Dietary factors in the modulation of Crohn's disease-like ileitis:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | kostenfrei https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121005-1100923-0-3 Inhaltsverzeichnis |
| Beschreibung: | 122 S. Ill., graph. Darst. |
Internformat
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| 100 | 1 | |a Wagner, Stefan |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Dietary factors in the modulation of Crohn's disease-like ileitis |c Stefan J. Wagner |
| 264 | 1 | |c 2012 | |
| 300 | |a 122 S. |b Ill., graph. Darst. | ||
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Datensatz im Suchindex
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| adam_text | IMAGE 1
TABLE OF CONTENTS
TABLE OF CONTENTS
TABLE OF CONTENTS 2
ABSTRACT 5
1. INTRODUCTION 6
1.1. INFLAMMATORY BOWEL DISEASE (IBD) 6
1.2. THE ROLE OF NUTRITION IN IBD 9
1.2.1. DIETARY FACTORS IN THE PATHOGENESIS O F IBD 9
1.2.2. MALNUTRITION IN IBD 11
1.3. MEDICAL THERAPY O F IBD 12
1.3.1. CONVENTIONAL THERAPY 12
1.3.2. BIOLOGICALS 13
1.4. NUTRITIONAL THERAPY IN IBD 15
1.4.1. MAINTENANCE OF REMISSION 15
1.4.2. INDUCTION OF REMISSION 16
1.5. CELIAC DISEASE 18
1.6. ANIMAL MODELS O F IBD 19
1.6.1. ILEITIS MODEL ( T N F 1 MOUSE) 19
1.6.2. COLITIS MODEL (IL-10 MOUSE) 19
1.6.3. T CELL TRANSFER MODEL OF COLITIS AND ILEITIS 20
1.6.4. ELEMENTAL DIET AND ANIMAL MODELS O F MUCOSAL INFLAMMATION 20
2. AIMS OF THE WORK 22
3. MATERIALS AND METHODS 23
3.1. ANIMALS 23
3.2. DIETS 24
3.3. HISTOLOGICAL SCORING 24
3.4. IMMUNOHISTOCHEMICAL LABELING 24
3.5. RNA ISOLATION, REVERSE TRANSCRIPTION AND REAL-TIME PCR 25
3.6. IEL/LPL ISOLATION 26
3.7. FLOW CYTOMETRY 27
3.8. PARTICLE SIZE DISTRIBUTION MEASUREMENT 27
3.9. FT-IR SPECTROSCOPY 27
3.10. CECAL LYSATES 28
2
HTTP://D-NB.INFO/1033250767
IMAGE 2
TABLE OF CONTENTS
3.11. DIETARY SUSPENSIONS 28
3.12. PEPTIC-TRYPTIC DIGESTION OF GLUTEN (PT-GLUTEN) 28
3.13. ISOLATION OF MLNS AND SPLENOCYTES 29
3.14. CELL CULTURE AND STIMULATION 29
3.15. CD4*T-CELL ISOLATION 30
3.16. GENERATION O F BM-DCS 30
3.17. COCULTURE OF BM-DCS AND CD4* T-CELLS 31
3.18. EUSA 3 1
3.19. STATISTICAL ANALYSIS 32
4. RESULTS 33
4.1. EFFECTS OF DIETARY INTERVENTION ON CROHN S DISEASE-LIKE ILEITIS 33
4.1.1. SEMI-SYNTHETIC DIET AMELIORATES ILEITIS IN TNF IW,E/WRMICE 33
4.1.2. QUANTITATIVE REAL-TIME PCR ANALYSIS OF T N F ^ ^ A N D WT MICE
36
4.1.3. CELLULAR ANALYSIS O F TNF W*E/WT AND WT MICE 39
4.1.4. TIME-DEPENDENT EFFECTS OF DIETARY INTERVENTION 44
4.1.5. RAPID DEVELOPMENT O F CHRONIC INTESTINAL INFLAMMATION IN TNF
M E/WTMICE 45
4.1.6. LOW CONCENTRATIONS O F CHOW DIET INDUCE CHRONIC ILEITIS IN TNF
M E/WTMICE 46
4.1.7. PARTICLE SIZE DISTRIBUTION MEASUREMENTS 49
4.1.8. FOURIER TRANSFORM INFRARED SPECTROSCOPY (FT-IR) ANALYSIS 51
4.1.9. ANTIGENICITY OF CECAL LYSATES IS NOT ALTERED BY EXPERIMENTAL DIET
56
4.1.10. CHOW SUSPENSIONS HAVE IMMUNOGENIC POTENTIAL 60
4.1.11. GLUTEN-FORTIFIED EXPERIMENTAL DIET INDUCES CHRONIC ILEITIS IN
