Biology and regulation of blood tissue barriers:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer Science + Business Media [u.a.]
2012
|
| Schriftenreihe: | Advances in experimental medicine and biology
763 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Includes bibliographical references and index |
| Beschreibung: | XX, 361 S. Ill., graph. Darst. |
| ISBN: | 9781461447108 1461447100 |
Internformat
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| 020 | |a 9781461447108 |c (hbk.) £139.50 |9 978-1-4614-4710-8 | ||
| 020 | |a 1461447100 |c (hbk.) £139.50 |9 1-4614-4710-0 | ||
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| 245 | 1 | 0 | |a Biology and regulation of blood tissue barriers |c ed. by C. Yan Cheng |
| 264 | 1 | |a New York, NY |b Springer Science + Business Media [u.a.] |c 2012 | |
| 300 | |a XX, 361 S. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Advances in experimental medicine and biology |v 763 | |
| 500 | |a Includes bibliographical references and index | ||
| 650 | 2 | |a Capillary Permeability | |
| 650 | 2 | |a Blood-Brain Barrier | |
| 650 | 2 | |a Blood-Retinal Barrier | |
| 650 | 2 | |a Blood-Air Barrier | |
| 650 | 2 | |a Blood-Testis Barrier | |
| 653 | |a Capillaries--Permeability. | ||
| 653 | |a Blood-brain barrier. | ||
| 653 | |a Blood banks. | ||
| 653 | |a Tissue banks. | ||
| 700 | 1 | |a Cheng, C. Yan |e Sonstige |4 oth | |
| 830 | 0 | |a Advances in experimental medicine and biology |v 763 |w (DE-604)BV000003102 |9 763 | |
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| 999 | |a oai:aleph.bib-bvb.de:BVB01-025438361 | ||
Datensatz im Suchindex
| _version_ | 1804149704654585856 |
|---|---|
| adam_text | Titel: Biology and regulation of blood tissue barriers
Autor: Cheng, C. Yan
Jahr: 2012
CONTENTS
1. REGULATION OF PERMEABILITY ACROSS
THE BLOOD-BRAIN BARRIER____...........
Alexander S. Easton
Abstract......................................................................................................................................... 1
Introduction.................................................................................................................................. 1
Permeability Defined--------.------------------------------------------.___________________3
Permeability Measured................................................................................................................ 4
Why Is BBB Permeability So Low and Is It a Static or Dynamic Entity?............................. 5
Changes in BBB Permeability during Inflammation................................................................ 7
The Relationship between BBB Permeability and Angiogenesis........................................... 11
The Effect of Neutrophils on BBB Permeability during Inflammation................................ 13
Conclusion—Where Do We Go from Here?____________________________________15
2. DRUG TRANSPORTERS AT BRAIN BARRIERS: EXPRESSION
AND REGULATION BY NEUROLOGICAL DISORDERS___________20
Tamima Ashraf, Olena Kis, Nilasha Banerjee and Reina Bendayan
Abstract_______________________________________________________________20
Introduction................................................................................................................................ 20
Physiology of the Blood-Brain Barrier................................................................................... 21
Mechanisms of Drug Permeability across the CNS................................................................ 24
Models to Study Drug Transport and Permeability............................................................... 26
Functional Expression and Localization of Families of Membrane Drug
Transporters in the CNS_______________________________________________28
Regulation of Membrane Drug Transporters by Neurological Disorders............................ 53
Conclusion.................................................................................................................................. 58
xvi CONTENTS
3. THE BLOOD-RETINA BARRIER: TIGHT JUNCTIONS
AND BARRIER MODULATION.................................................................70
Matthew Campbell and Peter Humphries
^LDSli ftCl••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••*•••••••••••••••••• ••••••••••••••••••••••••••••••••*•••••••••*•••••• ^
Introduction: General Anatomy of the Human Eye............................................................... 70
The Blood-Retina Barrier (BBS)_____________________________________________71
Tight Junctions__________________________________________________________72
Tight Junction Proteins------------------------------------------------------------------------------72
