Mitochondrial DNA, mitochondria, disease and stem cells:
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Totowa, NJ
Humana Press
2013
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| Series: | Stem cell biology and regenerative medicine
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| Subjects: | |
| Online Access: | DE-1102 DE-703 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource |
| ISBN: | 9781627031004 9781627031011 |
| DOI: | 10.1007/978-1-62703-101-1 |
Staff View
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Record in the Search Index
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MITOCHONDRIAL DNA, MITOCHONDRIA, DISEASE AND STEM CELLS
/
: 2013
TABLE OF CONTENTS / INHALTSVERZEICHNIS
CLINICAL APPROACH TO THE DIAGNOSIS OF MITOCHONDRIAL DISEASE
MITOCHONDRIAL DNA MUTATIONS AND THEIR EFFECTS ON COMPLEX I BIOGENESIS:
IMPLICATIONS FOR METABOLIC DISEASE
EMBRYONIC STEM CELLS: A SIGNALLING PERSPECTIVE
FROM OOCYTES AND PLURIPOTENT STEM CELLS TO FULLY DIFFERENTIATED FATES:
(ALSO) A MITOCHONDRIAL ODYSSEY
FROM PLURIPOTENCY TO DIFFERENTIATION: THE ROLE OF MTDNA IN STEM CELL
MODELS OF MITOCHONDRIAL DISEASES
THE ROLE OF MITOCHONDRIAL DNA IN TUMOR CELLS
ASSISTED REPRODUCTIVE TECHNOLOGIES TO PREVENT THE TRANSMISSION OF MTDNA
FROM ONE GENERATION TO THE NEXT
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
MITOCHONDRIAL DNA, MITOCHONDRIA, DISEASE AND STEM CELLS
/
: 2013
ABSTRACT / INHALTSTEXT
THIS VOLUME INVESTIGATES HOW THE MITOCHONDRIAL GENOME IS TRANSMITTED,
SEGREGATED, AND INHERITED. IT STARTS BY DESCRIBING MTDNA MUTATIONS AND
DELETIONS AND HOW THESE IMPACT ON THE OFFSPRING’S WELL-BEING. IT
PROGRESSES TO DISCUSS HOW MUTATIONS TO THE MTDNA-NUCLEAR-ENCODED
TRANSCRIPTION, REPLICATION AND TRANSLATIONAL FACTORS LEAD TO
MTDNA-DEPLETION SYNDROMES AND HOW THESE AFFECT CELLULAR FUNCTION AND
LEAD TO THE PATHOLOGY OF HUMAN MITOCHONDRIAL DISEASE. IT ALSO HIGHLIGHTS
THE IMPORTANCE OF THE MITOCHONDRIAL ASSEMBLY FACTORS AND HOW MUTATIONS
TO THESE CAN LEAD TO MITOCHONDRIAL DISEASE. THE READER IS THEN
INTRODUCED TO HOW MTDNA IS TRANSMITTED THROUGH THE OOCYTE AND HOW STEM
CELLS CAN BE USED TO STUDY MITOCHONDRIAL BIOGENESIS AND MTDNA
REPLICATION AND TRANSCRIPTION IN UNDIFFERENTIATED PLURIPOTENT AND
DIFFERENTIATING CELLS AND HOW MITOCHONDRIA ADAPT DURING THIS PROCESS. IT
THEN DISCUSSES HOW DISEASES LIKE CANCER ARE INITIATED AND REGULATED BY
MUTATIONS TO MITOCHONDRIAL DNA AND DYSFUNCTIONAL MITOCHONDRIA. FINALLY,
IT DRAWS ON ASSISTED REPRODUCTIVE TECHNOLOGIES TO DISCUSS HOW SOME OF
THESE APPROACHES MIGHT BE ADAPTED TO PREVENT THE TRANSMISSION OF MUTANT
AND DELETED MTDNA FROM ONE GENERATION TO THE NEXT
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. |
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| dewey-ones | 571 - Physiology & related subjects |
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| discipline | Biologie |
| doi_str_mv | 10.1007/978-1-62703-101-1 |
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| spelling | Mitochondrial DNA, mitochondria, disease and stem cells Justin C. St. John, ed. Totowa, NJ Humana Press 2013 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Stem cell biology and regenerative medicine Biowissenschaften Life sciences Cytology Stem cells Stammzelle (DE-588)4665329-6 gnd rswk-swf Mitochondriale DNS (DE-588)4202301-4 gnd rswk-swf Krankheit (DE-588)4032844-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Mitochondriale DNS (DE-588)4202301-4 s Krankheit (DE-588)4032844-2 s Stammzelle (DE-588)4665329-6 s DE-604 St. John, Justin C. Sonstige oth https://doi.org/10.1007/978-1-62703-101-1 Verlag Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025722794&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025722794&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Mitochondrial DNA, mitochondria, disease and stem cells Biowissenschaften Life sciences Cytology Stem cells Stammzelle (DE-588)4665329-6 gnd Mitochondriale DNS (DE-588)4202301-4 gnd Krankheit (DE-588)4032844-2 gnd |
| subject_GND | (DE-588)4665329-6 (DE-588)4202301-4 (DE-588)4032844-2 (DE-588)4143413-4 |
| title | Mitochondrial DNA, mitochondria, disease and stem cells |
| title_auth | Mitochondrial DNA, mitochondria, disease and stem cells |
| title_exact_search | Mitochondrial DNA, mitochondria, disease and stem cells |
| title_full | Mitochondrial DNA, mitochondria, disease and stem cells Justin C. St. John, ed. |
| title_fullStr | Mitochondrial DNA, mitochondria, disease and stem cells Justin C. St. John, ed. |
| title_full_unstemmed | Mitochondrial DNA, mitochondria, disease and stem cells Justin C. St. John, ed. |
| title_short | Mitochondrial DNA, mitochondria, disease and stem cells |
| title_sort | mitochondrial dna mitochondria disease and stem cells |
| topic | Biowissenschaften Life sciences Cytology Stem cells Stammzelle (DE-588)4665329-6 gnd Mitochondriale DNS (DE-588)4202301-4 gnd Krankheit (DE-588)4032844-2 gnd |
| topic_facet | Biowissenschaften Life sciences Cytology Stem cells Stammzelle Mitochondriale DNS Krankheit Aufsatzsammlung |
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