Merkel cell carcinoma: a multidisciplinary approach
Saved in:
| Format: | Book |
|---|---|
| Language: | English |
| Published: |
London
Imperial College Press
2011
|
| Series: | Molecular medicine and medicinal chemistry
2 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Klappentext |
| Physical Description: | XXXI, 341 S. Ill., graph. Darst. |
| ISBN: | 9781848163126 1848163126 |
Staff View
MARC
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| 245 | 1 | 0 | |a Merkel cell carcinoma |b a multidisciplinary approach |c ed.: Vernon K. Sondak ... |
| 264 | 1 | |a London |b Imperial College Press |c 2011 | |
| 300 | |a XXXI, 341 S. |b Ill., graph. Darst. | ||
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Record in the Search Index
| _version_ | 1804149250083258368 |
|---|---|
| adam_text | Contents
Contributors
xv
Foreword
Ronald
С.
DeConti, Jonathan S.
Zager, Jane L.
Messina
and Vernon K. Sondak
xxiii
Acknowledgments
xxvii
Introduction
Ronald
С
DeConti, Jonathan S.
Zager, Jane L.
Messina
and Vernon K. Sondak
xxix
Chapter
1.
Epidemiology and Etiology of
Merkel
Cell
Carcinoma
Maria Agelli and Limin X. Clegg
l.l Origin, Nomenclature and Histopathological
2
Coding
.2
Epidemiology
4
1.3
Characteristics of Cases
9
.4
Relative Survival
11
.5
Epidemiology of
Merkel
Cell Carcinoma of
14
Mucosal Anatomic Sites
1.6
Etiology
18
.7
Summary
24
References
26
VII
viii Contents
Chapter
2.
Basic Pathobiology of
Merkel
Cell Carcinoma
35
Jürgen
С.
Becker, David Schrama and
Roland Houben
■ =
2.1
Evasion of Apoptosis
35
2.2
Self-Sufficiency in Growth Signals
37
2.3
Insensitivity to Growth-Inhibitory Signals
39
2.4
Limitless
Replicative
Potential
45
2.5
Sustained Angiogenesis
46
2.6
Tissue Invasion and Metastasis
47
2.7
Escape from Immune Surveillance
49
2.8
Future Directions
50
References
50
Chapter
3.
Association Between
Merkel
Cell Polyomavirus
55
and
Merkel
Cell Carcinoma
Dana E. Rollison and
Jürgen
С.
Becker
3.1
Introduction: Viral Infections and Cancer
55
3.2 Merkel
Cell Carcinoma in the Context of
56
Immunosuppression
3.3
Polyomaviruses and Cancer
57
3.4 Merkel
Cell Polyomavirus
60
3.5 Merkel
Cell Polyomavirus in
Merkel
Cell
66
Carcinoma Tissues
3.6 Merkel
Cell Polyomavirus and
Merkel
Cell
69
Carcinoma Survival
3.7
MCPyV in Other Cancers
69
3.8
Conclusion and Future Directions
71
References
-. ..■· 73
Chapter
4.
Discovering
Merkel
Cell Carcinoma Through
81
Gene Expression Profiling
Ashani T. Weeraratna
4.1
Introduction
81
4.2
New Findings in
Merkel
Cell Carcinoma
81
Using Genomic Approaches
Contents
ix
4.3
Signaling Pathways Involved in
Merkel 84
Cell Carcinoma
4.4
Clinical Implications of Genomic
88
Approaches to
Merkel
Cell Carcinoma
References
89
Chapter
5.
Pathology of
Merkel
Cell Carcinoma
95
Jane L. Messina
5.1
Histogenesis of
Merkel
Cell Carcinoma
95
5.2
Light Microscopic Findings
97
5.3
Immunohistochemical Findings
106
5.4
Surgical Pathology of Sentinel Lymph Nodes
109
5.5
Ultrastructural
Findings
110
5.6
Cytopathology
112
5.7
Flow Cytometry
113
5.8
Conclusion
113
References
114
Chapter
6.
Clinical Recognition and Diagnosis of
Merkel 119
Cell Carcinoma
Mary
H. Lien, L.
>
Frank Glass and
Neil Alan Fenske
6.1
Clinical Features
119
6.2
Anatomic Distribution
122
6.3
AEIOU Acronym for
Merkel
Cell
123
Carcinoma
6.4
Differential Diagnoses
126
6.5
Diagnostic Workup
127
6.6
Summary
128
References
128
Chapter
7.
