Incremental ontology-based integration for translational medical research:
Saved in:
| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20130411-1119200-0-3 Inhaltsverzeichnis |
| Physical Description: | X, 173 S. Ill., graph. Darst. |
Staff View
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
1 INTRODUCTION 1
1.1 PROBLEM STATEMENT 1
1.2 CONTRIBUTIONS 3
1.3 OUTLINE 5
2 THE CHALLENGE: INTEGRATING D A T A FOR TRANSLATIONAL MEDICAL RESEARCH
7 2.1 USE CASES 7
2.1.1 DATA RETRIEVAL AND INTEGRATION OF KNOWLEDGE BASES 7
2.1.2 IT-SUPPORT FOR PATIENT RECRUITMENT 8
2.2 CHALLENGES AND REQUIREMENTS 9
2.2.1 DISTRIBUTION, AUTONOMY, HETEROGENEITY 9
2.2.2 CONTINUOUS EVOLUTION 11
2.2.3 DATA PRIVACY AND SECURITY 11
2.3 RELATED WORK 12
3 THE SOLUTION CONCEPT: INCREMENTAL ONTOLOGY-BASED INTEGRATION 15 3.1
RELATED WORK 15
3.1.1 ONTOLOGY-BASED INTEGRATION 15
3.1.2 DATASPACES 17
3.2 INCREMENTAL ONTOLOGY-BASED INTEGRATION 18
3.2.1 BASIC IDEAS 18
3.2.2 SEMANTIC WEB TECHNOLOGIES 20
3.2.3 IMPORTANT PROPERTIES OF RDF AND SPARQL 22
3.2.4 TECHNICAL REQUIREMENTS 22
3.3 SUMMARY AND PERSPECTIVES 26
4 LAYING T H E GROUNDWORK: ACCESSING BIOMEDICAL D A T A SOURCES 27 4.1
RELATED WORK 27
4.2 CHALLENGES AND REQUIREMENTS 30
4.3 RELATIONAL DBMS 31
4.3.1 TRANSFORMATION OPERATORS 32
4.3.2 TRANSFORMATION PROCESS 36
4.3.3 EVALUATION 40
4.4 HL7 MESSAGE STREAMS 43
4.4.1 TRANSFORMATION PROCESS 43
I
HTTP://D-NB.INFO/1036892670
IMAGE 2
CONTENTS
4.4.2 EVALUATION 45
4.5 RDF DATABASES 46
4.6 SUMMARY AND PERSPECTIVES 48
5 MAINTAINING LOCAL AUTONOMIES: DISTRIBUTED QUERY PROCESSING 4 9 5.1
RELATED WORK 50
5.2 INDEXING 54
5.2.1 TYPE INFORMATION 55
5.2.2 DATA ORGANIZATION 56
5.2.3 PARTITION TREES 56
5.3 QUERY OPTIMIZATION 57
5.3.1 PLAN SIMPLIFICATION 59
5.3.2 SIDEWAYS INFORMATION PASSING 62
5.3.3 POST-PROCESSING 64
5.3.4 MERGING QUERY GROUPS 65
5.4 QUERY EXECUTION 67
5.4.1 PRUNING REDUNDANT INTERMEDIATE RESULTS 68
5.4.2 CARDINALITY ESTIMATION 69
5.4.3 PREDICATE BINDING 71
5.4.4 BIND JOINS 72
5.4.5 SYSTEM ARCHITECTURE 76
5.5 EVALUATION 76
5.5.1 EVALUATION OF THE PRUNING POWER OF OUR APPROACH 77
5.5.2 EVALUATION WITH FEDBENCH 84
5.6 SUMMARY AND PERSPECTIVES 88
6 BRIDGING T H E GAPS: SEMANTIC INTEGRATION AND D A T A TRANSFORMATION
91 6.1 MANUAL ANNOTATION AND MAPPING 91
6.1.1 RELATED WORK 91
6.1.2 NAVIGATING THE DATASPACE 92
6.1.3 EDITING LOW-VOLUME DATA 94
6.2 AUTOMATED DATA TRANSFORMATION 94
6.2.1 RELATED WORK 95
6.2.2 BASIC CONCEPTS 96
6.2.3 OPTIMIZATIONS 98
6.2.4 EVALUATION 103
6.3 SEMANTIC REASONING 108
6.3.1 VOCABULARIES 109
6.3.2 EVALUATION 112
6.4 DATA DE-IDENTIFICATION 117
6.4.1 RELATED WORK 118
6.4.2 IMPLEMENTATION FRAMEWORK 123
6.4.3 THE FLASH ALGORITHM 127
6.4.4 EVALUATION 131
6.5 SUMMARY AND PERSPECTIVES 137
II CONTENTS
IMAGE 3
CONTENTS
7 PUTTING IT ALL TOGETHER: A PROTOTYPICAL IMPLEMENTATION 139
7.1 IMPLEMENTATION DETAILS 139
7.1.1 DATA ARCHITECTURE 139
7.1.2 PERMISSION MODEL 140
7.1.3 SYSTEM ARCHITECTURE 141
7.1.4 NETWORK PROTOCOL 144
7.2 A GRAPHICAL USER INTERFACE 145
7.3 SUMMARY AND PERSPECTIVES 149
8 SUMMARY AND OUTLOOK 151
CONTENTS III
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| spelling | Praßer, Fabian Verfasser aut Incremental ontology-based integration for translational medical research Fabian Praßer 2013 X, 173 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2013 Biomedizin (DE-588)4647152-2 gnd rswk-swf Strukturierte Daten (DE-588)4620514-7 gnd rswk-swf Integration (DE-588)4027238-2 gnd rswk-swf Ontologie Wissensverarbeitung (DE-588)4827894-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Strukturierte Daten (DE-588)4620514-7 s Biomedizin (DE-588)4647152-2 s Integration (DE-588)4027238-2 s Ontologie Wissensverarbeitung (DE-588)4827894-4 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20130411-1119200-0-3 http://mediatum.ub.tum.de/node?id=1119200 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20130411-1119200-0-3 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025971521&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Praßer, Fabian Incremental ontology-based integration for translational medical research Biomedizin (DE-588)4647152-2 gnd Strukturierte Daten (DE-588)4620514-7 gnd Integration (DE-588)4027238-2 gnd Ontologie Wissensverarbeitung (DE-588)4827894-4 gnd |
| subject_GND | (DE-588)4647152-2 (DE-588)4620514-7 (DE-588)4027238-2 (DE-588)4827894-4 (DE-588)4113937-9 |
| title | Incremental ontology-based integration for translational medical research |
| title_auth | Incremental ontology-based integration for translational medical research |
| title_exact_search | Incremental ontology-based integration for translational medical research |
| title_full | Incremental ontology-based integration for translational medical research Fabian Praßer |
| title_fullStr | Incremental ontology-based integration for translational medical research Fabian Praßer |
| title_full_unstemmed | Incremental ontology-based integration for translational medical research Fabian Praßer |
| title_short | Incremental ontology-based integration for translational medical research |
| title_sort | incremental ontology based integration for translational medical research |
| topic | Biomedizin (DE-588)4647152-2 gnd Strukturierte Daten (DE-588)4620514-7 gnd Integration (DE-588)4027238-2 gnd Ontologie Wissensverarbeitung (DE-588)4827894-4 gnd |
| topic_facet | Biomedizin Strukturierte Daten Integration Ontologie Wissensverarbeitung Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1119200 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20130411-1119200-0-3 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025971521&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT praßerfabian incrementalontologybasedintegrationfortranslationalmedicalresearch |