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Technical manual:

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Bibliographic Details
Format:	Book
Language:	English
Published:	Bethesda, Md. AABB 2011
Edition:	17. ed.
Subjects:	Blood Banks > Laboratory Manuals Blood banks > Handbooks, manuals, etc Blood > Transfusion > Handbooks, manuals, etc Bluttransfusion Standardisierung Blutbank
Online Access:	Inhaltsverzeichnis
Physical Description:	XXIII, 1038 S. Ill., graph. Darst.
ISBN:	9783805599627 9781563953156

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adam_text	Contents ♦ Preface ........................................................ix QUALITY ISSUES 1. Quality Management Systems: Theory and Practice ..........1 Tania L Motschman, MS. MTíASCPiSBB, CQAfASQ); Betsy W. lett, МШЅСР). CQAfASQìCQM/OE; and Susan L Wilkinson, EdD. MS. MTfASCPjSBB. CQA(ASQ) Quality Concepts ......................................................2 Practical Application of Quality Management Principles ..................4 Appendix 1-1. Glossary of Commonly Used Quality Terms ...............32 Appendix 12 Code of Federai Regulations Quality- Related References ___34 Appendix 1 -3. Statistical Tables for Binomial Distribution Used to Determine Adequate Sample Size and Level of Confidence for Validation of Pas«/Fall Data ........................................35 Appendix 1-4. Suggested Quality Control Performance Intervals for Equipment and Reagent» ..........................................37 2. Facilities, Woik Environment, and Safety ...................41 Betsy W. Jett, MT(ASCP), CQAÍASQKQMIOE; Susan L Wilkinson, Edu MS, MT(ASCP)SBB,CQA(ASQ); and Tanta L Momhman. MS, MTXASCPìSBB, CQAIASQ) Facilities ............................................................42 Safety Program ......................................................44 Fire Prevention ......................................................48 Electrical Safety .....................................................49 Chemical Safety .....................................................58 Radiation Safety .....................................................63 Shipping Hazardous Materials ........................................66 General Waste Management ..........................................67 Appendix 2-1. Safety Regulations and Recommendations Applicable to Health-Care Settings ..............................................71 xii ♦ AABB Technical Manual Appendix 2-2. General Guidelines for Safe Work Practices, Personal Protective Equipment, and Engineering Controls .....................73 Appendix 2-3. Biosafety Level 2 Precautions ............................77 Appendix 2-4. Sample List of Hazardous Chemicals that May Be Encountered in the Blood Bank .....................................78 Appendix 2-5. Specific Chemical Categories and How to Work Safely with Them ........................................................80 Аррепгііхг-б. Incidental Spill Response ................................82 Appendix 2-7. Managing Hazardous Chemical Spills .....................85 3. Regulatory Issues in Blood Banking ........................87 Glenn Ramsey, MD Federal Laws and Regulations for Drugs ................................87 Biological Products ..................................................88 Iicensure and Registration ............................................89 FDA Inspections .....................................................90 Blood-Related Devices ...............................................91 Hematopoietic Progenitor Cells as Tissues ..............................91 Managing Recalls and Withdrawals ....................................93 Medical Laboratory Laws and Regulations ..............................93 Hospital Regulations and Accreditation ................................96 State and Local Regulations ...........................................96 Conclusion ..........................................................96 4. Disaster Management ...................................103 Jamie Blietz, MBA, CAE; William P. FitzGerald, LTC USA (Ret); and Ruth D. Sylvester, Lt Col, USAF (Ret), MS, MT(ASCP)SBB Background ........................................................103 Business Operations Planning .......................................108 Working with Emergency Management Agencies .......................120 Regulatory Considerations in Emergencies ............................122 Testing the Disaster Plan ............................................124 Summary of Lessons Learned from Recent Disasters ...................125 Conclusion .........................................................125 Appendix 4-1. Internet Resources Related to State and Local Organizations ....................................................136 Appendix 4-2. General Internet Resources for Disaster Management .....136 BLOOD DONATION AND COLLECTION 5. Allogeneic and Autologous Blood Donor Selection .........137 AnneF. Eder, MD, PhD Historical Perspective ............................................... 138 Selection of Allogeneic Donors .......................................140 Table of Contents ♦ xiii Possible Measures of the Effectiveness of the Donor Interview .......... 147 Blood-Center-Defined Donor Eligibility Criteria ....................... 