Current Staging Systems for
Merkel
Cell
131
Carcinoma
Bianca
D. Lemos
and Paul Ngheim
7.1
Existing Staging Systems for
Merkel 132
Cell Carcinoma
χ
Contents
7.2
Toward a Consensus TNM Staging System
134
7.3
Prognostic Factors and Staging Beyond TNM
136
References
, 139
Chapter
8.
New Prognostic Factors in
Merkel
Cell Carcinoma
143
Charles
Knapp,
Jonathan S.
Zager,
Jane L. Messina and Vernon K. Sondak
8.1
Introduction
143
8.2
Standard
Histologie
Features
144
8.3
Immunohistochemical Staining
146
8.4
Viral Infection and Prognosis
152
8.5
Genetic Abnormalities and Prognosis
153
8.6
Predictors of Response to Therapy
154
8.7
Prospects for the Future
154
References
155
Chapter
9.
Imaging of
Merkel
Cell Carcinoma
159
Simon
Brodsky,
Jonathan S.
Zager
and Claudia G. Berman
9.1
Introduction
159
9.2
Initial Imaging of Clinically Node-Negative
160
Primary
Merkel
Cell Carcinoma
9.3
Regional Nodal Evaluation
—
Sentinel
160
Lymph Node Biopsy
9.4
The Role of Ultrasound in Evaluating
169
Regional Nodal Basins
9.5
Imaging of Patients with Stage III Disease
169
9.6
Imaging Modalities to Evaluate Metastatic
170
Merkel
Cell Carcinoma
9.7 Merkel
Cell Carcinoma from Unknown
176
Primary Sites
9.8
Follow-Up
176
9.9
Conclusion
177
References
177
Contents
x¡
Chapter
10.
Surgical Management of
Merkel
Cell Carcinoma
181
Melanie
D.
Prince,
С.
Wayne Cruse,
Vernon K. Sondak and Jonathan S.
Zager
10.1
Primary Tumor Excision
181
10.2
Surgical Management of Head and
185
Neck
Merkel
Cell Carcinoma
10.3
Reconstruction of the Excision Defect
185
10.4
Surgical Treatment of Regional
Merkel 188
Cell Carcinoma
10.5
Clinically Positive Lymph Node Involvement
194
10.6 Merkel
Cell Carcinoma from an Unknown
195
Primary
10.7
Surgical/Regional Therapy for In-Transit
196
Metastatic
Merkel
Cell Carcinoma
10.8
Surgical Treatment of Metastatic
Merkel 197
Cell Carcinoma
References
197
Chapter
11.
Special Considerations in the Surgical Management
201
of
Merkel
Cell Carcinoma in the Head and Neck
Melanie
L.
Aya-Äy,
Tapan A.
Padhya
and C. Wayne Cruse
11.1
Head and Neck Anatomy
201
11.2
Clinical Diagnosis
206
11.3
Surgical Excision
207
11.4
Lymphatic Mapping and Sentinel
208
Node Biopsy
11.5
Neck Dissection
210
11.6
Considerations in Reconstruction
210
References
216
Chapter
12.
The Role of Mohs
Micrographic
Surgery
221
in
Merkel
Cell Carcinoma
Basil S. Cherpelis
12.1
Introduction
221
xii Contents
12.2
Efficacy in
Merkel
Cell Carcinoma
224
12.3
Conclusion
226
References
. « 226
Chapter
13.
Radiation in the Management of Primary and
229
Regional
Merkel
Cell Carcinoma
George Hruby and John F. Thompson
13.1
Introduction
229
13.2
Definitive Radiation Treatment
229
13.3
Adjuvant Radiation Treatment
231
13.4
The Role of Chemoradiation in the
233
Treatment of
Merkel
Cell Carcinoma
References
· , 235
Chapter
14.
Management of Recurrent and Metastatic
239
Merkel
Cell Carcinoma
Ronald
C. DeConti
14.1
Local and In-Transit Recurrences
240
14.2
Nodal Recurrence
242
14.3
Nodal Disease with Unknown Primary
245
14.4
Distant Metastatic Disease
245
14.5
Toxicity
and Patient Selection Factors
249
14.6
The Future
. 252
References
■ -■■■■ 252
Chapter
15.
Adjuvant Chemotherapy of
Merkel 257
Cell Carcinoma
Ronald
С
DeConti
·
15.1
Neoaďjuvant
Chemotherapy
259
15.2
Post-Surgical Adjuvant Therapy Experiences
259
15.3
Concurrent Chemoradiotherapy
261
15.4
Future Directions
262
References
263
Contents
Chapter
16. The Potential
for Targeted Therapy of
267
Merkel
Cell Carcinoma
Wolfram A. Samlowski and
Jürgen
С.
