The role of Netrin-1 during acute inflammatory peritonitis:
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | IV, 61 S. Ill., graph. Darst. 21 cm |
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Record in the Search Index
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| adam_text | IMAGE 1
CONTENTS
TABLE OF CONTENTS I
LIST OF ABBREVIATIONS III
1 INTRODUCTION 1
1.1 INFLAMMATION AND PERITONITIS 1
1.1.1 THE IMMUNE SYSTEM 1
1.1.2 INFLAMMATION AND INFECTION 2
1.1.3 CYTOKINES 3
1.1.4 PERITONITIS 5
1.2 THE ROLE OF NEURONAL GUIDANCE PROTEINS DURING INFLAMMATION 7 1.3
NETRIN-1 AND ITS RECEPTORS 9
1.3.1 THE STRUCTURE AND FUNCTION OF NETRIN-1 9
1.3.2 THE RECEPTORS OF NETRIN-1 10
1.4 AIM AND FOCUS OF THIS STUDY 13
2 MATERIAL AND METHODS 14
2.1 ANIMAL EXPERIMENTS 14
2.2 CELL COUNTING 15
2.3 CELL STAINING 15
2.4 MPO ASSAY 15
2.5 PROTEIN ASSAY 15
2.6 ELISA 16
2.7 PCR 16
2.8 WESTERN BLOT 17
2.9 TISSUE SECTION 17
2.10 IMMUNOHISTOCHEMISTRY 18
2.11 DATA ANALYSIS 18
3 RESULTS 19
3.1 NETRIN-1 IS EXPRESSED OUTSIDE THE CENTRAL NERVOUS SYSTEM 19
3.2 NETRIN-1 IS REPRESSED DURING AN ACUTE INFLAMMATORY RESPONSE IN VIVO
AND IN VITRO 20
3.3 ENDOGENOUS NETRIN-1 CONTROLS ACUTE INFLAMMATORY PERITONITIS
IN-VIVO....22 3.4 EXOGENOUS NETRIN-1 DAMPENS INFLAMMATORY PERITONITIS IN
VIVO 27 3.5 EXOGENOUS NETRIN-1 DOES NOT REDUCE INFLAMMATORY PERITONITIS
IN A 2BAR -/- ANIMALS 32
4 DISCUSSION 38
4.1 NETRIN-1 IS EXPRESSED OUTSIDE THE CENTRAL NERVOUS SYSTEM 39
4.2 NETRIN-1 IS REPRESSED DURING AN ACUTE INFLAMMATORY RESPONSE IN-VIVO
AND IN-VITRO 40
HTTP://D-NB.INFO/1027751008
IMAGE 2
II
4.3 NETRIN-1 DAMPENS ACUTE INFLAMMATORY PERITONITIS IN VIVO 40
4.4 EXOGENOUS NETRIN-1 DOES NOT REDUCE INFLAMMATORY PERITONITIS IN A2BAR
-/- ANIMALS 42
4.5 CONCLUSION AND PROSPECT 44
5 SYNOPSIS 46
6 REFERENCES 50
7 ZUSAMMENFASSUNG 55
8 VEROFFENTLICHUNGEN 59
9 DANKSAGUNG 60
10 LEBENSLAUF 61
|
| any_adam_object | 1 |
| author | Gatidou, Dimitra 1985- |
| author_GND | (DE-588)1027285317 |
| author_facet | Gatidou, Dimitra 1985- |
| author_role | aut |
| author_sort | Gatidou, Dimitra 1985- |
| author_variant | d g dg |
| building | Verbundindex |
| bvnumber | BV040797618 |
| ctrlnum | (OCoLC)828200319 (DE-599)DNB1027751008 |
| dewey-full | 570 610 |
| dewey-hundreds | 500 - Natural sciences and mathematics 600 - Technology (Applied sciences) |
| dewey-ones | 570 - Biology 610 - Medicine and health |
| dewey-raw | 570 610 |
| dewey-search | 570 610 |
| dewey-sort | 3570 |
| dewey-tens | 570 - Biology 610 - Medicine and health |
| discipline | Biologie Medizin |
| format | Thesis Book |
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| indexdate | 2024-07-10T00:34:05Z |
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| spelling | Gatidou, Dimitra 1985- Verfasser (DE-588)1027285317 aut The role of Netrin-1 during acute inflammatory peritonitis vorgelegt von Dimitra Gatidou 2012 IV, 61 S. Ill., graph. Darst. 21 cm txt rdacontent n rdamedia nc rdacarrier Tübingen, Univ., Diss., 2012 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025777780&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Gatidou, Dimitra 1985- The role of Netrin-1 during acute inflammatory peritonitis |
| subject_GND | (DE-588)4113937-9 |
| title | The role of Netrin-1 during acute inflammatory peritonitis |
| title_auth | The role of Netrin-1 during acute inflammatory peritonitis |
| title_exact_search | The role of Netrin-1 during acute inflammatory peritonitis |
| title_full | The role of Netrin-1 during acute inflammatory peritonitis vorgelegt von Dimitra Gatidou |
| title_fullStr | The role of Netrin-1 during acute inflammatory peritonitis vorgelegt von Dimitra Gatidou |
| title_full_unstemmed | The role of Netrin-1 during acute inflammatory peritonitis vorgelegt von Dimitra Gatidou |
| title_short | The role of Netrin-1 during acute inflammatory peritonitis |
| title_sort | the role of netrin 1 during acute inflammatory peritonitis |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025777780&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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