Role of the transcriptome in breast cancer prevention:
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
New York [u.a.]
Springer US
2013
|
| Subjects: | |
| Online Access: | https://doi.org/10.1007/978-1-4614-4884-6 Inhaltsverzeichnis Klappentext |
| Physical Description: | XIII, 453 p. 135 illus., 121 illus. in color Ill., graph. Darst. |
| ISBN: | 9781461448839 |
| DOI: | 10.1007/978-1-4614-4884-6 |
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Record in the Search Index
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| adam_text | Contents
1
The Epidemiology of Breast Cancer and the Basis
for Prevention
............................................................................................ 1
1.1
Introduction
...................................................................................... 1
1.2
Rodent Models of Mammary Carcinogenesis
.................................. 5
1.3
Windows of Susceptibility to Carcinogenesis
.................................. 5
1.4
Prevention of Mammary Cancer by Pregnancy
............................... 7
1.5
Prevention of Mammary Cancer by Hormones
............................... 8
1.6
Effect of Pregnancy on Cancer Progression
..................................... 9
1.7
Effect of Hormones on Tumor Progression
..................................... 10
1.8
Hormones as Carcinogens
................................................................ 13
1.9
When Does a Full-Term Pregnancy Reduce Breast
Cancer Risk?
.................................................................................... 13
1.10
The Human Breast in Pregnancy and Disease
................................. 15
1.11
Breast Development Under the Endocrinological
Influence of Pregnancy
..................................................................... 17
1.12
Basis of the Protective Effect of Early Pregnancy
........................... 18
1.13
Influence of Fertility on Breast Cancer Risk
.................................... 20
1.13.1
Ovarian Aging and Fertility
............................................... 21
1.13.2
Aging of the Hypothalamic-Pituitary-Ovarian
Axis and Fertility
............................................................... 21
1.14
Concluding Remarks
........................................................................ 22
References
................................................................................................... 22
2
An In Vivo Model of Breast Cancer Prevention
..................................... 29
2.1
Introduction
...................................................................................... 29
2.2
The Differential Effect of Urinary hCG vs.
Recombinant
hCG
............................................................................ 30
2.2.1
Human Chorionic Gonadotropin
........................................ 30
2.2.2
Experimental Protocol
....................................................... 31
2.2.3
Effect of hCG in Mammary Cancer Prevention
................. 36
2.2.4
Effect of hCG on Mammary Cancer Therapy
.................... 39
Contents
2.2.5 Special
Studies.......................................................................
46
2.2.6
Considerations
....................................................................... 50
2.3
Time-Dependent Preventive Effects of Human Chorionic
Gonadotropin on Rat Mammary Carcinogenesis
............................... 52
2.3.1
hCG Effect on Body Weight and Gland Morphology
............ 53
2.3.2
hCG Effect on Tumorigenic Response to DMBA
................. 55
2.3.3
Considerations on the Dose and Timing
of hCG Treatment
.................................................................. 59
2.4
The Study of Side Effects of hCG in Reproduction
.......................... 64
2.4.1
Experimental Evidence
.......................................................... 64
2.4.2
Side Effector hCG
................................................................. 67
2.5
Concluding Remarks
.......................................................................... 67
References
................................................................................................... 68
Comparative Effects of the Preventive Effect of Pregnancy,
Steroidal Hormones, and hCG in the Transcriptomic
Profile of the Rat Mammary Gland
......................................................... 73
3.1
Introduction
........................................................................................ 73
3.2
Experimental Protocol
....................................................................... 74
3.3
Morphological Changes Induced by the Hormonal Treatment
.......... 75
3.4
Transcriptomic Profile
........................................................................ 76
3.4.1
Functional Significance of the Common Genes
Induced by the Three Preventive Modalities
......................... 88
3.4.2
Functional Significance of the Biological Processes
Overrepresented Among the Upregulated Genes
Induced by the Three Preventive Modalities
......................... 97
3.4.3
Transcriptome
Profile Induced by hCG
................................. 104
3.4.4
Transcriptome
Profile Induced by Pregnancy
........................ 114
3.4.5
Transcriptome
Profile Induced by Estrogen
and Progesterone
.................................................................... 118
3.5
Enrichment of the Genomic Signature of Prevention
