Cellular therapy of cancer: development of gene therapy based approaches
Gespeichert in:
| Format: | Buch |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
New Jersey [u.a.]
World Scientific
2014
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | VII, 201 S. graph. Darst. |
| ISBN: | 9789814295130 9814295132 |
Internformat
MARC
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| 245 | 1 | 0 | |a Cellular therapy of cancer |b development of gene therapy based approaches |c ed.: Robert E. Hawkins |
| 264 | 1 | |a New Jersey [u.a.] |b World Scientific |c 2014 | |
| 300 | |a VII, 201 S. |b graph. Darst. | ||
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Datensatz im Suchindex
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|---|---|
| adam_text | Contents
Chapter
1
Challenges of
Т
-Cell
Therapy
1
Naomi
Taylor, Anna Mondino
and Balbino
Álarcon
1.1
Т
-Cell
Homcostasis
1
1.2
Lymphopenia and Immune Responsiveness
to Self-Antigens
2
1.3
CD4 and CD8 T-Cell Differentiation States
3
1.4
T-Cell Persistence and Trafficking to Tumor
6
1.5
Choice of Target Antigen
9
References
9
Chapter
2
Gene Transfer into
Τ
Cells
19
David Gilham and Hinricb Abken
2.1
Introduction
19
2.2
γ-
Retro viral Vectors to Generate
Gene-Modified
Τ
Cells
21
2.3
The Potential Drawbacks of
γ-
Re
tro vir
al
Vectors for
Τ-
Cell Gene Therapy
22
2.4
Improving All Aspects of
γ
-Retroviral
Gene
Transfer to Preserve or Enhance
Antigen-Specific T-Cell Function In Vivo
26
2.5
Lentiviral Vectors to Transduce Minimally
Stimulated and Quiescent Primary Human
Τ
Cells
29
vi
Contents
2.6
Other Viral Vectors Used to Transduce
Primary Human
Τ
Cells
31
2.7
Non-
Viral Gene Transfer Into Primary
Human
Τ
Cells: Plasmid-Based Systems
33
2.8
Non-
Viral Gene Transfer Into Primary
Human
Τ
Cells: Transposon Technology
34
2.9
Non-Viral Gene Transfer Into Primary
Human
Τ
Cells:
RNA
Vectors
35
2.10
Mouse Models of Gene-Modified T-Cell
Therapy
38
2.11
Summary
38
References
39
Chapter
3
TCR-Engineered
Τ
cells
49
Reno
Debets
and Ton Schumacher
3.1
Introduction
49
3.2
Generation of TCR
Τ
Cells That are
Not or Minimally Self-Reactive
52
3.3
Generation of TCRT Cells with Enhanced
Functional Avidity
60
3.4
Next Steps in TCR Gene Therapy
67
References
70
Chapter
4
Т
-Bodies: Antibody-Based Engineered
T-Cell Receptors
83
John
Bridgeman,
Andreas A. Hombach,
David Gilham,
Zelig
Eshhar and Hinrich Abken
4.1
Overview
83
4.2
A Long Way to the One-Chain Format:
A Brief History of T-Bodies
84
4.3
From Structure to Function
85
4.4
Clinical Studies
103
4.5
Perspectives 111
4.6
Summary
116
References
117
Contents
vii
Chapter
5
Τ-
Cell Engineering and Expansion
—
GMP
Issues
131
Cor
Lamers
and Ryan Guest
5.1
Introduction
131
5.2
Clinical Vectors
133
5.3
Ex Vivo Generation of Gene-Modified
Τ
Cells
144
5.4
Data Management and Regulatory Aspects
163
5.5
Future Developments
165
References
167
Chapter
6
Clinical Trial Design
179
Robert Hawkins, John
Haan
en
and Fiona Thistle thw ait
e
6.1
Introduction
179
6.2
Background
179
6.3
TIL Therapy
181
6.4
Engineered
Τ
Cells
—
Clinical Trials
186
6.5
Toxicities and Safety of ACT
190
6.6
Future Strategies
193
6.7
Conclusions
196
References
196
Cancer
research
has progressed enormously in
recent years. This review volume will address
recent findings
ín
the area of T-cell therapy
for cancer, including use of tumour infiltrating
lymphocytes (TILs) as a therapy for melanoma,
choice of target antigens, advances in engineered
receptors, methods of gene transfer to
Τ
cells,
review of celt processing methods and clinical trial
design. Written by leadings scientists in the field,
this up-to-date review on cancer research will be
an important reference source to the researchers
and healthcare professionals in the field.
|
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| isbn | 9789814295130 9814295132 |
| language | English |
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| spelling | Cellular therapy of cancer development of gene therapy based approaches ed.: Robert E. Hawkins New Jersey [u.a.] World Scientific 2014 VII, 201 S. graph. Darst. txt rdacontent n rdamedia nc rdacarrier Krebs Medizin (DE-588)4073781-0 gnd rswk-swf Gentherapie (DE-588)4296957-8 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Krebs Medizin (DE-588)4073781-0 s Gentherapie (DE-588)4296957-8 s DE-604 Hawkins, Robert E. Sonstige oth Erscheint auch als Online-Ausgabe 978-981-4295-14-7 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025111356&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025111356&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Cellular therapy of cancer development of gene therapy based approaches Krebs Medizin (DE-588)4073781-0 gnd Gentherapie (DE-588)4296957-8 gnd |
| subject_GND | (DE-588)4073781-0 (DE-588)4296957-8 (DE-588)4143413-4 |
| title | Cellular therapy of cancer development of gene therapy based approaches |
| title_auth | Cellular therapy of cancer development of gene therapy based approaches |
| title_exact_search | Cellular therapy of cancer development of gene therapy based approaches |
| title_full | Cellular therapy of cancer development of gene therapy based approaches ed.: Robert E. Hawkins |
| title_fullStr | Cellular therapy of cancer development of gene therapy based approaches ed.: Robert E. Hawkins |
| title_full_unstemmed | Cellular therapy of cancer development of gene therapy based approaches ed.: Robert E. Hawkins |
| title_short | Cellular therapy of cancer |
| title_sort | cellular therapy of cancer development of gene therapy based approaches |
| title_sub | development of gene therapy based approaches |
| topic | Krebs Medizin (DE-588)4073781-0 gnd Gentherapie (DE-588)4296957-8 gnd |
| topic_facet | Krebs Medizin Gentherapie Aufsatzsammlung |
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