148 Abbreviated Donor History Questionnaire for Frequent Donors ........ 152 Postdonation Instructions ........................................... 152 Recipient-Specific Designated or Directed Blood Donation ......... 153 Appendix 5-1. Requirements for Allogeneic and Autologous Donor Qualification .............................................. 160 Appendix 5-2. The Donor History Questionnaire and Corresponding Regulations and Standards ........................................ 163 Appendix 5-3. Full-Length Donor History Questionnaire ............... 180 Appendix 5-4. Medication Deferral List for the Donor History Questionnaire ................................................... 184 Appendix 5-5. Blood Donor Educational Materials: Making Your Blood Donation Safe ............................................. 185 6. Whole Blood Collection and Component Processing at Blood Collection Centers ..............................187 Ram Kakaiya, MD, MBBS; Colleen A. Aronson, MT(ASCP)SBB; and Janajulleis, MBA, MTÇASCPiSBB Whole Blood Collection ............................................. 187 Blood Component Preparation and Processing ........................198 Descriptions of Major Blood Components ............................201 Blood Component Modification .....................................207 Quarantine ........................................................213 Labeling ...........................................................214 ISBT 128...........................................................216 Quality Control of Blood Components ...............................221 7. Blood Component Collection by Apheresis ................227 James W. Smith, MD, PhD Component Collection ..............................................227 Instruments and Systems for Donor Apheresis Collections ..............233 8. Infectious Disease Screening .............................239 SusanA.Galel.MD Historical Overview of Blood Donor Screening ........................239 Donor Screening Tests: General Aspects ..............................241 Residual Infectious Risks of Transfusion ..............................251 Screening for Specific Agents ........................................254 Pathogen Reduction Technology .....................................263 Summary ..........................................................264 xiv ♦ AABB Technical Manual 9. Storage, Monitoring, Pretransfusion Processing, and Distribution of Blood Components .....................271 William B. Lockwood, PhD, MD; Jill Leonard, MTCAMT); and Sandy L. Liles, MT(ASCP)SBB Blood and Blood Component Storage .................................272 Prestorage Processing ...............................................279 Poststorage Processing ..............................................279 Inspection, Shipping, Receiving into Inventory, Disposition, and Issue ... 284 BLOOD GROUPS 10. Molecular Biology and Immunology in Transfusion Medicine ............................................293 James C. Zimring, MD, PhD, and Steven L Spitalnik, MD Nucleic Acid Analysis ................................................293 Protein Analysis ....................................................307 Basic Immunologie Principles Underlying Transfusion Medicine ........313 11. Blood Group Genetics ...................................327 Christine Lomas-Francis, MSc, FIBMS Fundamental Principles of Genetics ..................................328 Inheritance of Genetic Traits .........................................337 Population Genetics .................................................348 Relationship Testing ................................................351 Blood Group Gene Mapping .........................................353 Chimerism .........................................................356 Blood Group Terminology ...........................................357 12. ABO, H, and Lewis Blood Groups and Structurally Related Antigens ......................................363 Laura Cooling, MD, MS ABO System ........................................................363 The H System .......................................................373 The Lewis System ...................................................376 I and і Antigens .....................................................378 PBlood Groups/GLOB Collection ....................................381 13. The Rh System ..........................................389 Stella T. Chou, MD, and Connie M. Westhoff, PhD, MTCASCPJSBB Terminology .......................................................390 RH Genes and Rh Proteins ...........................................393 Antigens ...........................................................394 RH Genotyping .....................................................403 Table of Contents ♦ xv Rhnull Syndrome and RhAG Blood Group System.......................404 Rh Structure and Function ..........................................404 Rh Antibodies .....................................................405 Technical Considerations for Rh Typing ..............................405 14. Other Blood Groups .....................................411 Geoff DanieL·, PhD, FRCPath The MNS System ...................................................411 The Lutheran System ...............................................417 The Kell and Kx Systems .............................................418 