Systems biology in drug discovery and development:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Hoboken, N.J.
Wiley
c2012
|
| Schriftenreihe: | Wiley series on technologies for the pharmaceutical industry
|
| Schlagworte: | |
| Online-Zugang: | TUM01 Volltext |
| Beschreibung: | Frontmatter -- Color Plates -- Introduction to Systems Biology in Approach. Introduction to Systems Biology in Drug Discovery and Development / Seth Michelson, Daniel L Young -- Methods for Biology: Model Construction and Analysis / Theresa Yuraszeck, Peter Chang, Kalyan Gayen, Eric Kwei, Henry Mirsky, Francis J Doyle -- Methods in Biology: Modeling Feedback Dynamics in Pathways / Peter Wellstead, Olaf Wolkenhauer -- Simulation of Population Variability in Pharmacokinetics / Jiansong Yang -- Applications to Drug Discovery. Applications of Systems Biology Approaches to Target Identification and Validation in Drug Discovery / Bart S Hendriks -- Lead Identification and Optimization / Seth Michelson -- Role of Core Biological Motifs in Dose Response Modeling: An Example with Switchlike Circuits / Sudin Bhattacharya, Qiang Zhang, Melvin E Andersen -- Mechanism-Based Pharmacokinetic Pharmacodynamic Modeling During Discovery and Early Development / Hans Peter Grimm, Ying Ou, Micaela Reddy, Pascale David-Pierson, Thierry Lav -- Applications to Drug Development. Developing Oncology Drugs Using Virtual Patients of Vascular Tumor Diseases / Zvia Agur, Naamah Bloch, Boris Gorelik, Marina Kleiman, Yuri Kogan, Yael Sagi, D Sidransky, Yael Ronen -- Systems Modeling Applied to Candidate Biomarker Identification / Ananth Kadambi, Daniel L Young, Kapil Gadkar -- Simulating Clinical Trials / Tom Parke -- Synergies with other Technologies. Pathway Analysis in Drug Discovery / Anton Yuryev -- Functional Mapping for Predicting Drug Response and Enabling Personalized Medicine / Yao Li, Wei Hou, Wei Zhao, Kwangmi Ahn, Rongling Wu -- Future Outlook for Systems Biology / Daniel L Young, Seth Michelson -- Index Includes bibliographical references and index Introduction to systems biology in drug discovery and development -- Methods for in silico biology : model construction and analysis -- Methods in in silico biology : modeling feedback dynamics in pathways -- Simulation of population variability in pharmacokinetics -- Applications of systems biology approaches to target identification and validation in drug discovery -- Lead identification and optimization -- The role of core biological motifs in dose-response modeling : an example with switch-like circuits -- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development -- Developing oncology drugs using virtual patients of vascular tumor diseases -- Systems modeling applied to candidate biomarker identification -- Simulating clinical trials -- Pathway analysis in drug discovery -- Functional mapping for predicting drug response and enabling personalized medicine -- Future outlook of systems biology |
| Beschreibung: | 1 Online-Ressource (xvii, 370 p.) |
| ISBN: | 0470261234 1118016416 1118016432 9780470261231 9781118016411 9781118016435 |
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| spelling | Systems biology in drug discovery and development edited by Daniel L. Young, Seth Michelson Hoboken, N.J. Wiley c2012 1 Online-Ressource (xvii, 370 p.) txt rdacontent c rdamedia cr rdacarrier Wiley series on technologies for the pharmaceutical industry Frontmatter -- Color Plates -- Introduction to Systems Biology in Approach. Introduction to Systems Biology in Drug Discovery and Development / Seth Michelson, Daniel L Young -- Methods for Biology: Model Construction and Analysis / Theresa Yuraszeck, Peter Chang, Kalyan Gayen, Eric Kwei, Henry Mirsky, Francis J Doyle -- Methods in Biology: Modeling Feedback Dynamics in Pathways / Peter Wellstead, Olaf Wolkenhauer -- Simulation of Population Variability in Pharmacokinetics / Jiansong Yang -- Applications to Drug Discovery. Applications of Systems Biology Approaches to Target Identification and Validation in Drug Discovery / Bart S Hendriks -- Lead Identification and Optimization / Seth Michelson -- Role of Core Biological Motifs in Dose Response Modeling: An Example with Switchlike Circuits / Sudin Bhattacharya, Qiang Zhang, Melvin E Andersen -- Mechanism-Based Pharmacokinetic Pharmacodynamic Modeling During Discovery and Early Development / Hans Peter Grimm, Ying Ou, Micaela Reddy, Pascale David-Pierson, Thierry Lav -- Applications to Drug