Philosophy of stem cell biology: knowledge in flesh and blood
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| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York
Palgrave Macmillan
2013
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| Edition: | 1. publ. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XX, 274 S. graph. Darst. cm |
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Record in the Search Index
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| adam_text | Titel: Philosophy of stem cell biology
Autor: Fagan, Melinda Bonnie
Jahr: 2013
Contents
List of Figures and Tables xi
Series Editor s Foreword xv
Acknowledgments xvii
1 Visceral Phenomena 1
1.1 Blood and guts 1
1.2 Aims and themes 4
1.3 Plan of the book 8
Part I
2 Stem Cell Concepts 15
2.1 Introduction 15
2.1.1 Overview and aims 15
2.1.2 Stem cell basics 16
2.2 Consensus definition 19
2.2.1 Self-renewal 20
2.2.2 Differentiation 22
2.3 Models: philosophical accounts 25
2.4 Abstract stem cell model 27
2.4.1 Structure 27
2.4.2 Representational assumptions 30
2.4.3 Specifying parameters 32
2.4.4 Application 34
2.5 Concrete methods 34
2.5.1 Induced pluripotent stem cells 34
2.5.2 Human embryonic stem cells 36
2.5.3 Blood stem cells (1970s-1980s) 37
2.6 Results 39
2.6.1 Robust framework 39
2.6.2 Conceptual divide 40
2.7 Models and theories 42
2.7.1 Unity and diversity 42
2.7.2 Price s equation 43
2.7.3 Models without theories 45
2.8 Conclusions 45
vii
viii Contents
3 Don t Know What You ve Got Til It s Gone: Evidence in
Stem Cell Experiments 48
3.1 Structure of experiments 48
3.2 Exemplars revisited 49
3.2.1 Human embryonic stem cells 50
3.2.2 Mouse blood stem cells 52
3.3 Cells and populations 53
3.3.1 General form of the problem 54
3.3.2 Philosophical accounts 55
3.3.3 Evidential gap 57
3.3.4 Scientific response 58
3.4 Population-level models 60
3.4.1 Stochastic model 60
3.4.2 Spleen colony assay 61
3.4.3 Evidence for population-level models 62
3.5 The stem cell uncertainty principle 64
3.6 Conclusions 68
4 A State of Uncertainty: Sternness and the Roles of Theory 70
4.1 The sternness alternative 70
4.2 Contrasting models 73
4.3 Evaluating models 77
4.4 Philosophical responses 78
4.5 General definition 80
4.6 Evidence for plasticity 82
4.7 Molecular genetic explanation 85
4.8 Conclusions 87
Part II
5 Mechanistic Explanation: The Joint Account 91
5.1 Introduction 91
5.2 Mechanisms 92
5.3 Law-based explanation 96
5.4 Causal explanation 99
5.4.1 The manipulability theory 99
5.4.2 The causal-mechanical account 100
5.5 Three problems 100
5.5.1 Ambiguity 101
5.5.2 Direction 102
5.5.3 Modularity 104
5.5.4 Motivating a new account 106
5.6 Jointness 107
Contents ix
5.7 Joint account of mechanistic explanation 110
5.7.1 Jointness condition for mechanisms 110
5.7.2 Advantages 111
5.7.3 Jointness and unification 114
5.8 Conclusion 115
6 Genes and Development: The Stem Cell Perspective 117
6.1 Introduction 117
6.2 Genes as difference-makers 119
6.3 Specificity and mechanistic explanation 121
6.4 Cell reprogramming 123
6.5 Waddington s epigenetic landscape 129
6.5.1 Developmental pathways 130
6.5.2 Genetic control 132
6.5.3 Unification 135
6.6 Reprogramming and the landscape 136
6.7 Regulatory genes 141
6.8 Conclusion 144
7 Pluripotent Model Organisms 146
7.1 Introduction 146
7.2 Model organisms in experimental biology 146
7.3 An epistemic challenge 148
7.4 Stem cell lines as model organisms 151
7.5 Origins of pluripotency research 154
