Cardiotoxicity of non-cardiovascular drugs (Wiley, 2010)
"First book to deal with this important area of adverse drug reactions -- cardiotoxicity is one of the major forms of toxicity seen in drugs and it accounts for most drug recalls and delays experienced in regulatory approvals. Covers four important therapeutic classes: psychoactive drugs; anticancer drugs; non-steroidal anti-inflammatory drugs; and anti-retroviral drugs. - Emphasis on the preclinical screening of drug cardiotoxicity, to enable drug developers to test for this toxicity before starting expensive clinical trials"--Provided by publisher
Includes bibliographical references and index
Front Matter -- Colour Plates -- Mitochondrial Dysfunction in Cell Injury and Cardiotoxicity / Fabio Di Lisa, Martina Semenzato, Andrea Carpi, Sara Menazza, Nina Kaludercic, Roberta Menabò, Marcella Canton -- Cardiovascular Liabilities of Drugs: Regulatory Aspects / Claudio Arrigoni -- Cellular Mechanisms, Molecular Targets, and Structure-Function Relationships in Drug-Induced Arrhythmias: Antihistamines, Psychoactive Drugs, and Antimicrobial Agents / Maria Virginia Soldovieri, Maurizio Taglialatela -- Cardiovascular Toxicity of Antitumor Drugs: Dimensions of the Problem in Children / Rebecca Scully, Steven E. Lipshultz -- Cardiovascular Toxicity of Antitumor Drugs: Dimension of the Problem in Adult Settings / Joseph R. Carver, Chaitali J. Desai -- Diagnostic Aspects of Cardiovascular Toxicity of Antitumor Drugs / Michael S. Ewer, Thomas M. Suter -- Cardiovascular Toxicity of Antitumor Drugs: Translating Molecular Mechanisms into Clinical Facts / Pierantonio Menna, Emanuela Salvatorelli, Carlo Salsano, Luca Gianni, Giorgio Minotti -- NSAID Action and the Foundations for Cardiovascular Toxicity / Anna L. Blobaum, Lawrence J. Marnett -- Cardiovascular Toxicities of NSAIDS: Epidemiologic Aspects / Antonio González-Pérez, Luis Alberto García Rodriguez -- Cardiovascular Toxicities of Life-Saving Drugs: Antiviral Therapy / James J. Kohler, William Lewis -- Index