Natural product biosynthesis by microorganisms and plants: B
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier, Acad. Press
2012
|
| Edition: | 1. ed. |
| Series: | Methods in enzymology
516 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | LVI, 393 S., [6] Bl. Ill., graph. Darst. |
| ISBN: | 9780123942913 |
Staff View
MARC
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| 245 | 1 | 0 | |a Natural product biosynthesis by microorganisms and plants |n B |c ed. by David A. Hopwood |
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Record in the Search Index
| _version_ | 1804149742703214592 |
|---|---|
| adam_text | CONTENTS
Contributors
xi
Preface
xv
Volumes in Series
xxi
Section
1
Peptides
1.
In Vivo Production of Thiopeptide Variants
3
Feifei Zhang and Wendy L. Kelly
1.
Introduction
3
2.
Generation of Thiopeptide Variants
7
References
19
2.
Microviridin Biosynthesis
25
Thomas K. Hemscheidt
1.
Introduction
26
2.
Reconstitution
In Vitro of the Cyclization Reactions of the Microviridin
Biosynthetic Pathway from P. agardhii
27
3.
Influence of Leader
Peptide
on the Cyclization Reactions
33
4.
Summary
34
Acknowledgments
35
References
35
3.
Cyclotide Isolation and Characterization
37
David J. Craik,
Sonia Troeira
Henriques, Joshua
S. Mylne,
and Conan K. Wang
1.
Introduction
38
2.
Isolation of Cyclotides from Plant Tissues
40
3.
Isolation of Nucleic Acids Encoding Cyclotide Precursors
42
4.
Mass Spectrometric Detection and Characterization of Cyclotides
48
5.
Structural Analysis of Cyclotides
51
6.
Membranolytic Assays of Cyclotides
51
7.
Summary
58
Acknowledgments
58
References
58
vi
Contents
4.
Ribosomally
Encoded Cyclic
Peptide
Toxins from Mushrooms
63
Jonathan D. Walton, Hong Luo, and Heather
Hallen-Adams
1.
Introduction
63
2.
Detection and Purification of Amanita Cyclic
Peptide
Toxins
66
3.
Identification of Cyclic
Peptide
Genes in Amanita and Other Fungi
69
4.
Purification and Assay of Prolyl Oligopeptidase (POP) from Mushrooms
70
5.
Immunodetection of POP in Mushroom Tissues
74
6.
Summary
75
Acknowledgments
76
References
76
5.
The Pictet-Spengler Mechanism Involved in the Biosynthesis
of Tetrahydroisoquinoline
Antitumor
Antibiotics: A Novel
Function for a Nonribosomal
Peptide Synthetase
79
Kento Koketsu, Atsushi
Minami,
Kenji Watanabe, Hiroki Oguri,
and Hideaki Oikawa
1.
Introduction
80
2.
Biosynthetic Analysis of THIQ Core Scaffold Assembly
81
3.
Reaction Mechanism for Constructing a Pentacyclic THIQ Core
Skeleton Catalyzed by a Novel Function for a Single NRPS Module
83
4.
Comparison Between Typical
Peptide
Synthesis and the
Pictet-Spengler Reaction Catalyzed by NRPS Machinery
85
5.
Reaction Profiles Affected by the Chain Length of the Acyl Moiety
86
6.
Multiple Roles for the Fatty Acyl Chain During the Maturation Process
in Late-Stage Biosynthesis
88
7.
Methods for Substrate Synthesis, Enzyme Preparation, and Assay Conditions
89
8.
Conclusion
96
Acknowledgments
97
References
97
Section
2
Other Compounds
6.
Discovery and Biosynthesis of Phosphonate and Phosphinate
Natural Products
101
Spencer
С
Peck, Jiangtao
Gao,
and Wilfred A. van
der Donk
1.
Introduction
102
2.
Spectrum of Phosphonate Natural Products: Structures and Bioactivities
102
3.
Biosynthetic Pathways
105
Contents
vii
4.
Screening
Bacteria
for Phosphorate Producing Gene Clusters
106
5.
Purification of Phosphonates/Phosphinates
108
6.
Structurai
Elucidation of Phosphonates
111
7.
A Wealth of Unusual Biosynthetic Enzymes
114
8.
