Histone deacetylase inhibitors as cancer therapeutics:
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Acad. Press
2012
|
| Schriftenreihe: | Advances in cancer research
116 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufn. für Zeitschr.-H. |
| Beschreibung: | XII, 270 S. Ill. |
| ISBN: | 9780123943873 |
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| 245 | 1 | 0 | |a Histone deacetylase inhibitors as cancer therapeutics |c ed. by Steven Grant |
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Datensatz im Suchindex
| _version_ | 1804149611212832768 |
|---|---|
| adam_text | Titel: Histone deacetylase inhibitors as cancer therapeutics
Autor: Grant, Steven
Jahr: 2012
CONTENTS
Contributors ;x
Preface Xi
1. Histone Deacetylase Inhibitors Disrupt the Mitotic Spindle
Assembly Checkpoint By Targeting Histone and
Nonhistone Proteins 1
Brian Gabrielli and Mellissa Brown
1. Introduction 2
2. HDACi Dysregulate Cell Cycle Progression 4
3. HDACi Disrupt Normal Mitosis 9
4. Mechanism of HDAG-lnduced Aberrant Mitosis 19
5. Conclusions 27
Acknowledgments 27
References 27
2. Mechanisms of Resistance to Histone Deacetylase Inhibitors 39
Ju-Hee Lee, Megan L. Choy, and Paul A. Marks
1. Introduction 40
2. Mechanisms of Resistance to HDAC Inhibitors 42
3. Clinical Trials of HDAC Inhibitors 54
4. Conclusion 69
Acknowledgments 70
References 70
3. HDAC Inhibitors: Roles of DNA Damage and Repair 87
Carine Robert and Feyruz V. Rassool
1. Introduction 88
2. HDACis and DNA Damage 93
3. HDACis and Oxidative Stress 105
4. SIRTs: DNA Damage and Oxidative Stress Responses 113
5. Concluding Remarks and Future Directions 118
Acknowledgments 119
References 11 g
vi
Contents
4. HDAC Inhibitor Modulation of Proteotoxicity as a Therapeutic
Approach in Cancer 131
David J. McConkey, Matthew White, and Wudan Yan
1. Background: The Cellular Response to Proteotoxicity 132
2. Proteotoxicity as a Therapeutic Target in Cancer 142
3. Summary and Future Directions 152
References 153
5. Intrinsic and Extrinsic Apoptotic Pathway Signaling as
Determinants of Histone Deacetylase Inhibitor
Antitumor Activity 165
Geoffrey M. Matthews, Andrea Newbold, and Ricky W. Johnstone
1. Introduction 166
2. The Intrinsic Apoptosis Pathway 167
3. HDACi Induce Apoptosis Via the Intrinsic Apoptosis Pathway 168
4. The Effects of HDACi on Antiapoptotic Bcl-2 Family Genes 170
5. Effects of HDACi on Proapoptotic BCL-2 Family Members 171
6. Effects of HDACi on Bid 171
7. Effects of HDACi on Bim 175
8. Effects of HDACi on Bmf 177
9. Effects of HDACi on Bad 179
10. Effects of HDACi on Noxa/Puma 180
11. Effects of HDACi on Bax and/or Bak 181
12. The Extrinsic Apoptosis Pathway 183
13. Effects of HDACi on the Extrinsic Apoptosis Pathway 184
14. Effects of HDACi on DR and Their Ligands 184
15. Concluding Remarks 188
Acknowledgments 188
References 189
6. Histone Deacetylase Inhibitors and Rational Combination
Therapies 199
Steven Grant and Yun Dai
1. Introduction 201
2. Histone Deacetylases 201
3. Histone Deacetylase Inhibitors 202
4. Determinants of HDAC Inhibitor Lethality 202
5. HDACI Strategies in Cancer Therapy 212
6. Summary and Future Directions 223
Contents
vii
Acknowledgments 224
References 224
7. HDAC Inhibitors and Chaperone Function 239
Rekha Rao, Warren Fiskus, Siddhartha Ganguly, Suman Kambhampati,
and Kapil N. Bhalla
1. Introduction 240
2. HDAC Inhibitors 241
3. Chaperones and Protein Homeostasis 242
4. Regulation of Hsp90 Chaperone Function by Reversible Acetylation 243
5. HDAC3 is the Nuclear Hsp90 Deacetylase 250
6. HDAC Inhibitor-Mediated Regulation of Hsp70 250
7. HDAC Regulation of Hsp40 252
8. Regulation of GRP78 Function by HDAC6 252
9. Concluding Remarks 256
References 257
Index
263
|
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| indexdate | 2024-07-10T00:25:47Z |
| institution | BVB |
| isbn | 9780123943873 |
| language | English |
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| series2 | Advances in cancer research |
| spelling | Histone deacetylase inhibitors as cancer therapeutics ed. by Steven Grant Amsterdam [u.a.] Acad. Press 2012 XII, 270 S. Ill. txt rdacontent n rdamedia nc rdacarrier Advances in cancer research 116 Einzelaufn. für Zeitschr.-H. Grant, Steven Sonstige oth HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025372975&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Histone deacetylase inhibitors as cancer therapeutics |
| title | Histone deacetylase inhibitors as cancer therapeutics |
| title_auth | Histone deacetylase inhibitors as cancer therapeutics |
| title_exact_search | Histone deacetylase inhibitors as cancer therapeutics |
| title_full | Histone deacetylase inhibitors as cancer therapeutics ed. by Steven Grant |
| title_fullStr | Histone deacetylase inhibitors as cancer therapeutics ed. by Steven Grant |
| title_full_unstemmed | Histone deacetylase inhibitors as cancer therapeutics ed. by Steven Grant |
| title_short | Histone deacetylase inhibitors as cancer therapeutics |
| title_sort | histone deacetylase inhibitors as cancer therapeutics |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025372975&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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