MicroRNAs in development:
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
Amsterdam [u.a.]
Elsevier Acad. Press
2012
|
| Edition: | 1. ed. |
| Series: | Current topics in developmental biology
99 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XII, 301 S., [7] Bl. graph. Darst. |
| ISBN: | 9780123870384 |
Staff View
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| 245 | 1 | 0 | |a MicroRNAs in development |c ed. by Eran Hornstein |
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Record in the Search Index
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| adam_text | Titel: MicroRNAs in development
Autor: Hornstein, Eran
Jahr: 2012
Contents
Contributors ix
Preface xi
1. Let s Make It Happen: The Role of let-7 MicroRNA in Development 1
Vanessa Mondol and Amy E. Pasquinelli
1. Introduction 2
2. The Discovery of miRNAs 7
3. The Role of let-7 in C- elegans Development 11
4. The Role of let-7 in Development and Disease Across Species 18
5. Conclusions 21
Acknowledgments 21
References 22
2. Evolution, Expression, and Developmental Function of
Hox-Embedded miRNAs 31
Jennifer H. Mansfield and Edwina McGlinn
1. Introduction 32
2. Genomic Organization and Evolution 36
3. Predicted Targets of Hox-Embedded miRNAs: A Role in Posterior
Prevalence, and More? 39
4. miR-10 42
5. miR-iab-4/miR-iab-8 45
6. miR-196 48
7. Summary and Conclusions 51
Acknowledgments 53
References 54
3. The Role of MicroRNAs in Muscle Development 59
Nicholas S. Sokol
1. Introduction 60
2. Muscle miRNA Regulatory Networks 60
3. Functional Analysis of miRNAs During Muscle Development 65
4. miRNAs in Muscle Stem Cells 73
vi Contents
5. Concluding Remarks 74
References 75
4. Small RNAs in Germ Cell Development 79
Torsten U. Banisch, Mehdi Goudarzi, and Erez Raz
1. Introduction: The Germ Cell Lineage and Small RNA Molecules 80
2. miRNAs in Germ Cell Development 85
3. Endogenous-siRNAs in Germ Cell Development 93
4. piRNAs in Germ Cell Development 95
5. Conclusion 99
Acknowledgments 100
References 100
5. Diverse Functions of MicroRNAs in Nervous System Development 115
Luisa Cochella and Oliver Hobert
1. Introduction 116
2. Diverse Roles of miRNAs in Nervous System Development and Function 117
3. Neuronal-Specific Aspects of miRNA Function 13a
4. Integration of miRNA Function into Gene Regulatory Networks 135
5. Concluding Remarks 139
Acknowledgments 139
References 139
6. MicroRNAs and Hematopoietic Cell Development 145
Ryan M. O Connell and David Baltimore
1. Introduction 146
2. The Emerging Importance of MicroRNAs During Hematopoietic
Development 147
3. Controlling MicroRNA-Mediated Repression of mRNATargets 152
4. MicroRNAs Regulate Different Stages of Hematopoiesis 155
5. MicroRNAs During Hematopoietic Stress and Disease 159
6. Concluding Remarks 163
Acknowledgments 166
References 167
7. A miR Image of Stem Cells and Their Lineages 175
Rui Yi and Elaine Fuchs
1. Introduction 176
2. The Discovery of miRs and Their Roles in Caenorhabditis elegans 177
3. The Biogenesis Pathways of miR 178
Contents vii
4. Mammalian Skin as a Model to Uncover How miRs Regulate Stem
Cell Biology and Tissue Morphogenesis 180
5. Insights into the Global Role of miRs in the Skin Epithelium:
Conditional Ablation of Dicer 181
6. Conditional Ablation of Dgcr8 184
7. Dissecting the Complexities of the Differential Expression
of miRs in Skin 184
8. miR-203 as a Tumor Suppressor? 186
9. Characterizing and Defining the Functions of Specific miRs that
are Differentially Expressed by HF Stem Cells 187
10. Delving Further into miR Functions in Stem Cells:
The Hematopoietic System 188
11. miR Function in Neural Stem Cells 190
12. miR Function in Muscle Stem Cells 191
13. miR Function in Cancer Stem Cells 191
14. Closing Remarks and Future Challenges 193
Acknowledgments 195
References 195
8. Exploiting Drosophila Genetics to Understand MicroRNA
Function and Regulation 201
Qi Dai, Peter Smibert, and Eric C. Lai
1. Introduction 202
2. Generation of miRNA Mutants 204
3. The Gal4-UAS System for Transgene Activation 213
4. Genetic Interactions and Epistasis Tests 218
5. Detecting miRNA Expression and Activity In Vivo 223
6. Conclusions and Future Prospects 228
Acknowledgments 230
References 230
9. Biological Robustness and the Role of MicroRNAs: A Network
Perspective 237
Nicolas Pelâez and Richard W. Carthew
1. MicroRNAs and Large-Scale Networks 238
2. MicroRNAs and Circuits 245
3. Conclusion 252
Acknowledgments 252
References 253
Index 257
Contents of Previous Volumes 263
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| isbn | 9780123870384 |
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| spelling | MicroRNAs in development ed. by Eran Hornstein 1. ed. Amsterdam [u.a.] Elsevier Acad. Press 2012 XII, 301 S., [7] Bl. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Current topics in developmental biology 99 miRNS (DE-588)7736808-3 gnd rswk-swf Entwicklungsphysiologie (DE-588)4152449-4 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Entwicklungsphysiologie (DE-588)4152449-4 s miRNS (DE-588)7736808-3 s DE-188 Hornstein, Eran Sonstige (DE-588)1022158899 oth Current topics in developmental biology 99 (DE-604)BV002685390 99 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025116440&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | MicroRNAs in development Current topics in developmental biology miRNS (DE-588)7736808-3 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd |
| subject_GND | (DE-588)7736808-3 (DE-588)4152449-4 (DE-588)4143413-4 |
| title | MicroRNAs in development |
| title_auth | MicroRNAs in development |
| title_exact_search | MicroRNAs in development |
| title_full | MicroRNAs in development ed. by Eran Hornstein |
| title_fullStr | MicroRNAs in development ed. by Eran Hornstein |
| title_full_unstemmed | MicroRNAs in development ed. by Eran Hornstein |
| title_short | MicroRNAs in development |
| title_sort | micrornas in development |
| topic | miRNS (DE-588)7736808-3 gnd Entwicklungsphysiologie (DE-588)4152449-4 gnd |
| topic_facet | miRNS Entwicklungsphysiologie Aufsatzsammlung |
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