Depression in narcolepsy: a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia
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| Main Author: | |
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| Format: | Thesis Book |
| Language: | English |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-258028 Volltext Inhaltsverzeichnis |
| Physical Description: | 177 Bl. graph. Darst. |
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| 245 | 1 | 0 | |a Depression in narcolepsy |b a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia |c vorgelegt von Cecilia Jara Opazo |
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| 650 | 0 | 7 | |a Kataplexie |0 (DE-588)4402904-4 |2 gnd |9 rswk-swf |
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Record in the Search Index
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| adam_text | IMAGE 1
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TABLE OF CONTENTS
1. GENERAL INTRODUCTION 6
2. THEORETICAL PART 8
2.1. DEFINITION OF EXCESSIVE DAYTIME SLEEPINESS 8
2.1.1. EVALUATION OF SLEEPINESS 8
2.1.2. CAUSES OF EXCESSIVE DAYTIME SLEEPINESS 9
2.1.3. HYPERSOMNIAS OF CENTRAL ORIGIN 9
2.2. NARCOLEPSY 13
2.2.1. THE HISTORY OF THE DIAGNOSIS OF NARCOLEPSY 13
2.2.2. CLASSIFICATION: NARCOLEPSY WITH AND WITHOUT CATAPLEXY 16
2.2.3. CLINICAL SYMPTOMS 18
2.2.4. ETIOLOGY 23
2.2.5. PATHOPHYSIOLOGY 25
2.2.6. EPIDEMIOLOGY 27
2.2.7. DIAGNOSIS 27
2.2.8. TREATMENT OF NARCOLEPSY 28
2.3. IDIOPATHIC HYPERSOMNIA 33
2.3.1. HISTORY OF THE DIAGNOSIS OF IDIOPATHIC HYPERSOMNIA 33
2.3.2. CLASSIFICATION: IDIOPATHIC HYPERSOMNIA WITH AND WITHOUT LONG
SLEEP TIME 35
2.3.3. CLINICAL SYMPTOMS 37
2.3.4. ETIOLOGY 38
2.3.5. PATHOPHYSIOLOGY 38
2.3.6. EPIDEMIOLOGY 38
2.3.7. .DIAGNOSIS 39
2.3.8. TREATMENT OF IDIOPATHIC HYPERSOMNIA 40
2.4. DEPRESSION 41
2.4.1. HISTORICAL ASPECTS OF DEPRESSION 41
2.4.2. CLASSIFICATION AND DIFFERENT NAMES FOR DEPRESSION 41
2.4.3. DIAGNOSIS OF DEPRESSION ACCORDING TO DSM-IV AND ICD-10 45
2.4.4. SEVERITY OF DEPRESSION ACCORDING TO DSM-IV AND ICD-10 48
2.4.5. CORE SYMPTOMS OF DEPRESSION 49
2.4.6. PROBLEMS IN THE DIAGNOSTIC OF DEPRESSION RELATED TO
HYPERSOMNIA...52
2.4.7. EPIDEMIOLOGY 53
HTTP://D-NB.INFO/1028789041
IMAGE 2
3
2.4.8. THEORIES ABOUT DEPRESSION RELATED TO SLEEP ABNORMALITIES 55
2.5. HYPERSOMNIA AND DEPRESSION 59
2.5.1. SIMILARITIES 59
2.5.2. POSSIBLE CAUSES OF DEPRESSION 61
2.5.3. PREVALENCE OF DEPRESSION IN NARCOLEPSY 64
2.5.4. PREVALENCE OF DEPRESSION IN IDIOPATHIC HYPERSOMNIA 66
2.5.5. KEY REFERENCES RELATED TO DEPRESSION AND DAYTIME SLEEPINESS 66
2.6. RESEARCH QUESTIONS AND HYPOTHESIS 68
3. EMPIRICAL PART I: DEPRESSIVE SYMPTOMS IN NARCOLEPSY WITH AND
WITHOUT CATAPLEXY AND IDIOPATHIC HYPERSOMNIA 70
3.1. INTRODUCTION 70
3.2. METHODS 72
3.2.1. PARTICIPANTS 72
3.2.2. PROCEDURE AND QUESTIONNAIRES 73
3.2.3. STATISTICAL ANALYSIS 75
3.3. RESULTS 77
3.3.1. DEMOGRAPHIC AND CLINICAL CHARACTERISTICS 77
3.3.2. DEPRESSIVE SYMPTOMS - UNIVARIATE ANALYSIS 79
3.3.3. VARIABLES INFLUENCING DEPRESSION- MULTIVARIATE ANALYSIS 89
4. EMPIRICAL PART II: NARCOLEPTICS WITH DEPRESSIVE SYMPTOMS COMPARED
TO PATIENTS WITH DEPRESSION 93
4.1. INTRODUCTION 93
4.2. METHODS 94
4.2.1. PROCEDURE AND QUESTIONNAIRES 94
4.2.2. PARTICIPANTS 95
4.2.3. STATISTICAL ANALYSIS 97
4.3. RESULTS 97
4.3.1. MEDICATION USE 97
4.3.2. COMPARISON OF MEAN SCORES AND GRADING DISTRIBUTION OF
DEPRESSIVE SYMPTOMS IN QUESTIONNAIRES 98
4.3.3. CORRELATIONS BETWEEN DIFFERENT MEASURES OF DEPRESSION 102
4.3.4. AGE AND SEX DIFFERENCES 106
4.3.5. SOMATIC AND AFFECTIVE ITEMS: DIFFERENCES BETWEEN GROUPS 107
IMAGE 3
4
4.3.6. DIFFERENCES IN THE STRUCTURE OF DEPRESSIVE SYMPTOMS BETWEEN
NARCOLEPTIC AND DEPRESSIVE PATIENTS 110
5. EMPIRICAL PART III: FACTOR ANALYSIS OF BECK DEPRESSION INVENTORY IN
PATIENTS WITH NARCOLEPSY 113
5.1. INTRODUCTION 113
5.2. METHOD 115
5.2.1. PARTICIPANTS 115