The Duffy System ...................................................421 The Kidd System ...................................................423 The Diego System ..................................................425 The Yt System ......................................................426 TheXg System .....................................................426 The Scianna System ................................................427 The Dombrock System ..............................................427 The Colton System .................................................428 The Landsteiner-Wiener System .....................................429 The Chido/Rodgers System ..........................................429 The Gerbich System ................................................429 The Cromer System .................................................430 The Knops System ..................................................430 The Indian System ..................................................431 The Ok System .....................................................431 The Raph System ...................................................432 The John Milton Hagen System ......................................432 The GILJ System ....................................................432 The RHAG System ..................................................432 Antigens That Do Not Belong to a Blood Group System ................432 ANTIGEN AND ANTIBODY TESTING 15. Pretransfusion Testing ..................................437 Katharine A Dowries, MD, and Ira A Shulman, MD Requests for Transfusion ...........................................437 Identification of Recipients and Labeling of Blood Samples ............438 Sample Requirements ..............................................441 Serologie Testing Principles .........................................442 Pretransfusion Tests ................................................445 Tubeless Methods for Pretransfusion Testing ..........................449 Comparison of Current Testing Results with Previous Records ..........450 Donor RBC Unit Testing ............................................451 Donor RBC Unit Selection ...........................................451 xvi ♦ AABB Technical Manual Compatibility Testing or Crossmatch (Serologie or Computer/ Electronic) .......................................................452 Interpretation of Antibody Screening and Crossmatch Results ...........453 Pretransfusion Orders ...............................................455 Availability of Compatible Blood .....................................455 Labeling of Blood and Blood Components with the Recipient s Information .....................................................455 Special Clinical Situations ...........................................457 16. Identification of Antibodies to Red Cell Antigens ...........463 Phyllis S. Walker, MS, MT(ASCP)SBB Significance of Alloantibodies ........................................463 Preanalytical Considerations .........................................464 Analytical Phase of Antibody Identification ............................464 Postanalytical Considerations: Selecting Blood for Transfusion ..........490 17. The Positive Direct Antiglobulin Test and Immune- Mediated Hemolysis ..................................497 Regina M. Leger, MSQA, MT(ASCP)SBB, CMQ/OECASQ) The Direct Antiglobulin Test .........................................497 Autoimmune Hemolytic Anemia .....................................501 Drug-Induced Immune Hemolytic Anemia ............................512 Appendix 17-1. Drugs Associated with a Positive DAT and/or Immune Hemolytic Anemia .......................................519 18. Platelet and Granulocyte Antigens and Antibodies .........523 Janice G. McFarland, MD Platelet Antigens and Antibodies .....................................523 Granulocyte Antigens and Antibodies .................................539 19. TheHLASystem ........................................547 Howard M. Gebel, PhD; Marilyn S. Pollack, PhD; and Robert A Bray, PhD Genetics of the Major Histocompatibility Complex .....................548 Biochemistry, Tissue Distribution, and Structure .......................552 Detection of H1A Antigens and Alíeles ................................557 Crossmatching and Detection of HLA Antibodies ......................559 The HLA System and Transfusion .....................................560 HLA Testing and Transplantation .....................................562 Other Clinically Significant Aspects of HLA ............................565 Summary ..........................................................566 Table of Contents Ψ xvii CLINICAL CONSIDERATIONS IN TRANSFUSION PRACTICE 20. Hemotherapy Decisions and Their Outcomes .............571 Theresa Nester, MD, and James P. AuBuchon, MD Red Cell Transfusion ................................................571 Platelet Transfusion ................................................579 Plasma Transfusion .................................................589 Cryoprecipitated AHF ...............................................594 Granulocytes .......................................................595 Plasma Derivatives .................................................597 21. Administration of Blood Components ....................617 Bonnie L S. Sink, BSN, RN, HP(ASCP) Events and Considerations Before Dispensing the Component ..........617 Dispensing and Transportation ......................................621 Events and Considerations Before Component Administration ..........622 Administration .....................................................624 Unique Transfusion Settings .........................................626 Conclusion ........................................................627 22. Perinatal Issues in Transfusion Practice ...................631 Melanies. Kennedy, MD Hemolytic Disease of the Fetus and Newborn .........................631 Rh Immune Globulin ...............................................636 ABO Hemolytic Disease .............................................639 Immune Thrombocytopenia .........................................639 23. Neonatal and Pediatric Transfusion Practice ..............645 Cassandra D. Josephson, MD Transfusion in Infants Less than 4 Months of Age ......................645 Transfusion in Older Infants (More than 4 Months of Age) and Children ........................................................660 Prevention of Adverse Effects of Transfusion in Neonates and Older Children ...................................................663 24. Patient Blood Management ..............................671 Jonathan H. Waters, MD Behavioral Changes .................................................671 Preoperative Anemia Management ...................................673 Perioperative Autotransfusion Program ...............................674 xviii ♦ AABB Technical Manual 25. Transfusion Support for Hematopoietic Stem Cell Transplant Recipients .................................687 Christopher A. Tormey, MD ABO and Non-ABO Red Cell Antigen Incompatible Transplantation ......688 Blood Component Considerations ....................................692 HSCT Recipients with HLA and/or Platelet Antibodies ..................698 Neutropenic Patients with Infection Unresponsive to Antimicrobial Therapy .........................................................699 Special Processing of Blood Components for the Recipients of HSCT .....699 Other Practical Considerations .......................................700 26. Therapeutic Apheresis ..................................707 Robertson D. Davenport, MD Principles ..........................................................707 Modalities ..........................................................708 Indications .........................................................709 Anticoagulation .....................................................717 Replacement Fluids .................................................717 Adverse Effects .....................................................718 Vascular Access .....................................................720 Patient Evaluation ..................................................722 27. Noninfectious Complications of Blood Transfusion ........727 Catherine A. Mazzei, MD; Mark A. Popovsky, MD; and Patricia M. Kopko, MD Hemovigilance .....................................................727 Recognition and Evaluation of a Suspected Transfusion Reaction .......728 Acute or Immediate Transfusion Reactions ............................737 Delayed Transfusion Reactions .......................................751 Fatality Reporting Requirements .....................................757 28. Approaches to Blood Utilization Auditing .................763 Alan Tinmouth, MD, FRCPC, MSc, and Simon Stanworth, MD, DPMI Rationale for Monitoring Blood Utilization ............................764 Types of Transfusion Audits ..........................................764 Interventions to Change Transfusion Practice ..........................769 Effectiveness of Monitoring and Interventions to Change Transfusion Practice ..............................................770 Selecting an Audit Process to Monitor Transfusions ....................770 Conclusion .........................................................772 Appendix 28-1. Example of a Transfusion Order Form ................. 776 Tableo/ Contents ♦ xix TRANSPLANTATION 29. Collecting and Processing Marrow Products for Transplantation ......................................779 Janice Davis-Sproul, MAS, MTfASCPjSBB; N. Rebecca Haley, MD; and John D. McMannis, PhD Diseases Treated with Hematopoietic Cell Transplantation .............780 Autologous Hematopoietic Cell Transplantation .......................780 Allogeneic Hematopoietic Cell Transplantation .......................780 Unrelated Donor Transplantation ....................................782 Histocompatibility ..................................................782 Graft-vs-Host Disease ...............................................783 Donor Eligibility ....................................................783 Marrow Harvest ....................................................784 Collection Targets ..................................................784 Clinical Considerations .............................................785 CD34 Antigen ......................................................785 Processing of HPC(M) Products ......................................785 Red Cell Incompatibilities ...........................................787 Short- and Long-Term