Modern methods in crop protection research:
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| Format: | Buch |
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2012
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| Beschreibung: | XXII, 420 S. Ill., graph. Darst. 240 mm x 170 mm |
| ISBN: | 3527331751 9783527331758 |
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| 245 | 1 | 0 | |a Modern methods in crop protection research |c ed. by Peter Jeschke ... |
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IMAGE 1
CONTENTS
PREFACE XV
LIST O F CONTRIBUTORS XIX
PART I METHODS FOR T H E DESIGN AND OPTIMIZATION O F NEW ACTIVE
INGREDIENTS 1
1 HIGH-THROUGHPUT SCREENING IN AGROCHEMICAL RESEARCH 3
MARK DREWES, KLAUS TIETJEN, AND THOMAS C. SPARKS
1.1 INTRODUCTION 3
1.2 TARGET-BASED HIGH-THROUGHPUT SCREENING 6
1.2.1 TARGETS 6
1.2.2 HIGH-THROUGHPUT SCREENING TECHNIQUES 9
1.3 OTHER SCREENING APPROACHES 13
1.3.1 HIGH-THROUGHPUT VIRTUAL SCREENING 13
1.4 IN VIVO HIGH-THROUGHPUT SCREENING 13
1.4.1 COMPOUND SOURCING A N D IN-SILICO SCREENING 15 1.5 CONCLUSIONS 17
ACKNOWLEDGMENTS 18 REFERENCES 18
2 COMPUTATIONAL APPROACHES IN AGRICULTURAL RESEARCH 21
KLAUS-JIIRGEN SCHLEIFER
2.1 INTRODUCTION 21
2.2 RESEARCH STRATEGIES 21
2.3 LIGAND-BASED APPROACHES 22
2.4 STRUCTURE-BASED APPROACHES 26
2.5 ESTIMATION O F ADVERSE EFFECTS 33
2.6 IN-SILICO TOXICOLOGY 34
2.7 PROGRAMS A N D DATABASES 34
2.7.1 IN-SILICO TOXICOLOGY MODELS 36
HTTP://D-NB.INFO/1020848251
IMAGE 2
V I I CONTENTS
2.8 CONCLUSION 3 9
REFERENCES 40
3 QUANTUM CHEMICAL METHODS IN T H E DESIGN O F AGROCHEMICALS 43
MICHAEL SCHINDLER
3.1 INTRODUCTION 43
3.2 COMPUTATIONAL Q U A N T U M CHEMISTRY: BASICS, CHALLENGES, A N D NEW
DEVELOPMENTS 4 4 3.3 M I N I M U M ENERGY STRUCTURES A N D POTENTIAL
ENERGY SURFACES 4 7
3.4 PHYSICO-CHEMICAL PROPERTIES 51
3.4.1 ELECTROSTATIC POTENTIAL, FUKUI FUNCTIONS, A N D FRONTIER ORBITALS
53 3.4.2 MAGNETIC PROPERTIES 5 5
3.4.3 PKA VALUES 5 7
3.4.4 SOLVATION FREE ENERGIES 59
3.4.5 ABSOLUTE CONFIGURATION O F CHIRAL MOLECULES 60 3.5 QUANTITATIVE
STRUCTURE-ACTIVITY RELATIONSHIPS 60 3.5.1 PROPERTY FIELDS, WAVELETS, A N
D MULTI-RESOLUTION ANALYSIS 61 3.5.2 THE COMFA STEROID DATASET 63
3.5.3 A NEONICOTINOID DATASET 64
3.6 OUDOOK 66
REFERENCES 67
4 THE UNIQUE ROLE O F HALOGEN SUBSTITUENTS IN T H E DESIGN
O F MODERN CROP PROTECTION COMPOUNDS 73 PETER JESCHKE
4.1 INTRODUCTION 73
4.2 THE HALOGEN SUBSTITUENT EFFECT 75
4.2.1 THE STERIC EFFECT 76
4.2.2 THE ELECTRONIC EFFECT 78