A Novel Therapeutic Strategy for Retinal Diseases................................................................ 77
RNAi Mediated Barrier Modulation---------------------------------------------------------------78
Adeno-Associated Virus (AAV)-Mediated Barrier Modulation............................................ 79
Conclusion..........................................................................................................—...............».... 81
4. THE INNER BLOOD-RETINAL BARRIER: MOLECULAR
STRUCTURE AND TRANSPORT BIOLOGY...........................................85
Ken-ichi Hosoya and Masanori Tachikawa
Abstract________________________________________________________________85
Introduction..........................—..................................................................................................85
Cellular Factors in Glio-Vascular Interface.............—...........................................................87
Molecular Structure of the Inner BRB------------------------------------------------------------87
Influx Transporters at the Inner Blood-Retinal Barrier........................................................ 89
GLUTI_________________________________________________________________90
ENT2---------------------------------------------------------------------------------------------------90
CAT1__________________________________________________________________91
TAUT__________________________________________________________________91
LAT1__________________________________________________________________91
xCT-----------------------------------------------------------------------------------------------------92
GlyTl__________________________________________________________________92
OCTN2________________________________________________________________93
CRT___________________________________________________________________93
SMVT_________________________________________________________________93
Other Transporters....................................................................................................................94
SR-BI---------------------------------------------------------------------------------------------------94
SIP and LPA Receptor_____________________________________________________95
Efflux Transporters at the Inner Blood-Retinal Barrier___________________________95
Oatpla4________________________________________________________________96
OAT3---------------------------------------------------------------------------------------------------96
System A(ATA2)_________________________________________________________97
ABCB1 (P-Glycoprotein)___________________________________________________97
ABCC4(MRP4)_________________________________________________________98
ABCG2(BCRP)_________________________________________________________98
nDLASn«t MMNHNIIUIIMMIIHMIHtMm»HII«HMHI«IMHtHHIMIHtl»HmtHIIHIMHttlll«IIHIIIMaiHMM»(««»HMH»HIH« Vi»
Conclusion.......................__............................................................................................ 100
Future Challenges....................................................................................................................100
CONTENTS xvii
5. ENDOTHELIAL AND EPITHELIAL BARRIERS
IN GRAFT-VERSUS-HOST DISEASE____________________________105
Sam C. Nalle and Jerrold R. Turner
Abstract______________________________________________________________105
Introduction............................................................................................................................. 105
Regulation of the ParaceOular Barrier.................................................................................. 107
MLCK-Mediated Barrier Dysfunction______.......___________...._____________.___110
Inflammatory Bowel Disease and Graft-Versus-Host Disease............................................. 114
Endothelial and Epithelial Barrier Dysfunction in Graft-Versus-Host Disease................ 119
Conclusion and Future Perspective...................................................................................... 121
6. STRUCTURE AND REGULATION OF INTESTINAL
EPITHELIAL TIGHT JUNCTIONS:
CURRENT CONCEPTS AND UNANSWERED QUESTIONS_______132
Andrei I. Ivanov
Abstract______________________________________________________________132
Introduction_______.-----------------------------------------------------------------------------132
Molecular Composition of Intestinal Epithelial TJs............................................................. 134
Dynamics of Epithelial TJs in Normal Conditions and Diseases........................................ 137
Unanswered Questions about Regulation of Intestinal Epithelial TJs....».»..»..........»»»... 139
