Platelet-vessel wall interactions in hemostasis and thrombosis:
Saved in:
| Main Author: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
[San Rafael, CA]
Morgan & Claypool
2010
|
| Series: | Synthesis lectures on integrated systems physiology - from molecules to function
|
| Subjects: | |
| Online Access: | TUM01 Volltext |
| Item Description: | Title from PDF t.p. (viewed Aug. 16, 2011) Includes bibliographical references Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions 1. Introduction -- 2. General characteristics of platelets -- Overview -- Platelet granules -- Alpha granules -- Dense granules -- Lysosomes -- Platelet adhesion molecules -- P-selectin -- Glycoprotein Ib/IX/V (GPIb/IX/V) -- Glycoprotein IIb/IIIa (GP IIb/IIIa) -- Collagen receptors -- G-protein-coupled receptors -- Thrombin -- Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) -- Prostanoids -- 3. Adhesion to Subendothelium Following Vascular Injury -- von Willebrand factor (vWF) -- Collagen -- Other Subendothelial Components -- Endogenous Mechanisms Preventing Platelet Adhesion to Endothelium -- Nitric Oxide -- Prostacyclin -- Ecto-adenosine diphosphatase (ADPase) -- Endothelial Surface Layer -- Mechanisms of Platelet Adhesion to Endothelium -- Endothelial P-Selectin-Dependent Mechanisms -- Endothelial vWF-Dependent Mechanisms -- Other Mechanisms -- 4. Platelet Aggregation -- Mechanisms of Platelet Aggregation -- Monitoring of Platelet Aggregation -- Ex Vivo Monitoring: Platelet Aggregometry -- In Vivo Monitoring of Platelet Aggregation -- 5. Platelet Recruitment and Blood Coagulation -- Role of Platelets -- Role of Platelet-Leukocyte Interactions -- 6. Arterial, Venous, and Microvascular Hemostasis/Thrombosis -- Venous Thrombosis -- Endothelial Injury -- Hypercoagulability -- Stasis -- Coexistence of Virchow's Triad Components: Cancer and Thrombosis -- Arterial Thrombosis -- Microvascular Thrombosis -- 7. Summary |
| Physical Description: | 1 Online-Ressource (xiii, 67 p.) Ill., graph. Darst. |
| ISBN: | 1615040390 1615040404 9781615040391 9781615040407 |
Staff View
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| 264 | 1 | |a [San Rafael, CA] |b Morgan & Claypool |c 2010 | |
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| 500 | |a Title from PDF t.p. (viewed Aug. 16, 2011) | ||
| 500 | |a Includes bibliographical references | ||
| 500 | |a Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions | ||
| 500 | |a 1. Introduction -- 2. General characteristics of platelets -- Overview -- Platelet granules -- Alpha granules -- Dense granules -- Lysosomes -- Platelet adhesion molecules -- P-selectin -- Glycoprotein Ib/IX/V (GPIb/IX/V) -- Glycoprotein IIb/IIIa (GP IIb/IIIa) -- Collagen receptors -- G-protein-coupled receptors -- Thrombin -- Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) -- Prostanoids -- 3. Adhesion to Subendothelium Following Vascular Injury -- von Willebrand factor (vWF) -- Collagen -- Other Subendothelial Components -- Endogenous Mechanisms Preventing Platelet Adhesion to Endothelium -- Nitric Oxide -- Prostacyclin -- Ecto-adenosine diphosphatase (ADPase) -- Endothelial Surface Layer -- Mechanisms of Platelet Adhesion to Endothelium -- Endothelial P-Selectin-Dependent Mechanisms -- Endothelial vWF-Dependent Mechanisms -- Other Mechanisms -- 4. Platelet Aggregation -- Mechanisms of Platelet Aggregation -- Monitoring of Platelet Aggregation -- Ex Vivo Monitoring: Platelet Aggregometry -- In Vivo Monitoring of Platelet Aggregation -- 5. Platelet Recruitment and Blood Coagulation -- Role of Platelets -- Role of Platelet-Leukocyte Interactions -- 6. Arterial, Venous, and Microvascular Hemostasis/Thrombosis -- Venous Thrombosis -- Endothelial Injury -- Hypercoagulability -- Stasis -- Coexistence of Virchow's Triad Components: Cancer and Thrombosis -- Arterial Thrombosis -- Microvascular Thrombosis -- 7. Summary | ||
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| id | DE-604.BV040473986 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:24:36Z |
| institution | BVB |
| isbn | 1615040390 1615040404 9781615040391 9781615040407 |
| language | English |
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| physical | 1 Online-Ressource (xiii, 67 p.) Ill., graph. Darst. |