4.2.2.1 ELECTRONEGATIVITIES O F HALOGENS A N D SELECTED ELEMENTS/GROUPS
O N THE PAULING SCALE 78 4.2.2.2 EFFECT O F HALOGEN POLARITY O F THE C -
H A L O G E N BOND 79 4.2.2.3 EFFECT O F HALOGENS O N PKA VALUE 79
4.2.2.4 IMPROVING METABOLIC, OXIDATIVE, A N D THERMAL STABILITY
WITH HALOGENS 80
4.2.3 EFFECT O F HALOGENS O N PHYSICO-CHEMICAL PROPERTIES 82 4.2.3.1
EFFECT O F HALOGENS O N MOLECULAR LIPOPHILICITY 8 2 4.2.3.2
CLASSIFICATION I N THE DISJOINT PRINCIPLE SPACE 84 4.2.4 EFFECT O F
HALOGENS O N SHIFT O F BIOLOGICAL ACTIVITY 84 4.3 INSECTICIDES A N D
ACARICIDES CONTAINING HALOGENS 86
4.3.1 VOLTAGE-GATED SODIUM CHANNEL (VGSCH) MODULATORS 86 4.3.1.1
PYRETHROIDS O F TYPE A 86
4.3.1.2 PYRETHROIDS O F TYPE B 89
IMAGE 3
CONTENTS I V I I
4.3.1.3 PYRETHROIDS O F TYPE C 90
4.3.2 VOLTAGE-GATED SODIUM CHANNEL (VGSCH) BLOCKERS 90 4.3.3 INHIBITORS
O F THE Y-AMINOBUTYRIC ACID (GABA) RECEPTOR/CHLORIDE IONOPHORE COMPLEX
91 4.3.4 INSECT GROWTH REGULATORS (IGRS) 93
4.3.5 MITOCHONDRIAL RESPIRATORY CHAIN 96
4.3.5.1 INHIBITORS O F MITOCHONDRIAL ELECTRON TRANSPORT AT COMPLEX I 96
4.3.5.2 INHIBITORS O F Q 0 SITE O F CYTOCHROME B C L - COMPLEX III 97
4.3.5.3 INHIBITORS O F MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION 97 4.3.6
RYANODINE RECEPTOR (RYR) EFFECTORS 98 4.4 FUNGICIDES CONTAINING HALOGENS
99
4.4.1 STEROL BIOSYNTHESIS INHIBITORS (SBIS) A N D DEMETHYLATION
INHIBITORS (DMIS) 99
4.4.2 MITOCHONDRIAL RESPIRATORY CHAIN 101
4.4.2.1 INHIBITORS O F SUCCINATE DEHYDROGENASE (SDH) - COMPLEX II 101
4.4.2.2 INHIBITORS O F Q 0 SITE O F CYTOCHROME B C L - COMPLEX III 104
4.4.2.3 NADH INHIBITORS - COMPLEX I 107
4.4.3 FUNGICIDES ACTING O N SIGNAL TRANSDUCTION 107 4.5 PLANT GROWTH
REGULATORS (PGRS) CONTAINING HALOGENS 108 4.5.1 REDUCTION O F INTERNODE
ELONGATION: INHIBITION O F GIBBERELLIN BIOSYNTHESIS 108
4.6 HERBICIDES CONTAINING HALOGENS 109
4.6.1 INHIBITORS O F CAROTENOID BIOSYNTHESIS: PHYTOENE DESATURASE (PDS)
INHIBITORS 109 4.6.2 INHIBITORS O F ACETOLACTATE SYNTHASE (ALS) 111
4.6.2.1 SULFONYLUREA HERBICIDES 111 4.6.2.2
SULFONYLAMINOCARBONYL-TRIAZOLONE HERBICIDES (SACTS) 115
4.6.2.3 TRIAZOLOPYRIMIDINE HERBICIDES 116 4.6.3 PROTOPORPHYRINOGEN IX
OXIDASE (PPO) 117 4.7 SUMMARY A N D OUTLOOK 119
REFERENCES 119
PART II NEW METHODS TO IDENTIFY T H E MODE O F ACTION O F ACTIVE
INGREDIENTS 129
5 RNA INTERFERENCE (RNAI) FOR FUNCTIONAL GENOMICS STUDIES AND AS A TOOL
FOR CROP PROTECTION 131 BERND ESSIGMANN, ERIC PAGET, AND FREDERIC
SCHMITT
5.1 INTRODUCTION 131
5.2 RNA SILENCING PATHWAYS 131