........................ 123
3.6
Concluding Remarks
.......................................................................... 178
References
................................................................................................... 178
The Use of In Vitro Three-Dimensional System
for Studying Breast Cancer and Preventing Agents
.............................. 191
4.1
Introduction
........................................................................................ 191
4.2
The Three-dimensional Growth of Human Breast
Epithelial Cells
................................................................................... 192
4.3
Importance of an In Vitro Model
....................................................... 194
4.3.1
Developing a Carcinogenicity Index for Testing
the Carcinogenicity of Environmental Agents
..................... 196
4.3.2
Construction of an Index of Carcinogenesis
........................ 197
4.3.3
Design
.................................................................................. 198
4.4
An In Vitro In Vivo Model for Studying the Basal
Breast Cancer
................................................................................... 199
Contents
4.5 Stem
Cell and the Asymmetric Cell Division
.................................. 206
4.5.1
Genomic Alterations in the trMCF Cells Indicate
That the Asymmetric Cell Division Is the
Target Mechanism of Neoplastic Transformation
................ 207
4.5.2
Cell Partitioning in Asymmetric Cell Division
.................... 208
4.5.3
Mitotic Apparatus
................................................................ 213
4.5.4
Cell Polarity and Asymmetric Cell Division
....................... 214
4.5.5
Cell Positioning and Asymmetric Cell Division
.................. 215
4.6
The Molecular Pathway of Epithelial Mesenchymal Transition
...... 216
4.7
The Metastatic Phenotype
................................................................ 217
4.8
Human Chorionic Gonadotropin Prevents the Transformed
Phenotypes Induced by
17ß-Estradiol
in Human Breast Epithelial Cells
..................................................... 223
4.8.1
Human Chorionic Gonadotropin Prevented
the Formation of Solid Masses Induced
by
17ß-Estradiol (E2)........................................................... 226
4.8.2
Human Chorionic Gonadotropin Induced
Longer Tubules with Tertiary Branching
............................. 226
4.8.3
The
17ß-Estradiol
(E,)
Treatment Increased
Cell Proliferation
...... ............................................................ 228
4.9
Concluding and Summary Remarks
................................................ 231
References
................................................................................................. 232
Methodological Approach for Studying the Human Breast
.................. 243
5.1
Introduction
...................................................................................... 243
5.2
Recruitment and Consent Process
.................................................... 243
5.3
Specimen Collection Procedures
..................................................... 261
5.4
Laser Capture Microdissection
........................................................ 262
5.5
RNA
Preservation for Affymetrix Studies
....................................... 263
5.6
RNA
Extraction for mRNA Sequencing
.......................................... 265
5.6.1
Total
RNA
Isolation
............................................................. 265
5.7
PicoPure®
DNA
Extraction Kit
........................................................ 265
5.8
RNA
Processing and Quality Control for cDNA
Microarray Analysis
......................................................................... 266
5.9
Blood Collection for Hormone Determination
................................ 267
5.10
Blood Collection for Genomic Analysis
.......................................... 267
References
................................................................................................... 267
The
Transcriptome
of Breast Cancer Prevention
.................................. 269
6.1
Introduction
...................................................................................... 269
6.2
Methodologie
Approach
.................................................................. 270
6.3
The Genomic Analysis
..................................................................... 285
6.4
Functional Significance of the Signature of Pregnancy
................... 300
6.4.1
The Spliceosome Machinery
................................................ 301
6.4.2
Non-coding RNAs
................................................................ 304
6.4.3
Downstream to the Estrogen Receptor Pathway
.................. 304
Contents
6.4.4
Cell Communication
.......................................................... 305
6.4.5
Insulin-Like Growth Factor
1............................................. 305
6.5
Concluding Remarks
........................................................................ 305
References
................................................................................................... 306
Chromatin Remodeling and Pregnancy-Induced Differentiation
........ 309
7.1
Introduction
........................................................................................ 309
7.2
The Methodological Approach
