Adiponectin:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam [u.a.]
Elsevier
2012
|
| Schriftenreihe: | Vitamins and hormones
90 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | Einzelaufn. für Zeitschr.-H. |
| Beschreibung: | XX, 450 S. graph. Darst. |
Internformat
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Datensatz im Suchindex
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|---|---|
| adam_text | Titel: Adiponectin
Autor: Litwack, Gerald
Jahr: 2012
CONTENTS
Contributors xiii
Preface xix
1. Lifestyle Factors Increasing Adiponectin Synthesis and Secretion 1
Justine M. Tishinsky, David J. Dyck, and Lindsay E. Robinson
1. Introduction 2
2. Lifestyle Factors That Increase Adiponectin Synthesis and Secretion 5
3. Mechanisms for Lifestyle-Mediated Effects on Adiponectin 15
4. Conclusions 22
References 22
2. Molecular Tools to Characterize Adiponectin Activity 31
Cathleen Juhl and Annette G. Beck-Sickinger
1. Introduction 32
2. Analysis of the Cellular Biology 34
3. Protein Structures 39
4. Searching for New Interaction Partners 42
5. Signaling Cascades and Physiological Effect 47
6. Conclusion 51
References 52
3. Nutritional and Hormonal Modulation of Adiponectin and its
Receptors adipoRI and adipoR2 57
Cristiane de Oliveira, Ana Barbosa Marcondes de Mattos, Carolina Biz
Rodrigues Silva, Joäo Felipe Mota, and Juliane Costa Silva Zemdegs
1. Introduction 58
2. Nutritional Regulation of Adiponectin and Adiponectin Receptors 60
3. Hormonal Regulation of Adiponectin and Adiponectin Receptors 69
4. Conclusion 79
References 79
viii
Contents
4. Regulation and Function of Adiponectin Receptors
in Skeletal Muscle 95
Yaniv Lustig, Rina Hemi, and Hannah Kanety
1. Introduction 96
2. Adiponectin and Adiponectin Receptors 96
3. Adiponectin Signaling and Function in Skeletal Muscle 98
4. Transcriptional Regulation of AdipoRs in Skeletal Muscle Under Different
Physiological and Pathophysiological Conditions 101
5. Molecular Mechanisms Regulating Muscle AdipoRs Transcription 110
6. Posttranscriptional Regulation of AdipoRs in Skeletal Muscle 111
7. Concluding Remarks 115
Acknowledgments 115
References 116
5. Screening for Adiponectin Secretion Regulators 125
Kyosuke Hino and Hidetaka Nagata
1. Introduction 125
2. PPARy-Dependent Adiponectin Secretion Regulators 129
3. PPAR y-lndependent Adiponectin Secretion Regulators 133
4. Other Adiponectin Secretion Regulators 133
5. Conclusions 135
References 135
6. Adiponectin and PPAR-y: Cooperative and Interdependent
Actions of Two Key Regulators of Metabolism 143
Olga Astapova and Todd Leff
1. PPARy Activity Correlates with Adiponectin Hormone Levels 144
2. PPARy Regulates Adiponectin Gene Transcription 149
3. PPARy Regulates Adiponectin Hormone Secretion 153
4. PPARy and Adiponectin Regulate Similar Physiological Pathways 155
5. Conclusion 157
References 157
7. Glucocorticoid Effects on Adiponectin Expression 163
Siddharth Sukumaran, Debra C. DuBois, William J. Jusko, and
Richard R. Almon
1. Introduction 154
2. Glucocorticoids and Their Effects on Gene Expression 164
Contents
ix
3. Effects of GC and Adiponectin on Energy Metabolism 167
4. In Vitro and Animal Studies on the Effects of GC on Adiponectin
Expression 168
5. Clinical Studies on the Effects of GC on Adiponectin Expression 173
6. Other Hormones, Factors, and Conditions That Regulate Adiponectin
Expression and Their Relationship to GC 176
7. Potential Reasons for Contradictory Results on the Effects of GC on
Adiponectin Expression and Methods That can be Useful in
Gaining Better Insight About This Regulation 178
8. Conclusion 181
Acknowlegment 182
References 182
