY
EPIGENETIC REGULATIONS OF MRNAS AND MIRNAS BY NUTRACEUTICALS
TOWARDS CURATIVE CANCER THERAPY WITH MASPIN: A UNIQUE WINDOW OF
OPPORTUNITY TO TARGET CANCER DORMANCY
INDEX
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
EPIGENETICS AND CANCER
/
: 2013
ABSTRACT / INHALTSTEXT
OVERALL, THIS BOOK ILLUSTRATES THE COMPLEXITIES OF THE REGULATION AND
DEREGULATION OF GENES MEDIATED THROUGH EPIGENETICS IN THE DEVELOPMENT
AND PROGRESSION OF HUMAN MALIGNANCIES. ALL THE ARTICLES HAVE BEEN
CAREFULLY CHOSEN TO REPRESENT SEVERAL CANCER SYSTEMS WITH STATE OF OUR
KNOWLEDGE ON THE ROLE OF EPIGENETIC DEREGULATION OF MICRORNAS (MIRNAS)
AND THEIR TARGET MRNAS ALONG WITH EPIGENETIC DEREGULATION OF MRNAS. THIS
BOOK ALSO ILLUSTRATES THE ROLE OF SEVERAL DIETARY AGENTS, COLLECTIVELY
CALLED NUTRACEUTICALS OR NATURAL AGENTS IN MODULATING THE EPIGENETIC
REPROGRAMMING OF MIRNAS AND MRNAS FOR THE PREVENTION AND/OR TREATMENT OF
HUMAN MALIGNANCIES.IT IS WELL KNOWN THAT GENETIC ABERRATIONS, ESPECIALLY
INHERITED THROUGH PARENTS (SOMATIC GENETIC ALTERATIONS) CONTRIBUTE TO
THE DEVELOPMENT OF LESS THAN 10% OF ALL CANCER YET EPIGENETIC
ALTERATIONS IN GENES ESPECIALLY THROUGH SELECTIVE METHYLATION AND
ACETYLATION APPEARS TO BE RESPONSIBLE FOR THE DEVELOPMENT AND
PROGRESSION OF THE VAST MAJORITY OF ALL CANCERS. THEREFORE,
UNDERSTANDING THE ROLE OF EPIGENETICS IN THE REGULATION OF GENES
ESPECIALLY THROUGH DEREGULATED EXPRESSION OF MIRNAS AS PRESENTED IN THIS
BOOK WILL ALLOW SCIENTISTS TO DEVISE TARGETED THERAPEUTIC STRATEGIES FOR
RE-EXPRESSION OF THE LOST GENES OR DOWN-REGULATE THE GENES THAT ARE
OVER-EXPRESSED IN ORDER TO ERADICATE CANCER.IT IS HOPED THAT TARGETING
EPIGENETICS WILL NOT ONLY TARGET CANCER CELLS BUT IT WILL ALSO TARGET
THE TUMOR MICROENVIRONMENT (MORE LIKE THE ENTIRE TUMOR ENVIRONMENT SUCH
AS THE ENTIRE HOST) FOR ACHIEVING BETTER TREATMENT OUTCOMES FOR PATIENTS
DIAGNOSED WITH CANCER WHICH WILL LEAD TO ACHIEVE THE LONG-TERM OBJECTIVE
FOR COMPLETE ERADICATION OF CANCER. THIS BOOK CONTAINS FIFTEEN CHAPTERS
WHICH BEGINS WITH THE CONCEPT OF SYSTEMS AND NETWORK BIOLOGY FOR
INVESTIGATING THE EPIGENETICS OF CANCER FOLLOWED BY A SERIES OF ARTICLES
ON THE ROLE OF MIRNAS AND THEIR TARGET GENES IN THE BIOLOGY OF
PANCREATIC CANCER AND OTHER CANCERS SUCH AS BREAST, KIDNEY, PROSTATE AND
AND COLON.SINCE IT IS BECOMING INCREASINGLY CLEAR THAT CANCER STEM CELLS
(CSCS) ARE IMPORTANT IN THE DEVELOPMENT AND PROGRESSION OF CANCER, AND
CSCS ARE IMPORTANT IN THERAPEUTIC RESISTANCE, TREATMENT FAILURE AND
TUMOR RECURRENCE, THUS THE IMPORTANCE OF CSCS AND EPIGENETICS HAS BEEN
HIGHLIGHTED BY A VERY TIMELY ARTICLE ON EPIGENETIC VARIATIONS OF STEM
CELL MARKERS IN CANCER INCLUDING MIRNAS. MOREOVER, JUST TARGETING
HETEROGENEOUS CANCER CELL POPULATIONS MAY NOT BE OPTIMAL TO ERADICATE
TUMORS AND FOR WHICH ONE MUST TAKE A HOLISTIC APPROACH FOR DEVELOPING
DRUGS THAT COULD ALSO TARGET THE TUMOR MICROENVIRONMENT AND TUMOR
DORMANCY THAT ARE REGULATED THROUGH EPIGENETICS. KEEPING ABREAST WITH
THIS THOUGHT PROCESS THE CONCLUDING CHAPTER PROVIDES A CONCEPT TOWARDS
CURATIVE CANCER THERAPY WITH MASPIN, WHICH COULD BE A UNIQUE WINDOW OF
OPPORTUNITY TO TARGET TUMOR DORMANCY.THEREFORE, IT SUGGEST THAT
TARGETING THE TUMOR DORMANCY AND THE TUMOR MICROENVIRONMENT USING NOVEL
THERAPEUTICS SPECIFICALLY BY TARGETING EPIGENETICS WOULD BECOME THE
FUTURE OF MEDICINE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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| spellingShingle | Epigenetics and cancer Biowissenschaften Medizin Medicine Science (General) Life sciences Krebs Medizin (DE-588)4073781-0 gnd Epigenetik (DE-588)7566079-9 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)7566079-9 (DE-588)4143413-4 |
| title | Epigenetics and cancer |
| title_auth | Epigenetics and cancer |
| title_exact_search | Epigenetics and cancer |
| title_full | Epigenetics and cancer Fazlul H. Sarkar, ed. |
| title_fullStr | Epigenetics and cancer Fazlul H. Sarkar, ed. |
| title_full_unstemmed | Epigenetics and cancer Fazlul H. Sarkar, ed. |
| title_short | Epigenetics and cancer |
| title_sort | epigenetics and cancer |
| topic | Biowissenschaften Medizin Medicine Science (General) Life sciences Krebs Medizin (DE-588)4073781-0 gnd Epigenetik (DE-588)7566079-9 gnd |
| topic_facet | Biowissenschaften Medizin Medicine Science (General) Life sciences Krebs Medizin Epigenetik Aufsatzsammlung |
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