Bioactive heterocyclic compound classes: [2] Pharmaceuticals
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Weinheim
Wiley-VCH
2012
|
| Online-Zugang: | Inhaltstext Inhaltsverzeichnis |
| Beschreibung: | XV, 356 S. graph. Darst. 240 mm x 170 mm |
| ISBN: | 3527333959 9783527333950 9783527664450 |
Internformat
MARC
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| 245 | 1 | 0 | |a Bioactive heterocyclic compound classes |n [2] |p Pharmaceuticals |c ed. by Clemens Lamberth and Jürgen Dinges |
| 264 | 1 | |a Weinheim |b Wiley-VCH |c 2012 | |
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| 336 | |b txt |2 rdacontent | ||
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| 700 | 1 | |a Lamberth, Clemens |e Sonstige |0 (DE-588)102697433X |4 oth | |
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Datensatz im Suchindex
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IMAGE 1
CONTENTS
PREFACE XI LIST OF CONTRIBUTORS XIII
INTRODUCTION 1
1 THE SIGNIFICANCE O F HETEROCYDES FOR PHARMACEUTICALS AND AGROCHEMICALS
3 CLEMENS LAMBERTH AND JIIRGEN DINGES
1.1 INTRODUCTION 3
1.2 HETEROCYCLES AS FRAMEWORK OF BIOLOGICALLY ACTIVE COMPOUNDS 4 1.3
FINE-TUNING THE PHYSICOCHEMICAL PROPERTIES WITH HETEROCYCLES 6 1.4
HETEROCYCLES AS PRODRUGS 6
1.5 HETEROCYCLES AS PEPTIDOMIMETICS 7 1.6 HETEROCYCLES AS ISOSTERIC
REPLACEMENT O F FUNCTIONAL GROUPS 8 1.7 HETEROCYCLES AS ISOSTERIC
REPLACEMENT O F ALICYCLIC RINGS 11 1.8 HETEROCYCLES AS ISOSTERIC
REPLACEMENT OF OTHER HETEROCYCLIC RINGS 13
REFERENCES 16
PART I NEUROLOGICAL DISORDERS 21
2 TROPANE-BASED ALKALOIDS AS MUSCARINIC ANTAGONISTS FOR THE TREATMENT OF
ASTHMA, OBSTRUCTIVE PULMONARY DISEASE, AND MOTION SICKNESS 23 MICHAEL L.
SCHULTE AND CRAIG W. LINDSLEY 2.1 INTRODUCTION 23
2.2 HISTORY 23
2.3 SYNTHESIS 25
2.4 MODE OF ACTION 29
2.5 STRUCTURE-ACTIVITY RELATIONSHIPS 32 REFERENCES 34
HTTP://D-NB.INFO/1020848324
IMAGE 2
VI | CONTENTS
3 MORPHINONE-BASED OPIOID RECEPTOR AGONIST ANALGESICS 37
STEPHANIE M. NG
3.1 INTRODUCTION 37
3.2 HISTORY 37
3.3 SYNTHESIS 40
3.4 MODE O F ACTION 43
3.5 STRUCTURE-ACTIVITY RELATIONSHIP 44 REFERENCES 48
4 BARBITURIC ACID-BASED CABA(A) RECEPTOR MODULATORS FOR THE TREATMENT O
F SLEEP DISORDER AND EPILEPSY AND AS ANESTHETICS 51 INGO JANSER AND ROMY
JANSER
4.1 INTRODUCTION 51
4.2 HISTORY 52
4.2.1 BARBITURATES IN THE TREATMENT O F SLEEP DISORDERS 55 4.2.2
BARBITURATES IN THE TREATMENT O F EPILEPSY 55 4.2.3 BARBITURATES AS
ANESTHETICS 56 4.3 SYNTHESIS 57
4.4 MODE O F ACTION 60
4.5 STRUCTURE-ACTIVITY RELATIONSHIP 62 4.5.1 5,5-DISUBSTITUTION 62 4.5.2
SUBSTITUTION AT THE NITROGENS 63 REFERENCES 63
5 PHENOTHIAZINE-BASED DOPAMINE D 2 ANTAGONISTS FOR THE TREATMENT O F
SCHIZOPHRENIA 65 CRISTIANA A. ZAHARIA
5.1 INTRODUCTION 65
5.2 HISTORY 65
5.3 SYNTHESIS 70
5.4 MODE OF ACTION 72
5.5 STRUCTURE-ACTIVITY RELATIONSHIPS 76 REFERENCES 77
6 ARYLPIPERAZINE-BASED 5-HT-|A RECEPTOR PARTIAL AGONISTS AND 5-HT2A
ANTAGONISTS FOR THE TREATMENT O F AUTISM, DEPRESSION, ANXIETY,
