Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY [u.a.]
Springer
2013
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| Schriftenreihe: | Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems
4 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function. Describes ion and molecular carriers and receptors. Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 9781461443704 |
| DOI: | 10.1007/978-1-4614-4370-4 |
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| 500 | |a The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function. Describes ion and molecular carriers and receptors. Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows | ||
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Datensatz im Suchindex
| _version_ | 1804150074382483456 |
|---|---|
| adam_text | INTRACELLULAR SIGNALING MEDIATORS IN THE CIRCULATORY AND VENTILATORY
SYSTEMS
/ THIRIET, MARC
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
1. INTRODUCTION
2. SIGNALING LIPIDS
3. PREAMBLE TO CYTOPLASMIC PROTEIN KINASES
4. CYTOPLASMIC PROTEIN TYROSINE KINASES
5. CYTOPLASMIC PROTEIN SERINE/THREONINE KINASES
6. DUAL-SPECIFICITY PROTEIN KINASES
7. MITOGEN-ACTIVATED PROTEIN KINASE MODULE
8. DUAL-SPECIFICITY PROTEIN KINASES
9. GUANOSINE TRIPHOSPHATASES AND THEIR REGULATORS
10. OTHER MAJOR TYPES OF SIGNALING MEDIATORS
11. SIGNALING PATHWAYS
12. CONCLUSION
REFERENCES
LIST OF CURRENTLY USED PREFIXES AND SUFFIXES
LIST OF ALIASES.-COMPLEMENTARY LISTS OF NOTATIONS
INDEX
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
INTRACELLULAR SIGNALING MEDIATORS IN THE CIRCULATORY AND VENTILATORY
SYSTEMS
/ THIRIET, MARC
: 2013
ABSTRACT / INHALTSTEXT
THE VOLUMES IN THIS AUTHORITATIVE SERIES PRESENT A MULTIDISCIPLINARY
APPROACH TO MODELING AND SIMULATION OF FLOWS IN THE CARDIOVASCULAR AND
VENTILATORY SYSTEMS, ESPECIALLY MULTISCALE MODELING AND COUPLED
SIMULATIONS. THE CARDIOVASCULAR AND RESPIRATORY SYSTEMS ARE TIGHTLY
COUPLED, AS THEIR PRIMARY FUNCTION IS TO SUPPLY OXYGEN TO AND REMOVE
CARBON DIOXIDE FROM THE BODY S CELLS. BECAUSE PHYSIOLOGICAL CONDUITS
HAVE DEFORMABLE AND REACTIVE WALLS, MACROSCOPIC FLOW BEHAVIOR AND
PREDICTION MUST BE COUPLED TO PHENOMENOLOGICAL MODELS OF NANO- AND
MICROSCOPIC EVENTS IN A CORRECTOR SCHEME OF REGULATED MECHANISMS WHEN
THE VESSEL LUMEN CALIBER VARIES MARKEDLY. THEREFORE, INVESTIGATION OF
FLOWS OF BLOOD AND AIR IN PHYSIOLOGICAL CONDUITS REQUIRES AN
UNDERSTANDING OF THE BIOLOGY, CHEMISTRY, AND PHYSICS OF THESE SYSTEMS
TOGETHER WITH THE MATHEMATICAL TOOLS TO DESCRIBE THEIR FUNCTIONING.
VOLUME 4 IS DEVOTED TO MAJOR SETS OF INTRACELLULAR MEDIATORS THAT
TRANSMIT SIGNALS UPON STIMULATION OF CELL-SURFACE RECEPTORS.
ACTIVATION OF SIGNALING EFFECTORS TRIGGERS THE RELEASE OF SUBSTANCES
STORED IN CELLULAR ORGANELLES AND/OR GENE TRANSCRIPTION AND PROTEIN
SYNTHESIS. COMPLEX STAGES OF CELL SIGNALING CAN BE STUDIED USING PROPER
MATHEMATICAL MODELS, ONCE THE ROLE OF EACH COMPONENT IS CAREFULLY
HANDLED. VOLUME 4 ALSO REVIEWS VARIOUS CATEGORIES OF CYTOSOLIC AND/OR
NUCLEAR MEDIATORS AND ILLUSTRATES SOME MAJOR SIGNAL TRANSDUCTION
PATHWAYS, SUCH AS NFKAPPAB AXIS, OXYGEN SENSING, AND
MECHANOTRANSDUCTION. REVIEWS SIGNALING PATHWAYS IN THE REGULATION OF
CIRCULATORY AND RESPIRATORY FUNCTION DESCRIBES ION AND MOLECULAR
CARRIERS AND RECEPTORS INTEGRATES BIOLOGY, CHEMISTRY, AND PHYSICS FOR A
MULTIDISCIPLINARY UNDERSTANDING OF PHYSIOLOGICAL FLOWS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| spelling | Thiriet, Marc Verfasser (DE-588)1019322721 aut Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems Marc Thiriet New York, NY [u.a.] Springer 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems 4 The volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to and remove carbon dioxide from the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to phenomenological models of nano- and microscopic events in a corrector scheme of regulated mechanisms when the vessel lumen caliber varies markedly. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems together with the mathematical tools to describe their functioning. Volume 4 is devoted to major sets of intracellular mediators that transmit signals upon stimulation of cell-surface receptors. Activation of signaling effectors triggers the release of substances stored in cellular organelles and/or gene transcription and protein synthesis. Complex stages of cell signaling can be studied using proper mathematical models, once the role of each component is carefully handled. Volume 4 also reviews various categories of cytosolic and/or nuclear mediators and illustrates some major signal transduction pathways, such as NFkappaB axis, oxygen sensing, and mechanotransduction. Reviews signaling pathways in the regulation of circulatory and respiratory function. Describes ion and molecular carriers and receptors. Integrates biology, chemistry, and physics for a multidisciplinary understanding of physiological flows Physics Cardiology Biological models Hydraulic engineering Biomedical engineering Biophysics and Biological Physics Biomedical Engineering Mathematical and Computational Biology Systems Biology Engineering Fluid Dynamics Erscheint auch als Druckausgabe 978-1-4614-4369-8 Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems 4 (DE-604)BV041546699 4 https://doi.org/10.1007/978-1-4614-4370-4 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025730900&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025730900&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Thiriet, Marc Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems Biomathematical and Biomechanical Modeling of the Circulatory and Ventilatory Systems Physics Cardiology Biological models Hydraulic engineering Biomedical engineering Biophysics and Biological Physics Biomedical Engineering Mathematical and Computational Biology Systems Biology Engineering Fluid Dynamics |
| title | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems |
| title_auth | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems |
| title_exact_search | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems |
| title_full | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems Marc Thiriet |
| title_fullStr | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems Marc Thiriet |
| title_full_unstemmed | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems Marc Thiriet |
| title_short | Intracellular Signaling Mediators in the Circulatory and Ventilatory Systems |
| title_sort | intracellular signaling mediators in the circulatory and ventilatory systems |
| topic | Physics Cardiology Biological models Hydraulic engineering Biomedical engineering Biophysics and Biological Physics Biomedical Engineering Mathematical and Computational Biology Systems Biology Engineering Fluid Dynamics |
| topic_facet | Physics Cardiology Biological models Hydraulic engineering Biomedical engineering Biophysics and Biological Physics Biomedical Engineering Mathematical and Computational Biology Systems Biology Engineering Fluid Dynamics |
| url | https://doi.org/10.1007/978-1-4614-4370-4 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025730900&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025730900&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV041546699 |
| work_keys_str_mv | AT thirietmarc intracellularsignalingmediatorsinthecirculatoryandventilatorysystems |