Conclusion and Outlook
117
Acknowledgments
117
References
117
7.
RlmN and AtsB as Models for the Overproduction
and Characterization of Radical SAM Proteins
125
Nicholas D. Lanz, Tyler L. Grove,
Camelia Baleanu Gogonea,
Kyung-Hoon Lee, Carsten Krebs,
and Squire J. Booker
1.
Introduction
126
2.
RlmN as a Model for Gene Expression and Overproduction of RS Proteins
128
3.
RlmN as a Model for Purification of RS Proteins
133
4.
Overproduction and Purification of
£
coli Flavodoxin
and
Flavodoxin
Reducíase
139
5.
AtsB as a Model for Determination of Configuration and Stoichiometry of
Iron-Sulfur Clusters in RS Enzymes
141
6.
Activity Determination of RS Enzymes
146
Acknowledgments
148
References
148
8.
Fe(ll)-Dependent,
Uridine-S -Monophosphate a-Ketoglutarate
Dioxygenases in the Synthesis of 5-Modified Nucleosides
153
Zhaoyong Yang, Jason Unrine, Koichi Nonaka, and Steven G. Van
Lanen
1.
Introduction
154
2.
Methods
156
3.
Summary
165
Acknowledg
ments
165
References
165
Section
3
Tailoring Reactions
9.
Tailoring Reactions Catalyzed by Heme-Dependent Enzymes:
Spectroscopie
Characterization of the L-Tryptophan-Nitrating
Cytochrome P450 TxtE
171
Sarah M. Barry and Gregory
L
Challis
viii Contents
1.
Introduction
172
2.
Overexpression, Purification, and Characterization
of the Novel
Nitrating
CYP TxtE
182
3.
Protein Characterization Using UV-vis Spectroscopy
183
4.
Ligand and Substrate Binding
187
5.
Summary
190
Acknowledgment
191
References
191
10.
Oxidative Tailoring Reactions Catalyzed by Nonheme
Iron-Dependent Enzymes: Streptorubin
В
Biosynthesis
as an Example
195
Paulina K. Sydor and Gregory
L Challis
1.
Introduction
196
2.
Examples of Tailoring Reactions Catalyzed by Nonheme
Iron- and Oxygen-Dependent Enzymes
197
3.
Heterologous Expression and Functional Investigation of the
S. coelicolor redH and redG Genes in Streptomyces albus
206
4.
Conclusions
213
Acknowledgment
213
References
213
11.
The Rare
Fluorinated
Natural Products and Biotechnological
Prospects for Fluorine Enzymology
219
K.K. Jason Chan and David O Hagan
1.
Introduction
220
2.
Production of Fluoroacetate and 4-Fluorothreonine from S. cattleya
223
3.
Enzyme
1 :
Fluorinase
224
4.
Enzyme
2:
Purine
Nucleoside Phosphorylase
226
5.
Enzyme
3:
Isomerase
228
6.
Enzyme
4:
Aldolase
229
7.
Enzyme
5:
Transaldolase (Pyridoxal Phosphate)
230
8.
Enzyme
6:
Aldehyde Dehydrogenase
230
9.
Generation of a Novel Fluorometabolite by Genetic Engineering
231
10.
Summary
233
Acknowledgments
233
References
233
Contents
¡χ
12.
Enzymatic Chlorination and Bromination
237
Karl-Heinz
van
Pée
1.
Introduction
238
2.
FADH^-Dependent
Halogenases
240
3.
Characterization of FAD^-Dependent
Halogenases
244
4.
Nonheme Iron, cc-Ketoglutarate- and C^-Dependent
Halogenases
251
References
254
13.
Prenyltransferases of the Dimethylallyltryptophan Synthase
Superfamily
259
Xia Yu and Shu-Ming Li
1.
Introduction
260
2.
Spore Preparation
263
3.
Cultivation of Fungi
264
4.
RNA
and
DNA
Isolation and cDNA Synthesis
264
5.
Gene Cloning
265
6.
Protein Overproduction
267
7.
Preparation of Stock Solutions for Enzyme Assays
270
8.
Biochemical Characterization of Prenyltransferases
271
9.
Chemoenzymatic Synthesis of Prenylated Compounds
272
10.
HPLC
274
11.