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| spelling | Rumbaut, Rolando E. Verfasser aut Platelet-vessel wall interactions in hemostasis and thrombosis Rolando E. Rumbaut and Perumal Thiagarajan [San Rafael, CA] Morgan & Claypool 2010 1 Online-Ressource (xiii, 67 p.) Ill., graph. Darst. txt rdacontent c rdamedia cr rdacarrier Synthesis lectures on integrated systems physiology - from molecules to function Title from PDF t.p. (viewed Aug. 16, 2011) Includes bibliographical references Platelets are essential mediators of the physiologic process of hemostasis and pathologic thrombosis. While platelets do not interact with vascular walls under normal conditions, vascular injury or inflammation result in a coordinated series of events including platelet adhesion, aggregation, and promotion of coagulation. In this review, we describe the primary mechanisms involved in these responses in various vascular beds of both macro- and microvessels, and outline key unresolved aspects of these important interactions 1. Introduction -- 2. General characteristics of platelets -- Overview -- Platelet granules -- Alpha granules -- Dense granules -- Lysosomes -- Platelet adhesion molecules -- P-selectin -- Glycoprotein Ib/IX/V (GPIb/IX/V) -- Glycoprotein IIb/IIIa (GP IIb/IIIa) -- Collagen receptors -- G-protein-coupled receptors -- Thrombin -- Adenosine diphosphate (ADP) and adenosine triphosphate (ATP) -- Prostanoids -- 3. Adhesion to Subendothelium Following Vascular Injury -- von Willebrand factor (vWF) -- Collagen -- Other Subendothelial Components -- Endogenous Mechanisms Preventing Platelet Adhesion to Endothelium -- Nitric Oxide -- Prostacyclin -- Ecto-adenosine diphosphatase (ADPase) -- Endothelial Surface Layer -- Mechanisms of Platelet Adhesion to Endothelium -- Endothelial P-Selectin-Dependent Mechanisms -- Endothelial vWF-Dependent Mechanisms -- Other Mechanisms -- 4. Platelet Aggregation -- Mechanisms of Platelet Aggregation -- Monitoring of Platelet Aggregation -- Ex Vivo Monitoring: Platelet Aggregometry -- In Vivo Monitoring of Platelet Aggregation -- 5. Platelet Recruitment and Blood Coagulation -- Role of Platelets -- Role of Platelet-Leukocyte Interactions -- 6. Arterial, Venous, and Microvascular Hemostasis/Thrombosis -- Venous Thrombosis -- Endothelial Injury -- Hypercoagulability -- Stasis -- Coexistence of Virchow's Triad Components: Cancer and Thrombosis -- Arterial Thrombosis -- Microvascular Thrombosis -- 7. Summary e-book [online only] / Referex / [NTU Lib] MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Medizin Blood Platelets / physiology Hemostasis / physiology Microcirculation / physiology Thrombosis / physiopathology Blood platelets Blood / Coagulation MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh Thiagarajan, Perumal Sonstige oth http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=440484 Verlag Volltext |
| spellingShingle | Rumbaut, Rolando E. Platelet-vessel wall interactions in hemostasis and thrombosis e-book [online only] / Referex / [NTU Lib] MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Medizin Blood Platelets / physiology Hemostasis / physiology Microcirculation / physiology Thrombosis / physiopathology Blood platelets Blood / Coagulation MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh |
| title | Platelet-vessel wall interactions in hemostasis and thrombosis |
| title_auth | Platelet-vessel wall interactions in hemostasis and thrombosis |
| title_exact_search | Platelet-vessel wall interactions in hemostasis and thrombosis |
| title_full | Platelet-vessel wall interactions in hemostasis and thrombosis Rolando E. Rumbaut and Perumal Thiagarajan |
| title_fullStr | Platelet-vessel wall interactions in hemostasis and thrombosis Rolando E. Rumbaut and Perumal Thiagarajan |
| title_full_unstemmed | Platelet-vessel wall interactions in hemostasis and thrombosis Rolando E. Rumbaut and Perumal Thiagarajan |
| title_short | Platelet-vessel wall interactions in hemostasis and thrombosis |
| title_sort | platelet vessel wall interactions in hemostasis and thrombosis |
| topic | e-book [online only] / Referex / [NTU Lib] MEDICAL / Physiology bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology bisacsh Medizin Blood Platelets / physiology Hemostasis / physiology Microcirculation / physiology Thrombosis / physiopathology Blood platelets Blood / Coagulation MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh |
| topic_facet | e-book [online only] / Referex / [NTU Lib] MEDICAL / Physiology SCIENCE / Life Sciences / Human Anatomy & Physiology Medizin Blood Platelets / physiology Hemostasis / physiology Microcirculation / physiology Thrombosis / physiopathology Blood platelets Blood / Coagulation MEDICAL / Physiology / bisacsh SCIENCE / Life Sciences / Human Anatomy & Physiology / bisacsh |
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