Influence of natural food compounds on DNA stability:
Saved in:
| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2012
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| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis |
| Item Description: | Zsfassung in dt. und engl. Sprache |
| Physical Description: | 119 Bl. Ill., graph. Darst. |
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| 100 | 1 | |a Glaser, Nina |d 1983- |e Verfasser |0 (DE-588)1026932556 |4 aut | |
| 245 | 1 | 0 | |a Influence of natural food compounds on DNA stability |c von Nina Glaser |
| 246 | 1 | 3 | |a Einfluss natürlicher Nahrungsbestandteile auf die DNA Stabilität |
| 264 | 1 | |c 2012 | |
| 300 | |a 119 Bl. |b Ill., graph. Darst. | ||
| 336 | |b txt |2 rdacontent | ||
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Record in the Search Index
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| adam_text | IMAGE 1
TABLE OF CONTENTS
ABBREVIATIONS 1
1 INTRODUCTION 3
1.1 DNA DAMAGE 3
1.2 OXIDATIVE STRESS 4
1.3 GSH 5
1.4 NATURAL FOOD COMPOUNDS 6
PART I: INFLUENCE OF PATULIN AND RESVERATROL ON DNA STABILITY 7 1.4.1
PATULIN 7 1.4.1.1 GENERAL ASPECTS 7
1.4.1.2 SOURCES AND IMPACT 7
1.4.1.3 KINETICS 8
1.4.1.4 ACUTE AND CHRONICAL TOXICITY 9
1.4.1.5 GENOTOXICITY 10
1.4.2 RESVERATROL 11
1.4.2.1 GENERAL ASPECTS 11
1.4.2.2 SOURCES AND IMPACT 11
1.4.2.3 KINETICS 72
1.4.2.4 HEALTH PROMOTING EFFECTS 12
1.5 PART II : EFFECTS OF AN ANTHOCYANIN RICH EXCTRACT ON HYPERTENSIVE
RATS 14
1.5.1 GENERAL ASPECTS OF ANTHOCYANINS 14
1.5.2 KINETIC 15 1.5.3 ACUTE AND CHRONIC TOXICITY 16
1.5.4 HEALTH-PROMOTING PROPERTIES 17
1.5.5 DACAPO EXTRACT 18
1.5.6 RENIN-ANGIOTENSIN SYSTEM 18
1.5.7 REN-2 RATS 19
1.6 OBJECTIVES 21
2 EXPERIMENTAL PROCEDURES 23
2.1 PART I: INFLUENCE OF PATULIN AND RESVERATROL ON DNA STABILITY 23
2.1.1 MATERIALS 23
2.1.2 CELL CULTURE 23
2.1.3 VIABILITY ASSAY 24
2.1.4 MICRONUCLEUS ASSAY 24
2.1.5 KINETOCHORE-STAINING 26
2.1.6 COMET ASSAY 27
2.1.8 GSH 30
2.1.9 DCF ! 30
2.1.10 FRAP ASSAY 31
2.1.11 CELL CYCLE ANALYSIS 32
HTTP://D-NB.INFO/1026932726
IMAGE 2
2.2 PART II: EFFECTS OF AN ANTHOCYANIN RICH EXCTRACT ON
HYPERTENSIVE RATS 33
2.2.1 EXPERIMENTAL PROCEDURE 33
2.2.2 COMET ASSAY 35
2.2.3 Y - H 2 A X - S T A I N I N G 36
2.2.4 DHE-STAINING 39
2.2.5 FRAP ANALYSIS 40
2.3 STATISTIC 40
3 RESULTS 41
3.1 PART I: INFLUENCE OF PATULIN AND RESVERATROL ON DNA STABILITY 41
3.1.1 VIABILITY ASSAY AFTER PATULIN TREATMENT 41
3.1.2 INFLUENCE OF PATULIN IN MICRONUCLEUS ASSAY 41
3.1.3 INFLUENCE OF GSH ON PATULIN-INDUCED MICRONUCLEI AND NUCLEOPLASMS
BRIDGES 42 3.1.4 KINETOCHORE ANALYSIS OF PATULIN-INDUCED MICRONUCLEI 44
3.1.5 TIME COURSE OF NPB FORMATION AFTER PATULIN TREATMENT 44
3.1.6 INFLUENCE OF PATULIN IN A MODIFIED VERSION OF COMET ASSAY 45
3.1.7 EFFECTS OF PATULIN ON TUBULIN 46
3.1.8 COMET ASSAY WITH PATULIN 51
3.1.9 INFLUENCE OF GSH IN COMET ASSAY 52
3.1.10 OXIDATIVE STRESS MEASUREMENT AFTER PATULIN TREATMENT 53
3.1.11 CELLULAR GSH LEVEL AFTER PATULIN TREATMENT 54
3.1.12 EFFECTS OF RESVERATROL ON PATULIN-INDUCED MICRONUCLEUS FORMATION
56 3.1.13 KINETOCHORE ANALYSIS OF RESVERATROL-INDUCED MICRONUCLEI 56
3.1.14 VIABILITY AFTER RESVERATROL TREATMENT 57
3.1.15 FRAP ASSAY WITH RESVERATROL 58
3.1.16 OXIDATIVE STRESS AFTER RESVERATROL TREATMENT 59
