Secondary plant metabolites and gut health: functional studies on porcine small intestine in vitro models
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121015-1100344-0-9 Inhaltsverzeichnis |
| Item Description: | Zsfassung in dt. Sprache |
| Physical Description: | Getr. Zählung Ill., graph. Darst. |
Staff View
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| 100 | 1 | |a Müller, Jakob |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Secondary plant metabolites and gut health |b functional studies on porcine small intestine in vitro models |c Jakob Maximilian Müller |
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Record in the Search Index
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|---|---|
| adam_text | IMAGE 1
CONTENT
ABBREVIATIONS I
ABSTRACT II
ZUSAMMENFASSUNG IV
BACKGROUND 1
SECONDARY PLANT METABOLITES AND GUT HEALTH 1
CINEOLE, RESPIRATORY THERAPY IN THE GUT 5
GREEN TEA, EPIGALLOCATECHIN GALLATE AND ITS RECEPTOR 7
IN VITRO APPROACH 14
NON-INVASIVE ONLINE MONITORING VIA ELECTRIC CELL-SUBSTRATE IMPEDANCE
SENSING 14
SWITCHING PHYSIOLOGICAL PATHWAYS BY RNA INTERFERENCE 15
EXTENDING SCOPE TO EPIGENETIC LEVEL 19
AIM OF THE STUDY 21
EXPERIMENTAL 22
CELL CULTURE 22
BASIC MAINTENANCE 22
IPI-2I 22
IPEC-J2 22
HEK-293 23
METABOLITE ASSAYS 23
METABOLITE PROFILING 23
PHYSIOLOGICAL PROFILING 24
KNOCKDOWN ASSAY 24
VIRUS APPLICATION 25
DRUG TREATMENTS 25
HTTP://D-NB.INFO/1033251534
IMAGE 2
METHYLATION ASSAYS 26
ALTERATION OF METHYLATION PATTERNS BY MANIPULATION OF PHYSIOLOGICAL
PATHWAYS 26
METHYLATION INHIBITION BY PHYSIOLOGICAL ACTIVE SUBSTANCES 26
NUCLEIC ACID ANALYSIS 27
VIRUS TITRATION BY ABSOLUTE QUANTIFICATION OF WHOLE ADENOVIRAL PARTICLES
27
EXTRACTION OF INTACT VIRAL GENOMES 27
QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION (QPCR) 27
RELATIVE QUANTIFICATION OF GENE EXPRESSION LEVELS 28
TOTAL RNA EXTRACTION AND QUALITY CONTROL 28
REVERSE TRANSCRIPTION QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION
(RT-QPCR) 28
LUMINOMETRIC METHYLATION ASSAY 31
GENOMIC DNA EXTRACTION 31
MEASUREMENT OF GLOBAL DNA METHYLATION 31
RNA INTERFERENCE 32
SH-OLIGONUCLEOTIDE DESIGN 32
CLONING 35
VIRUS PRODUCTION 35
KNOCKDOWN EVALUATION 36
ELECTRIC CELL-SUBSTRATE IMPEDANCE SENSING 4 0
VIRAL CYTOTOXICITY 40
DRUG EFFECTS 41
LETHAL DOSE DETERMINATION 41
WOUND HEALING ASSAY 41
GAS CHROMATOGRAPHY-MASS SPECTROMETRY 42
METABOLITE SCREENING 42
METABOLITE QUANTIFICATION 42
LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY 43
IMAGE 3
RESULTS AND DISCUSSION 44
MANIPULATION OF CELL PHYSIOLOGY BY ADENOVIRAL MEDIATED KNOCKDOWNS 44
ADJUSTING THE EFFECTOR TO FIRM PARAMETERS 44
EVALUATE CYTOTOXIC ACCESSORY SYMPTOMS 48
EFFECTS OF SECONDARY PLANT COMPOUNDS 51
CINEOLE 52
LETHAL DOSE DETERMINATION 52
INTESTINAL METABOLIZATION 54
IMPACT ON INTESTINAL GENE EXPRESSION 56
EPIGALLOCATECHIN GALLATE 60
EGCG CONTENT OF DIFFERENT TEA VARIETIES 60
MOLECULAR IMPACT DURING INTESTINAL IMMUNE SIGNALING 61
67LR: A POTENTIAL TARGET FOR EGCG IN CANCER PREVENTION? 65
CONCLUSIONS 76
REFERENCES 78
ACKNOWLEDGEMENT I
SCIENTIFIC COMMUNICATIONS II
CURRICULUM VITAE IV
APPENDIX V
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| spelling | Müller, Jakob Verfasser aut Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models Jakob Maximilian Müller 2012 Getr. Zählung Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. Sprache München, Techn. Univ., Diss., 2012 Cytotoxizität (DE-588)4193696-6 gnd rswk-swf Epigallocatechingallat Epigallocatechin-3-gallat (DE-588)4818303-9 gnd rswk-swf Cineol (DE-588)4255205-9 gnd rswk-swf Pflanzeninhaltsstoff (DE-588)4139067-2 gnd rswk-swf Gesundheitsförderung (DE-588)4294611-6 gnd rswk-swf Darm (DE-588)4011061-8 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Darm (DE-588)4011061-8 s Pflanzeninhaltsstoff (DE-588)4139067-2 s Epigallocatechingallat Epigallocatechin-3-gallat (DE-588)4818303-9 s Cineol (DE-588)4255205-9 s Gesundheitsförderung (DE-588)4294611-6 s Cytotoxizität (DE-588)4193696-6 s b DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20121015-1100344-0-9 http://mediatum.ub.tum.de/node?id=1100344 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121015-1100344-0-9 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025718153&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Müller, Jakob Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models Cytotoxizität (DE-588)4193696-6 gnd Epigallocatechingallat Epigallocatechin-3-gallat (DE-588)4818303-9 gnd Cineol (DE-588)4255205-9 gnd Pflanzeninhaltsstoff (DE-588)4139067-2 gnd Gesundheitsförderung (DE-588)4294611-6 gnd Darm (DE-588)4011061-8 gnd |
| subject_GND | (DE-588)4193696-6 (DE-588)4818303-9 (DE-588)4255205-9 (DE-588)4139067-2 (DE-588)4294611-6 (DE-588)4011061-8 (DE-588)4113937-9 |
| title | Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models |
| title_auth | Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models |
| title_exact_search | Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models |
| title_full | Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models Jakob Maximilian Müller |
| title_fullStr | Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models Jakob Maximilian Müller |
| title_full_unstemmed | Secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models Jakob Maximilian Müller |
| title_short | Secondary plant metabolites and gut health |
| title_sort | secondary plant metabolites and gut health functional studies on porcine small intestine in vitro models |
| title_sub | functional studies on porcine small intestine in vitro models |
| topic | Cytotoxizität (DE-588)4193696-6 gnd Epigallocatechingallat Epigallocatechin-3-gallat (DE-588)4818303-9 gnd Cineol (DE-588)4255205-9 gnd Pflanzeninhaltsstoff (DE-588)4139067-2 gnd Gesundheitsförderung (DE-588)4294611-6 gnd Darm (DE-588)4011061-8 gnd |
| topic_facet | Cytotoxizität Epigallocatechingallat Epigallocatechin-3-gallat Cineol Pflanzeninhaltsstoff Gesundheitsförderung Darm Hochschulschrift |
| url | http://mediatum.ub.tum.de/node?id=1100344 https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121015-1100344-0-9 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025718153&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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