Autophagy of the nervous system: cellular self-digestion in neurons and neurological diseases
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Singapore [u.a.]
World Scientific Publ.
2012
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | XIV, 426 S. Ill., graph. Darst. |
| ISBN: | 9789814350440 9814350443 |
Staff View
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Record in the Search Index
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| adam_text | CONTENTS
Contributors
Preface
vu
xiii
Section
1 Neuronal
Aiitophagy: Cellular Process and Regulation
1
Chapter I The Cellular Process of Autophagy and Control
of Autophagy in Neurons
3
Nicole C. McKnight, Noboru Mizushima and Zhenyu Yue
Chapter
2
Autophagosome Maturation, Endocytosis and
Neurodegenerative
Disease
37
A/ Yamamoto and Anne
Simonsen
Chapter
3
Cross-Talk Between the Ubiquitin-Proteasome System
and Macroautophagy
59
Serhiy Panidv and Terje Johansen
Chapter
4
Chaperone-Mediated Autophagy (CMA) in Neurons
87
Maria Xilouri, Hsiao-Yu Peng and
Leónidas
Stefanis
Chapter
5
Maintaining Autophagic Balance: A Role for Brakes
105
Salvatore
J.
Cherra,
Ш
and Charleen
T. Chu
Section
2
Autophagy
and Neurological Diseases
Chapter
6
Autophagy
and Its Cross-Talk with Cell Death
in Neural Development
Sabrina Di Bartolomeo
and Francesco Cecconi
Chapter
7
Autophagy in the Retina: Development, Physiology
and Pathology
Patricia
Boya
127
129
149
vi
Contents
Chapter
8
Genetic Mouse Models for Elucidation
of Autophagy-Lysosomal Systems in Neurons
under Physiologic and Pathologic Conditions
175
Masaaki Komatsu, Masato Koike, Yoshinobu Ichimura
and Yasuo Uchiyama
Chapter
9
Autophagy in Amyotrophic Lateral Sclerosis
205
József
Gal and Haining Zhu
Chapter
10
Autophagy Failure in Alzheimer s Disease
and Lysosomal Storage Disorders: A Common Pathway
to Neurodegeneration?
237
Devin M.
Wolfe and Ralph A. Nixon
Chapter
11
Autophagy in
Huntington s
and Parkinson s Diseases:
Pathogenic Mechanisms and Therapeutic Potentials
259
Junghyun
Lim,
Lauren G. Friedman,
Nicole C. McKnight and Zhenyu Yue
Chapter
12
Metabolism, Autophagy and Neurodegeneration
285
W. Haung Yu and Karen E. Duff
Chapter
13
The Potential of Autophagy Regulation in the Treatment
of
Neurodegenerative
Diseases
305
Ashley R. Winslow, Zeyn W. Green-Thompson
and David C. Rubinsztein
Chapter
14
Lysosome Storage Disorders on the Brain: The Autophagy-
Lysosome Pathway Contributes to Disease Pathophysiology
and May be Utilized for Therapeutic Benefit
331
John J.
Snacka
Section
3
Specialized Autophagy:
Тік
New Frontier
355
Chapter
15
Autophagy
—
Roles in Synaptic Structure and Function
357
Daniela
Hernandez and David Sulzer
Chapter
16 Neuronal Mitochondrial
Transport and Turnover
via Mitophagy
375
Zu-Hang Sheng and
Charleen
T. Chu
Chapter
17
Role of Autophagy in
Neunte
Degeneration in Vitro
407
Yi Yang, Xiaoxiang Zheng and Tatsuro Koike
Index
423
Autophagy
of the Nervous System
Cellular Self-Digestion in Neurons and Neurological Diseases
What is autophagy? Why would neurons digest parts of themselves through
autophagy? How can autophagy save the lives of cells under some conditions,
but act as an accomplice to cell death in others? By what mechanisms are
autophagy-related processes dysregulated in neurological diseases, and are
there therapeutic strategies to compensate for their dysfunction? This book
provides an expert view of major concepts in autophagy research with a focus
on autophagy in neurons. Experimental evidence for evolutionarily conserved
and specialized regulatory mechanisms for autophagy in the mammalian
nervous system will be presented, including recent data on braking mechanisms.
Areas of intersection with cell death, the ubiquitin-proteasome system, chaper-
one-mediated autophagy, and the endocytic pathway will be reviewed, along
with emerging areas of mitochondrial autophagy (mitophagy) and the
autophagic regulation of neuritic/synaptic processes. Advances in delineating
mechanisms by which autophagy is involved in the pathophysiology of neuro¬
logical disorders, including Alzheimer s, Parkinson s, Huntington s, amyotrophic
lateral sclerosis, ischemia/hypoxia and lysosomal storage diseases, will be
discussed along with current drug development strategies targeting autophagy.
|
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| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.655 |
| dewey-search | 571.655 |
| dewey-sort | 3571.655 |
| dewey-tens | 570 - Biology |
| discipline | Biologie Medizin |
| format | Book |
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| illustrated | Illustrated |
| indexdate | 2024-07-10T00:33:13Z |
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| isbn | 9789814350440 9814350443 |
| language | English |
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| physical | XIV, 426 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | World Scientific Publ. |
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| spelling | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases ed.: Zhenyu Yue ... Singapore [u.a.] World Scientific Publ. 2012 XIV, 426 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Nervensystem (DE-588)4041643-4 gnd rswk-swf Autophagie Physiologie (DE-588)4441664-7 gnd rswk-swf Nervenzelle (DE-588)4041649-5 gnd rswk-swf Autophagie Physiologie (DE-588)4441664-7 s Nervensystem (DE-588)4041643-4 s DE-604 Nervenzelle (DE-588)4041649-5 s b DE-604 Yue, Zhenyu Sonstige oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025734540&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025734540&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases Nervensystem (DE-588)4041643-4 gnd Autophagie Physiologie (DE-588)4441664-7 gnd Nervenzelle (DE-588)4041649-5 gnd |
| subject_GND | (DE-588)4041643-4 (DE-588)4441664-7 (DE-588)4041649-5 |
| title | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases |
| title_auth | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases |
| title_exact_search | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases |
| title_full | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases ed.: Zhenyu Yue ... |
| title_fullStr | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases ed.: Zhenyu Yue ... |
| title_full_unstemmed | Autophagy of the nervous system cellular self-digestion in neurons and neurological diseases ed.: Zhenyu Yue ... |
| title_short | Autophagy of the nervous system |
| title_sort | autophagy of the nervous system cellular self digestion in neurons and neurological diseases |
| title_sub | cellular self-digestion in neurons and neurological diseases |
| topic | Nervensystem (DE-588)4041643-4 gnd Autophagie Physiologie (DE-588)4441664-7 gnd Nervenzelle (DE-588)4041649-5 gnd |
| topic_facet | Nervensystem Autophagie Physiologie Nervenzelle |
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