Summary
276
Acknowledgments
276
References
276
14.
Serine
Carboxypeptidase-Like Acyltransferases from Plants
279
Sam T. Mugford and
Carsten Milkowski
1.
Introduction
280
2.
Methods in SCPL Acyltransferase Research
284
3.
Summary
294
Acknowledgments
295
References
295
15.
^Methylideneimidazole-S-One-Containing Aminomutases
in Enediyne Biosynthesis
299
Jeremy R. Lohman and Ben Shen
1.
introduction
300
2.
Methods
310
x
Contents
3.
Conclusion
315
Acknowledgment
317
References
317
16.
Tailoring Enzymes Acting on Carrier Protein-Tethered
Substrates in Natural Product Biosynthesis
321
Shuangjun
Lin, Tingting
Huang, and Ben Shen
1.
Introduction
322
2.
Methods
331
3.
Conclusion
339
Acknowledgment
340
References
340
17.
High-Throughput
Colorimetrie
Assays for Nucleotide Sugar
Formation and Glycosyl Transfer
345
Richard W. Gantt and Jon S. Thorson
1.
Introduction
346
2.
Purification of the Glycosyltransferase OleD
348
3.
Colorimetrie
Assay for NDP-Sugar Formation
351
4.
Coupled Reactions for Glycosyl Transfer
352
5.
High-Throughput
Colorimetrie
Coupled Assay for Glycosyl Transfer
356
6.
Summary
359
References
359
Author Index
361
Subject Index
385
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| genre_facet | Aufsatzsammlung |
| id | DE-604.BV040631556 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:27:52Z |
| institution | BVB |
| isbn | 9780123942913 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025458809 |
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| series | Methods in enzymology |
| series2 | Methods in enzymology |
| spelling | Natural product biosynthesis by microorganisms and plants B ed. by David A. Hopwood 1. ed. Amsterdam [u.a.] Elsevier, Acad. Press 2012 LVI, 393 S., [6] Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Methods in enzymology 516 Methods in enzymology ... Mikroorganismus (DE-588)4039226-0 gnd rswk-swf Biochemische Methode (DE-588)4319880-6 gnd rswk-swf Naturstoff (DE-588)4041418-8 gnd rswk-swf Biosynthese (DE-588)4006902-3 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Naturstoff (DE-588)4041418-8 s Biosynthese (DE-588)4006902-3 s Mikroorganismus (DE-588)4039226-0 s Biochemische Methode (DE-588)4319880-6 s DE-604 Hopwood, David A. Sonstige oth (DE-604)BV040543707 2 Methods in enzymology 516 (DE-604)BV000000938 516 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025458809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Natural product biosynthesis by microorganisms and plants Methods in enzymology Mikroorganismus (DE-588)4039226-0 gnd Biochemische Methode (DE-588)4319880-6 gnd Naturstoff (DE-588)4041418-8 gnd Biosynthese (DE-588)4006902-3 gnd |
| subject_GND | (DE-588)4039226-0 (DE-588)4319880-6 (DE-588)4041418-8 (DE-588)4006902-3 (DE-588)4143413-4 |
| title | Natural product biosynthesis by microorganisms and plants |
| title_auth | Natural product biosynthesis by microorganisms and plants |
| title_exact_search | Natural product biosynthesis by microorganisms and plants |
| title_full | Natural product biosynthesis by microorganisms and plants B ed. by David A. Hopwood |
| title_fullStr | Natural product biosynthesis by microorganisms and plants B ed. by David A. Hopwood |
| title_full_unstemmed | Natural product biosynthesis by microorganisms and plants B ed. by David A. Hopwood |
| title_short | Natural product biosynthesis by microorganisms and plants |
| title_sort | natural product biosynthesis by microorganisms and plants |
| topic | Mikroorganismus (DE-588)4039226-0 gnd Biochemische Methode (DE-588)4319880-6 gnd Naturstoff (DE-588)4041418-8 gnd Biosynthese (DE-588)4006902-3 gnd |
| topic_facet | Mikroorganismus Biochemische Methode Naturstoff Biosynthese Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025458809&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV040543707 (DE-604)BV000000938 |
| work_keys_str_mv | AT hopwooddavida naturalproductbiosynthesisbymicroorganismsandplantsb |