5.2.1 THE MICRORNA (MIRNA) PATHWAY 133 5.2.2 THE SMALL INTERFERING
PATHWAY (SIRNA) 134 5.3 RNAI AS A TOOL FOR FUNCTIONAL GENOMICS I N
PLANTS 134
IMAGE 4
V I I I I CONTENTS
5.4 RNAI AS A TOOL FOR ENGINEERING RESISTANCE AGAINST FUNGI
A N D OOMYCETES 138
5.5 RNAI AS A TOOL FOR ENGINEERING INSECT RESISTANCE 140
5.6 RNAI AS A TOOL FOR ENGINEERING NEMATODES RESISTANCE 142
5.7 RNAI AS A TOOL FOR ENGINEERING VIRUS RESISTANCE 144
5.8 RNAI AS A TOOL FOR ENGINEERING BACTERIA RESISTANCE 149
5.9 RNAI AS A TOOL FOR ENGINEERING PARASITIC WEED RESISTANCE 150 5.10
RNAI SAFETY I N CROP PLANTS 153
5.11 SUMMARY A N D OUTLOOK 153
REFERENCES 153
6 FAST IDENTIFICATION O F T H E MODE O F ACTION O F HERBICIDES
BY DNA CHIPS 161 PETER ECLCES AND MARCO BUSCH
6.1 INTRODUCTION 161
6.2 GENE EXPRESSION PROFILING: A METHOD TO MEASURE CHANGES O F THE
COMPLETE TRANSCRIPTOME 162 6.3 CLASSIFICATION O F THE MODE O F ACTION O
F A N HERBICIDE 164
6.4 IDENTIFICATION O F PRODRUGS BY GENE EXPRESSION PROFILING 165 6.5
ANALYZING THE AFFECTED METABOLIC PATHWAYS 169
6.6 GENE EXPRESSION PROFILING: PART O F A TOOLBOX FOR MODE O F ACTION
DETERMINATION 171 REFERENCES 172
7 MODERN APPROACHES FOR ELUCIDATING T H E MODE O F ACTION O F
NEUROMUSCULAR INSECTICIDES 175 DANIEL CORDOVA
7.1 INTRODUCTION 175
7.2 BIOCHEMICAL A N D ELECTROPHYSIOLOGICAL APPROACHES 176 7.2.1
BIOCHEMICAL STUDIES 176
7.2.2 ELECTROPHYSIOLOGICAL STUDIES O N NATIVE A N D EXPRESSED TARGETS
179 7.2.2.1 WHOLE-CELL VOLTAGE CLAMP STUDIES 179 7.2.2.2 OOCYTE
EXPRESSION STUDIES 180 7.2.3 AUTOMATED TWO-ELECTRODE VOLTAGE-CLAMP TEVC
RECORDING
PLATFORMS 182
7.3 FLUORESCENCE-BASED APPROACHES FOR MODE O F ACTION ELUCIDATION 183
7.3.1 CALCIUM-SENSITIVE PROBES 183
7.3.2 VOLTAGE-SENSITIVE PROBES 186
7.4 GENOMIC APPROACHES FOR TARGET SITE ELUCIDATION 187
7.4.1 CHEMICAL-TO-GENE SCREENING 187
7.4.2 DOUBLE-STRANDED RNA INTERFERENCE 190 7.4.3 METABOLOMICS 191
IMAGE 5
CONTENTS I I X
7.5 CONCLUSION 191
REFERENCES 192
8 NEW TARGETS FOR FUNGICIDES 197
KLAUS TIETJEN AND PETER H. SCHREIER
8.1 INTRODUCTION: CURRENT FUNGICIDE TARGETS 197
8.2 A RETROSPECTIVE LOOK AT THE DISCOVERY O F TARGETS FOR FUNGICIDES 199
8.3 NEW SOURCES FOR NEW FUNGICIDE TARGETS I N THE FUTURE? 199
8.4 METHODS TO IDENTIFY A NOVEL TARGET FOR A GIVEN COMPOUND 200
8.4.1 MICROSCOPY A N D CELLULAR IMAGING 200
8.4.2 CULTIVATION O N SELECTIVE MEDIA 200
8.4.3 INCORPORATION O F ISOTOPICALLY LABELED PRECURSORS A N D
METABOLOMICS 201 8.4.4 AFFINITY METHODS 201
8.4.5 RESISTANCE MUTANT SCREENING 201
8.4.6 GENE EXPRESSION PROFILING A N D PROTEOMICS 202 8.5 METHODS O F