Storage .......................................790 Transportation and Shipping ........................................792 Thawing and Infusion ...............................................792 Evaluation and Quality Control of Hematopoietic Products .............792 Regulations ........................................................794 Standards ..........................................................794 30. Hematopoietic Progenitor Cells Collected by Apheresis .....801 Thomas A. Lane, MD, and John D. McMannis, PhD Biology of HPC Mobilization .........................................802 Clinical Mobilization Regimens ......................................802 Preparation and Administration of HPQA) ............................808 Clinical Use of НРС(А) ..............................................809 Clinical Transplantation Outcomes of HPC(A) vs HPC(M) Grafts ........813 Selection of an HPC(A) or HPC(M) Graft vs an HPC(C) Graft ............814 31. Umbilical Cord Blood ...................................823 David H. McKenna, MD; Diane M. Kadidlo, MTfASCPìSBB; Jeffrey McCullough, MD; and Donna M. Regan, MT(ASCP)SBB Introduction .......................................................823 Donor-Related Issues ...............................................824 Collection .........................................................827 Processing .........................................................829 Shipment ..........................................................832 Receipt of UCB for Transplantation ..................................833 Thawing and Washing of UCB .......................................834 xx τ ΑΑΒΒ Technical Manual Infusion of UCB ....................................................835 Regulations and Standards ...........................................837 Novel UCB-Derived Cellular Therapies ................................839 32. Human Tissue Allografts and the Hospital Transfusion Service ...............................................849 Lance D. Trainar, MD, and Rita Α. Reik, MD Tissue Transplantation..............................................849 Regulations and Standards ...........................................853 Hospital Tissue Services .............................................854 Responsibility for Hospital-Based Tissue Services ......................854 METHODS Methods Introduction .........................................863 1. General Laboratory Methods .............................865 Introduction .......................................................865 Method 1-1. Shipping Hazardous Materials ............................865 Method 1-1-1. Monitoring Temperature During Shipment of Blood ......868 Method 1-2. Treating Incompletely Clotted Specimens .................868 Method 1-3. Solution Preparation Procedure ..........................869 Method 1-4. Serum Dilution Procedure ...............................871 Method 1-5. Dilution of Percentage Solutions Procedure ................872 Method 1-6. Preparing a 3% Red Cell Suspension ......................872 Method 1-7. Preparing and Using Phosphate Buffer ....................873 Method 1-8. Reading and Grading Tube Agglutination ..................873 2. Red Cell Typing .........................................875 Method 2-1. Determining ABO Group of Red Cells—Slide Test ..........875 Method 2-2. Determining ABO Group of Red Cells and Serum — Tube Test ........................................................876 Method 2-3. Determining ABO Group of Red Cells and Serum — Microplate Test ..................................................877 Method 2-4. Initial Investigation of ABO Grouping Discrepancies Procedure .......................................................878 Method 2-5. Detecting Weak A and В Antigens and Antibodies by Cold Temperature Enhancement ..................................879 Method 2-6. Confirming Weak A and В Antigens Using Enzyme- Treated Red Cells .................................................879 Method 2-7. Confirming Weak A or В Subgroup by Adsorption and Elution ..........................................................880 Method 2-8. Testing Saliva for А, В, Н, Lea, and Leb Antigens .............881 Method 2-9. Confirming Anti -ΑΙ in an A2 or Weak A Subgroup ...........883 Method 2-10. Resolving ABO Discrepancies Caused by Unexpected Alloantibodies ....................................................884 Table of Contents ♦ xxi Method 2-11. Determining Serum Group Without Centrifugation .......884 Method 2-12. Determining Rh (D) Type—Slide Test ....................885 Method 2-13. Determining Rh (D) Type—Tube Test ....................885 Method 2-14. Determining Rh (D) Type — Microplate Test ..............886 Method 2-15. Testing for Weak D .....................................887 Method 2-16. Preparing and Using Lectins ............................888 Method 2-17. Removing Autoantibody by Warm Saline Washes .........889 Method 2-18. Using Sulfhydryl Reagents to Disperse Autoagglutination .. 