Conclusion_________...________..—.--------.......-------------------------------------------143
7. POLARITY PROTEIN COMPLEX SCRIBBLE/Lgl/Dlg
AND EPITHELIAL CELL BARRIERS___________________________149
Wen-Hui Su, Dolores D. Mruk, Elissa W.P. Wong, Wing-Yee Lui and C. Yan Cheng
Abstract______________________________________________________________150
Introduction..».».».»....»..»»»»....».»....»».»».»...»»»»».....»».»»»»»»»...».»...»....»...».»»....» 150
Identification and Molecular Structure of Scribble Complex Components».».».».»..».»» 152
Relationship between Cell Junctions and Cell Polarity in Epithelial Cells-----------------155
Scribble Complex in Regulating Cell Junction Dynamics and Cell Polarity..................... 156
Scribble Complex Participates in Cell Signaling Cascades-----------------------------------160
The Scribble Module and Mammalian Epithelial Barrier Function.................................. 161
Conclusion and Future Perspectives...................................................................................... 165
8. THE BLOOD-BILIARY BARRIER, TIGHT JUNCTIONS
AND HUMAN LIVER DISEASES___________________________.........171
Nikki P. Lee
Abstract______________________________________________________________171
Introduction.»»...».»».»...»»»»».»...»»»......—.»..»...»».»..»...»»».»..»..»..—.»»»».»»»....—171
Anatomy and Physiological Functions of TJs in the Liver..»».»»».......».....»...»..»»..»»..... 172
Molecular Components of TJ in the Mammalian Liver..........................................—......... 173
Junction-to-Junction Interaction at TJ in the Liver................................—......................... 176
Involvement of TJ Molecules in Liver Diseases.................-----............................................ 177
Conclusion and Future Perspectives.»........»»»..»......»».......»......»»»»»..»..........»......»»»»181
xyili CONTENTS
9. THE BLOOD-FOLLICLE BARRIER (BFB) IN DISEASE
AND IN OVARIAN FUNCTION---------------------------------------------------186
Michelle K.Y. Siu and C. Yan Cheng
Introduction: the Concept of the Blood-Follicle Barrier (BFB)------------------------------186
Composition of the Br B .„.,....•.«?»,«••»•..»•...••..»».¦•«••«»•»•»••»•••»•»•••»•»»•••••*•»•»•••»»••»»»»•.»•»•» j.o /
The BFB in Polycystic Ovary and Ovarian Cancer.............................................................. 189
The Permeability Barrier Function of the BFB: Selective Transport Processes
versus Mere Filtration .»..»..»..........»..»..».»....»»»...»..................»»«•»•»..»••.»—»—»••• 190
Conclusion and Future Perspectives...—.....—.----------.------.--------------.-------.......... 190
10. PHYSIOLOGY AND PATHOPHYSIOLOGY OF THE EPITHELIAL
BARRIER OF THE FEMALE REPRODUCTIVE TRACT:
ROLE OF ION CHANNELS__________________________________......193
Hsiao Chang Chan, Hui Chen, Yechun Ruan and Tingting Sun
Abstract_______________________________________________________________193
Introduction____.___.........—.—.------.---------------------------.----------------------------193
The Luminal Fluid Microenvironment and Selective Epithelial Barrier....----------------194
Luminal Fluid Microenvironment in Different Segments of the Female
Genital Tract_______________________________________________________194
Regulation of Ion Channels and Selective Permeability of the Epithelial
Barrier in Reproduction.................................................................................................. 200
Hormonal Regulation of Ion Channel Expression and Fluid Secretion/Absorption...»..»... 201
Interaction between ENaC and Cl--Channels—A Switching Mechanism.......................... 204
Regulation of ENaC and Physiological Implications................................................... 204
Regulation of CFTR-Mediated Bicarbonate Secretion and Its Effect
on Sperm Capacitation and Embryo Development»».»»»»......»».»....»...»»......»....... 205
Defective Ion Channel Expression/Function and Dysregulated Barrier
Function in Diseases............»..»..»...».....».»...»...»......».»....»»»»»»..»..»»...»..»»..»..».. 206
Defective Epithelial Bicarbonate Secretion and Infertility in CF____._______________206
Excessive CFTR-Dependent Fluid Accumulation in OHSS_______________________208
Infection-Induced CFTR Upregulation in Hydrosalpinx and Female Infertility.....____209
Conclusion—.---------....__._____._____._________.______._________.___.________210
11. THE BLOOD-EPIDIDYMIS BARRIER AND HUMAN
MALE FERTILITY________________.......................................................218
Evemie Dube and Daniel G. Cyr
Abstract_______________________________________________________________218
