The ethical challenges of human research: selected essays
Saved in:
| Main Author: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Oxford [u.a.]
Oxford Univ. Press
2012
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Item Description: | Includes bibliographical references |
| Physical Description: | XXIV, 322 S. graph. Darst. |
| ISBN: | 9780199896202 0199896208 |
Staff View
MARC
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| 245 | 1 | 0 | |a The ethical challenges of human research |b selected essays |c Franklin G. Miller |
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| 500 | |a Includes bibliographical references | ||
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
Sources
xi
Acknowledgments
xiii
Preface
xv
Part
і
Protecting Human Subjects in Clinical Research:
A General Perspective
One Situating research ethics: Revisiting Beecher and Jonas
3
Two Facing up to paternalism in research ethics
17
WITH A WERTHEIMER
Three Limits to research risks
36
WITH
S
JOFFE
Part
h
Study Design
Four Psychiatric symptom-provoking studies: An ethical appraisal
51
WITH
DL ROSENSTEIN
Five The ethical challenge of infection-inducing challenge
experiments
65
WITH
С
GRADY
Six Placebo-controlled trials in psychiatric research: An ethical
perspective
76
Seven What makes placebo-controlled trials unethical?
94
WITH
H
BRODY
Viii CONTENTS
Eight Ethical issues concerning research in complementary and
alternative medicine
105
WITH
EJ EMANUEL,
DL ROSENSTEIN,
SE
STRAUS
Nine Sham surgery: An ethical analysis
118
Ten Benefit in phase
1
oncology trials: Therapeutic misconception
or reasonable treatment option?
131
WITH
S
JOFFE
Eleven Deception in research on the placebo effect
144
WITH
D
WENDLER,
L
SWARTZMAN
Twelve Debriefing and accountability in deceptive research
159
WITH JP
GLUCK, D WENDLER
Part III Therapeutic Orientation and Equipoise
Thirteen Professional integrity in clinical research
177
WITH
DL ROSENSTEIN,
EG
DERENZO
Fourteen The therapeutic orientation to clinical trials
192
WITH
DL ROSENSTEIN
Fifteen A critique of clinical equipoise: Therapeutic misconception
in the ethics of clinical trials
199
WITH
H BRODY
Sixteen Clinical equipoise and the incoherence of research ethics
217
WITH
H BRODY
Seventeen Equipoise and the Dilemma of Randomized Clinical Trials
231
WITH
S
JOFFE
Part IV Consent
Eighteen Evaluating the therapeutic misconception
WITH
S
JOFFE
243
CONTENTS
ІХ
Nineteen Is it ethical to keep interim findings of randomized
controlled trials confidential?
256
WITH
D
WENDLER
Twenty Research on medical records without informed consent
266
Twenty One Coverage with evidence development: Ethical issues
and policy implications
278
WITH SD PEARSON
Twenty Two The fair transaction model of informed consent:
An alternative to autonomous authorization
291
WITH A WERTHEIMER
Index
307
The use of human beings as research subjects
poses distinctive ethical issues Subjects of
medica!
research are exposed to risks of harm for the sake
of generating scientific knowledge that can benefit
future patients and society. Ethical analysis of the
challenges posed by research involving human
subjects requires carefu! attention to the contextual
details of scientific experimentation This book
contains
22
essays by Franklin
G Mitier
on research
ethics written over
a
15-year period. With the
exception
of the first essay, all have been previously
published in bioethics and medical ¡oumals.
The boc* ¡s a ranged ;r:!c ton
p,.) *1· P ľ*
Orv
acceptable
;¡m:*s
to reseat
^ѕкѕ
Tr... e--s.:rrs ¡n
Ddrt Two
ЄХіКП.ПЄ
eth Ci!