890 Method 2-19. Using Gentle Heat Elution to Test Red Cells with a Positive DAT .....................................................890 Method 2-20. Dissociating IgG by Chloroquine for Antigen Testing of Red Cells with a Positive DAT ......................................891 Method 2-21. Using Acid Glycine/EDTA to Remove Antibodies from Red Cells ........................................................892 Method 2-22. Separating Transfused from Autologous Red Cells by Simple Centrifugation ............................................893 Method 2-23. Separating Transfused from Autologous Red Cells in Patients with Hemoglobin S Disease ...............................894 3. Antibody Detection, Identification, and Compatibility Testing ..............................................897 Method 3-1. Using Immediate-Spin Compatibility Testing to Demonstrate ABO Incompatibility .................................897 Method 3-2. Detecting Antibodies to Red Cell Antigens — Indirect Antiglobulin Tests ................................................898 Method 3-2-1. Saline Indirect Antiglobulin Test Procedure .............898 Method 3-2-2. Albumin or LISS-Additive Indirect Antiglobulin Test Procedure ...................................................899 Method 3-2-3. LISS Indirect Antiglobulin Test Procedure ...............899 Method 3-2-4. PEG Indirect Antiglobulin Test Procedure ...............899 Method 3-3. Prewarming Procedure ..................................900 Method 3-4. Detecting Antibodies in the Presence of Rouleaux — Saline Replacement ..............................................901 Method 3-5. Enzyme Procedures .....................................902 Method 3-5-1. Preparing Ficin Enzyme Stock, 1% w/v ..................902 Method 3-5-2. Preparing Papáin Enzyme Stock, 1% w/v ................902 Method 3-5-3. Standardizing Enzyme Procedures ......................903 Method 3-5-4. Evaluating Enzyme-Treated Red Cells ...................903 Method 3-5-5. One-Stage Enzyme Procedure ..........................904 Method 3-5-6. Two-Stage Enzyme Procedure ..........................905 Method 3-6. Performing a Direct Antiglobulin Test .....................905 Method 3-7. Antibody Titration Procedure ............................907 Method 3-8. Using Sulfhydryl Reagents to Distinguish IgM from IgG Antibodies ..................................................909 Method 3-9. Using Plasma Inhibition to Distinguish Anti-Ch and -Rg from Other Antibodies with Similar Characteristics ..............911 Method 3-10. Treating Red Cells Using DTT or AET ....................912 Method 3-11. Neutralizing Anti-Sda with Urine ........................913 xxii ♦ AABB Technical Manual Method 3-12. Adsorption Procedure ..................................914 Method 3-13. Using the American Rare Donor Program .................914 4. Investigation of a Positive DAT ...........................917 Eluates .............................................................917 Method 4-1. Cold-Acid Elution Procedure .............................917 Method 4-2. Glycine-HCl/EDTA Elution Procedure .....................918 Method 4-3. Heat Elution Procedure ..................................919 Method 4-4. Lui Freeze-Thaw Elution Procedure .......................919 Immune Hemolytic Anemia Serum/Plasma Methods ...................920 Method 4-5. Cold Autoadsorption Procedure ..........................920 Method 4-6. Determining the Specificity of Cold-Reactive Autoagglutinins . 921 Method 4-7. Cold Agglutinin Titer Procedure ..........................923 Method 4-8. Adsorbing Warm-Reactive Autoantibodies Using Autologous Red Cells ............................................ 924 Method 4-9. Adsorbing Warm-Reactive Autoantibodies Using Allogeneic Red Cells ..............................................925 Method 4-10. Polyethylene Glycol Adsorption Procedure ...............927 Method 4-11. Performing the Donath-Landsteiner Test .................928 Method 4-12. Detecting Drug Antibodies by Testing Drug-Treated Red Cells ........................................................929 Method 4-13. Detecting Drug Antibodies by Testing in the Presence of Drug ......................................................... 930 5. Hemolytic Disease of the Fetus and Newborn ..............933 Method 5-1. Testing for Fetomaternal Hemorrhage—The Rosette Test ... 933 Method 5-2. Testing for fetomaternal hemorrhage — Modified Kleihauer-BetkeTest ..............................................934 Method 5-3. Using Antibody Titration Studies to Assist in Early Detection of Hemolytic Disease of the Fetus and Newborn ...........935 6. Blood Collection, Component Preparation, and Storage ___939 Method 6-1. Screening Donors for Anemia — Copper Sulfate Method .....939 Method 6-2. Preparing the Donor s Arm for Blood Collection ............940 Method 6-3. Collecting Blood and Samples for Processing and Compatibility Tests ...............................................941 Method 6-4. Preparing Red Blood Cells from Whole Blood ..............944 Method 6-5. Preparing Prestorage Red Blood Cells Leukocytes Reduced from Whole Blood .......................................945 Method 6-6. Rejuvenating Red Blood Cells .............................946 Method 6-7. Using High-Concentration Glycerol to Cryopreserve Red Cells—Meryman Method ......................................947 Method 6-8. Using High-Concentration Glycerol to Cryopreserve Red Cells— Valeri Method .........................................949 Method 6-9. Checking the Adequacy of Deglycerolization of Red Blood Cells ..................................................952 Method 