Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
2012
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| Series: | Biological science
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| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 114 S. Ill., graph. Darst., Kt. |
| ISBN: | 9783863871949 |
Staff View
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Record in the Search Index
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| adam_text |
IMAGE 1
TABLE OF CONTENT
ZUSAMMENFASSUNG S U M M A R Y
LIST O F ABBREVATIONS 11
1 INTRODUCTION 14
1.1 CLINICAL S Y M P T O M S A N D EPIDEMIOLOGY O F HANTAVIRUSES 15
1.2 G E N O M E ORGANISATION, VIRUS STRUCTURE A N D REPLICATION 17
1.3 I M M U N E RESPONSE TO HANTAVIRUS INFECTION 2 0
1.4 PREVENTION A N D TREATMENT 3 2
2 A I M S A N D OBJECTIVES 3 4
3 MATERIALS A N D M E T H O D S 3 5
3.1 MATERIALS 3 5
3.1.1 BACTERIA 3 5
3.1.2 CELL LINES A N D P R I M A R Y CELLS 3 5
3.1.3 VIRUSES 3 5
3.1.4 PLASMIDS 3 6
3.1.5 CHEMICALS A N D REAGENTS 3 7
3.1.6 BUFFERS A N D SOLUTIONS 4 0
3.1.7 ANTIBODIES 4 1
3.1.8 KITS 4 1
3.1.9 INSTRUMENTS 4 2
3.1.10 SOFTWARE 4 3
3.1.11 CONSUMABLES 4 3
3.2 M E T H O D S 4 4
3.2.1 ETHICS 4 4
3.2.2 CELL BIOLOGICAL M E T H O D S 4 4
3.2.3 VIROLOGICAL M E T H O D S 4 6
3.2.4 MOLECULAR BIOLOGICAL M E T H O D S 4 8
8
HTTP://D-NB.INFO/1025236963
IMAGE 2
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6 1
62
6 5
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6 9
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7 5
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8 3
8 4
3.2.5 IMMUNOLOGICAL M E T H O D S
3.2.6 STATISTICS
RESULTS
R O L E O F PATTERN RECOGNITION RECEPTORS I N CONTROLLING H T N V
INFECTION
4.1.1 HANTAVIRUS INFECTION O F H U M A N LUNG EPITHELIAL CELLS
4.1.2 INCREASED H T N V REPLICATION IN R I G - I K D A 5 4 9 CELLS
4.1.3 R I G - I IS ACTIVATED B Y H T N V N O R F
4.1.4 H T N V N O R F EXPRESSION STIMULATES R I G - I THROUGH D S R N A
STRUCTURE
4.1.5 ANTIVIRAL RESPONSE AFTER TRANSFECTION O F H T N V N R N A INTO A 5
4 9 CELLS
4.1.6 L A C K O F ANTIVIRAL INNATE RESPONSES IN STABLE RIG-I K N O C K -
D O W N CELLS AFTER
H T N V INFECTION
4.1.7 INTERFERON RESPONSES IN H T N V INFECTED ALVEOLAR EPITHELIAL CELLS
4.1.8 I N F L A M M A S O M E S IN HANTAVIRUS INFECTION
M E C H A N I S M O F HANTAVIRUS-INDUCED M H C - I UPREGULATION
4.2.1 M H C - I UPREGULATION O N HANTAVIRUS-INFECTED EPITHELIAL CELLS
4.2.2 R I G - I A N D T R I F IS ESSENTIAL FOR HANTAVIRUS-MEDIATED M H C
- 1 UP-REGULATION
4.2.3 M H C - I UP-REGULATION O N HANTAVIRUS-INFECTED CELLS IS R I G - I
D E P E N D E N T A N D
I F N INDEPENDENT
4.2.4 DIFFERENTIAL M H C - I EXPRESSION W I T H PATHOGENIC A N D
APATHOGENIC HANTAVI
RUSES
4.2.5 PROTEASOME A N D ANTIGEN PRESENTATION M A C H I N E R Y ARE
INDISPENSABLE FOR H L A
CLASS I UP-REGULATION IN H T N V INFECTION
4.2.6 H T N V - I N F E C T E D D C S CROSS-PRESENT ANTIGEN T O
HLA-RESTRICTED T CELLS
DISCUSSION
R N A HELICASE RETINOIC ACID-INDUCIBLE G E N E I IS A SENSOR O F H T N V
REPLICATION
5.1.1 R I G - I IS A SENSOR O F H T N V REPLICATION
5.1.2 H T N V N O R F ACTIVATES R I G - I SIGNALLING
5.1.3 R O L E O F INTERFERONS IN HANTAVIRUS INFECTION
5.1.4 I N F L A M M A S O M E ACTIVATION IN H T N V - I N F E C T E D
DENDRITIC CELLS