IDENTIFYING NOVEL TARGETS WITHOUT PRE-EXISTING INHIBITORS 202 8.5.1
BIOCHEMICAL IDEAS TO GENERATE NOVEL FUNGICIDE TARGETS 203
8.5.2 GENOMICS A N D PROTEOMICS 203
8.6 NON-PROTEIN TARGETS 213
8.7 RESISTANCE INDUCERS 213
8.8 BENEFICIAL SIDE EFFECTS O F COMMERCIAL FUNGICIDES 214
8.9 CONCLUDING REMARKS 214
REFERENCES 214
PART III NEW METHODS TO IMPROVE T H E BIOAVAILABILITY O F ACTIVE
INGREDIENTS 217
9 NEW FORMULATION DEVELOPMENTS 219
ROLFPONTZEN AND ARNOLDUS W.P. VERMEER
9.1 INTRODUCTION 219
9.2 DRIVERS FOR FORMULATION TYPE DECISIONS 223
9.3 DESCRIPTION O F FORMULATION TYPES, THEIR PROPERTIES, A N D PROBLEMS
DURING DEVELOPMENT 225 9.3.1 PESTICIDES DISSOLVED IN A LIQUID CONTINUOUS
PHASE 225 9.3.2 CRYSTALLINE PESTICIDES I N A LIQUID CONTINUOUS PHASE 228
9.3.3 PESTICIDES I N A SOLID MATRIX 232
9.4 BIOAVAILABILITY OPTIMIZATION 235
9.4.1 SPRAY FORMATION A N D RETENTION 236
9.4.2 SPRAY DEPOSIT FORMATION A N D PROPERTIES 238
9.4.3 CUTICULAR PENETRATION 240
9.4.3.1 CUTICULAR PENETRATION TEST 242
IMAGE 6
X CONTENTS
9.4.3.2 EFFECT O F FORMULATION O N CUTICULAR PENETRATION 243
9.5 CONCLUSIONS A N D OUTLOOK 246
REFERENCES 247
10 POLYMORPHISM AND T H E ORGANIC SOLID STATE: INFLUENCE ON T H E
OPTIMIZATION O F AGROCHEMICALS 249 BRITTA OLENIK AND GERHARD THIDKING
10.1 INTRODUCTION 249
10.2 THEORETICAL PRINCIPLES O F POLYMORPHISM 250
10.2.1 THE SOLID STATE 250
10.2.2 DEFINITION O F POLYMORPHISM 251
10.2.3 THERMODYNAMICS 251
10.2.3.1 MONOTROPISM A N D ENANTIOTROPISM 251 10.2.3.2 ENERGY
TEMPERATURE DIAGRAMS A N D THE RULES 252 10.2.4 KINETICS O F
CRYSTALLIZATION: NUCLEATION 254 10.3 ANALYTICAL CHARACTERIZATION O F
POLYMORPHS 255 10.3.1 DIFFERENTIAL THERMAL ANALYSIS A N D DIFFERENTIAL
SCANNING
CALORIMETRY 256
10.3.2 THERMOGRAVIMETRY 258
10.3.3 HOT-STAGE MICROSCOPY 259
10.3.4 IR A N D RAMAN SPECTROSCOPIES 261
10.3.5 X-RAY ANALYSIS 265
10.4 PATENTABILITY O F POLYMORPHS 268
10.5 SUMMARY A N D OUTLOOK 270
ACKNOWLEDGMENTS 270 REFERENCES 270
11 THE DETERMINATION O F ABRAHAM DESCRIPTORS AND THEIR APPLICATION TO
CROP PROTECTION RESEARCH 273 ERIC D. CLARKE AND LAURA J. MALLON
11.1 INTRODUCTION 273
11.2 DEFINITION O F ABRAHAM DESCRIPTORS 274
11.3 DETERMINATION O F ABRAHAM DESCRIPTORS: GENERAL APPROACH 275 11.3.1
V A N D E DESCRIPTORS 276
11.3.2 A, B, A N D S DESCRIPTORS 277
11.3.3 A, B, S, A N D L DESCRIPTORS 277
11.3.4 LSER EQUATIONS FOR USE I N DETERMINING DESCRIPTORS 278 11.3.5
PREDICTION O F ABRAHAM DESCRIPTORS 280 11.4 DETERMINATION O F ABRAHAM
DESCRIPTORS: PHYSICAL PROPERTIES 281 11.5 DETERMINATION O F ABRAHAM