.......................................................... 310
7.3
Architecture of Postmenopausal Women s Breast
............................. 310
7.4
Transcriptomic Differences
................................................................ 316
7.5
Functional Significance
...................................................................... 323
7.6
Evidence of a Shifting of the Stem Cell Population
in the Human Breast
.......................................................................... 324
7.7
Role of Noncoding
RNA
in Chromatin Remodeling
......................... 324
7.8
Inducing Chromatin Remodeling by HCG
........................................ 326
7.9
Relevance of Chromatin Remodeling in Breast
Cancer Prevention
.............................................................................. 331
References
................................................................................................... 332
The Role of Spliceosome in the Human Breast
...................................... 337
8.1
Introduction
........................................................................................ 337
8.2
The Splicing Mechanism
................................................................... 337
8.3
Spliceosome Assembly
...................................................................... 342
8.4
The Role of Spliceosome in the Human Breast
................................. 343
8.4.1
Internal Methy
lation
of mRNA and
the Methyltransferase Like
3................................................. 345
8.4.2
Formation of Pre-mRNP or Heterogeneous
Nuclear Ribonucleoproteins
.................................................. 346
8.4.3
Formation of the Spliceosome
E
Complex
............................ 356
8.5
mRNA
3
End Processing
.................................................................. 365
8.6
Other Accessory Proteins Related to the
Splicing Mechanism
.......................................................................... 367
8.7
Other Transcripts That Could Play a Role in
RNA
Splicing in the Human Breast
............................................................ 369
8.8
Functional Role of the Spliceosomes in Breast
Cancer Prevention
.............................................................................. 378
References
................................................................................................... 379
Noncoding RNAs and Breast Cancer Prevention
................................... 391
9.1
Introduction
........................................................................................ 391
9.2
Nuclear
Organdíes
and ncRNAs
....................................................... 392
9.3
Defining the RNAs
............................................................................. 394
9.4
Noncoding RNAs
............................................................................... 395
9.4.1
Noncoding
RNA
Classes
....................................................... 395
9.4.2
Long Noncoding RNAs
......................................................... 395
9.5
Noncoding
RNA
in the Parous Breast
and its Implications in Cancer Prevention
......................................... 397
Contents xiii
9.6
The Functional Role of XIST
............................................................ 398
9.7
The Functional Role of NEATl
......................................................... 400
9.8
The Functional Role of NEAT2
......................................................... 402
References
................................................................................................. 403
10
The Role of Stem Cell in Breast Cancer Prevention
............................ 409
10.1
Evidence for a Stem Cell in the Mammary Gland
......................... 409
10.2
Cell Markers for Identifying the Stem Cell
in the Mammary Gland
.................................................................. 410
10.3
Estrogen Receptor as a Marker of Stem Cells
in the Mammary Gland
.................................................................. 412
10.3.1
Estrogen Receptor Beta and the Breast Stem Cells
.......... 413
10.3.2
Influence of the
Stroma
in the Genomic
Profile of the MCF-10F Cell that Behaves
as a Stem Cell In Vitro
...................................................... 416
10.3.3
The MCF-10F Cell as the Stem Cell
in Estrogen-Induced Carcinogenesis
................................ 418
10.4
The Evidence for the Shifting of Stem Cell
1
to Stem Cell
2
in the Mammary Gland Post-Pregnancy
........................................ 419
10.5
Isolation of the Stem Cells from the Rat Mammary Gland
........... 422
10.5.1
Isolation of Stem Ceils
..................................................... 422
10.5.2
Mammosphere Culture Conditions
................................... 422
10.5.3
Effect of hCG the Mimicking Hormone
of Pregnancy in Mammospheres Formation
..................... 425
10.5.4
Characterization of Cells from Mammospheres
............... 425
10.6
The Importance of the Mammary Gland Stem Cell
and Pregnancy in the Prevention of Breast Cancer
........................ 431
References
................................................................................................. 432
Index
................................................................................................................. 441
Jose
Russo
■ Irma
H.