5.2.2. PROCEDURE AND QUESTIONNAIRE 115
5.2.3. STATISTICAL ANALYSIS 115
5.3. RESULTS 117
5.3.1. SOMATIC AND COGNITIVE ITEMS OF BDI 117
5.3.2. EXPLORATORY FACTOR ANALYSIS (EFAS) 118
6. DISCUSSION 121
6.1. DISCUSSION EMPIRICAL PART I: DEPRESSIVE SYMPTOMS IN NARCOLEPSY
WITH
AND WITHOUT CATAPLEXY AND IDIOPATHIC HYPERSOMNIA 121
6.1.1. PREDICTORS OF DEPRESSIVE SYMPTOMS 121
6.1.2. PRESENCE OF CATAPLEXY 122
6.1.3. SIMILARITIES WITH OTHER STUDIES 123
6.2. DISCUSSION EMPIRICAL PART II: NARCOLEPTICS WITH DEPRESSIVE
SYMPTOMS
COMPARED WITH PATIENTS WITH DEPRESSION 124
6.2.1. SLEEPINESS 124
6.2.2. SUBJECTIVE AND UNSPECIFIED QUESTION: DO YOU FEEL DEPRESSED? 126
6.3. DISCUSSION EMPIRICAL PART III: FACTOR ANALYSIS OF BECK DEPRESSION
INVENTORY IN PATIENTS WITH NARCOLEPSY 128
6.3.1. NEGATIVE ATTITUDE TOWARD SELF 128
6.3.2. COGNITIVE DIMENSION 129
6.4. OVERALL FINDINGS OF ALL THREE STUDIES 130
6.4.1. SIMILAR SEVERITY OF DEPRESSION IN NC+ AND NC- 130
6.4.2. DAYTIME SLEEPINESS SCORES AND MOOD STATE 131
6.4.3. EXCLUDING ITEMS RELATED TO SLEEPINESS FROM QUESTIONNAIRES 131
6.4.4. DETERMINANTS OF DEPRESSION IN NARCOLEPSY 132
6.4.5. DISTINCTIVE DEPRESSIVE SYMPTOMS BETWEEN NARCOLEPSY AND
DEPRESSION 133
IMAGE 4
5
6.4.6. RELEVANT ITEMS CONTRIBUTING TO DEPRESSION IN NARCOLEPSY
PATIENTS 134
6.4.7. LIMITATIONS OF THE DISSERTATION 135
6.4.8. FUTURE RESEARCH DIRECTIONS 136
7. CONCLUSION 138
8. SUMMARY 140
8.1. ENGLISH SUMMARY 140
8.2. GERMAN SUMMARY 143
8.3. SPANISH SUMMARY 145
9. REFERENCES 147
10. INDEX OF FIGURES AND TABLES 160
10.1. INDEX OF FIGURES 160
10.2. INDEX OF TABLES 161
11. APPENDICES 164
12. ACKNOWLEDGMENTS 176
13. DECLARATION 177
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| spelling | Jara Opazo, Cecilia Verfasser aut Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia vorgelegt von Cecilia Jara Opazo 2011 177 Bl. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Dissertation Universität Regensburg 2012 Depression (DE-588)4011474-0 gnd rswk-swf Kataplexie (DE-588)4402904-4 gnd rswk-swf Narkolepsie (DE-588)4200507-3 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Depression (DE-588)4011474-0 s Narkolepsie (DE-588)4200507-3 s Kataplexie (DE-588)4402904-4 s DE-604 Erscheint auch als Online-Ausgabe urn:nbn:de:bvb:355-epub-258028 https://nbn-resolving.org/urn:nbn:de:bvb:355-epub-258028 Resolving-System http://epub.uni-regensburg.de/25802/ Verlag kostenfrei Volltext DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025292278&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Jara Opazo, Cecilia Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia Depression (DE-588)4011474-0 gnd Kataplexie (DE-588)4402904-4 gnd Narkolepsie (DE-588)4200507-3 gnd |
| subject_GND | (DE-588)4011474-0 (DE-588)4402904-4 (DE-588)4200507-3 (DE-588)4113937-9 |
| title | Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia |
| title_auth | Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia |
| title_exact_search | Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia |
| title_full | Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia vorgelegt von Cecilia Jara Opazo |
| title_fullStr | Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia vorgelegt von Cecilia Jara Opazo |
| title_full_unstemmed | Depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia vorgelegt von Cecilia Jara Opazo |
| title_short | Depression in narcolepsy |
| title_sort | depression in narcolepsy a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia |
| title_sub | a comparative analysis of depression severity and daytime sleepiness in patients with narcolepsy and idiopathic hypersomnia |
| topic | Depression (DE-588)4011474-0 gnd Kataplexie (DE-588)4402904-4 gnd Narkolepsie (DE-588)4200507-3 gnd |
| topic_facet | Depression Kataplexie Narkolepsie Hochschulschrift |
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