Single-use technology in biopharmaceutical manufacture (Wiley, 2011)
Front Matter -- Basics. Single-Use Equipment in Biopharmaceutical Manufacture: A Brief Introduction / Dieter Eibl, Thorsten Peuker, Regine Eibl -- Single-Use Bag Systems for Storage, Transportation, Freezing, and Thawing / Nathalie Riesen, Regine Eibl -- Bag Mixing Systems for Single-Use / S̲ren Werner, Matthias Kraume, Dieter Eibl -- Single-Use Bioreactors--An Overview / Regine Eibl, Christian Ḻffelholz, Dieter Eibl -- Systems for Coupling and Sampling / Sebastian Rothe, Dieter Eibl -- Disposable Sensor Systems / Patrick Lindner, Christian Endres, Arne Bluma, Tim Hpfner, Anne Glindkamp, Claas Haake, Daniel Landgrebe, Daniel Riechers, Richard Baumfalk, Bernd Hitzmann, Thomas Scheper, Kenneth F Reardon -- Bioinformatics and Single Use / Barbara A Paldus, Mark D Selker -- Single-Use Downstream Equipment / Alexander Tappe, Uwe Gottschalk -- Single-Use Technology for Formulation and Filling Application / Jens Kubischik, Michael Schaupp --
- Production of Disposable Bags: A Manufacturer's Report / Steven Vanhamel, Charlotte Masy -- Disposable Filter Devices / Thomas Loewe, Mandar Dixit -- Biopharmaceutical Manufacturing Facilities Integrating Single-Use Systems / Thorsten Peuker, Dieter Eibl -- An Introduction to the Validation and Qualification of Disposables Used in Biomanufacture--A User's Perspective / Tobias Merseburger -- Waste Treatment Options, and the Environmental Impact of Single-Use Systems / Urs Baier -- Next-Generation Single-Use Bioreactor Technology and the Future of Biomanufacturing: A Summary from the Manufacturer's and User's Perspective / Brian Lee, Eric Langer, Ran Zheng -- Application Reports and Case Studies. Disposable SuperSpinner: Characteristics and Typical Applications / Andreas Kocourek, Jacqueline Herrmann, Lidija Lisica, Irina Bauer, Regine Eibl -- A New Scale-Down Approach for the Rapid Development of 21/BEVS-Based Processes--A Case Study / Christoph Ries, Corinne John, Regine Eibl --
- Practical Aspects of Establishing Pharmaceutical Recombinant Proteins from Research to Development in Disposable Bioreactors / Joerg Schmidt, Claudia Probst, Cornelia Fux -- Single-Use Stirred Tank Reactor BIOSTAT CultiBag STR: Characterization and Applications / Ute Noack, Davy De Wilde, Francis Verhoeye, Edward Balbirnie, Wolfgang Kahlert, Thorsten Adams, Gerhard Greller, Oscar-Werner Reif -- Single-Use Bioreactor Platform for Microbial Fermentation / Parrish M Galliher, Geoff Hodge, Patrick Guertin, Lawrence Chew, Ted Deloggio -- Growth of BY-2 Suspension Cells and Plantibody Production in Single-Use Bioreactors / Nicole Raven, Stefan Schillberg, Janina Kirchhoff, Johanna Br̃ndli, Nicole Imseng, Regine Eibl -- CFD as a Tool to Characterize Single-Use Bioreactors / Christian Ḻffelholz, Stephan C Kaiser, S̲ren Werner, Dieter Eibl --
- Automated Disposable Systems: Application Reports / Nicola Franscini, Iris Poggendorf, Clara Cavelier, Jens M Kelm, Wolfgang Moritz, Ursula Graf-Hausner -- New Single-Use Sensors for Online Measurement of Glucose and Lactate: The Answer to the PAT Initiative / Stefan Spichiger, Ursula E Spichiger-Keller -- Disposable Chromatography for Large-Scale Biomanufacturing / Andř Pastor, Sťphan Barbe -- Single-Use Virus Clearance Technologies in Biopharmaceutical Manufacturing: Case Studies / Suma Ray, Sherri Dolan -- A Single-Use Technology Platform for Downstream Processing: Mobius FlexReady Solutions / Gerd Walter -- The Manufacture of mAbs--A Comparison of Performance and Process Time between Traditional and Ready-to-Use Disposable Systems / Jakob Liderfelt, Gustav Rodrigo, Annika Forss -- Going Fully Disposable--Current Possibilities: A Case Study from Crucell / Alfred Luitjens, Alain Pralong --
- Production Costs in Biotech Facilities: Single-Use versus Multiple-Use Equipment for Antibody Manufacture / Anke Seeger, David Estap̌ -- Index