Development. Developing Oncology Drugs Using Virtual Patients of Vascular Tumor Diseases / Zvia Agur, Naamah Bloch, Boris Gorelik, Marina Kleiman, Yuri Kogan, Yael Sagi, D Sidransky, Yael Ronen -- Systems Modeling Applied to Candidate Biomarker Identification / Ananth Kadambi, Daniel L Young, Kapil Gadkar -- Simulating Clinical Trials / Tom Parke -- Synergies with other Technologies. Pathway Analysis in Drug Discovery / Anton Yuryev -- Functional Mapping for Predicting Drug Response and Enabling Personalized Medicine / Yao Li, Wei Hou, Wei Zhao, Kwangmi Ahn, Rongling Wu -- Future Outlook for Systems Biology / Daniel L Young, Seth Michelson -- Index Includes bibliographical references and index Introduction to systems biology in drug discovery and development -- Methods for in silico biology : model construction and analysis -- Methods in in silico biology : modeling feedback dynamics in pathways -- Simulation of population variability in pharmacokinetics -- Applications of systems biology approaches to target identification and validation in drug discovery -- Lead identification and optimization -- The role of core biological motifs in dose-response modeling : an example with switch-like circuits -- Mechanism based pharmacokinetic-pharmacodynamic modeling during discovery and early development -- Developing oncology drugs using virtual patients of vascular tumor diseases -- Systems modeling applied to candidate biomarker identification -- Simulating clinical trials -- Pathway analysis in drug discovery -- Functional mapping for predicting drug response and enabling personalized medicine -- Future outlook of systems biology Online-Ausgabe Hoboken, N.J. Wiley InterScience605 L Online-Ausgabe Medizin Drug development Systems biology Drug Discovery / methods Models, Biological Pharmacokinetics Pharmacological Processes Systems Biology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh Arzneimitteldesign (DE-588)4278218-1 gnd rswk-swf Systembiologie (DE-588)4809615-5 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Arzneimittelentwicklung (DE-588)4143176-5 s Arzneimitteldesign (DE-588)4278218-1 s Systembiologie (DE-588)4809615-5 s 2\p DE-604 Young, Daniel L. Sonstige oth Michelson, Seth Sonstige oth Reproduktion von Systems biology in drug discovery and development c2012 http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=396240 Verlag Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Systems biology in drug discovery and development Medizin Drug development Systems biology Drug Discovery / methods Models, Biological Pharmacokinetics Pharmacological Processes Systems Biology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh Arzneimitteldesign (DE-588)4278218-1 gnd Systembiologie (DE-588)4809615-5 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4278218-1 (DE-588)4809615-5 (DE-588)4143176-5 (DE-588)4143413-4 |
| title | Systems biology in drug discovery and development |
| title_auth | Systems biology in drug discovery and development |
| title_exact_search | Systems biology in drug discovery and development |
| title_full | Systems biology in drug discovery and development edited by Daniel L. Young, Seth Michelson |
| title_fullStr | Systems biology in drug discovery and development edited by Daniel L. Young, Seth Michelson |
| title_full_unstemmed | Systems biology in drug discovery and development edited by Daniel L. Young, Seth Michelson |
| title_short | Systems biology in drug discovery and development |
| title_sort | systems biology in drug discovery and development |
| topic | Medizin Drug development Systems biology Drug Discovery / methods Models, Biological Pharmacokinetics Pharmacological Processes Systems Biology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh Arzneimitteldesign (DE-588)4278218-1 gnd Systembiologie (DE-588)4809615-5 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | Medizin Drug development Systems biology Drug Discovery / methods Models, Biological Pharmacokinetics Pharmacological Processes Systems Biology / methods MEDICAL / Drug Guides / bisacsh MEDICAL / Nursing / Pharmacology / bisacsh MEDICAL / Pharmacology / bisacsh MEDICAL / Pharmacy / bisacsh Arzneimitteldesign Systembiologie Arzneimittelentwicklung Aufsatzsammlung |
| url | http://search.ebscohost.com/login.aspx?direct=true&scope=site&db=nlebk&db=nlabk&AN=396240 |
| work_keys_str_mv | AT youngdaniell systemsbiologyindrugdiscoveryanddevelopment AT michelsonseth systemsbiologyindrugdiscoveryanddevelopment |