6-10. Preparing Fresh Frozen Plasma from Whole Blood ........953 Table of Contents ♦ xxiii Method 6-11. Preparing Cryoprecipitated AHF from Whole Blood .......953 Method 6-12. Thawing and Pooling Cryoprecipitated AHF ..............954 Method 6-13. Preparing Platelets from Whole Blood ...................955 Method 6-14. Removing Plasma from Platelets (Volume Reduction) .....957 7. Transplantation of Cells and Tissue .......................959 Method 7-1. Infusing Cryopreserved Hematopoietic Cells ..............959 Method 7-2. Processing Umbilical Cord Blood .........................960 Method 7-3. Investigating Adverse Events and Infections Following Tissue Allograft Use ..............................................961 8. Quality Control .........................................965 Method 8-1. Validating Copper Sulfate Solution .......................965 Method 8-2. Standardizing and Calibrating Thermometers .............965 Method 8-2-1. Checking Liquid-in-Glass Laboratory Thermometers .....966 Method 8-2-2. Checking Electronic Oral Thermometers ................967 Method 8-3. Testing Blood Storage Equipment Alarms .................967 Method 8-3-1. Testing Refrigerator Alarms ............................967 Method 8-3-2. Testing Freezer Alarms ................................969 Method 8-4. Calibrating Centrifuges for Platelet Separation .............970 Method 8-5. Calibrating a Serologie Centrifuge ........................972 Method 8-6. Testing Automatic Cell Washers ..........................974 Method 8-7. Monitoring Cell Counts of Apheresis Components .........975 Method 8-8. Counting Residual White Cells in Leukocyte-Reduced Blood and Components — Manual Method ..........................975 APPENDICES Appendix 1. Normal Values in Adults .................................979 Appendix 2. Selected Normal Values in Children .......................980 Appendix 3. Typical Normal Values in Tests of Hemostasis and Coagulation (Adults) .............................................982 Appendix 4. Coagulation Factor Values in Platelet Concentrates .........982 Appendix 5. Approximate Normal Values for Red Cell, Plasma, and Blood Volumes ..................................................983 Appendix 6. Blood Group Antigens Assigned to Systems ................984 Appendix 7. Examples of Gene, Antigen, and Phenotype Symbols in Conventional and International Society of Blood Transfusion Terminology .....................................................989 Appendix 8. Examples of Correct and Incorrect Terminology ............989 Appendix 9. Distribution of ABO/Rh Phenotypes by Race or Ethnicity ... 990 Appendix 10. Example of a Maximum Surgical Blood Order Schedule ----991 Appendix 11. Directory of Organizations ..............................992 Appendix 12. Resources for Safety Information ........................994 Index ........................................................997
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illustrated	Illustrated
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institution	BVB
institution_GND	(DE-588)1030446-0
isbn	9783805599627 9781563953156
language	English
oai_aleph_id	oai:aleph.bib-bvb.de:BVB01-025429275
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physical	XXIII, 1038 S. Ill., graph. Darst.
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spelling	Technical manual ed. by John D. Roback ... 17. ed. Bethesda, Md. AABB 2011 XXIII, 1038 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Blood Banks Laboratory Manuals Blood banks Handbooks, manuals, etc Blood Transfusion Handbooks, manuals, etc Bluttransfusion (DE-588)4007293-9 gnd rswk-swf Standardisierung (DE-588)4056914-7 gnd rswk-swf Blutbank (DE-588)4146063-7 gnd rswk-swf Bluttransfusion (DE-588)4007293-9 s Blutbank (DE-588)4146063-7 s Standardisierung (DE-588)4056914-7 s b DE-604 Roback, John D. Sonstige oth American Association of Blood Banks Sonstige (DE-588)1030446-0 oth Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025429275&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Technical manual Blood Banks Laboratory Manuals Blood banks Handbooks, manuals, etc Blood Transfusion Handbooks, manuals, etc Bluttransfusion (DE-588)4007293-9 gnd Standardisierung (DE-588)4056914-7 gnd Blutbank (DE-588)4146063-7 gnd
subject_GND	(DE-588)4007293-9 (DE-588)4056914-7 (DE-588)4146063-7
title	Technical manual
title_auth	Technical manual
title_exact_search	Technical manual
title_full	Technical manual ed. by John D. Roback ...
title_fullStr	Technical manual ed. by John D. Roback ...
title_full_unstemmed	Technical manual ed. by John D. Roback ...
title_short	Technical manual
title_sort	technical manual
topic	Blood Banks Laboratory Manuals Blood banks Handbooks, manuals, etc Blood Transfusion Handbooks, manuals, etc Bluttransfusion (DE-588)4007293-9 gnd Standardisierung (DE-588)4056914-7 gnd Blutbank (DE-588)4146063-7 gnd
topic_facet	Blood Banks Laboratory Manuals Blood banks Handbooks, manuals, etc Blood Transfusion Handbooks, manuals, etc Bluttransfusion Standardisierung Blutbank
url	http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025429275&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT robackjohnd technicalmanual AT americanassociationofbloodbanks technicalmanual

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