8. Adiponectin and Reproduction 187
Esther Dos Santos, René Pecquery, Philippe de Mazancourt, and
Marie-Noëlle Dieudonné
1. Introduction 188
2. Adiponectin and Adiponectin Signaling 188
3. Adiponectin: Main Functions in Human 191
4. Adiponectin and Steroidogenesis 192
5. Adiponectin and Placental Functions 194
6. Adiponectin and Pregnancy-Associated Pathologies 197
7. Conclusions and Perspectives 201
References 201
9. Adiponectin and Its Receptors in Preimplantation Embryo
Development 211
Stefan Ci kos
1. Introduction 212
2. Adiponectin and Fertility 213
3. Overview of Preimplantation Embryo Development 214
4. Expression of Adiponectin and Adiponectin Receptors in
Oocytes and Preimplantation Embryos 215
5. Potential Roles of Adiponectin in Oocyte and Early
Embryo Development 221
6. Conclusions 230
Acknowledgment 231
References 231
x Contents
10. Adiponectin and the Control of Female Reproductive Functions 239
Marie-France Palin, V. Vilceu Bordignon, and Bruce D. Murphy
1. Introduction 240
2. Adiponectin in Ovarian Functions 243
3. Adiponectin in Pregnancy 257
4. Adiponectin Action on the Central Nervous System and the
Pituitary Gland 269
5. Conclusion 271
Acknowledgments 272
References 272
11. Adiponectin in the Heart and Vascular System 289
Min Ding, Eva M. Rzucidlo, Jennifer C. Davey, Yi Xie, Renjing Liu, Yu Jin,
Lindsey Stavola, and Kathleen A. Martin
1. Introduction to Adiponectin 290
2. Adiponectin and CVD in Humans 293
3. Protective Effects of Adiponectin in the Cardiovascular System: Evidence
from Rodent and In Vitro Studies 298
4. Conclusions/Future Questions 308
References 308
12. Adiponectin Interactions in Bone and Cartilage Biology
and Disease 321
Massimiliano Ruscica, Liliana Steffani, and Paolo Magni
1. Introduction 322
2. Adipose, Bone, and Cartilage Relationships: Observations in Humans 323
3. Adiponectin, Bone, and Cartilage: Interactions in Humans 326
4. Adiponectin, Bone, and Cartilage: Experimental Observations 329
5. Conclusions 331
References 332
13. Lipid-Lowering Drugs and Circulating Adiponectin
Desiree Wanders, Eric P. Plaisance, and Robert L. Judd
1. Introduction
2. Adiponectin
3. Statins
4. Fibrates
5. Niacin
6. Omega-3 Fatty Acids
341
342
343
344
351
356
360
Contents xi
7. Conclusions 365
Acknowledgment 366
References 366
14. Adiponectin and lnterleukin-6 in Inflammation-Associated
Disease 375
Li Li and Li-Ling Wu
1. Introduction 376
2. Biological Actions and Signaling Pathways Activated by Adiponectin 377
3. Interaction Between Adiponectin and IL-6 in Regulating Diabetic State 379
4. Interaction Between Adiponectin and IL-6 in Regulating Cardiovascular
Disease 382
5. Interaction Between Adiponectin and IL-6 in Regulating Autoimmune
Disease 387
6. Conclusion 388
References 389
15. New Insights into Anticarcinogenic Properties of Adiponectin:
A Potential Therapeutic Approach in Breast Cancer? 397
Laetitia Delort, Thierry Jardé, Virginie Dubois, Marie-Paule Vasson,
and Florence Caldefie-Chézet
1. Introduction 398
2. Adiponectinemia 399
3. Adiponectin and Breast Cancer Risk 402
4. Adiponectin as Therapeutic Target 411
5. Conclusion 412
References 413
16. Adiponectin: A Novel Link Between Adipocytes and COPD 419
Yoshito Takeda, Kaori Nakanishi, Isao Tachibana, and Atsushi Kumanogoh
1. Introduction 420
2. Structure of APN: Similarity to Surfactant Proteins 421
3. Expression and Regulation of APN in the Lung 422
4. COPD-Like Phenotype in APN-KO Mice 424
5. Mechanisms of COPD-Like Phenotype in APN-KO Mice 426
6. Therapeutic Potential of APN 428
7. Conclusion 430
References 431
Index
437
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