DESCRIPTORS: EXAMPLES 283
11.5.1 HERBICIDES: DIURON (1) 284
11.5.2 HERBICIDES: SIMAZINE (2) A N D ATRAZINE (3) 285 11.5.3
HERBICIDES: ACETOCHLOR (4) A N D ALACHLOR (5) 288
IMAGE 7
CONTENTS | X I
11.5.4 INSECTICIDES: FIPRONIL (6) 289
11.5.5 INSECTICIDES: IMIDACLOPRID (7) 290 11.5.6 INSECTICIDES:
CHLORANTRANILIPROLE (8) 292 11.5.7 INSECTICIDES: THIAMETHOXAM (9) 293
11.5.8 FUNGICIDES: AZOXYSTROBIN (10) 294 11.5.9 PLANT GROWTH REGULATOR:
PACLOBUTRAZOL (11) 295 11.6 APPLICATION O F ABRAHAM DESCRIPTORS:
DESCRIPTOR
PROFILES 296
11.7 APPLICATION O F ABRAHAM DESCRIPTORS: LFER ANALYSIS 297 11.7.1 LFERS
FOR RP-HPLC SYSTEMS 297 11.7.2 LFERS FOR SOIL SORPTION COEFFICIENT (KOC)
299 11.7.3 LFERS FOR PARTITIONING INTO PLANT CUTICLES 300 11.7.4 LFERS
FOR ROOT CONCENTRATION FACTOR (RCF) 300 11.7.5 LFER FOR TRANSPIRATION
STREAM CONCENTRATION FACTOR 301 11.8 APPLICATION O F ABRAHAM
DESCRIPTORS: GENERALITY OF
APPROACH 301 ACKNOWLEDGMENTS 302 REFERENCES 302
PART IV MODERN METHODS FOR RISK ASSESSMENT 307
12 ECOLOGICAL MODELING IN PESTICIDE RISK ASSESSMENT: CHANCES AND
CHALLENGES 309 WALTER SCHMITT
12.1 INTRODUCTION 309
12.2 ECOLOGICAL MODELS I N THE REGULATORY ENVIRONMENT 311 12.2.1
CONSIDERATION O F REALISTIC EXPOSURE PATTERNS 312 12.2.2 EXTRAPOLATION
TO POPULATION LEVEL: THE LINK TO PROTECTION GOALS 313
12.2.3 EXTRAPOLATION TO ORGANIZATION LEVELS ABOVE POPULATIONS 314 12.3 A
N OVERVIEW O F MODEL APPROACHES 315
12.3.1 TOXICOKINETIC MODELS 316
12.3.2 POPULATION MODELS 319
12.3.2.1 DIFFERENTIAL EQUATION MODELS 319 12.3.2.2 MATRIX MODELS 320
12.3.2.3 INDIVIDUAL-BASED MODELS 322 12.3.3 ECOSYSTEM OR FOOD-WEB MODELS
325 12.4 REGULATORY CHALLENGES 328
REFERENCES 331
IMAGE 8
X I I | CONTENTS
13 THE USE O F METABOLOMICS IN VIVO FOR THE DEVELOPMENT
O F AGROCHEMICAL PRODUCTS 335 HENNICKE G. KAMP, DOERTHE AHLBORY-DIEKER,
ERIC FABIAN, MICHAEL HEROLD, GERHARD KRENNRICH, EDGAR LEIBOLD, ROLF
LOOSER, WERNER MELLERT, ALEXANDRE PROKOUDINE, VOLKER STRAUSS TILMANN
WALK, J A N WIEMER, AND BENNARD VAN
RAVENZWAAY
13.1 INTRODUCTION TO METABOLOMICS 335
13.2 METAMAPTOX DATA BASE 336
13.2.1 METHODS 336
13.2.1.1 ANIMAL TREATMENT A N D MAINTENANCE CONDITIONS 336 13.2.1.2
BLOOD SAMPLING A N D METABOLITE PROFILING 336 13.3 EVALUATION O F
METABOLOME DATA 3 3 7
13.3.1 DATA PROCESSING 3 3 7
13.3.1.1 METABOLITE PROFILING 337 13.3.1.2 METABOLOME PATTERNS 337
13.3.1.3 WHOLE-PROFILE COMPARISON 338 13.4 USE O F METABOLOME DATA FOR
DEVELOPMENT O F AGROCHEMICALS 339 13.4.1 GENERAL APPLICABILITY 339