PSYCHOSIS, AND SCHIZOPHRENIA 81 IRINI AKRITOPOULOU-ZANZE 6.1
INTRODUCTION 81
6.2 HISTORY 81
6.3 SYNTHESIS 85
6.4 MODE O F ACTION 88
6.5 STRUCTURE-ACTIVITY RELATIONSHIP 89 REFERENCES 96
IMAGE 3
CONTENTS VIL
7 ARYLPIPERIDINE-BASED DOPAMINE D 2 ANTAGONISTS/5-HTJ^ ANTAGONISTS FOR
THE TREATMENT O F AUTISM, DEPRESSION, SCHIZOPHRENIA, AND BIPOLAR
DISORDER 99 YING WANG
7.1 INTRODUCTION 99
7.2 HISTORY 99
7.3 SYNTHESIS 106
7.4 MODE O F ACTION 109
7.5 STRUCTURE-ACTIVITY RELATIONSHIP 111 REFERENCES 113
8 DIBENZAZEPINE-BASED SODIUM CHANNEL BLOCKERS FOR THE TREATMENT O F
NEUROPATHIC PAIN 115 DEREK W. NELSON 8.1 INTRODUCTION 115
8.2 HISTORY 115
8.3 SYNTHESIS 119
8.4 MODE O F ACTION 124
8.5 STRUCTURE-ACTIVITY RELATIONSHIPS 128 REFERENCES 130
PART II CARDIOVASCULAR DISEASES 135
9 DIHYDROPYRIDINE-BASED CALCIUM CHANNEL BLOCKERS FOR THE TREATMENT OF
ANGINA PECTORIS AND HYPERTENSION 137 MILAN BRUNCKO 9.1 INTRODUCTION 137
9.2 HISTORY 139
9.3 SYNTHESIS 141
9.4 MODE OF ACTION 144
9.5 STRUCTURE-ACTIVITY RELATIONSHIP 148 REFERENCES 149
10 TETRAZOLE-BASED ANGIOTENSIN II TYPE 1 (AT N ) ANTAGONISTS FOR THE
TREATMENT OF HEART FAILURE AND CONGESTIVE HYPERTENSION 153 EDWARD C.
LAWSON, BRIAN C. SHOOK, AND JAMES C. LANTER 10.1 INTRODUCTION 153
10.2 HISTORY 154
10.3 SYNTHESIS 157
10.4 MODE O F ACTION 159
10.5 STRUCTURE-ACTIVITY RELATIONSHIP 161 REFERENCES 163
IMAGE 4
V I I I I CONTENTS
11 THIAZIDE-BASED DIURETICS FOR THE TREATMENT O F HYPERTENSION
AND GENITOURINARY DISORDERS 169 JIIRGEN DINGES 11.1 INTRODUCTION 169
11.2 HISTORY 169
11.3 SYNTHESIS 174
11.4 MODE O F ACTION 177
11.5 STRUCTURE-ACTIVITY RELATIONSHIP 179 REFERENCES 180
12 TETRAHYDROPYRANONE-BASED HMG-COA REDUCTASE INHIBITORS FOR THE
TREATMENT O F ARTERIAL HYPERCHOLESTEROLEMIA 183 HONGYU ZHAO 12.1
INTRODUCTION 183
12.2 HISTORY 183
12.3 SYNTHESIS 188
12.4 MODE O F ACTION 191
12.5 STRUCTURE-ACTIVITY RELATIONSHIP 192 12.5.1 THE HYDROPHILIC
DIHYDROXYPENTANOIC ACID PORTION 192 12.5.2 THE SAR O F NATURAL STATINS
192
12.5.3 SAR O F SYNTHETIC STATINS 195 12.5.4 LIVER-SELECTIVE HMGCOA
INHIBITORS 197 12.5.5 X-RAY CRYSTAL STRUCTURES 197 REFERENCES 198
PART III INFECTIOUS DISEASES 201
13 ADENINE-BASED REVERSE TRANSCRIPTASE INHIBITORS AS ANTI-HIV AGENTS 203
ALASTAIR DONALD 13.1 INTRODUCTION 203
13.2 HISTORY 203
13.3 SYNTHESIS 209
13.4 MODE O F ACTION 212
13.5 STRUCTURE-ACTIVITY RELATIONSHIP 212 REFERENCES 214
14 GUANINE-BASED NUCLEOSIDE ANALOGS AS ANTIVIRAL AGENTS 217 MAURIZIO
FRANZINI 14.1 INTRODUCTION 217
14.2 HISTORY 219
14.3 SYNTHESIS 221
14.4 MODE O F ACTION 227
14.5 STRUCTURE-ACTIVITY RELATIONSHIP 229 REFERENCES 232
IMAGE 5
CONTENTS IIX
15 PENICILLIN AND CEPHALOSPORIN ANTIBIOTICS 237
MICHAEL Z. HOEMANN 15.1 INTRODUCTION 237
15.2 HISTORY 237
15.3 SYNTHESIS 239
15.3.1 TOTAL SYNTHESES 239 15.3.2 CORE MODIFICATIONS 243 15.4 MODE OF
ACTION 248
15.5 STRUCTURE-ACTIVITY RELATIONSHIPS 250 REFERENCES 251
PART IV ONCOLOGY 255
16 PYRIMIDINE-BASED KINASE INHIBITORS IN CANCER CHEMOTHERAPY 257 ROBERT