ŕS-jeS
Γ
study
deŞ g
í*
Ciucitìs etrxoai
analyses cf con!rover>ia;
ty
fies
of
medical
experimentation
.......
studies that provoke
psychiatric symptoms, induce infections, provide
patients with placebos that withhold proven effective
treatments
да
ađmineter
fake invasive procedures,
test experimental
treatmenb
in cancer patients who
have exhausted ail standard treatment optois. and
employ the use
d
deception to generate scientifically
vaNd data. Part Three offers a systematic aifeque
of The therapeutic orientatat* to
ейгмеаі
trais
and
the
principie
di
cttmcai eqwp&se. which is widely
rejprţied
as
a fundamentat
noon for randomized
treatment studies. Part Four takes up a range
of ethcal
issues
reŁafeng
to informed consent !or
research part-tctoaikm, inciucitng
exarrarsaöor»
of
the !fwapeutic misc.orceot;»1 ar-d pifesentatcs»1
of a revel appstsacft to
tne vaM<ty
of consent,
the far transact»» mode*.
An abumg theme,
iteťtopeí
m
many of tf>e essays
s
that tfse
eîft*cs
ti cfeic« resesfctì
s «Bporîantty datèrent
from
і*
евжѕ
rf
medícat
care.
■ .· ■ ■■ ■
i-t
■■ .--
,;
■>} ·■■ < ;
ľ-
is a member of the
V
seni»
faculty in the Department of Bioethics, National
¡¿Institutes
¿í
Health
(NIH)
and Special Expert. National
InstJttjteofMeniaJ Hearth Intramural Research
l-přogřan*
Òr.
MBter has co-authored Death, Dying,
s-
-and
UrţaoŢraisplantBtian
with Robert Truog, (Oxford
v1ÌirwerstyPiies$.2ÒÌ2),
edited five
boote
and written
,
numerous pubfished articies ¡n medical and bioethics
.
tournais on
ttie etttics of clinical research, ethical
,.
issues concerning death and dying, professional
{fite^îţH.
health policy, pragmatism
.ind bioethcs,
■·
and the placebo effect Dr.
МШсг к
a fellow ot the
·-.
Hastif^s Center, a Faculty Affiliate at the KennrJy
·-■
Instììute
of
ЕШкѕ,
and Associate Professor of Publ.o
- Health in the EAwsbn of
Medical
Ethics. Department
f
of
PiÁftr
Health, Wei«
Medicai
Colege.
|
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| id | DE-604.BV040754866 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:33:13Z |
| institution | BVB |
| isbn | 9780199896202 0199896208 |
| language | English |
| lccn | 2012008758 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025734554 |
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| physical | XXIV, 322 S. graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Oxford Univ. Press |
| record_format | marc |
| spelling | Miller, Franklin G. Verfasser (DE-588)141587660 aut The ethical challenges of human research selected essays Franklin G. Miller Oxford [u.a.] Oxford Univ. Press 2012 XXIV, 322 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references Human Experimentation ethics Collected Works Clinical Trials as Topic ethics Collected Works Placebos Collected Works Medizinische Ethik (DE-588)4074672-0 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 gnd rswk-swf Klinisches Experiment (DE-588)4164223-5 s Medizinische Ethik (DE-588)4074672-0 s DE-604 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025734554&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025734554&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Miller, Franklin G. The ethical challenges of human research selected essays Human Experimentation ethics Collected Works Clinical Trials as Topic ethics Collected Works Placebos Collected Works Medizinische Ethik (DE-588)4074672-0 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| subject_GND | (DE-588)4074672-0 (DE-588)4164223-5 |
| title | The ethical challenges of human research selected essays |
| title_auth | The ethical challenges of human research selected essays |
| title_exact_search | The ethical challenges of human research selected essays |
| title_full | The ethical challenges of human research selected essays Franklin G. Miller |
| title_fullStr | The ethical challenges of human research selected essays Franklin G. Miller |
| title_full_unstemmed | The ethical challenges of human research selected essays Franklin G. Miller |
| title_short | The ethical challenges of human research |
| title_sort | the ethical challenges of human research selected essays |
| title_sub | selected essays |
| topic | Human Experimentation ethics Collected Works Clinical Trials as Topic ethics Collected Works Placebos Collected Works Medizinische Ethik (DE-588)4074672-0 gnd Klinisches Experiment (DE-588)4164223-5 gnd |
| topic_facet | Human Experimentation ethics Collected Works Clinical Trials as Topic ethics Collected Works Placebos Collected Works Medizinische Ethik Klinisches Experiment |
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