13.4.2 CASE STUDIES 339
13.4.2.1 LIVER ENZYME INDUCTION 339 13.4.2.2 LIVER CANCER 342
13.4.3 CHEMICAL CATEGORIES 344
13.5 DISCUSSION 345
13.5.1 CHALLENGES A N D CHANCES CONCERNING THE USE O F METABOLITE
PROFILING IN TOXICOLOGY 345 13.5.2 APPLICABILITY O F THE METAMAPTOX
DATA BASE 347 13.6 CONCLUDING REMARKS 347
REFERENCES 348
14 SAFETY EVALUATION O F NEW PESTICIDE ACTIVE INGREDIENTS: ENQUIRY-LED
APPROACH TO DATA GENERATION 351 PAUL PARSONS
14.1 BACKGROUND 351
14.2 WHAT IS THE PURPOSE O F MAMMALIAN TOXICITY STUDIES? 354 14.3
ADDRESSING THE KNOWLEDGE NEEDS O F RISK ASSESSORS 358 14.4 OPPORTUNITIES
FOR GENERATING DATA O F DIRECT RELEVANCE TO H U M A N HEALTH RISK
ASSESSMENT WITHIN THE EXISTING TESTING PARADIGM 362
14.4.1 DOSE SELECTION FOR CARCINOGENICITY STUDIES 362 14.4.2 INTEGRATING
TOXICOKINETICS INTO TOXICITY STUDY DESIGNS 365 14.5 ENQUIRY-LED DATA
GENERATION STRATEGIES 367
14.5.1 KEY QUESTIONS TO CONSIDER WHILE IDENTIFYING LEAD MOLECULES 369
14.5.2 KEY QUESTIONS TO CONSIDER W H E N SELECTING CANDIDATES FOR FULL
DEVELOPMENT 370
IMAGE 9
CONTENTS | X I I I
14.5.3 KEY QUESTIONS TO CONSIDER FOR A COMPOUND I N FULL
DEVELOPMENT 371
14.6 CONCLUSIONS 371
REFERENCES 378
15 ENDOCRINE DISRUPTION: DEFINITION AND SCREENING ASPECTS IN T H E LIGHT
O F T H E EUROPEAN CROP PROTECTION LAW 381 SUSANNE N. KOLLE, BURKHARD
FLICK, TZUTZUY RAMIREZ, ROLAND BUESEN, HENNICKE G. KAMP, AND BENNARD VAN
RAVENZWAAY
15.1 INTRODUCTION 381
15.2 ENDOCRINE DISRUPTION: DEFINITIONS 382
15.3 CURRENT REGULATORY SITUATION I N THE EU 382
15.4 US EPA ENDOCRINE DISRUPTOR SCREENING PROGRAM A N D OECD CONCEPTUAL
FRAMEWORK FOR T H E TESTING A N D ASSESSMENT OF ENDOCRINE-DISRUPTING
CHEMICALS 384 15.5 ECETOC APPROACH 385
15.6 METHODS TO ASSESS ENDOCRINE MODES O F ACTION A N D
ENDOCRINE-RELATED ADVERSE EFFECTS I N SCREENING A N D REGULATORY
CONTEXTS 388 15.6.1 IN-VITRO ASSAYS 388
15.6.2 IN-VIVO ASSAYS 391
15.7 PROPOSAL FOR DECISION CRITERIA FOR EDCS: REGULATORY AGENCIES 397
REFERENCES 397
INDEX 401 |
| any_adam_object | 1 |
| building | Verbundindex |
| bvnumber | BV040496792 |
| classification_rvk | ZC 28000 |
| classification_tum | LAN 240f |
| ctrlnum | (OCoLC)816293722 (DE-599)DNB1020848251 |
| dewey-full | 632.9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 632 - Plant injuries, diseases, pests |
| dewey-raw | 632.9 |
| dewey-search | 632.9 |
| dewey-sort | 3632.9 |
| dewey-tens | 630 - Agriculture and related technologies |
| discipline | Chemie / Pharmazie Agrarwissenschaft Agrar-/Forst-/Ernährungs-/Haushaltswissenschaft / Gartenbau Pflanzenbau |
