miR-200 is a potent regulator of cancer progression by repressing EMT and stemness:
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Enth. außerdem 4 Sonderabdr. aus verschiedenen Zeitschr. |
| Physical Description: | 38, [45] S. Ill., graph. Darst. 30 cm |
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| adam_text | IMAGE 1
TABLE O F CONTENTS
I. LIST O F PUBLICATIONS 1
II. ZUSAMMENFASSUNG 3
III. SUMMARY 5
1 INTRODUCTION 7
1.1 CANCER 7
1.2 METASTASIS FORMATION 7
1.3 EPITHELIAL-MESENCHYMAL TRANSITION (EMT) 9
1.4 CANCER STEM CELLS - MIGRATING CANCER STEM CELLS 10
1.5 ZEB1 11
1.6 MICRORNAS: BIOGENESIS AND REGULATORY FUNCTION 13
1.7 THE MIR-200 FAMILY 15
1.8 OBJECTIVES O F THIS THESIS 16
2 DISCUSSION 17
2.1 RESULTS 17
2.1.1 ZEB1 REPRESSES MIR-200 FAMILY EXPRESSION 17
2.1.2 MIR-200 PROMOTES EPITHELIAL DIFFERENTIATION AND PREVENTS MIGRATION
AND INVASION 18
2.1.3 MIR-200 TARGETS EMT-INDUCING AND PROINVASIVE FACTORS 18
2.1.4 MIR-200C TARGETS STERNNESS ASSOCIATED FACTORS 2 0
2.1.5 MIR-200 TARGETS THE NOTCH SIGNALING PATHWAY 2 2
2.1.6 MIR-200 TARGETS SEVERAL COMPONENTS O F THE CTBP-COMPLEX 22
2.1.7 CLINICAL RELEVANCE: MIR-200 EXPRESSION IN BREAST AND PANCREATIC
CANCER 23
2.2 SUMMARY AND PERSPECTIVES 2 4
3 REFERENCES 2 8
4 APPENDIX 35
4.1 ABBREVIATIONS 35
4.2 ACKNOWLEDGEMENTS 36
4.3 CURRICULUM VITAE 37
4.4 ORIGINAL PUBLICATIONS 38
HTTP://D-NB.INFO/1025450256
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| spelling | Burk, Ulrike Christina 1981- Verfasser (DE-588)1024577376 aut miR-200 is a potent regulator of cancer progression by repressing EMT and stemness vorgelegt von Ulrike Christina Burk 2012 38, [45] S. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Enth. außerdem 4 Sonderabdr. aus verschiedenen Zeitschr. Freiburg (Breisgau), Univ., Diss., 2012 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025371016&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Burk, Ulrike Christina 1981- miR-200 is a potent regulator of cancer progression by repressing EMT and stemness |
| subject_GND | (DE-588)4113937-9 |
| title | miR-200 is a potent regulator of cancer progression by repressing EMT and stemness |
| title_auth | miR-200 is a potent regulator of cancer progression by repressing EMT and stemness |
| title_exact_search | miR-200 is a potent regulator of cancer progression by repressing EMT and stemness |
| title_full | miR-200 is a potent regulator of cancer progression by repressing EMT and stemness vorgelegt von Ulrike Christina Burk |
| title_fullStr | miR-200 is a potent regulator of cancer progression by repressing EMT and stemness vorgelegt von Ulrike Christina Burk |
| title_full_unstemmed | miR-200 is a potent regulator of cancer progression by repressing EMT and stemness vorgelegt von Ulrike Christina Burk |
| title_short | miR-200 is a potent regulator of cancer progression by repressing EMT and stemness |
| title_sort | mir 200 is a potent regulator of cancer progression by repressing emt and stemness |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025371016&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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