7.5.1 Embryonal carcinoma 154
7.5.2 Mouse ESC 159
7.5.3 Human ESC 161
7.6 Model epistemology 165
7.7 Conclusion 169
8 Social Experiments 171
8.1 Introduction 171
8.2 Experiment and theory 173
8.3 Blood stem cells (I) 175
8.4 Resolution of controversy 179
8.4.1 Advance 179
8.4.2 Not the real stem cells 181
8.4.3 Indiscriminate glamourization? 182
8.5 Blood stem cells (II) 183
8.5.1 Division of labor 183
8.5.2 Center of collaboration 185
8.6 Contrast in experimenting communities 187
x Contents
8.7 Further examples 189
8.7.1 Spleen colonies 190
8.7.2 Cancer stem cells 191
8.8 Conclusion 192
Part III
9 Integrating Stem Cell and Systems Biology 197
9.1 Introduction 197
9.2 Systems biology: overview 197
9.3 Mathematical modeling of cellular systems 204
9.3.1 Molecular mechanism 204
9.3.2 Wiring diagram 205
9.3.3 Formal framework 206
9.3.4 Solutions and derivation 208
9.4 Waddington s landscape revisited 209
9.4.1 Bottom-up regulatory networks 209
9.4.2 Top-side experiments 211
9.5 Explaining cell development 213
9.6 Models and experiments 216
9.6.1 Unifying models 217
9.6.2 Microarray experiments 217
9.6.3 General principles 219
9.7 Conclusion 222
10 Clinical Values 224
10.1 Introduction 224
10.2 Translational research 224
10.3 Value-free science 227
10.4 Values in stem cell biology 231
10.5 Conclusion 235
Notes 239
Bibliography 251
Index 261
|
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| spelling | Fagan, Melinda Bonnie ca. 20./21. Jh. Verfasser (DE-588)1031402233 aut Philosophy of stem cell biology knowledge in flesh and blood Melinda Bonnie Fagan 1. publ. New York Palgrave Macmillan 2013 XX, 274 S. graph. Darst. cm txt rdacontent n rdamedia nc rdacarrier Stem cells Systems biology Clinical medicine Klinische Medizin (DE-588)4134748-1 gnd rswk-swf Stammzelle (DE-588)4665329-6 gnd rswk-swf Systembiologie (DE-588)4809615-5 gnd rswk-swf Stammzelle (DE-588)4665329-6 s Systembiologie (DE-588)4809615-5 s Klinische Medizin (DE-588)4134748-1 s b DE-604 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025775743&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Fagan, Melinda Bonnie ca. 20./21. Jh Philosophy of stem cell biology knowledge in flesh and blood Stem cells Systems biology Clinical medicine Klinische Medizin (DE-588)4134748-1 gnd Stammzelle (DE-588)4665329-6 gnd Systembiologie (DE-588)4809615-5 gnd |
| subject_GND | (DE-588)4134748-1 (DE-588)4665329-6 (DE-588)4809615-5 |
| title | Philosophy of stem cell biology knowledge in flesh and blood |
| title_auth | Philosophy of stem cell biology knowledge in flesh and blood |
| title_exact_search | Philosophy of stem cell biology knowledge in flesh and blood |
| title_full | Philosophy of stem cell biology knowledge in flesh and blood Melinda Bonnie Fagan |
| title_fullStr | Philosophy of stem cell biology knowledge in flesh and blood Melinda Bonnie Fagan |
| title_full_unstemmed | Philosophy of stem cell biology knowledge in flesh and blood Melinda Bonnie Fagan |
| title_short | Philosophy of stem cell biology |
| title_sort | philosophy of stem cell biology knowledge in flesh and blood |
| title_sub | knowledge in flesh and blood |
| topic | Stem cells Systems biology Clinical medicine Klinische Medizin (DE-588)4134748-1 gnd Stammzelle (DE-588)4665329-6 gnd Systembiologie (DE-588)4809615-5 gnd |
| topic_facet | Stem cells Systems biology Clinical medicine Klinische Medizin Stammzelle Systembiologie |
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