Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2009
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 66 S. graph. Darst. 21 cm |
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MARC
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| 264 | 1 | |c 2009 | |
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Record in the Search Index
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|---|---|
| adam_text | TABLE
OF
CONTENTS
PAGE
TABLE
OF
CONTENTS
..............................................................................................
1
LIST
OF
FIGURES
AND
TABLES
.................................................................................
3
ABBREVIATIONS
.....................................................................................................
4
1.
INTRODUCTION
....................................................................................................
5
1.1.
HISTORY
..........................................................................................................
5
1.2.
HBV
CLASSIFICATION
.......................................................................................
6
1.3.
VIRION
STRUCTURE
.............................................................................................
6
1.4.
GENOME
ORGANIZATION
..................................................................................
7
1.5.
VIRAL
REPLICATION
............................................................................................
8
1.6.
CLINICAL
IMPORTANCE
AND
MANIFESTATIONS
.......................................................
9
1.7.
GENETIC
DIVERSITY
............................................................................
12
1.7.1.
MUTATIONS
IN
THE
C
GENE
............................................................................
12
1.7.2.
THE
S
GENE
MUTATIONS
...............................................................................
13
1.7.3.
THE
POLYMERASE
GENE
MUTATIONS
..............................................................
15
1.8.
HBV
ANTIVIRAL
AGENTS
....................................................................................
15
1.9.
MUTATIONS
ASSOCIATED
WITH
DRUG
RESISTANCE
..................................................
16
1.9.1.
LAMIVUDINE
DRUG
RESISTANCE
VARIANTS
........................................................
16
1.9.2.
ADEVOFIR
DIPIVOXIL
DURG
RESISTANCE
VARIANTS
................................................
17
1.9.3.
TELBIVUDINE
AND
ENTECAVIR
DRUG
RESISTANCE
VARIANTS
.................................
18
1.10.
TENOFOVIR
DISOPROXIL
FUMARATE
(TDF)
..........................................................
19
1.10.1.
CLINICAL
EFFICIENCY
OF
TDF
........................................................................
19
1.10.2.
TENOFOVIR
DISOPROXIL
FUMARATE
DRUG
RESISTANCE
VARIANTS
..........................
20
1.11.
HBEAG-NEGATIVE
PATIENTS
AND
DRUG
RESISTANCE
VARIANTS
.............................
21
1.12.
AIMS
OF
THE
PROJECT
.....................................................................................
23
2.
PAPER
I
.............................................................................................................
25
THE
RTA194T
POLYMERASE
MUTATION
IMPACTS
VIRAL
REPLICATION
AND
SUSCEPTIBILITY
TO
TENOFOVIR
IN
HEPATITIS
B
E
ANTIGEN-POSITIVE
AND
HEPATITIS
B
E
ANTIGEN-NEGATIVE
HEPATITIS
B
VIRUS
STRAINS
3.
PAPER
II
............................................................................................................
34
ANALYSIS
OF
AN
HBSAG-NEGATIVE
HEPATITIS
B
VIRUS
MUTANT
SELECTED
IN
A
TENOFOVIR
TREATED
HIV-HBV
CO-INFECTED
PATIENT
4.
DISCUSSION
AND
OUTLOOK
...............................................................................
39
4.1.
DEVELOPMENT
OF
ANTIVIRAL
RESISTANCE
.............................................................
40
4.2.
DRUG
POTENCY
...............................................................................................
41
4.3.
TREATMENT
AND
ANTIVIRAL
DRUG
RESISTANCE
......................................................
42
4.4.
ANTIVIRAL
EFFICACY
OF
TENOFOVIR
DISOPROXIL
FUMARATE
.........................................
44
4.5.
RESISTANCE
TO
TENOFOVIR
DISOPROXIL
FUMARATE
.................................................
46
4.6.
THE
RTA194T
AND
THE
RTV191L
REPLICATION
FITNESS
..........................................
45
4.7.
HBEAG-NEGATIVE
RTA194T
AND
RTV191L
REPLICATION
FITNESS
............................
47
4.8.
DRUG
SUSCEPTIBILITY
OF
RTA194T
AND
RTV191L
VARIANTS
.....................................
50
4.9.
OUTLOOK
AND
FUTURE
PROSPECTS
.......................................................................
52
6.
REFERENCES
.....................................................................................................
54
7.
CURRICULUM
VITAE
............................................................................................
67
|
| any_adam_object | 1 |
| author | Amini-Bavil-Olyaee, Samad 1973- |
| author_GND | (DE-588)1019021292 |
| author_facet | Amini-Bavil-Olyaee, Samad 1973- |
| author_role | aut |
| author_sort | Amini-Bavil-Olyaee, Samad 1973- |
| author_variant | s a b sab |
| building | Verbundindex |
| bvnumber | BV041022131 |
| ctrlnum | (OCoLC)781632320 (DE-599)DNB1019306416 |
| discipline | Medizin |
| format | Thesis Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-10T00:37:13Z |
| institution | BVB |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025999686 |
| oclc_num | 781632320 |
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| physical | 66 S. graph. Darst. 21 cm |
| publishDate | 2009 |
| publishDateSearch | 2009 |
| publishDateSort | 2009 |
| record_format | marc |
| spelling | Amini-Bavil-Olyaee, Samad 1973- Verfasser (DE-588)1019021292 aut Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz vorgelegt von Samad Amini-Bavil-Olyaee 2009 66 S. graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Aachen, Techn. Hochsch., Diss., 2009 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025999686&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Amini-Bavil-Olyaee, Samad 1973- Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz |
| subject_GND | (DE-588)4113937-9 |
| title | Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz |
| title_auth | Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz |
| title_exact_search | Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz |
| title_full | Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz vorgelegt von Samad Amini-Bavil-Olyaee |
| title_fullStr | Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz vorgelegt von Samad Amini-Bavil-Olyaee |
| title_full_unstemmed | Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz vorgelegt von Samad Amini-Bavil-Olyaee |
| title_short | Einfluss von Mutationen im Hepatitis B Virus auf Virusreplikation und Medikamentenresistenz |
| title_sort | einfluss von mutationen im hepatitis b virus auf virusreplikation und medikamentenresistenz |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025999686&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT aminibavilolyaeesamad einflussvonmutationenimhepatitisbvirusaufvirusreplikationundmedikamentenresistenz |