Russo
Role of the
Transcriptome
in Breast Cancer Prevention
This book is designed for advanced students and researchers in cell biology, biochemistry,
molecular biology, medicine in general, and cancer in particular. It provides the latest
data on the
transcriptome
ot
the mammary gland in order to establish the molecular
and cellular basis ot differentiation that lead to cancer prevention. Die authors have
based their work on the epidemiological evidence that early first full term pregnancy
is a protective factor against breast cancer, knowledge that has been confirmed in
in vivo
atui
in vitro experimental systems that have demonstrated mechanistically how
the differentiation takes place. The analysis of the female s breast
transcriptome
has
demonstrated that the first reproductive event
reprograms
the organ by imprinting a
specific genomic signature. This repiogramming takes place at the chromatin level by
changing the transcriptional process. The modification of the transcriptional control
is due to the expression of non-coding RXA sequences and post-transcriptional control
driven by the spiiceosome. The plasticity of the genome ot the human breast makes
possible a reprogramming that is not only induced by the physiological process of
pregnancy but by the use of hormones mimicking pregnancy. The role of stern cells
and their reprogramming during differentiation are presented as a new paradigm in
breast cancer prevention.
Jose
Russo,
M D,
FC AP
Inna
H.
Russo, MD, FCAP, FASCP
|
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| id | DE-604.BV040705972 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:32:08Z |
| institution | BVB |
| isbn | 9781461448839 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025686412 |
| oclc_num | 825163035 |
| open_access_boolean | |
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| owner_facet | DE-355 DE-BY-UBR |
| physical | XIII, 453 p. 135 illus., 121 illus. in color Ill., graph. Darst. |
| publishDate | 2013 |
| publishDateSearch | 2013 |
| publishDateSort | 2013 |
| publisher | Springer US |
| record_format | marc |
| spelling | Russo, Jose 1942- Verfasser (DE-588)1164725238 aut Role of the transcriptome in breast cancer prevention Jose Russo ; Irma H. Russo New York [u.a.] Springer US 2013 XIII, 453 p. 135 illus., 121 illus. in color Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Medizin Medicine Oncology Toxicology Prävention (DE-588)4076308-0 gnd rswk-swf Brustkrebs (DE-588)4008528-4 gnd rswk-swf Brustkrebs (DE-588)4008528-4 s Prävention (DE-588)4076308-0 s DE-604 Russo, Irma H. Verfasser aut Erscheint auch als Online-Ausgabe 978-1-4614-4884-6 https://doi.org/10.1007/978-1-4614-4884-6 Resolving-System Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025686412&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025686412&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Russo, Jose 1942- Russo, Irma H. Role of the transcriptome in breast cancer prevention Medizin Medicine Oncology Toxicology Prävention (DE-588)4076308-0 gnd Brustkrebs (DE-588)4008528-4 gnd |
| subject_GND | (DE-588)4076308-0 (DE-588)4008528-4 |
| title | Role of the transcriptome in breast cancer prevention |
| title_auth | Role of the transcriptome in breast cancer prevention |
| title_exact_search | Role of the transcriptome in breast cancer prevention |
| title_full | Role of the transcriptome in breast cancer prevention Jose Russo ; Irma H. Russo |
| title_fullStr | Role of the transcriptome in breast cancer prevention Jose Russo ; Irma H. Russo |
| title_full_unstemmed | Role of the transcriptome in breast cancer prevention Jose Russo ; Irma H. Russo |
| title_short | Role of the transcriptome in breast cancer prevention |
| title_sort | role of the transcriptome in breast cancer prevention |
| topic | Medizin Medicine Oncology Toxicology Prävention (DE-588)4076308-0 gnd Brustkrebs (DE-588)4008528-4 gnd |
| topic_facet | Medizin Medicine Oncology Toxicology Prävention Brustkrebs |
| url | https://doi.org/10.1007/978-1-4614-4884-6 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025686412&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025686412&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT russojose roleofthetranscriptomeinbreastcancerprevention AT russoirmah roleofthetranscriptomeinbreastcancerprevention |