Introduction.».»...».„....„..„...„...„....„...,..„„..„».„..„„»„„.„„„„„.„„„„„„„„„...„.............„..„.218
Structure of the Human Epididymis .»......»...........».„»„..„„..„..„„.„„„„.„„„„»„„„„„„„„„. 219
Involvement of the Human Epididymis in Sperm Maturation____________.________220
Characteristics of the Blood-Epididymis Barrier .»...».....»..»...»„.„»»......„.»...„„..»..„„..„ 220
Composition of Epididymal Tight Junctions»..........»..»»»»..»..»»»»»»»»».»»..»»»»»»».». 221
Regulation of Epididymal Tight Junctions...».»».».»».»...».»»»»...».......»»»»».»».......»..... 225
Interactions of Tight Junctions with Adherens Junctions.».»».......».»».........»...».»»..»...» 226
The Blood-Epididymis and Human Pathologies_______._______........___...__.____.__228
Biological Tools to Study the Blood-Epididymis Barrier_________________________230
i^uuCiusion. •«•**»**•*•*•»*»«»•*•*•••**••••••••*••••*••**••••••••••»••.•«.?•••*.««.„,»,..„,„».„»„„„.„,„..„.„,#M„#-„#„„,„#. 23 v
CONTENTS xh
12. BLOOD-TISSUE BARRIERS: MORPHOFUNCTIONAL
AND IMMUNOLOGICAL ASPECTS OF THE BLOOD-TESTIS
AND BLOOD-EPIDIDYMAL BARRIERS________________________237
Luiz R. Franca, Sarah A. Auharek, Rex A. Hess, Jannette M. Dufour
and Barry T. Hinton
Abstract______________________________________________________________237
Introduction....»..»»......»»»»..»»»».».».»»»»».».»»»»»».».»»..»»»»....»»»»»»..»»»»»»».».... 237
The Morphological Aspects of the BIood-Testis Barrier...................................................... 239
The Physiological Aspects of the Blood-Testis and Blood-Epididymal Barriers»»»»»»»» 246
The Immunological Aspects of the Blood-Testis and Blood-Epididymal Barriers............ 249
Conclusion and Future Perspectives...................................................................................... 253
13. GAP JUNCTIONS AND BLOOD-TISSUE BARRIERS_________________260
Michelle W.M. Li, Dolores D. Mruk and C. Yan Cheng
Abstract---------------------------------------------------------------------------------------------260
Introduction»..»..»»..»..»».»».»».»»».»..»..»»...»»»»».»...»».».»».»»»»...»»»».»»..»»».»».»» 260
Connexins—The Basics: Structures, Functions and Regulation»»...»».»»»»...»»»».».....» 261
Connexins/GJ and Barrier Function..».......».»»»»..»»..»».»»»».»».»...»..».».»».»»..»»»__. 269
Connexin-Mediated Bystander Effects____________________________»______...... 273
Conclusion and Future Perspectives...................................................................................... 274
14. TRANSCRIPTIONAL REGULATION OF CELL ADHESION
AT THE BLOOD-TESTIS BARRIER
AND SPERMATOGENESIS IN THE TESTIS--------------------------------281
Wing-Yee Lui and C. Yan Cheng
Abstract______________________________________________________________281
Introduction.»......»»»»».».»».»»»»»»»......»»..»»....».....».»..».»».»...»»»»».»»..».»»»»».....» 281
Transcription Factors in Sertoli and Germ Cells Crucial to Spermatogenesis__.______282
Transcription Factors Involved in the Maintenance of Spermatogonia! Stem Cells____286
Transcription Factors Involved in Germ Cell Differentiation and Spermiogenesis-------287
Transcription Factors Involved in Anchoring Junction Dynamics
in the Seminiferous Epithelium...............................................—„.»..»»»..»»»»»»»„..»288
Conclusion................................................................................................................................ 291
15. c-Src AND c-Yes ARE TWO UNLIKELY PARTNERS
OF SPERMATOGENESIS AND THEIR ROLES
IN BLOOD-TESTIS BARRIER DYNAMICS...........................................295
Xiang Xiao, Dolores D. Mruk, Faith L. Cheng and C. Yan Cheng
Abstract______________________________________________________________295
Introduction..............................................................................................................................296
General Structure of SFKs and a Comparison between c-Src and c-Yes-------------------299
Divergent Roles of c-Src and c-Yes during Carcinogenesis-----------------------------------301
SFKs in the Testis___________________________________________________.......303
SFK and Spermatogonia! Stem Cell Proliferation---------------------------------------------305
c-Src on Cell Adhesion, Blood-Testis Barrier and Spermatogenesis»----------...---------„305
xx CONTENTS
c-Yes on Cell Adhesion, Blood-Testis Barrier and Spermatogenesis-------------.------.—307
An Emerging Model by Which SFKs Regulate Spermatogenesis in Particular
Blood-Testis Barrier Dynamics in the Seminiferous Epithelium-------.----------------310
Conclusion and Future Perspectives...................................................................................... 310
16. ROLE OFP-GLYCOPROTEIN AT THE BLOOD-TESTIS