3.1.17 CELLULAR GSH LEVEL AFTER RESVERATROL TREATMENT 60
3.2 PART II: EFFECTS OF AN ANTHOCYANINS RICH EXCTRACT ON HYPERTENSIVE
RATS 62
3.2.1 GENERAL PHYSICAL CONDITIONS 62
3.2.2 BLOOD PRESSURE 64
3.2.3 COMET ASSAY 66
3.2.4 Y-H2AX-STAINING 68
3.2.5 DHE-STAINING 71
3.2.6 FRAP EXTRACT 73
3.2.7 PLASMA ANTIOXIDANT CAPACITY ASSESSED BY THE FRAP ASSAY 73
4 DISCUSSION 75
4.1 PART I: INFLUENCE OF PATULIN AND RESVERATROL ON DNA STABILITY 75
4.2 PART II: EFFECTS OF AN ANTHOCYANINS RICH EXCTRACT ON HYPERTENSIVE
RATS 84
5 SUMMARY 93
IMAGE 3
6 ZUSAMMENFASSUNG 95
7 REFERENCES 98
8 ACKNOWLEDGEMENT 115
9 CURRICULUM VITAE 116
10 AFFIDAVIT 119
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| spelling | Glaser, Nina 1983- Verfasser (DE-588)1026932556 aut Influence of natural food compounds on DNA stability von Nina Glaser Einfluss natürlicher Nahrungsbestandteile auf die DNA Stabilität 2012 119 Bl. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Zsfassung in dt. und engl. Sprache Würzburg, Univ., Diss., 2012 Mutagenität (DE-588)4120777-4 gnd rswk-swf Anthocyane (DE-588)4142621-6 gnd rswk-swf Oxidativer Stress (DE-588)4353497-1 gnd rswk-swf Patulin (DE-588)4316069-4 gnd rswk-swf Resveratrol (DE-588)4392967-9 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Patulin (DE-588)4316069-4 s Anthocyane (DE-588)4142621-6 s Resveratrol (DE-588)4392967-9 s Mutagenität (DE-588)4120777-4 s Oxidativer Stress (DE-588)4353497-1 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:20-opus-72872 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-72872 Resolving-System kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025348893&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Glaser, Nina 1983- Influence of natural food compounds on DNA stability Mutagenität (DE-588)4120777-4 gnd Anthocyane (DE-588)4142621-6 gnd Oxidativer Stress (DE-588)4353497-1 gnd Patulin (DE-588)4316069-4 gnd Resveratrol (DE-588)4392967-9 gnd |
| subject_GND | (DE-588)4120777-4 (DE-588)4142621-6 (DE-588)4353497-1 (DE-588)4316069-4 (DE-588)4392967-9 (DE-588)4113937-9 |
| title | Influence of natural food compounds on DNA stability |
| title_alt | Einfluss natürlicher Nahrungsbestandteile auf die DNA Stabilität |
| title_auth | Influence of natural food compounds on DNA stability |
| title_exact_search | Influence of natural food compounds on DNA stability |
| title_full | Influence of natural food compounds on DNA stability von Nina Glaser |
| title_fullStr | Influence of natural food compounds on DNA stability von Nina Glaser |
| title_full_unstemmed | Influence of natural food compounds on DNA stability von Nina Glaser |
| title_short | Influence of natural food compounds on DNA stability |
| title_sort | influence of natural food compounds on dna stability |
| topic | Mutagenität (DE-588)4120777-4 gnd Anthocyane (DE-588)4142621-6 gnd Oxidativer Stress (DE-588)4353497-1 gnd Patulin (DE-588)4316069-4 gnd Resveratrol (DE-588)4392967-9 gnd |
| topic_facet | Mutagenität Anthocyane Oxidativer Stress Patulin Resveratrol Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-72872 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025348893&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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