Becker
16.1
Potential Molecular Targets in
Merkel
268
Cell Carcinoma
16.2
Recently Completed Clinical Trials of
271
Signaling Inhibitors
16.3
Future Directions
272
References
273
Chapter
17.
Potential for Immunotherapy in
Merkel
Cell
279
Carcinoma
Kelly M. McLean, Ronald C. DeConti
and
Vernou
К.
Sondak
17.1
Introduction
279
17.2
Parallels with
Neuroendocrine
281
Tumor Therapy
17.3
Application of Immunotherapy
283
Techniques from Melanoma
17.4
Potential Viral Protein Derived
285
Immunotherapy Targets
17.5
Other Protein Targets
287
17.6
Challenges
291
17.7
Conclusion
293
References
293
Chapter
18.
Establishing a Multidisciplinary
Merkel
Cell
303
Carcinoma Clinic
Evans C. Bailey, Sandra L. Wong
and Christopher K. Bichakjian
18.1
Benefits of Multidisciplinary Care
303
18.2
Developing a Multidisciplinary
Merkel 307
Cell Carcinoma Clinic
References
310
xiv Contents
Appendix
I. Guidelines for Individualized
Management 313
and Opportunities for Further
Research
Christopher A. Puleo, Jonathan S.
Zager
and Vernon
К.
Sondak
Appendix
II.
Merkel
Cell Carcinoma: Information for Patients,
319
Families and
Caregivers
Frequently Asked Questions
Mary H. Lien, Darcelle
Welker,
Stephanie Andrews
and Paul Nghiem
Appendix III. Internet Resources Relating to
Merkel
Cell
323
Carcinoma for Providers, Patients, Family
Members and Caregivers
Rosalind E. Atchison, Angie Paniagua
and Jane L. Messina
Index
329
Merkel
cell carcinoma is an uncommon but not rare aggressive cutaneous
malignancy. It has many similarities to melanoma, particularly in the need
for aggressive multidisciplinary treatment, but far less is known about this
disease by most practicing physicians. This book summarizes all of the
existing knowledge about
Merkel
cell carcinoma and provides a much-
needed perspective on future opportunities for diagnostic and therapeutic
advances. It offers practical how to advice on diagnosis, treatment and
follow-up, and also insight into how to establish a multidisciplinary
Merkel
cell carcinoma clinic. In addition, it will serve as a unique resource for trainees
(medical students, residents and fellows) as well as for
Merkel
cell carcinoma
patients and their advocates and caregivers. There is currently no such
textbook, even an outdated one, covering this topic. V;
|
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| id | DE-604.BV040252685 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T00:20:02Z |
| institution | BVB |
| isbn | 9781848163126 1848163126 |
| language | English |
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| physical | XXXI, 341 S. Ill., graph. Darst. |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Imperial College Press |
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| series | Molecular medicine and medicinal chemistry |
| series2 | Molecular medicine and medicinal chemistry |
| spelling | Merkel cell carcinoma a multidisciplinary approach ed.: Vernon K. Sondak ... London Imperial College Press 2011 XXXI, 341 S. Ill., graph. Darst. txt rdacontent n rdamedia nc rdacarrier Molecular medicine and medicinal chemistry 2 Merkel-Zellkarzinom (DE-588)4613919-9 gnd rswk-swf Merkel-Zellkarzinom (DE-588)4613919-9 s DE-604 Sondak, Vernon K. Sonstige oth Molecular medicine and medicinal chemistry 2 (DE-604)BV036891092 2 Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025108621&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025108621&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Merkel cell carcinoma a multidisciplinary approach Molecular medicine and medicinal chemistry Merkel-Zellkarzinom (DE-588)4613919-9 gnd |
| subject_GND | (DE-588)4613919-9 |
| title | Merkel cell carcinoma a multidisciplinary approach |
| title_auth | Merkel cell carcinoma a multidisciplinary approach |
| title_exact_search | Merkel cell carcinoma a multidisciplinary approach |
| title_full | Merkel cell carcinoma a multidisciplinary approach ed.: Vernon K. Sondak ... |
| title_fullStr | Merkel cell carcinoma a multidisciplinary approach ed.: Vernon K. Sondak ... |
| title_full_unstemmed | Merkel cell carcinoma a multidisciplinary approach ed.: Vernon K. Sondak ... |
| title_short | Merkel cell carcinoma |
| title_sort | merkel cell carcinoma a multidisciplinary approach |
| title_sub | a multidisciplinary approach |
| topic | Merkel-Zellkarzinom (DE-588)4613919-9 gnd |
| topic_facet | Merkel-Zellkarzinom |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025108621&sequence=000003&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=025108621&sequence=000004&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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