BARRIER ON ADJUDIN DISTRIBUTION IN THE TESTIS:
A REVISIT OF RECENT DATA____________________...........................318
Linlin Su, Pranitha Jenardhanan, Dolores D. Mruk, Premendu P. Mathur,
Yan-ho Cheng, Ka-Wai Mok, Michele Bonanomi, Bruno Silvestrini
and C. Yan Cheng
Abstract_______________________________________________________________319
Introduction.___.______.___....................................—.______...__________.________319
Adjudin and Its Bioavailability in the Testis............................_________________....___319
Drug Transporters and Blood-Testis Barrier (BTB) Dynamics________.____________320
P-Glycoprotein Regulates the Bioavailability of Adjudin in the Testis_______________321
Interactions of Adjudin with P-Glycoprotein in Rats and Humans:
A Molecular Modeling Analysis...................................................................................... 322
Conclusion____________________________________________________________331
17. THE APICAL ECTOPLASMIC SPECIALIZATION-BLOOD-TESTIS
BARRIER FUNCTIONAL AXIS IS A NOVEL TARGET
FOR MALE CONTRACEPTION...............................................................334
Ka-Wai Mok, Pearl P.Y. Lie, Dolores D. Mruk, Jayakanthan Mannu,
Premendu P. Mathur, Bruno Silvestrini and C. Yan Cheng
Abstract___»_________________.________.__._________________________.___335
Introduction.........._____..._______...___._____________....______________.__.____335
The Apical ES-BTB Functional Axis_________________________________________337
Drug Transport at the BTB________________________________________________339
Interaction of Adjudin with Integrin at the Apical ES and Occludin at the BTB_____„ 340
The Apical ES-BTB Axis Is a Prime Target for Male Contraceptive Development_____346
The Role of BTB in the Differentiation of Spermatogonia/Spermatogonia!
Stem Cells (SSC)____________________________________________________350
Conclusion and Future Perspectives________.__......__._______.__......_______..„„..» 351
INDEX........................................................................................................................357
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| id | DE-604.BV040610782 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:27:16Z |
| institution | BVB |
| isbn | 9781461447108 1461447100 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025438361 |
| oclc_num | 814422861 |
| open_access_boolean | |
| owner | DE-12 |
| owner_facet | DE-12 |
| physical | XX, 361 S. Ill., graph. Darst. |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Springer Science + Business Media [u.a.] |
| record_format | marc |
| series | Advances in experimental medicine and biology |
| series2 | Advances in experimental medicine and biology |
| spelling | Biology and regulation of blood tissue barriers ed. by C. Yan Cheng New York, NY Springer Science + Business Media [u.a.] 2012 XX, 361 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Advances in experimental medicine and biology 763 Includes bibliographical references and index Capillary Permeability Blood-Brain Barrier Blood-Retinal Barrier Blood-Air Barrier Blood-Testis Barrier Capillaries--Permeability. Blood-brain barrier. Blood banks. Tissue banks. Cheng, C. Yan Sonstige oth Advances in experimental medicine and biology 763 (DE-604)BV000003102 763 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025438361&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Biology and regulation of blood tissue barriers Advances in experimental medicine and biology Capillary Permeability Blood-Brain Barrier Blood-Retinal Barrier Blood-Air Barrier Blood-Testis Barrier |
| title | Biology and regulation of blood tissue barriers |
| title_auth | Biology and regulation of blood tissue barriers |
| title_exact_search | Biology and regulation of blood tissue barriers |
| title_full | Biology and regulation of blood tissue barriers ed. by C. Yan Cheng |
| title_fullStr | Biology and regulation of blood tissue barriers ed. by C. Yan Cheng |
| title_full_unstemmed | Biology and regulation of blood tissue barriers ed. by C. Yan Cheng |
| title_short | Biology and regulation of blood tissue barriers |
| title_sort | biology and regulation of blood tissue barriers |
| topic | Capillary Permeability Blood-Brain Barrier Blood-Retinal Barrier Blood-Air Barrier Blood-Testis Barrier |
| topic_facet | Capillary Permeability Blood-Brain Barrier Blood-Retinal Barrier Blood-Air Barrier Blood-Testis Barrier |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025438361&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV000003102 |
| work_keys_str_mv | AT chengcyan biologyandregulationofbloodtissuebarriers |