TNF MNE/WTMICE 63
4.1.12. EFFECTS OF A WHEAT DEPLETED CHOW DIET ON TISSUE PATHOLOGY IN TNF
AAR/WT MICE 69
4.2. DIETARY MODULATION OF IL-10 COLITIS BY EXPERIMENTAL DIET 72
4.3. EXPERIMENTAL DIET IN THE MODULATION OF ADOPTIVE TRANSFER COLITIS
AND ILEITIS 74
5. DISCUSSION 79
5.1. EFFECTS OF DIETARY INTERVENTION ON CROHN S DISEASE-LIKE ILEITIS 80
5.2. GLUTEN AND CROHN S DISEASE-LIKE ILEITIS 86
5.3. IMPACT OF EXPERIMENTAL DIET ON I M I C E AND T-CELL TRANSFER
COLITIS 88
5.4. CONCLUSION AND OUTLOOK 90
6. APPENDIX 92
LIST OF FIGURES 99
LIST OF TABLES 102
ABBREVIATIONS 103
REFERENCES 105
3
IMAGE 3
TABLE OF CONTENTS
ACKNOWLEDGMENTS 118
PUBLICATIONS AND PRESENTATIONS 119
CURRICULUM VITAE 121
ERKLARUNG 122
4
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| spelling | Wagner, Stefan Verfasser aut Dietary factors in the modulation of Crohn's disease-like ileitis Stefan J. Wagner 2012 122 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier München, Techn. Univ., Diss., 2012 Sprue (DE-588)4182595-0 gnd rswk-swf Maus (DE-588)4169148-9 gnd rswk-swf Chronische Darmentzündung (DE-588)4273697-3 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Chronische Darmentzündung (DE-588)4273697-3 s Sprue (DE-588)4182595-0 s Maus (DE-588)4169148-9 s Tiermodell (DE-588)4140660-6 s b DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:91-diss-20121005-1100923-0-3 http://mediatum.ub.tum.de/node?id=1100923 Verlag kostenfrei Volltext https://nbn-resolving.org/urn:nbn:de:bvb:91-diss-20121005-1100923-0-3 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025700700&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Wagner, Stefan Dietary factors in the modulation of Crohn's disease-like ileitis Sprue (DE-588)4182595-0 gnd Maus (DE-588)4169148-9 gnd Chronische Darmentzündung (DE-588)4273697-3 gnd Tiermodell (DE-588)4140660-6 gnd |
| subject_GND | (DE-588)4182595-0 (DE-588)4169148-9 (DE-588)4273697-3 (DE-588)4140660-6 (DE-588)4113937-9 |
| title | Dietary factors in the modulation of Crohn's disease-like ileitis |
| title_auth | Dietary factors in the modulation of Crohn's disease-like ileitis |
| title_exact_search | Dietary factors in the modulation of Crohn's disease-like ileitis |
| title_full | Dietary factors in the modulation of Crohn's disease-like ileitis Stefan J. Wagner |
| title_fullStr | Dietary factors in the modulation of Crohn's disease-like ileitis Stefan J. Wagner |
| title_full_unstemmed | Dietary factors in the modulation of Crohn's disease-like ileitis Stefan J. Wagner |
| title_short | Dietary factors in the modulation of Crohn's disease-like ileitis |
| title_sort | dietary factors in the modulation of crohn s disease like ileitis |
| topic | Sprue (DE-588)4182595-0 gnd Maus (DE-588)4169148-9 gnd Chronische Darmentzündung (DE-588)4273697-3 gnd Tiermodell (DE-588)4140660-6 gnd |
| topic_facet | Sprue Maus Chronische Darmentzündung Tiermodell Hochschulschrift |
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