Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design:
Saved in:
| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | Volltext https://nbn-resolving.org/ urn:nbn:de:bvb:355-epub-265559 Inhaltsverzeichnis |
| Physical Description: | 87 Bl. Ill., graph. Darst. |
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| 245 | 1 | 0 | |a Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design |c vorgelegt von Linn Carstensen |
| 246 | 1 | 3 | |a Conservation of the folding mechanism between a thermostable (betaalpha)8-barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design |
| 264 | 1 | |c 2012 | |
| 300 | |a 87 Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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| 502 | |a Regensburg, Univ., Diss., 2012 | ||
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| 650 | 0 | 7 | |a Barrel |g alpha, beta- |0 (DE-588)4739602-7 |2 gnd |9 rswk-swf |
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Record in the Search Index
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| adam_text | IMAGE 1
INDEX OF CONTENTS
ABSTRACT 1
KURZFASSUNG DER ARBEIT 3
1 INTRODUCTION 5
1.1 PROTEIN STABILITY 5
1.2 PROTEINS FROM HYPERTHERMOPHILIC ORGANISMS SHOW AN INCREASED
STABILITY 6
1.3 PROTEIN FOLDING 7
1.4 NATURAL SELECTION FOR AN OPTIMAL ENERGY LANDSCAPE O F FOLDING 8
1.5 THE (PA)G-BARREL FOLD 8
1.6 EVOLUTION O F THE (PA)G-BARREL FOLD 10
1.6.1 DIVERGENT VERSUS CONVERGENT EVOLUTION O F (PA)G-BARREL PROTEINS 10
1.6.2 MIMICKING THE EVOLUTION O F THE (PA )8 -BARREL FOLD FROM A (PA )4
-HALF-BARREL 11
1.7 FOLDING MECHANISMS O F (PA)G-BARREL PROTEINS 14
1.8 AIM O F THIS WORK 14
2 SUMMARY AND DISCUSSION 16
2.1 STABILITY AND FOLDING O F HISF, SYML, AND SYM2 16
2.1.1 UNFOLDING EQUILIBRIUM O F HISF IS ATTAINED SLOWLY AND ADEQUATELY
DESCRIBED BY THE
TWO-STATE MODEL 16
2.1.2 THE DIFFERENT THERMODYNAMIC STABILITIES O F HISF, SYML, AND SYM2
ARE CAUSED BY
THEIR DIFFERENT UNFOLDING RATES 16
2.1.3 HISF FOLDS VIA A SEQUENTIAL MECHANISM 20
2.1.4 SYML AND SYM2 SHOW AN IDENTICAL FOLDING MECHANISM AS HISF 21
2.1.5 STRUCTURAL PROPERTIES O F THE REFOLDING INTERMEDIATES O F HISF,
SYML, AND SYM2 24
2.2 IMPLICATIONS FOR THE EVOLUTION O F (PA)8-BARRELS 29
2.2.1 THE FOLDING O F HISF RESEMBLES OTHER (PA)G-BARRELS 29
2.2.2 SYML AND SYM2 ARE MODELS FOR AN EVOLUTIONARY PRECURSOR O F HISF 30
2.3 COMPARISON WITH THE FOLDING MECHANISM O F OTHER CHARACTERIZED
PROTEINS 31
3 ABBREVIATIONS 32
HTTP://D-NB.INFO/1029897085
IMAGE 2
4 LITERATURE 35
5 LIST OF PUBLICATIONS 43
6 PERSONAL CONTRIBUTION 44
7 PUBLICATIONS 45
PUBLICATION A 45
PUBLICATION B 63
|
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| discipline | Biologie |
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| spelling | Carstensen, Linn Verfasser aut Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design vorgelegt von Linn Carstensen Conservation of the folding mechanism between a thermostable (betaalpha)8-barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design 2012 87 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Regensburg, Univ., Diss., 2012 Evolution (DE-588)4071050-6 gnd rswk-swf Proteinfaltung (DE-588)4324567-5 gnd rswk-swf Barrel alpha, beta- (DE-588)4739602-7 gnd rswk-swf Temperaturbeständigkeit (DE-588)4184690-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Barrel alpha, beta- (DE-588)4739602-7 s Temperaturbeständigkeit (DE-588)4184690-4 s Proteinfaltung (DE-588)4324567-5 s Evolution (DE-588)4071050-6 s b DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:355-epub-265559 http://epub.uni-regensburg.de/26555/ Verlag kostenfrei Volltext https://nbn-resolving.org/ urn:nbn:de:bvb:355-epub-265559 Resolving-System DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025365011&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Carstensen, Linn Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design Evolution (DE-588)4071050-6 gnd Proteinfaltung (DE-588)4324567-5 gnd Barrel alpha, beta- (DE-588)4739602-7 gnd Temperaturbeständigkeit (DE-588)4184690-4 gnd |
| subject_GND | (DE-588)4071050-6 (DE-588)4324567-5 (DE-588)4739602-7 (DE-588)4184690-4 (DE-588)4113937-9 |
| title | Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design |
| title_alt | Conservation of the folding mechanism between a thermostable (betaalpha)8-barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design |
| title_auth | Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design |
| title_exact_search | Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design |
| title_full | Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design vorgelegt von Linn Carstensen |
| title_fullStr | Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design vorgelegt von Linn Carstensen |
| title_full_unstemmed | Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design vorgelegt von Linn Carstensen |
| title_short | Conservation of the folding mechanism between a thermostable (betaalpha) 8 -barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design |
| title_sort | conservation of the folding mechanism between a thermostable betaalpha 8 barrel enzyme its evolutionary relatives and ancestral precursors generated by protein design |
| topic | Evolution (DE-588)4071050-6 gnd Proteinfaltung (DE-588)4324567-5 gnd Barrel alpha, beta- (DE-588)4739602-7 gnd Temperaturbeständigkeit (DE-588)4184690-4 gnd |
| topic_facet | Evolution Proteinfaltung Barrel alpha, beta- Temperaturbeständigkeit Hochschulschrift |
| url | http://epub.uni-regensburg.de/26555/ https://nbn-resolving.org/ urn:nbn:de:bvb:355-epub-265559 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025365011&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT carstensenlinn conservationofthefoldingmechanismbetweenathermostablebetaalpha8barrelenzymeitsevolutionaryrelativesandancestralprecursorsgeneratedbyproteindesign |