An introduction to medicinal chemistry:
This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
2013
|
| Edition: | 5. ed. |
| Subjects: | |
| Online Access: | Klappentext Inhaltsverzeichnis |
| Summary: | This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug. |
| Item Description: | Hier auch später erschienene, unveränderte Nachdrucke |
| Physical Description: | XXIII, 789 S. Ill., graph. Darst. |
| ISBN: | 9780199697397 |
Staff View
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| 100 | 1 | |a Patrick, Graham L. |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a An introduction to medicinal chemistry |c Graham L. Patrick |
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Record in the Search Index
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| adam_text | An Introduction to Medicinal Chemistry
is the leading text for university courses
on this subject. Renowned for being a
textbook loved equally by both students
and lecturers, it offers complete coverage
in an accessible and engaging style.
Coverage of 99 drugs not featured in the
previous edition.
Six new boxes cover topics such as Cyciodextrms
as drug scavengers . The structure-based drug
design of cnzotmib . and Designing a non-
steroidal glucocorticoid agonist .
A new case study on steroidal anti-inflammatory
agents and over 25 new sections provide
additional depth in subject areas including
Tethers and anchors and Short-acting
8 blockers
Updated online content includes *10 new
molecular modelling exercises and sixteen
new web articles
Brief contents
List of boxes
Acronyms and abbreviations
1 Drugs and drug targets: an overview
PART A Drug targets
2 Protein structure and function
3 Enzymes: structure and function
4 Receptors: structure and function
5 Receptors and signal transduction
6 Nucleic acids.· structure and function
PART B Pharmacodynamics and
pharmacokinetics
7 Enzymes as drug targets
8 Receptors as drug targets
9 Nucleic acids as drug targets
10 Miscellaneous drug targets
11 Pharmacokinetics and related topics
Case study 1: Statins
PART C Drug discovery, design, and
development
12 Drug discovery: finding a lead
13 Drug design: optimizing target interactions
14 Drug design: optimizing access to the target
15 Getting the drug to market
Case study 2; The design of angiotensin-
converting enzyme (ACE) inhibitors
Case study Artemisinin and related
antimalarial drugs
Case study 4: The design of oxamniquine
PART D Tools of the trade
16 Combinatorial and parallel synthesis 313
17 Computers in medicinal chemistry 337
18 Quantitative structure-activity relationships
(QSAR) 383
Case study 5: Design of a thymidylate synthase
inhibitor 407
PART E Selected topics in medicinal chemistry
19 Antibacterial agents 413
20 Antiviral agents 468
21 Anticancer agents 514
22 Cholinergics, anticholinergics, and
anticholinesterases 578
23 Drugs acting on the adrenergic
nervous system 609
24 The opioid analgesics 632
25 Anti-ulcer agents 659
Case study 6: Steroidal anti-inflammatory agents 689
Case Study 7: Current research into
antidepressant agents 700
Appendix 1 Essential amino acids 705
Appendix 2 The standard genetic code 706
Appendix 3 Statistical data for quantitative
structure-activity relationships (QSAR) 707
Appendix 4 The action of nerves 711
Appendix 5 Microorganisms 715
Appendix 6 Drugs and their trade names 717
Appendix 7 Trade names and drugs 722
Appendix 8 Hydrogen bonding interactions 728
Appendix 9 Drug properties 730
Glossary 741
General further reading 761
Index 763
xix
xxi
1
17
30
42
58
71
87
102
120
135
153
178
189
215
248
274
292
299
305
|
| any_adam_object | 1 |
| author | Patrick, Graham L. |
| author_facet | Patrick, Graham L. |
| author_role | aut |
| author_sort | Patrick, Graham L. |
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| building | Verbundindex |
| bvnumber | BV040906475 |
| callnumber-first | R - Medicine |
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| callnumber-search | RS403 |
| callnumber-sort | RS 3403 |
| callnumber-subject | RS - Pharmacy |
| classification_rvk | VS 5000 VS 5010 XI 1800 YV 3300 |
| classification_tum | CHE 893f MED 960f |
| ctrlnum | (OCoLC)844040019 (DE-599)BVBBV040906475 |
| dewey-full | 615.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.19 |
| dewey-search | 615.19 |
| dewey-sort | 3615.19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Chemie Medizin |
| edition | 5. ed. |
| format | Book |
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| institution | BVB |
| isbn | 9780199697397 |
| language | English |
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| physical | XXIII, 789 S. Ill., graph. Darst. |
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| spelling | Patrick, Graham L. Verfasser aut An introduction to medicinal chemistry Graham L. Patrick Medicinal chemistry 5. ed. Oxford [u.a.] Oxford Univ. Press 2013 XXIII, 789 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Hier auch später erschienene, unveränderte Nachdrucke This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug. Pharmaceutical chemistry Physiologische Chemie (DE-588)4076124-1 gnd rswk-swf Pharmazeutische Chemie (DE-588)4132158-3 gnd rswk-swf (DE-588)4151278-9 Einführung gnd-content Pharmazeutische Chemie (DE-588)4132158-3 s DE-604 Physiologische Chemie (DE-588)4076124-1 s 1\p DE-604 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025885899&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Klappentext Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025885899&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Patrick, Graham L. An introduction to medicinal chemistry Pharmaceutical chemistry Physiologische Chemie (DE-588)4076124-1 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd |
| subject_GND | (DE-588)4076124-1 (DE-588)4132158-3 (DE-588)4151278-9 |
| title | An introduction to medicinal chemistry |
| title_alt | Medicinal chemistry |
| title_auth | An introduction to medicinal chemistry |
| title_exact_search | An introduction to medicinal chemistry |
| title_full | An introduction to medicinal chemistry Graham L. Patrick |
| title_fullStr | An introduction to medicinal chemistry Graham L. Patrick |
| title_full_unstemmed | An introduction to medicinal chemistry Graham L. Patrick |
| title_short | An introduction to medicinal chemistry |
| title_sort | an introduction to medicinal chemistry |
| topic | Pharmaceutical chemistry Physiologische Chemie (DE-588)4076124-1 gnd Pharmazeutische Chemie (DE-588)4132158-3 gnd |
| topic_facet | Pharmaceutical chemistry Physiologische Chemie Pharmazeutische Chemie Einführung |
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