HANTAVIRUS ACTIVATION O F M H C CLASS I A N T I G E N PRESENTATION
THROUGH H U M A N I N
9
IMAGE 3
NATE SENSORS
5.2.1 HANTAVIRUS-UPREGULATES CELL SURFACE M H C - I 8 4
5.2.2 HANTAVIRUS MODULATES PATTERN RECOGNITION RECEPTORS TO INCREASE M H
C - I EX- 8 6
PRESSION
5.2.3 IMPORTANCE O F PROTEASOME A N D ANTIGEN PRESENTATION M A C H I N E
R Y 8 7
5.2.4 HANTAVIRUS INFECTED CELLS CROSS-PRESENT ANTIGEN TO PEPTIDE
SPECIFIC H L A RE- 8 8
STRICTED T CELLS
6 O U T L O O K 9 1
7 REFERENCE 9 3
A P P E N D I X 1 0 9
A C K N O W L E D G E M E N T 1 1 0
C U R R I C U L U M VITAE 1 1 1
L I S T O F PUBLICATIONS 1 0 3
EIDESTATTLICHE E R K L A R U N G 1 1 4
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| isbn | 9783863871949 |
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| physical | 114 S. Ill., graph. Darst., Kt. |
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| spelling | Lalwani, Pritesh Jaychand 1985- Verfasser (DE-588)1025049233 aut Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells von Pritesh Jaychand Lalwani 2012 114 S. Ill., graph. Darst., Kt. txt rdacontent n rdamedia nc rdacarrier Biological science Zugl.: Berlin, Humboldt-Univ., Diss., 2012 Antigenpräsentation (DE-588)4211468-8 gnd rswk-swf Hanta-Virus (DE-588)4586349-0 gnd rswk-swf Pathogenität (DE-588)4205990-2 gnd rswk-swf Antigenrezeptor (DE-588)4410980-5 gnd rswk-swf MHC Klasse I (DE-588)4313494-4 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Hanta-Virus (DE-588)4586349-0 s Pathogenität (DE-588)4205990-2 s Antigenpräsentation (DE-588)4211468-8 s MHC Klasse I (DE-588)4313494-4 s Antigenrezeptor (DE-588)4410980-5 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025215510&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Lalwani, Pritesh Jaychand 1985- Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells Antigenpräsentation (DE-588)4211468-8 gnd Hanta-Virus (DE-588)4586349-0 gnd Pathogenität (DE-588)4205990-2 gnd Antigenrezeptor (DE-588)4410980-5 gnd MHC Klasse I (DE-588)4313494-4 gnd |
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| title | Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells |
| title_auth | Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells |
| title_exact_search | Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells |
| title_full | Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells von Pritesh Jaychand Lalwani |
| title_fullStr | Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells von Pritesh Jaychand Lalwani |
| title_full_unstemmed | Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells von Pritesh Jaychand Lalwani |
| title_short | Hantavirus-driven mechanisms enhancing the MHC class I antigen presentaion machinery in human cells |
| title_sort | hantavirus driven mechanisms enhancing the mhc class i antigen presentaion machinery in human cells |
| topic | Antigenpräsentation (DE-588)4211468-8 gnd Hanta-Virus (DE-588)4586349-0 gnd Pathogenität (DE-588)4205990-2 gnd Antigenrezeptor (DE-588)4410980-5 gnd MHC Klasse I (DE-588)4313494-4 gnd |
| topic_facet | Antigenpräsentation Hanta-Virus Pathogenität Antigenrezeptor MHC Klasse I Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025215510&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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