| format | Book |
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| id | DE-604.BV040496792 |
| illustrated | Illustrated |
| indexdate | 2024-08-21T00:15:48Z |
| institution | BVB |
| isbn | 3527331751 9783527331758 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-025343656 |
| oclc_num | 816293722 |
| open_access_boolean | |
| owner | DE-1028 DE-11 DE-355 DE-BY-UBR |
| owner_facet | DE-1028 DE-11 DE-355 DE-BY-UBR |
| physical | XXII, 420 S. Ill., graph. Darst. 240 mm x 170 mm |
| publishDate | 2012 |
| publishDateSearch | 2012 |
| publishDateSort | 2012 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Modern methods in crop protection research ed. by Peter Jeschke ... Weinheim Wiley-VCH 2012 XXII, 420 S. Ill., graph. Darst. 240 mm x 170 mm txt rdacontent n rdamedia nc rdacarrier Pflanzenschutzmittel (DE-588)4045587-7 gnd rswk-swf Agrikulturchemie (DE-588)4000788-1 gnd rswk-swf Pflanzenschutzmittel (DE-588)4045587-7 s Agrikulturchemie (DE-588)4000788-1 s DE-604 Jeschke, Peter Sonstige oth Erscheint auch als Online-Ausgabe, PDF 978-3-527-65593-9 X:MVB text/html http://deposit.dnb.de/cgi-bin/dokserv?id=3994894&prov=M&dok_var=1&dok_ext=htm Inhaltstext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025343656&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Modern methods in crop protection research Pflanzenschutzmittel (DE-588)4045587-7 gnd Agrikulturchemie (DE-588)4000788-1 gnd |
| subject_GND | (DE-588)4045587-7 (DE-588)4000788-1 |
| title | Modern methods in crop protection research |
| title_auth | Modern methods in crop protection research |
| title_exact_search | Modern methods in crop protection research |
| title_full | Modern methods in crop protection research ed. by Peter Jeschke ... |
| title_fullStr | Modern methods in crop protection research ed. by Peter Jeschke ... |
| title_full_unstemmed | Modern methods in crop protection research ed. by Peter Jeschke ... |
| title_short | Modern methods in crop protection research |
| title_sort | modern methods in crop protection research |
| topic | Pflanzenschutzmittel (DE-588)4045587-7 gnd Agrikulturchemie (DE-588)4000788-1 gnd |
| topic_facet | Pflanzenschutzmittel Agrikulturchemie |
| url | http://deposit.dnb.de/cgi-bin/dokserv?id=3994894&prov=M&dok_var=1&dok_ext=htm http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025343656&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT jeschkepeter modernmethodsincropprotectionresearch |