MAH 16.1 INTRODUCTION 257
16.2 HISTORY 257
16.3 SYNTHESIS 261
16.4 MODE O F ACTION 264
16.5 STRUCTURE-ACTIVITY RELATIONSHIP 266 REFERENCES 269
17 BENZYL TRIAZOLE-BASED AROMATASE INHIBITORS FOR THE TREATMENT O F
BREAST CANCER 275 DAWN GEORGE AND STACY VAN EPPS 17.1 INTRODUCTION 275
17.2 HISTORY 275
17.3 SYNTHESIS 277
17.4 MODE O F ACTION 281
17.5 STRUCTURE-ACTIVITY RELATIONSHIP 282 REFERENCES 286
PARTV INFLAMMATION AND GASTROINTESTINAL DISEASES 289
18 ACETONIDE-BASED GLUCOCORTICOIDS FOR THE TREATMENT O F ASTHMA, SKIN
INFLAMMATION, AND DISEASES O F THE EYE 291 KEVIN P. CUSACK, VIKRAM G.
KALTHOD, RAJARATHNAM E. REDDY, AND SANJAY R. CHEMBURKAR 18.1
INTRODUCTION 291
18.2 HISTORY 293
18.3 SYNTHESIS 297
18.4 MODE O F ACTION 304
18.4.1 ASTHMA 306
18.4.2 SKIN INFLAMMATION 307 18.4.3 EYE DISEASE 307
IMAGE 6
X | CONTENTS
18.5 STRUCTURE-ACTIVITY RELATIONSHIP 308
REFERENCES 311
19 BENZIMIDAZOLE-BASED H + /K + -ATPASE INHIBITORS FOR THE TREATMENT O F
GASTROESOPHAGEAL REFLUX DISEASE 313 STEVE SWANN 19.1 INTRODUCTION 313
19.2 HISTORY 313
19.3 SYNTHESIS 316
19.4 MODE O F ACTION 319
19.5 STRUCTURE-ACTIVITY RELATIONSHIPS 320 REFERENCES 324
PART VI METABOLIC DISEASES 327
20 THIAZOLIDINEDIONE-BASED INSULIN SENSITIZERS:PPAR-Y AGONISTS FOR THE
TREATMENT O F TYPE 2 DIABETES 329 STEVEN RICHARDS 20.1 INTRODUCTION 329
20.2 HISTORY 329
20.3 SYNTHESIS 337
20.4 MODE O F ACTION 343
20.5 STRUCTURE-ACTIVITY RELATIONSHIP 344 REFERENCES 345
INDEX 349 |
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| spelling | Bioactive heterocyclic compound classes [2] Pharmaceuticals ed. by Clemens Lamberth and Jürgen Dinges Weinheim Wiley-VCH 2012 XV, 356 S. graph. Darst. 240 mm x 170 mm txt rdacontent n rdamedia nc rdacarrier Lamberth, Clemens Sonstige (DE-588)102697433X oth Dinges, Jürgen 1961- Sonstige (DE-588)172677157 oth (DE-604)BV040506627 2 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-66447-4 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-66446-7 Erscheint auch als Online-Ausgabe, PDF 978-3-527-66448-1 text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3994902&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025353285&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Bioactive heterocyclic compound classes |
| title | Bioactive heterocyclic compound classes |
| title_auth | Bioactive heterocyclic compound classes |
| title_exact_search | Bioactive heterocyclic compound classes |
| title_full | Bioactive heterocyclic compound classes [2] Pharmaceuticals ed. by Clemens Lamberth and Jürgen Dinges |
| title_fullStr | Bioactive heterocyclic compound classes [2] Pharmaceuticals ed. by Clemens Lamberth and Jürgen Dinges |
| title_full_unstemmed | Bioactive heterocyclic compound classes [2] Pharmaceuticals ed. by Clemens Lamberth and Jürgen Dinges |
| title_short | Bioactive heterocyclic compound classes |
| title_sort | bioactive heterocyclic compound classes pharmaceuticals |
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